genes influencing susceptibility to immunosuppression and leukemia
Báo cáo y học: "Host factors influencing susceptibility to HIV infection and AIDS progression" ppsx
... regards to HIV infection, cytokines can be grouped into HIV-inducing (TNF- α, TNF-β, IL-1, and IL-6), and HIV-suppressive (IFN-α, IFN-β, and IL-16) IFN-gamma and IL-4 display both stimulatory and ... in vivo data monitoring disease progression [12] Factors influencing susceptibility to infection and the course of disease can be grouped into three categories: 1) viral factors determining the ... (DEFA1 and DEFA3), and β-defensins (DEFB4, DEFB103, and DEFB104) are known to be polymorphic in copy number [160-162] Transcription of these genes correlates with copy number, and it is tempting to...
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Tài liệu Static and Dynamic Analysis of the Internet’s Susceptibility to Faults and Attacks docx
... leading to the creation of new Internet topology generators Tangmunarunkit et al divide network topology generators into two categories [38]: Structural and Degree-Based network generators Other ... network topology and that building an effective topology generator is at least as important as protocol simulations Previously, the Waxman generator [35], which is a variant of the Erdos-Renyi random ... method to simulate network protocols is using the real Internet topology instead of using Internet topology generators, which innately limits our ability to develop, for example, network protocols...
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Báo cáo sinh học: "Support for single major genes influencing fat androstenone level and development of bulbo-urethral glands in young boars MN Fouilloux" potx
... released into the blood and finally stored in the adipose tissue Reported coefficients of correlation between fat androstenone level and boar taint intensity, as assessed by laboratory panels, ... class I - - = = on boars belonging to the foundation stock Go and to generations and The SLA class I antigens were defined by microlymphocytotoxicity testing as described by Renard et al (1988) ... analyses, heritabilities and phenotypic and genetic correlations for fat androstenone level and bulbo-urethral gland size were estimated by procedure using the VCE (variance component and Kovac, 1990)...
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Báo cáo y học: " Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy" pot
... Table In addition to four SNPs in or flanking conserved sequences, we genotyped six known SNPS in the IL4 and IL13 genes to evaluate LD patterns between these genes and the CNEs and evaluate the ... other atopic phenotypes Thus, in the Hutterites, variation in the IL13 gene is strongly associated with total serum IgE and allergic sensitization to mold allergens, and to a lesser extent to cockroach ... SNPs and pairwise haplotypes (see Results), and we considered significant P-values to be
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Báo cáo y học: "Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study" ppsx
... plasminogen activator, tissue type (PLAT) [17] and plasminogen activator inhibitor-1 (PAI-1) [18] They were selected as appropriate candidates to participate in RA susceptibility and studied in ... associated with susceptibility to, and severity of, chronic periodontitis J Periodontol 2005, 76:1056-1060 Mercado FB, Marshall RI, Bartold PM: Inter-relationships between rheumatoid arthritis and periodontal ... sample donors for their collaboration and Drs Antonio Mera, Manuel Caamaño, Jorge Blanco and Santos Insua for providing access to their patients Lorena Fernandez-Blanco collaborated in the selection...
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Tài liệu Báo cáo khoa học: Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion pptx
... cell susceptibility to Yersinia invasion Yersinia virulence factors are injected into target host cell molecules to manipulate signalling pathways during invasion in order to prevent uptake and ... PAGE gel and Coomassie Blue staining, and the band corresponding to a modified OTUB1 (rectangle) was excised and digested with trypsin The peptide mixture was analysed by a nano-UPLC-QTOF tandem ... increased binding to YpkA Mimicry of OTUB1 phosphorylation modulates susceptibility to Yersinia invasion If the interaction between OTUB1 and YpkA were relevant for increased susceptibility to invasion,...
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Tài liệu Báo cáo Y học: Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor pot
... Heath, J.K (1997) An antagonist for the leukemia inhibitory factor receptor inhibits leukemia inhibitory factor, cardiotrophin-1, ciliary neurotrophic factor, and oncostatin M J Biol Chem 272, 26947–26952 ... axotomized motoneurons in adult mice J Neurosci 17, 6999– 7006 Sleeman, M.W., Anderson, K.D., Lambert, P.D., Yancopoulos, G.D & Wiegand, S.J (2000) The ciliary neurotrophic factor and its receptor, ... resulting length of 31 amino acids, in analogy to Hyper-IL-6 and Hyper-IL-11, is presumably sufficient to connect both molecules and to allow access of CNTF to its CNTF-R binding site In a similar approach,...
