genetic basis of gestational trophoblastic disease
Báo cáo sinh học: "The complex genetic basis of simple behavio" ppt
... neurobehavioral diseases mainly reflect the effects of large numbers of genetic variants of relatively small effect and, therefore, that genetic dissection of such traits will require investigation of samples ... important form of corroboration of the role of a given gene in contributing to complex behavioral traits Demonstrations of the importance of pleiotropy in the genetic regulation of behavioral ... advantages over genetic mapping of disease phenotypes themselves First, it is hypothesized that endophenotypes are more directly associated with genetic variation than is disease Second, unlike disease, ...
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báo cáo khoa học: " Genetic mapping of wild introgressions into cultivated peanut: a way toward enlarging the genetic basis of a recent allotetraploid" docx
... introgression of a small fraction of the wild genome species while keeping the genetic background of the cultivated is a good mean to explore the largely untapped reservoir of useful alleles of interest ... application of molecular breeding approaches for the genetic improvement of cultivated peanut Up to date, few genetic linkage maps have been published in Arachis At the diploid level, three genetic ... due to the low level of polymorphism between cultivated peanut varieties, QTLs have been detected attesting of the interest of molecular breeding tools in genetic improvement of peanut Burow et...
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Elucidating the genetic basis of severe obesity learning from the experiments of nature
... GENETIC BASIS OF SEVERE OBESITY: LEARNING FROM THE EXPERIMENTS OF NATURE DR LEE YUNG SENG MBBS, MMED (PAED MED), MRCP (UK), MRCPCH, FAMS A THESIS SUBMITTED FOR THE DEGREE OF PH.D DEPARTMENT OF ... of Cys28Phe and Leu37Phe 92 B) Co-segregation of C28F and L37F with overweight/obesity in 93 families 4-3 Structure of POMC and location of mutations 95 4-4 Sequence alignment of N-terminus of ... genes of this cohort were screened by direct sequencing The POMC gene of more than 900 DNA samples from the Genetics of Obesity Study (GOOS) (Cambridge, UK) were screened using a combination of...
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The genetic basis of type 2 diabetes in a multi ethnic population in singapore
... environmental factors) are most likely the cause of familial aggregation of diseases 7.3 THE COMPLEXITY OF THE GENETICS OF TYPE DIABETES Genetic studies of diseases have traditionally relied on two ... impact of a family history of diabetes; to further assess the genetic basis of type diabetes, we next examine the contribution of recently identified novel T2DM susceptibility loci on the risk of ... polygenic disease, it would be erroneous to think that the genetic variance of this disease might be explained by a few genes Quite the opposite actually, as illustrated by the recent explosion of genetic...
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Genetic epidemiology of coronary artery disease
... lipid profiles are not optimal The lipid profile in HongKong Chinese was not different 18 1.6 Genetic basis of coronary artery disease from that of North Americans Twenty one percent of male ... 1.6 Genetic basis of coronary artery disease • in regulation of blood pressure • reverse cholesterol transport • formation, regulation and growth of atherosclerotic lesions • early development of ... Summary viii List of Publications x List of Abbreviations xi List of Tables xiv List of Figures xv Introduction to Coronary Artery Disease 1.1 Definition of coronary artery disease ...
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Molecular Basis of Pulmonary Disease Insights from Rare Lung Disorders pdf
... MD, University of Maryland, Circa 1950 (1) Abstract The National Institutes of Health Of ce of Rare Diseases (ORD) defines a rare or orphan disease as a disorder with a prevalence of fewer than ... Molecular Basis of Pulmonary Disease R ESPIRATORY M EDICINE Sharon R Rounds, MD, S ERIES E DITOR Molecular Basis of Pulmonary Disease, edited by Francis X McCormack, ... prevents the occurrence of an outcome of interest This might be a study of time until disease progression or overall survival In these types of study designs, it is the person-years of follow-up that...
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GENOMIC DISORDERS The Genomic Basis of Disease doc
... (3) elucidation of the chemical basis of heredity, the molecular basis of disease has been addressed in the context of how mutations affect the structure, function, or regulation of a gene or its ... GENOMIC DISORDERS The Genomic Basis of Disease Edited by JAMES R LUPSKI, MD, PhD / PAWEL STANKIEWICZ, MD, PhD Department of Molecular and Human Genetics Baylor College of Medicine, Houston, TX © ... analysis of the human genome has enabled detection of genome changes heretofore not observed because of technology limitations Whereas agarose gel electrophoresis enables detection of changes of the...
