genetic etiology of breast and reproductive cancers
Association analysis of genetic variation of estrogen related candidate genes in breast and endometrial cancers
... DEPARTMENT OF EPIDEMIOLOGY AND PUBLIC HEALTH YONG LOO LIN SCHOOL OF MEDICINE NATIONAL UNVERISTIY OF SINGAPORE Association Analysis of Genetic Variation of Estrogen Related Candidate Genes in Breast and ... ESR2 and breast cancer risk 7.5 Candidate gene based genetic association study Candidate genes are chosen in genetic association studies based on previous knowledge of mechanisms of diseases In breast ... 7.2 Subtypes of breast and endometrial cancer 23 7.3 Determination of ER phenotype and reliability of testing .25 7.4 Genetic polymorphisms in Estrogen Receptor .29 7.5 Candidate gene...
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The functional investigation of forkhead factor FOXQ1 in human breast and colon cancers
... similarities with basal-like breast cancer in terms of genetic makeup and tumor behavior Overall, triple-negative and basal-like breast cancer accounts for 12-17% of all types of breast cancer (Cleator, ... 6 1.2.1 Epidemiology of breast cancer 6 1.2.2 Internal structure of mammary gland 6 1.2.3 Subtypes of breast cancer 9 1.2.4 Treatment of breast cancer 11 ... Calster, Vanden Bempt et al 2009) Both triple-negative and basal-like breast cancers are more likely than other subtypes of breast cancers to metastasize, particularly to the lungs and brain,...
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Tài liệu The Contribution of Sexual and Reproductive Health Services to the Fight against HIV/AIDS: A Review pptx
... protection, and HIV prevention, and expanded outreach to those at greater risk of STIs/HIV For others, such as antenatal care and STI care for adolescents and core transmitters of HIV, some form of ‘‘integration’’ ... health care and family planning facilities should offer the widest achievable range of safe and effective family planning methods, essential obstetric care, prevention and management of reproductive ... (including for sexual and reproductive health services), and the urgency to respond to AIDS, tuberculosis and malaria, has created numerous obstacles Organisation of sexual and reproductive health...
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GENETIC MANIPULATION OF DNA AND PROTEIN – EXAMPLES FROM CURRENT RESEARCH pptx
... domain of Gal4 of yeast (pGAD424-X) A suspected interacting Genetic Manipulation of DNA and Protein – Examples from Current Research Fig Crystal structure of Tus-Ter complex of E coli and RTP ... Kolter and Helinski, 1978) and in its host E coli (Kuempel et al., 1977) The terminus region of R6K was identified and sequenced (Bastia et al., 1981) and subsequently shown to consist of a pair of ... 2-hybrid based selection of random mutations (described below), and biochemical characterizations of the mutant forms of the Tus protein, many aspects of the mechanism of replication fork arrest...
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Genetic Manipulation of DNA and Protein – Examples from Current Research Edited by David Figurski potx
... domain of Gal4 of yeast (pGAD424-X) A suspected interacting Genetic Manipulation of DNA and Protein – Examples from Current Research Fig Crystal structure of Tus-Ter complex of E coli and RTP ... Kolter and Helinski, 1978) and in its host E coli (Kuempel et al., 1977) The terminus region of R6K was identified and sequenced (Bastia et al., 1981) and subsequently shown to consist of a pair of ... 2-hybrid based selection of random mutations (described below), and biochemical characterizations of the mutant forms of the Tus protein, many aspects of the mechanism of replication fork arrest...
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TOWARDS A COMPREHENSIVE APPROACH OF SEXUAL AND REPRODUCTIVE RIGHTS AND NEEDS OF WOMEN DISPLACED BY WAR AND ARMED CONFLICT pptx
... Improve health and nutritional status of women, especially pregnant, and of infants and children By 2005: 60% of PHC and FP facilities should offer prevention and management of reproductive tract ... the sexual and reproductive rights and needs of women displaced by war and armed conflict The basic assumption of the guide is that sexual and reproductive rights are human rights, and more specifically ... contribution of specific projects to coordinated efforts in the field of SRH The guide focuses on the sexual and reproductive rights and needs of women in emergencies and in the stabilized phase of conflict...
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Báo cáo khoa học: Molecular and genetic characterization of osmosensing and signal transduction in the nematode Caenorhabditis elegans docx
... process of interest, allows genes to be ordered into pathways, and can provide important and novel mechanistic insights into the molecular structure and function of proteins In addition to forward genetic ... genes also causes accumulation of damaged proteins and activation of gpdh-1 expression Green arrows and red lines indicate activation and inhibition, respectively Role of cuticle collagens in regulating ... proteins [11] Mutant alleles of three of these genes, osr-1, osm-7 and osm-11, have been characterized and shown to cause constitutive accumulation of glycerol [25,29] osr-1 and osm-7 are expressed...
