genetic approaches for modi cation of adenoviral tropism
Báo cáo hóa học: " Modification of Conductive Polymer for Polymeric Anodes of Flexible Organic Light-Emitting Diodes" pdf
... 614 sulfoxide (DMSO), glycerol, and sorbitol, etc [11–14] Conformational modi cation, morphology modi cations, and reduction of the Coulombic interaction by a screening effect were proposed ... alcohol, each for 10 min, respectively The substrates were then dried in a vacuum oven for 12 h at 60 °C At last, the substrates were treated by mild O2 plasma for Modi cation of PEDOT:PSS DMSO, ... Fig The size of pristine PEDOT:PSS is 100–400 nm, much larger than 30–100 nm obtained after the modi cation The PEDOT:PSS particles become much smaller and more uniform after the modi cation, thus...
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Báo cáo hóa học: "Modification of alumina matrices through chemical etching and electroless deposition of nano-Au array for amperometric sensing" pot
... electrical properties of alumina matrices, the EIS spectra were taken at each step of alumina formation and modi cation Figure depicts typical Bode plots of the electrode admittance of the aluminum ... chemical pore widening for sw 60 min); (2) after formation of Zn0 layer at the bottom of the pores by immersion in a solution of Zn/Ni fluorborates for min; (3) after replacement of zinc by gold via ... precursors for the porous anodic oxide film fabrication The samples in the form of the flagshape plates (7 · · 0.2) mm were annealed at 500 °C for h, chemically cleaned, rinsed, and electropolished before...
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Tài liệu Báo cáo khoa học: Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion pptx
... an MOI of 10 : for h Cell extracts were prepared and two forms of OTUB1 (31 kDa unmodified form and 37 kDa modi ed form) were visualized using OTUB1 antibodies (E) OTUB1 37 kDa form is phosphorylated ... light chain; *, a smaller form of OTUB1 was also detected) (C) Modi cation of OTUB1 during Yersinia invasion HEK293T were infected with Y enterocolitica at an MOI of 10 : for h, followed by cell ... also thank Dr C Wright (University of Oxford, UK) for assistance with the isolation of primary monocytes and Dr A Simmons and J Baker (University of Oxford, UK) for providing buffy coats from the...
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Báo cáo khoa học: Mass spectrometric characterization of the covalent modification of the nitrogenase Fe-protein in Azoarcus sp. BH72 ppt
... Unmodified Fe-protein; B, modi ed Fe-protein Fig Analysis of both nitrogenase Fe-protein isoforms from conventional Coomassie stained SDS ⁄ PAGE gels by MALDI-TOF MS MALDITOF spectrum of the unmodified ... might be effective for the analysis of other types of modi cations on nitrogenase Fe-proteins Probably, it also provides a new method for the investigation of other labile modi cations on proteins ... and Discussion Site-directed mutagenesis of the target arginine of dinitrogenase reductase An indication for the covalent modi cation of one subunit of dinitrogenase reductase in Azoarcus sp...
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Báo cáo khoa học: Ionizing radiation utilizes c-Jun N-terminal kinase for amplification of mitochondrial apoptotic cell death in human cervical cancer cells pptx
... modulations of the conformation of Bax and Bak Inhibition of caspase-8 by a specific inhibitor, caspase inhibitor (z-IETD-fmk), prevented radiation-induced conformational changes of Bax and Bak ... control (G) Effect of overexpression of an Ser70-specific mutant form of Bcl-2 (S70A) on radiation-induced Bcl-2 phosphorylation HeLa cells transfected with the Ser70-specific mutant form of Bcl-2 (S70A) ... of a mutant form of Bcl-2 (S70A-Bcl-2), in which Ser70 of Bcl-2 is replaced by Ala, effectively inhibited radiationinduced downregulation of Bcl-2 These results suggest that phosphorylation of...
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Báo cáo khoa học: Differential post-translational modification of CD63 molecules during maturation of human dendritic cells potx
... appearance of isoforms of CD63 of 50 and 70 kDa, respectively Together, these data indicate that the 70 kDa isoform of CD63 is a result of post-translational modi cations of the 34 kDa isoform ... cells, besides the 34 kDa form of CD63, eight additional spots of 50 kDa were resolved The shapes of these spots indicated that they represent forms of CD63 that have been modi ed post-translationally ... described modi cation of CD63 (this study) and the previously reported appearance of tubules occurs 12–20 h after maturation [26] Whether there is a direct role for CD63 in the formation of tubules...
