genes genomic instability and cancer

... BMC Cancer (2018) 18:8 DOI 10.1186/s12885-017-3976-z RESEARCH ARTICLE Open Access Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic ... prostate cancer, focusing on genomic instability and somatic copy number alterations (CNA) Methods: Whole-slide images of The Cancer Genome Atlas Project (TCGA, N = 260) and the Canadian Prostate Cancer ... carcinoma, Prostate cancer, Copy number alteration, Aggressive disease, Genomic instability Background Prostate cancer is heterogeneous regarding its pathologic features, genetic background and clinical

Ngày tải lên: 24/07/2020, 00:15

... mitosis and tumorigenesis Mol Cancer Res 2007, 5:1–10 Shichiri M, Yoshinaga K, Hisatomi H, Sugihara K, Hirata Y: Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and ... chewing habits and these cancers Several studies in different animal species have shown positive induction of tumors in both target (cheek-pouch, esophagus and stomach) and non-target (lung and liver) ... to induce cancer and simultaneously evaluate the expression pattern of certain genes which play an important role in the initial process of carcinogenesis The chemical composition and pharmacological

Ngày tải lên: 05/11/2020, 06:48

... genomic hybridization and transcriptomic analyses of 10 adult-type GCTs to obtain a picture of the genomic landscape of this cancer type and to identify new candidate co-driver genes Results: Our ... genomic landscape of this cancer type and to identify new candidate (co-)driver genes (termed henceforth driver genes for simplicity) Methods Ethics statement This research involves human samples and ... broken, amplified/duplicated or deleted genes Many of these genes, such as AKT1, RUNX1 and LIMA1, are known to be involved in cancer and related processes Further genomic explorations suggest that

Ngày tải lên: 29/09/2020, 15:55

... (hereditary breast and prostate cancer risk); RAD51C, BRIP1 (hereditary breast and ovarian cancer risk); and RAD51D (hereditary ovarian cancer risk) (Table 1) Most of these genes are associated ... survival rates for melanoma skin cancer by stage? [http:// www.cancer.org/cancer/skincancer-melanoma/detailedguide/melanomaskin-cancer-survival-rates] Judkins et al BMC Cancer (2015) 15:215 10 11 ... gastric cancer syndrome); BMPR1A, SMAD4 (juvenile polyposis syndrome); BARD1 (hereditary breast cancer risk); CHEK2 (hereditary breast, colorectal and prostate cancer risk); CDK4 (melanoma cancer

Ngày tải lên: 30/09/2020, 11:52

... 545, and 546) and exon 20 (codons 1043 and 1047) PCR primers and sequencing primers were designed using the PyroMark Assay Design 2.0 software (Qiagen) Forward (F) and reverse (R) PCR primers and ... Colorectal cancer (CRC) is the third most common cancer and the second most common cause of cancerrelated death in Sweden [1] Metastatic disease is present at diagnosis in 20-25% of patients and another ... recurrence and “disseminated” for stages II and III with recurrence together with stage IV Only colon cancers were selected as rectal cancers are often treated preoperatively with radiation and/or

Ngày tải lên: 30/09/2020, 13:06

... migration- and cancer-related genes correlating with metastasis Selected genes were silenced using siRNA, and their roles in cell migration and invasion were determined in transwell migration and Matrigel ... steps in this process Spontaneous and experimental models of metastasis in mice have allowed us to discover and analyze new genes and biomarkers and to test anti-cancer drugs within complex microenvironments ... in prostate cancer Keywords: Prostate cancer, Invasion, Migration, Metastasis, Angiogenesis, Lymphangiogenesis, Lymph node, EpCAM, Integrin, Beta4, uPA, New model Background Prostate cancer affects

Ngày tải lên: 05/11/2020, 00:39

... determine genomic imbalance patterns within cytobands Recently, genomic and cDNA arrays (reviewed in Ref [15]) have provided more detailed maps of genomic copy number alterations in tumors and, in ... expression and array comparative genomic hybridization (aCGH) analyses to address genomic imbalance and concurrent expression alterations associated with intrinsic drug resistance in ovarian cancer ... Fisher Exact Test: Differential Cytoband Regions Between Resistant and Sensitive Groups Cytoband Mb Size (Mb Range) P Range* Gene of Interest within Cytoband (Cytoband)y Relative Copy Nb Change (R/S)z