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Báo cáo khoa học: "Genetic control of pulp and timber properties in maritime pine (Pinus pinaster Ait.)" docx
... between traits x and y and σpy is the phenotypic standard deviation of trait y Finally, because of the high number of traits contributing to wood quality and the general requirement of forest tree ... combining ability (SCA) of the cross between the i-th and the j-th parent and εijk is the residual term The additive and dominance variances are:σ = 4σ and σ = 4σ and and the phenotypic variance ... determinism of a large set of wood properties in a half diallel Genetic parameters including heritabilities and genetic correlations are presented and a breeding strategy for the utilisation of maritime...
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Báo cáo sinh học: "Genetic variability of age and weight at puberty, ovulation rate and embryo survival in gilts and relations with production traits" pot
... differences and genetic parameters of age and weight at first estrus, ovulation rate and embryo survival and their relationships with production traits in gilts MATERIALS AND METHODS Animals and data ... Conversely, the parents of most dams and the paternal grandams were generally unknown Part of these data were previously analyzed by Legault (1973) and Legault and Gruand (1981), but genetic parameter ... The value of selecting for early puberty and/ or components of litter size depends on their genetic variability and genetic relationships with other economically important traits The aim of the present...
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Báo cáo y học: "Genetic polymorphism of ACE and the angiotensin II type1 receptor genes in children with chronic kidney disease" pps
... component of RAS and it determines the vasoactive peptide angiotensin-II Its inhibition reduces the pace of progression of the majority of chronic nephropathies [13,14] Among the candidate genes of ... interaction of multiple environmental and genetic factors Several studies had shown a relationship between genetic variants of the renin-angiotensin system genes and renal diseases as well as the rate of ... prevalence of LVH than group ID The highest LVMI was found in 15 athletes with ACE-DD and AGTR1-AC/CC genotypes and the lowest value of LVMI was found in the case of ACE-ID and AGTR1-AA The presence of...
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Báo cáo y học: " Genetic polymorphism of ACE and the angiotensin II type1 receptor genes in children with chronic kidney disease" pot
... component of RAS and it determines the vasoactive peptide angiotensin-II Its inhibition reduces the pace of progression of the majority of chronic nephropathies [13,14] Among the candidate genes of ... interaction of multiple environmental and genetic factors Several studies had shown a relationship between genetic variants of the renin-angiotensin system genes and renal diseases as well as the rate of ... prevalence of LVH than group ID The highest LVMI was found in 15 athletes with ACE-DD and AGTR1-AC/CC genotypes and the lowest value of LVMI was found in the case of ACE-ID and AGTR1-AA The presence of...
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Báo cáo sinh học: "Genetic analyses of Bantam and selected low-weight White Plymouth Rock chickens and their crosses. I. Growth, immunoresponsiveness and carcass " pdf
... at 5, 12 and 19 d after an intravenous injection of 0.1 ml of a 0.25% suspension of SRBC given at 10 wk of age Response was quantified by the microhemoagglutinin procedure of Wegmann and Smithies ... Comparison of linear regressions (r = 0.85) for growth of BBBB and l LLLL populations indicated significantly different slopes Body weights of males and females from all populations at and 28 wk of age ... significant and positive This difference in mode of inheritance for relative heart and lung in weight-selected populations is of interest because one is of mesodermal (heart) and the other of entodermal...
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Báo cáo sinh học: "Genetic analyses of Bantam and selected low-weight White Plymouth Rock chickens and their crosses. II. Onset of sexual maturity and egg production" ppt
... influence of a major gene and of sex-linkage on age at sexual maturity of these populations was examined MATERIALS AND METHODS White Plymouth Rock Bantams (supplied by CJ Wabeck, University of Maryland) ... by crossing of BB, BL, LB and LL chickens, randomly chosen samples of 15 males per line were placed in cages and checked weekly from wk of age for semen production Age at production of first semen ... Reciprocal effects were significant for maturity of males, age and body weight at first egg of females and weights of 1st and 10th eggs Influence of heterosis was evident for age at sexual maturity...