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Báo cáo khoa học: Actin as target for modification by bacterial protein toxins docx
... TccC3 modi es Thr148 (marked in Fig 1) So far, threonine residues were not known to be acceptor amino acids for modi cation by ADP-ribosylation The finding of a different modi cation site of actin ... binding site of the N-terminal part of thymosin-b4, but it appears conceivable that ADP-ribosylation of Thr148 also modi es the binding of gelsolin, of proteins of the ADF ⁄ cofilin family and of profilin ... The nucleation of actin polymerization occurred not before the ADP-ribosylated actin was exchanged for non -modi ed actin A recent study confirmed the formation of a ternary complex of gelsolin with...
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Báo cáo khoa học: Role of glutaredoxin 2 and cytosolic thioredoxins in cysteinyl-based redox modification of the 20S proteasome docx
... reduction of S-glutathionylated proteasome by Grx2 would increase Cysteinyl-based modi cation of the 20S proteasome Fig Effect of Grx2 on proteasomal hydrolytic activities To test for the recovery of ... Cysteinyl-based modi cation of the 20S proteasome G M Silva et al A B C Fig Stimulation of Grx2-dependent proteasome deglutathionylation by cardiolipin (A) Increased degradation of Grx2 in the presence of ... identi cation of nucleotide-sensitive proteasomeinteracting proteins by mass spectrometric analysis of affinity-purified proteasomes Mol Biol Cell 11, 3425– 3439 Cysteinyl-based modi cation of the...
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Báo cáo khoa học: "Alternative Approaches for Generating Bodies of Grammar Rules" docx
... for all parts of speech) In Figure we plot all values of PP and MS computed for different values of alpha, for each training set (i.e., left and right) From the plots we can identify values of ... automaton is of a better quality than another if the values of the indicators are lower for the first than for the second Our aim is to find a value of alpha that produces an automaton of better quality ... value of PP, while, moreover, the value of MS provides us with information about the generalization capacity of automata: the lower the value of MS, the larger the generalization capacities of the...
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Báo cáo khoa học: Perturbation of membrane microdomains in GLC4 multidrug-resistant lung cancer cells ) modification of ABCC1 (MRP1) localization and functionality docx
... observed after 10 of incubation; this was not modi ed by a longer time of incubation Effect of cholesterol depletion on the rate of MRP1-mediated efflux of PIRA Cells were incubated for 10 with various ... 30 with mm MbCD; in both cases, no modi cation of the rate of MRP1mediated efflux of GSH was observed Effect of Triton derivatives on the MRP1-mediated efflux of PIRA Triton X-45 (n ¼ 5) and Triton ... any modi cation of the fluorescence signal For the intracellular GSH determination, cells (2 · 106) suspended in mL of buffer were disrupted by sonication on ice (3 · 10 s, power 2) The rate of...
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báo cáo hóa học:" Research Article A Variable Step-Size Proportionate Affine Projection Algorithm for Identification of Sparse Impulse Response" pot
... square-root operations For practical applications, such as network echo cancellation, the value of projection order P is usually in the range of 2–8 Therefore, the computational complexity of the proposed ... demonstrates excellent performance by combining the fast proportionate algorithm with variable step-size technique for identi cation of sparse impulse response The organization of this article is as ... Algorithm Formulation Our objective is to find a variable step-size approach that is applicable to PAPAs Unfortunately, because of the presence of G(t), it is very difficult to analyze the transient performance...
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Báo cáo hóa học: " Wettability Modification of Nanomaterials by Low-Energy Electron Flux" pptx
... has many potential applications in many fields of modern nanotechnology such as prevention of aggregation of the particles [11], modi cation of chemical stability, variation of their tribological ... sort of surface interactions Electron- and UV-Induced Surface Modi cation of Powders The experiments conducted and the implemented estimations allow finding basic features of surface modi cation of ... nanomaterials using quantitative analyses of wettability data Basic Thermodynamic Approaches The fundamental basis for understanding fine mechanisms of surface modi cation of nanomaterials is to carry out...