Ngày tải lên: 02/11/2022, 11:36

... 2015 accepted: 02 March 2016 Published: 16 March 2016 Chromatin interactions and candidate genes at ten prostate cancer risk loci Meijun Du1, Lori Tillmans2, Jianzhong Gao3, Ping Gao5, Tiezheng Yuan1, ... cis-interactions at ten prostate cancer risk loci in six cell lines We identified significant physical interactions between risk regions and their potential target genes including CAPG at 2p11.2, ... associated with prostate cancer risk However, the vast majority of these SNPs lie in noncoding regions of the genome To test whether these risk SNPs regulate their target genes through long-range

Ngày tải lên: 24/11/2022, 17:51

... to that of the parental strain, and we discovered and localised a duplicated and translocated region encoding ORF50 and A6 as well as partial sequences of ORF48 and A7 Since this duplication is ... loss of virulence has been associated with genomic rearrangements, including duplications generally involving the ORF50, A6, A7 and A10 genes17,18 A7 and A10 encode putative glycoproteins whereas ... accepted: 09 November 2016 Published: 07 December 2016 Genomic duplication and translocation of reactivation transactivator and bZIP-homolog genes is a conserved event in alcelaphine herpesvirus

Ngày tải lên: 04/12/2022, 10:35

... groups and demonstrated the important differences between VTE in adults and pediatric patients and called for evidence- based guidelines for management and prevention of VTE in neonates and children. ... lives” and issued a call for action stating that DVT and PE constitute major health problem in the USA and more people die of PE than motor vehicle accidents, breast cancer or AIDS, and physicians, ... Future directions There are several outstanding issues such as standardization of preanalytical and. .. hyperhomocysteinemia, and 22 Pathophysiology and Clinical Aspects of Venous

Ngày tải lên: 19/02/2014, 23:20

... example PET and MR and ultrasound and MR, there will be a need to have standardization in order to follow longitudinal studies of response to therapy Cancer is a multi-factorial disease and imaging ... detection of small cancers and depicts significantly more cancers and at smaller size and lower stage than does a physical examination, which detects independently extremely few cancers Mammographic ... of imaging in cancer management is shown in Figure and is based on screening and symptomatic disease management The future role of imaging in cancer management is shown in Figure and is concerned

Ngày tải lên: 06/03/2014, 00:22

... region.>> 2 Children and Cancer Children and Cancer CHILDHOOD CANCER CHILDHOOD CANCER OBJECTIVES  To discuss childhood cancer  To address the links between childhood environments and adult onset of cancer ... CH. Childhood cancer epidemiology in low-income countries. Cancer, 2007, 112;3:461-472 8 Children and Cancer Children and Cancer CAUSES OF CHILDHOOD CANCERS CAUSES OF CHILDHOOD CANCERS 1. Identified ... POTENTIAL CANCER CLUSTERS 6. QUESTIONS FROM PARENTS <<READ SLIDE>> 4 Children and Cancer Children and Cancer * Rates are per 100,000 population and age adjusted to the 2000 US standard

Ngày tải lên: 06/03/2014, 01:20

... colorectal, and prostate cancers, and even a 40–50 percent decrease in lung cancer, along with similar reductions in cancers at other sites Such a diet would be conducive to preventing cancer and would ... fruits and vegetables reduces lung cancer; an additional 20 to 33 percent reduction in lung cancers is estimated [1] Steinmetz and Potter reviewed the relationship between fruits, vegetables, and cancer ... a high fruit and vegetable diet would reduce cancers of the mouth and pharynx, esophagus, lung, stomach, and colon and rectum; evidence of probable risk reduction was found for cancers of the

Ngày tải lên: 06/03/2014, 02:21

... the ability of CDT to induce genomic instability Effects of colibactin on genomic instability The effects of colibactin in induction of DNA damage in vivo and genomic instability in vitro were studied ... 4581 Bacterial genotoxins and genomic instability L Guerra et al (DNA resection); and (c) phosphorylation ⁄ activation of CHK2 and p53 that lead to cell cycle arrest and, in ultimate instances, ... Bacterial genotoxins and genomic instability L Guerra et al which promotes cell survival, and has been demonstrated to contribute to tumor formation in models of colitis-associated cancer and hepatocellular...