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Báo cáo khoa học: Molecular basis of cerebral neurodegeneration in prion diseases pdf
... trigger the generation of ‘toxic’ CtmPrP [11] This would link transmissible and genetic prion diseases and provide a common pathway of neurodegeneration in prion disease Of note, another group ... Regardless, the exact mechanism of the study clearly emphasizes a critical role of the GPI anchor of PrP in the pathogenesis of prion diseases No central nervous system toxicity of PrP missing the GPI-anchor ... significantly increased generation of Ctm PrP In addition, several pieces of evidence have linked CtmPrP to neurodegeneration in transgenic mice Toxicity of transmembrane isoforms of PrP The evidence that...
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Báo cáo sinh học: " Genetic characterisation of the recent foot-and-mouth disease virus subtype A/IRN/2005" pptx
... Bayesian4phylogenetic analysis of the 1D genome region of the A/IRN/2005 sublineage (red) and related published sequences Figure (black) Bayesian phylogenetic analysis of the 1D genome region of the ... FMDV in Pakistan Open Session of the Research Group of the European Commission for the Control of Foot-and-Mouth Disease (EUFMD) International Control of Foot-and-Mouth Disease: Tools, trends and ... Commission for the Control of Foot-and-Mouth Disease (EUFMD): RECOMMENDATIONS of the 73rd session of the executive committee european commission for the control of foot-and-mouth disease (EUFMD) Istanbul,...
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Báo cáo hóa học: " Genetic characterisation of the recent foot-and-mouth disease virus subtype A/IRN/2005" ppt
... Bayesian4phylogenetic analysis of the 1D genome region of the A/IRN/2005 sublineage (red) and related published sequences Figure (black) Bayesian phylogenetic analysis of the 1D genome region of the ... FMDV in Pakistan Open Session of the Research Group of the European Commission for the Control of Foot-and-Mouth Disease (EUFMD) International Control of Foot-and-Mouth Disease: Tools, trends and ... Commission for the Control of Foot-and-Mouth Disease (EUFMD): RECOMMENDATIONS of the 73rd session of the executive committee european commission for the control of foot-and-mouth disease (EUFMD) Istanbul,...
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THE MOLECULAR BASIS OF PLANT GENETIC DIVERSITY pdf
... Preface The purpose of The Molecular Basis of Plant Genetic Diversity is to provide a glimpse into the dynamic process of genetic variation by presenting the thoughts of some of the scientists ... detection of genetic variation/diversity has greatly enhanced studies of evolution There is The Molecular Basis of Plant Genetic Diversity no doubt that genetic variation influences the fitness of individuals, ... genes of value for plant improvement Furthermore, knowledge of population structure of genetic resources is necessary for the development of strategies for appropriate conservation of genetic...
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Báo cáo y học: "Genetic control of disease in an experimental model for Sjögren’s syndrome Åsa Andersson" potx
... chromosome [1] Dissections of disease loci in models for autoimmune diseases have shown that one locus can contain more than one gene linked to disease [5,6] In one study, a locus of approximately 20 ... erythematosus 1) This might suggest shared disease pathways in different models for autoimmune diseases controlled by the same genes within this interval On the basis of potential candidate genes located ... for SjS disease phenotypes: saliva production, sialadenitis, and anti-nuclear antibodies By this strategy, the critical genetic interval, containing a gene (or genes) controlling the disease...
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Báo cáo y học: "Genetic control of disease in an experimental model for Sjögren’s syndrome" pdf
... chromosome [1] Dissections of disease loci in models for autoimmune diseases have shown that one locus can contain more than one gene linked to disease [5,6] In one study, a locus of approximately 20 ... erythematosus 1) This might suggest shared disease pathways in different models for autoimmune diseases controlled by the same genes within this interval On the basis of potential candidate genes located ... for SjS disease phenotypes: saliva production, sialadenitis, and anti-nuclear antibodies By this strategy, the critical genetic interval, containing a gene (or genes) controlling the disease...
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Báo cáo y học: "Genetic polymorphism of ACE and the angiotensin II type1 receptor genes in children with chronic kidney disease" pps
... relevant to renal disease The genetic polymorphisms of these key components of RAS provide a basis for studying the relationship between genetic variants and the development of vascular and/or ... component of RAS and it determines the vasoactive peptide angiotensin-II Its inhibition reduces the pace of progression of the majority of chronic nephropathies [13,14] Among the candidate genes of ... cardiovascular (CVD) disease [21] The aim of the present study was to investigate the association between polymorphisms of the ACE and AT1RA1166C genes and the occurrence of renal disease in 76 advanced...