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Báo cáo khoa học: " Genetic analysis of ORF5 of recent Korean porcine reproductive and respiratory syndrome viruses (PRRSVs) in viremic sera collected from MLV-vaccinating or non-vaccinating farms" ppsx
... Vorwald AC, Lager KM Genetic variation and phylogenetic relationships of 22 porcine reproductive and respiratory syndrome virus (PRRSV) field strains based on sequence analysis of open reading frame ... putative M (ORF 6) and N (ORF 7) genes of porcine reproductive and respiratory syndrome virus (PRRSV): implication for the existence of two genotypes of PRRSV in the U.S.A and Europe Arch Virol ... J, Liu W, Liu DX Determination of the complete nucleotide sequence of a vaccine strain of porcine reproductive and respiratory syndrome virus and identification of the Nsp2 gene with a unique...
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Báo cáo sinh học: "A genetic evaluation of male reproductive fitness at early and late age in Drosophila melanogaster treated with" docx
... consisting of > 400 individuals of each sex per generation, was allowed to attain linkage equilibrium through > 30 generations of random mating A sample of 26 sires and 78 dams were taken at random and ... Quantitative genetic parameters for number of offspring as well as more standard genetic endpoints ( eg, sex proportion) were estimated in a succession of different broods at early and late age ... number of both female and male offspring and a high sterility among individuals from pre-meiotic cells is an indication of germinal selection The objective of this study was to explore the effect of...
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Optimal placement of horizontal - and vertical - axis wind turbines in a wind farm for maximum power generation using a genetic algorithm
... [4] of the wake and apply it to determine the wake of a VAWT Now, the cross-section area of the streamtube is a square of width 2R and height H instead of a circle From the conservation of momentum, ... G., Li X and Zhang X Optimal Micro-Siting of Wind Turbines by Genetic Algorithms Based on Improved Wind and Turbine Models Proc of Joint 48th IEEE Conference on Decision and Control and 28th ... optimization with genetic algorithm Figure Schematic of Werle's wake model [5] Wake, power and cost modeling of a VAWT 3.1 Single stream model of a VAWT The book by Manwell, McGowan and Rogers [7]...
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Tài liệu Voices of Fear and Safety¿ Women¿s ambivalence towards breast cancer and breast health: a qualitative study from Jordan pdf
... associated with suffering and death; b) fear of the risk of diminished femininity and husband’s rejection; c) fear of social stigmatization of the disease, and d) apprehensions about breast health examinations ... and breast cancer does not mean the end of life” (2, 2) Comfort in acquiring breast health knowledge and skills In all the FGDs, women talked about seeing or hearing about breast cancer and breast ... preference of female health providers, opposition of the husband or other male family members, lack of perceived benefits, perceptions that breast cancer is fatal and not curable, lack of time and lack...
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Tài liệu Sexual and Reproductive Health of HIV Positive Women and Adolescent Girls: A Dialogue on Rights, Policies and Services ppt
... and the Ukraine iii) Summary of Main Issues Raised The overarching issue - at the root of barriers to care, lack of services and low quality of existing care - was the high degree of stigma and ... Services and Policies Week 1: Sexual and reproductive health services for HIV-positive women: issues of concern and obstacles to care • • Which sexual and reproductive health issues of concern ... Discrimination and Rights Violations Stigmatizing and discriminatory attitudes toward HIV-positive women (and men) lie at the root of many human rights concerns and violations, and result in poor quality of...
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Tài liệu Sexual and reproductive health needs of adolescents perinatally infected with HIV in Uganda pptx
... Young People and HIV AIDS, and the Sexual and Reproductive Health Minimum Package for Uganda.4 The National Policy Guidelines and Service Standards for Sexual and Reproductive Health and Rights ... Standards for Sexual and Reproductive Health and Rights, Kampala, Uganda Ministry of Health (MOH) [Uganda] and ORC Macro 2006 Uganda HIV/AIDS SeroBehavioural survey 2004-2005, Calverton, Maryland, ... ministries and national-level institutions Uganda AIDS Commission Ministry of Health (Reproductive Health Unit) Ministry of Gender, Labour and Social Development Ministry of Education and Sports...
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Tài liệu Produced jointly by the British HIV Association (BHIVA), the British Association for Sexual Health & HIV (BASHH) and the Faculty of Family Planning & Reproductive Health Care doc
... and behavioural aspects of sexual and reproductive health- IV An updated understanding of HIV prevention, risk behaviour, reproduction and mother/father perspectives should feed into policy and ... costs and risks of multiple pregnancy and ovarian hyperstimulation associated with IVF and ICSI treatment Effect of HIV on semen parameters and the outcome of sperm washing IUI The majority of HIV-positive ... Introduction and general issues Addressing the sexual and reproductive health needs of people living with HIV/AIDS in the era of successful HIV therapy The incidence and prevalence of HIV infections...
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