Ngày tải lên: 14/03/2014, 22:20

... where 144 genes were analyzed, the number of candidate phrases, the average number of affected phrases, and the number of iterations all were independent of input length, and the selection and replacement ... and 373 [29] Increased expression of these miRNAs led to down regulation of LATS2 and to tumorigenesis The miRNA 372 and 373 target sequence (AGCACTTATT) is located in the UTR of LATS2 mRNA and ... regulate genes important for tumorigenesis and MDLcompress is able to identify these targets, it follows that MDLcompress could be used to directly identify genes that are important for tumorigenesis...

Ngày tải lên: 22/06/2014, 19:20

... PTPRQ, and GPSM2 [5-7] Capture libraries Exons and the flanking 40 bp into introns of 246 human genes were selected for capture and sequencing The 246 genes are listed in Additional file 1, and ... TW, MK and KBA conceived and designed the experiments and analyses and wrote the paper ZB, HS, DL, SS, MF, BD, MS, MR, SL, EL-L and MK ascertained the families, collected DNA samples, and assessed ... probands and their extended families Results Targeted capture of exons and flanking sequences of 246 genes We developed a targeted capture pool for identifying mutations in all known human genes...

Ngày tải lên: 09/08/2014, 23:20

... important agronomic genes such as AP2 are regulated in cereal hybrids Results Structure of the AP2-like genes from H vulgare and H chilense and their predicted proteins Genomic DNA and complete cDNA ... (line H106) and H chilense (lines H1 and H208), and their predicted proteins were searched using BLASTn and BLASTp algorithms Results showed a high homology to many floral homeotic genes and their ... characteristics of the genomic DNA, its open reading frame (ORF) and the resulting protein of the AP2-like genes from H vulgare cv Betzes (H106) and H chilense lines H11 and H208, and comparisons with...

Ngày tải lên: 12/08/2014, 03:20

... cofactor and breast and endometrial cancer 7.5.3 Estrogen metabolism enzymes and ER cofactor genes are drug targets for breast and endometrial cancer treatments Current endocrine therapy for breast cancer ... estrogen metabolism genes and breast and endometrial cancer risk Study II: Interaction analysis between ESR1 and ER cofactor genes and their effect on the risk of ER positive breast cancer Study III: ... endometrial cancer and their risk factors 7.1.1 Breast cancer incidence Breast cancer is the most common cancer in women(1) and the incidence is increasing Globally, new cases of breast cancer accounted...

Ngày tải lên: 09/09/2015, 17:58

... While the genomic complexity in MM suggests ongoing genomic instability, the mechanism underlying this is unclear Genomic instability in cancer is broadly categorized into mutational instability, ... transformation The understanding of early events in MM pathogenesis may provide important diagnostic and therapeutic information 17 Chapter Chromosomal instability in MM 2.1 Landscape of genomic aberrations ... transcriptional differences between MM and MGUS and that analyzing these differentially expressed genes in terms 16 of functional genesets may provide insights into pathways and transcriptional programs...

Ngày tải lên: 11/09/2015, 09:58

... and Cancer 4.3.1 Overexpression of Human UO-44 in Ovarian Cancers 4.3.2 Expression of Human UO-44 in Ovarian Tissues and Cancer Cell lines 4.3.3 Inhibition of Ovarian Cancer Cell Attachment and ... carcinogenesis and demonstrates that each effect and response occurs is possibly tissue specific 1.2.1 Exposure of Estrogen and the Risk of Ovarian Cancer Ovarian cancer is the sixth most common cancer ... Glands 5.3 Human UO-44 and Ovarian Cancers 5.3.1 Estrogen-regulated Proteins as Potential New Markers for Ovarian Cancers 5.3.2 HuUO-44 – A Protein Involved in Ovarian Cancer Cell Adhesion and...

Ngày tải lên: 14/09/2015, 21:59