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Báo cáo khoa học: Tumor suppressor p16INK4a ) modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells ppt
... growth regulator in p16INK4a-positive cells and the mentioned SK-N-MC neuroblastoma model It is reactive, too, with other carcinoma cells [28] and was related to differentiation and apoptosis after ... cancer and normal tissue revealed differential gene activities, especially up-regulation for b4GalT-V (factor 9.91) and b4GalT-I (factor 2.54) and an inverse regulation for GnT-IVa and b (factors ... route towards re-establishing susceptibility for anoikis The presented results lend credit to a scenario of finetuned and co-ordinated events translating into alterations of protein–protein and...
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Plant reproductive susceptibility to habitat fragmentation: review and synthesis through a meta-analysis pptx
... trees; Vi, vines), and habitat type (Bo, boreal; Gr, grassland; Shl, shrubland; Te, temperate; Tp, tropical) Reviews and Syntheses Reproductive susceptibility to fragmentation 973 to the 95% bias-corrected ... differential reproductive susceptibility of plants to habitat Reproductive susceptibility to fragmentation 969 fragmentation in relation to their compatibility systems and degree of pollination ... interact with both generalist and specialist pollinators, would tend to loose their specialist pollinator fraction from their assemblages and retain their generalist pollinators Thus, decreases in...
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Báo cáo khoa học: "Scots pine susceptibility to attack by Tomicus piniperda (L) as related to pruning date and attack density" pps
... was stable during the procedure and close to the standard 15 °C (up to the first living whorl at m height) transported to the laboratory within 24 h, and cold-stored at +2 °C until the next day ... capacity to translocate carbohydrates to the area under attack (Christiansen and Ericsson, 1986; Miller and Berryman, 1986; Långström et al, 1992) Hence, manipula- tion of needle biomass and tree ... of the total sapwood area; see Waring and Pitman, 1980; for a discussion of the underlying physiological assumptions, see Waring and Pitman, 1985), and sapwood percentage were calculated and used...
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Báo cáo y học: "Higher susceptibility to Fas ligand induced apoptosis and altered α modulation of cell death by tumor necrosis factor-α in periarticular tenocytes from patients with knee joint osteoarthritis" ppt
... [8,9] Apoptosis is a physiological process and is a highly selective way to eliminate aged and injured cells In addition to internal pathways that trigger apoptosis mainly in response to cytotoxic ... of cell growth and apoptosis in tenocytes under normal conditions and in degenerative diseases, such as OA Changes in apoptotic pathways appear to be of importance to the pathogenesis of degenerative ... the apoptosis-inducing receptor Fas in periarticular tenocytes of patients with OA and studied their susceptibility to apoptosis in the presence or absence of recombinant human FasL and TNF-α...
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Báo cáo y học: "Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis" pdf
... increased susceptibility to infections, malignancies and autoimmune/inflammatory disorders Although GCA-specific autoantibodies have not been described, antibodies against a broad range of human autoantigens ... to play important roles in the initiation and regulation of many immunological and inflammatory processes and to amplify and refine the immune response to an infection Activating FcγRs (FcγRI, ... potential to mediate Fc gamma receptor (FcγR) cross-linking and trigger downstream effector functions [22] The FcγRs, which bind IgG containing immune complexes/IgG autoantibodies, have been shown to...
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Báo cáo y học: "The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets" pptx
... with laboratory work and data analysis; New Zealand research nurses Gael Hewett and Jill James for assistance in recruiting patients; and the Health Research Council of New Zealand and Arthritis ... fourZealand and Oxford sample sets Caucasian cohorts: Jacq and colleagues [20], Wellcome Trust Case Control Consortium (WTCCC) [25], New Zealand and Oxford sample sets (a) Fixed effects model (b) Random ... contributions JEH-M and TRM helped to design the study, oversee its execution, and prepare the manuscript KAR, AJP-G and MEM provided technical support PG, AAH, PBBJ, LKS and PH helped to provide clinical...
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Báo cáo khoa hoc:"Heritability of susceptibility to Salmonella enteritidis infection in fowls and test of the role of the chromosome carrying the NRAMP1 gene" ppt
... Resistance to Salmonella infection in chicks 213 is a parent of the commercial cross and were derived from 29 sires mated to a maximum of dams (i.e a total of 89 dams) In experiment and 2, all ... animals hatched on the same day and were reared in and rooms respectively All eggs were from pathogen free flocks known to be free of Salmonella, and were hatched and reared at the “station de recherches ... spleen and genital organs See Tables II and III Heritabilities for the number of Salmonella were estimated as 0.02±0.04 and 0.05±0.05 for the liver; 0.29±0.07 and 0.10±0.06 for the spleen; and 0.16±0.05...