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Báo cáo y học: " Genetic polymorphism of ACE and the angiotensin II type1 receptor genes in children with chronic kidney disease" pot
... relevant to renal disease The genetic polymorphisms of these key components of RAS provide a basis for studying the relationship between genetic variants and the development of vascular and/or ... component of RAS and it determines the vasoactive peptide angiotensin-II Its inhibition reduces the pace of progression of the majority of chronic nephropathies [13,14] Among the candidate genes of ... cardiovascular (CVD) disease [21] The aim of the present study was to investigate the association between polymorphisms of the ACE and AT1RA1166C genes and the occurrence of renal disease in 76 advanced...
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báo cáo khoa học: " Multi-locus models of genetic risk of disease" pptx
... risk of disease in monozygotic twins of diseased individuals; λOG, recurrence risk of disease in grandoffspring of diseased grandparents; λOP, recurrence risk of disease in offspring of diseased ... http://genomemedicine.com/content/2/2/10 risk of disease in relatives of diseased individuals for relatives of type R; λSib, recurrence risk of disease in sibs of diseased individuals; τ, the risk (probability) of disease of a risk ... probability) of disease of an individual given their multilocus genotype of x risk alleles out of a possible 2n, where n is the number of loci that contribute to the genetic variance of the disease; ...
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Báo cáo y học: "Genetic characterization of the cell-adapted PanAsia strain of foot-and-mouth disease virus O/Fujian/CHA/5/99 isolated from swine" doc
... outbreaks of foot and mouth disease in countries of east Asia Rev sci tech Off int Epiz 2002, 21:459-463 Dunn CS, Donaldson AI: Natural adaption to pigs of a Taiwanese isolate of foot-and-mouth disease ... pathogenicity of cloven-hoofed animals inoculated with foot-and-mouth disease virus O/JPN/2000 isolate Office International des Epizooties, Report of the Second OIE Meeting of Foot and Mouth Disease ... the finding of molecular basis for the derivation of genetic mutants by utilizing reverse genetics These studies may help us to clarify how is it that the mutations responsible for genetic diversity...
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báo cáo khoa học: " Molecular characterisation and genetic mapping of candidate genes for qualitative disease resistance in perennial ryegrass (Lolium perenne L.)" doc
... to each of these diseases is currently recognised as an important mode of infection control The obligate outbreeding reproductive habit of perennial ryegrass [10] leads to high levels of genetic ... xlpcat-561cg xlpffta.1 Figure Genetic linkage maps of LGs 1–4 from the NA6 parental genotype of the F1(NA6 × AU6) cross Genetic linkage maps of LGs 1–4 from the NA6 parental genotype of the F1(NA6 × AU6) ... xlpthc.2 xlpmads4.2 Figure Genetic linkage maps of LGs 5–7 from the NA6 parental genotype of the F1(NA6 × AU6) cross Genetic linkage maps of LGs 5–7 from the NA6 parental genotype of the F1(NA6 × AU6)...
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Báo cáo y học: "Theoretical basis to measure the impact of shortlasting control of an infectious disease on the epidemic peak" pps
... distribution of the generation time [25] Sensitivity analysis In addition to the analysis of empirical data, we also examine sensitivity of the height and time of peak prevalence to different values of ... Figure The impact of summer holiday on the transmission dynamics of influenza A (H1N1-2009) A Comparison of the observed and predicted weekly counts of the estimated number of influenza cases ... presence of intervention, respectively The time length of intervention, t1 is fixed at Day 50 B Sensitivity of relative peak prevalence of infectious individuals to the time length of the intervention,...
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Báo cáo sinh học: " Correlations of genetic resistance of chickens to Marek’s disease viruses with vaccination protection and in vivo response to" pptx
... by comparisons of related genetic groups that have undergone various degrees of selection There were such sets of genetics groups of Leghorns, each originating from a different genetic base population ... mitogenic response of chicken lymphocytes Poultry Sci 62, 579-584 Schat KA, Calnek BW, Fabricant J (1981) Influence of oncogenicity of Marek’s disease virus on evaluation of genetic resistance ... The 1B Relationship of genetic resistance to MD and vaccination protection Incidence of Marek’s disease in the non-vaccinated birds exposed by contact to RB-LB in exp at weeks of age (fig 2) was...
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