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Báo cáo hóa học: " Effects of Gas Composition on Highly Efficient Surface Modification of Multi-Walled Carbon Nanotubes by Cation Treatment" pptx
... bonding in this case Therefore, even with the addition of 20 vol.% H2 (H2/O2 of 10/40 (sccm/sccm)) in gas, there is still a significant removal of amorphous carbon and formation of oxygen-containing ... is minimized Note that the amount of surface defects is important for functional groups to form on the nanotube surface [10] In order to evaluate the formation of defects on the nanotube surface ... the defect density on the walls of the MWCNTs [30] Therefore, the intensity ratio can be used to evaluate the formation of defects which are preferential sites for functionalization As expected,...
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Báo cáo hóa học: " A Fully Automated Environment for Verification of Virtual Prototypes" potx
... The presence of two types of information flowing through the FIFO communications channels of the model is assumed The first type of information consists of parameters, responsible for controlling ... Refinement information Veri cation Veri cation patterns (level n) Veri cation pattern refinement Veri cation patterns (level n + 1) Final product Figure 6: Conceptual view of parallel refinement of the ... veri cation patterns Figure 7: Structure of the environment for automatic generation of veri cation patterns original veri cation patterns, but is a necessary component in the newly created verification...
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Non Faraday Electrochemical Modification of Catalysts Activity pot
... thicknesses of the order of 30 nm are reached because of the thermal migration of promoting ions and concomitant atomic similarity of EPOC and MSIs, still, r values of the order of 10 are obtained ... Electrochemical Theory | Non Faraday Electrochemical Modi cation of Catalysts Activity 71 72 Electrochemical Theory | Non Faraday Electrochemical Modi cation of Catalysts Activity U WR (V) Ϫ0.8 80 Ϫ0.4 ... Figure Nonfaradaic electrochemical modi cation of catalytic activity (NEMCA) and its origin on Pt/YSZ catalyst electrodes Transient effect of the application of a constant current (a, b) or constant...
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Báo cáo sinh học: "On the relevance of three genetic models for the description of genetic variance in small populations undergoing selection" docx
... number of effective loci was of greater concern than the real number of loci This point is also of great concern in this study Indeed, results of molecular genetics indicate, for most of the ... the effect of linkage on the prediction of genetic variance over time in the FFM The effect of linkage was not studied in the model of Chevalet, as assuming ri! ! 0.5 for any pair of loci (i,j) ... description of the selection process in finite populations only for a large number of loci higher = = = 4.4 Effect of inequality between loci effects Predictions of the genetic variance for 000 biallelic...
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báo cáo khoa học: "Predictive genetic testing for the identification of high-risk groups: a simulation study on the impact of predictive ability" pot
... between applications Our observations have implications for health care applications of genetic testing, but also for the direct-toconsumer offer of personal genome tests via the internet For health ... Comparison of the graphs (Figure 2a-c) shows that for thresholds within the observed range of genetic risk scores, sensitivity and PPV were higher for higher ORs of the individual polymorphisms When, for ... distribution of genetic risk scores in affected and non-affected individuals for different ORs of the variants included In our simulation study that included 50 genetic variants, the theoretical range of...
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Báo cáo sinh học: "Genetic parameters for lactation traits of milking ewes: protein content and composition, fat, somatic cells and individual laboratory cheese yield" ppt
... determined for each milk sample of milk recording [38] Thus, it is of great interest to estimate the genetic parameters of the lactation mean of individual laboratory cheese yield for this trait ... little information is available on the genetic parameters of lactation measures for somatic cell count (LSCC) or the relationships between LSCC and yield or the composition of the milk of dairy ... day records of somatic cell count were transformed to their logarithmic form [2] From the ANCHE data le other available pertinent information included the date of milk sampling, number of suckled...
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Developing high throughput chemical approaches for proteomic profiling of aspartic proteases and protein kinases
... platform for proteome profiling of aspartic proteases in cellular lysates Chapter and describes the cell permeable, photo-affinity drug-like probes for proteome profiling of cellular on/off-targets ... Inhibition profiles of the 152-member library against aspartic proteases 42 3.4 Profiling of P falciparum aspartic proteases 44 3.5 Profiling, identification and proteome characterization of P falciparum ... brief overview of applications of high-throughput technologies in chemical proteomics Much attention will be focused on studies of high-throughput strategies for proteomic profiling of aspartic...
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