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Báo cáo khoa hoc:" Role of HOXA7 to HOXA13 and PBX1 genes in various forms of MRKH syndrome (congenital absence of uterus and vagina)" ppt
... involvement of major developmental genes such as HOX genes [9-12] The homeobox (HOX) genes belong to a large family of 39 genes organized in four clusters, HOXA, HOXB, HOXC and HOXD, each on a different ... Wellik DM, Capecchi MR: Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton Science 2003, 301:363-367 McGinnis W, Krumlauf R: Homeobox genes and axial patterning Cell 1992, ... according to standard procedures [36] Local ethical review and consenting procedures were followed PCR primers were designed to amplify HOXA7, HOXA9, HOXA10, HOXA11, HOXA13 (Table 1) and PBX1...
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Báo cáo khoa hoc:" Genetic polymorphisms and susceptibility to lung disease" ppsx
... exposed to Bacillus anthracis spores develop pulmonary disease, the most lifethreatening form of anthrax infection, it would be important to identify factors that lead to susceptibility to this ... other polymorphisms that affect susceptibility to Bacillus anthracis Although the genes that we chose seemed to be reasonable candidates; there are many additional genes encoding products that could ... of genes that may modulate the expression of hereditary hemochromatosis: Transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (IRP)-1 and...
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Báo cáo y học: "Does CD4+CD25+foxp3+ cell (Treg) and IL-10 profile determine susceptibility to immune reconstitution inflammatory syndrome (IRIS) in HIV disease" pdf
... Inflammation 2008, 5:2 avidity yielding Th0 cells and effector T-cells to mediate the generation of proinflammatory cytokines in response to cell-signaling factors (IL-2, IL-6 etc.) We propose that IRIS ... HL: Oral tolerance: immune mechanisms and treatment of autoimmune diseases Immunol Today 1997, 18:335-343 Aandahl EM, Michaelsson J, Moretto WJ, Hecht FM, Nixon DF: Human CD4+ CD25+ regulatory T ... zoster, herpesviruses, and cytomegalovirus) and non-infectious (autoimmune) burdens [2-10] Of the subjects that are initiated on HAART, only a proportion progress to develop IRIS and the remaining...
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báo cáo khoa học: " Analysis of anther transcriptomes to identify genes contributing to meiosis and male gametophyte development in rice" pptx
... correspond to annotated genes, and in some instances more than one probe-set corresponds to annotated genes Therefore, in order to identify the unique probe-sets that correspond to annotated genes, ... expressed genes was found to be 2.0%, 0.5% and 0.3% in SCP, MA and PMA, respectively The cumulative anther transcriptome was compared with the previously generated transcriptomes of root, leaf and ... transcriptome with 4,554 commonly expressed genes in anther and seed stages However, a much lower level of similarity between the anther and root (2,488), and anther and leaf (1,265) transcriptomes...
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báo cáo khoa học: "Chemical and transcriptional responses of Norway spruce genotypes with different susceptibility to Heterobasidion spp. infection." ppsx
... with different susceptibility to Heterobasidion annosum s.l infection The aim was to find associations between the transcriptome and chemical profiles to the level of susceptibility to Heterobasidion ... mm in diameter and inoculated with H annosum, were prepared according to Stenlid & Swedjemark [37], and attached to the wounds with Parafilm® The roots assigned to wounding were handled identically ... isogroups and isotigs in the reference file as a reference The count data were aligned in R and imported into the R-package DESeq [50] and normalized on number of counts and subjected to further...
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báo cáo khoa học: " PR genes of apple: identification and expression in response to elicitors and inoculation with Erwinia amylovora" doc
... at each time point Elicitor treatment Elicitors were sprayed to run-off using a hand-pumped atomizing sprayer Elicitors were diluted in water and were applied to hours into the light cycle INA ... showed symptoms sooner and induced PR genes more rapidly than the snip method The florist's frog and slice methods seemed equivalent with respect to PR gene induction and the severity and rate ... three apple PR-1 genes and the type member, PR-1a from tobacco Alignment Alignment of the deduced amino acid sequences of three apple PR-1 genes and the type member, PR-1a from tobacco (GeneBank:CAA29392)...
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