genes genomic instability and cancer
Báo cáo khoa học: Do bacterial genotoxins contribute to chronic inflammation, genomic instability and tumor progression? pot
Ngày tải lên :
14/03/2014, 22:20
... the ability of CDT to induce genomic instability Effects of colibactin on genomic instability The effects of colibactin in induction of DNA damage in vivo and genomic instability in vitro were studied ... 4581 Bacterial genotoxins and genomic instability L Guerra et al (DNA resection); and (c) phosphorylation ⁄ activation of CHK2 and p53 that lead to cell cycle arrest and, in ultimate instances, ... Bacterial genotoxins and genomic instability L Guerra et al which promotes cell survival, and has been demonstrated to contribute to tumor formation in models of colitis-associated cancer and hepatocellular...
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Báo cáo y học: "Morphological instability and cancer invasion: a ''''splashing water drop'''' analogy" potx
Ngày tải lên :
13/08/2014, 16:21
... fate determination and phenotype Cancer Res 2006, 66:7833-7836 Cristini V, Frieboes HB, Gatenby R, Caserta S, Ferrari M, Sinek J: Morphologic instability and cancer invasion Clin Cancer Res 2005, ... gliomas J Neurosurg 1995, 83:298-307 Fidler IJ: The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited Nat Rev Cancer 2003, 3:453-458 Postovit L-M, Seftor EA, Seftor REB, ... proliferative, and enzymatic characterizations J Neurosurg 1997, 87:602-609 Vander Wal RL, Berger GM, Mozes SD: The combined influence of a rough surface and thin fluid film upon the splashing threshold and...
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Báo cáo hóa học: " Research Article MicroRNA Target Detection and Analysis for Genes Related to Breast Cancer Using MDLcompress" pdf
Ngày tải lên :
22/06/2014, 19:20
... where 144 genes were analyzed, the number of candidate phrases, the average number of affected phrases, and the number of iterations all were independent of input length, and the selection and replacement ... and 373 [29] Increased expression of these miRNAs led to down regulation of LATS2 and to tumorigenesis The miRNA 372 and 373 target sequence (AGCACTTATT) is located in the UTR of LATS2 mRNA and ... regulate genes important for tumorigenesis and MDLcompress is able to identify these targets, it follows that MDLcompress could be used to directly identify genes that are important for tumorigenesis...
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Báo cáo y học: "Targeted genomic capture and massively parallel sequencing to identify genes for hereditary hearing loss in middle eastern families" pot
Ngày tải lên :
09/08/2014, 23:20
... PTPRQ, and GPSM2 [5-7] Capture libraries Exons and the flanking 40 bp into introns of 246 human genes were selected for capture and sequencing The 246 genes are listed in Additional file 1, and ... TW, MK and KBA conceived and designed the experiments and analyses and wrote the paper ZB, HS, DL, SS, MF, BD, MS, MR, SL, EL-L and MK ascertained the families, collected DNA samples, and assessed ... probands and their extended families Results Targeted capture of exons and flanking sequences of 246 genes We developed a targeted capture pool for identifying mutations in all known human genes...
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báo cáo khoa học: " Comparative genomic analysis and expression of the APETALA2-like genes from barley, wheat, and barley-wheat amphiploids" pdf
Ngày tải lên :
12/08/2014, 03:20
... important agronomic genes such as AP2 are regulated in cereal hybrids Results Structure of the AP2-like genes from H vulgare and H chilense and their predicted proteins Genomic DNA and complete cDNA ... (line H106) and H chilense (lines H1 and H208), and their predicted proteins were searched using BLASTn and BLASTp algorithms Results showed a high homology to many floral homeotic genes and their ... characteristics of the genomic DNA, its open reading frame (ORF) and the resulting protein of the AP2-like genes from H vulgare cv Betzes (H106) and H chilense lines H11 and H208, and comparisons with...
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Association analysis of genetic variation of estrogen related candidate genes in breast and endometrial cancers
Ngày tải lên :
09/09/2015, 17:58
... cofactor and breast and endometrial cancer 7.5.3 Estrogen metabolism enzymes and ER cofactor genes are drug targets for breast and endometrial cancer treatments Current endocrine therapy for breast cancer ... estrogen metabolism genes and breast and endometrial cancer risk Study II: Interaction analysis between ESR1 and ER cofactor genes and their effect on the risk of ER positive breast cancer Study III: ... endometrial cancer and their risk factors 7.1.1 Breast cancer incidence Breast cancer is the most common cancer in women(1) and the incidence is increasing Globally, new cases of breast cancer accounted...
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Unraveling genomic instability in multiple myeloma mechanisms, biological and clinical implications
Ngày tải lên :
11/09/2015, 09:58
... While the genomic complexity in MM suggests ongoing genomic instability, the mechanism underlying this is unclear Genomic instability in cancer is broadly categorized into mutational instability, ... transformation The understanding of early events in MM pathogenesis may provide important diagnostic and therapeutic information 17 Chapter Chromosomal instability in MM 2.1 Landscape of genomic aberrations ... transcriptional differences between MM and MGUS and that analyzing these differentially expressed genes in terms 16 of functional genesets may provide insights into pathways and transcriptional programs...
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Genomic organization and functional characterization of a novel cancer associated gene u0 44
Ngày tải lên :
14/09/2015, 21:59
... and Cancer 4.3.1 Overexpression of Human UO-44 in Ovarian Cancers 4.3.2 Expression of Human UO-44 in Ovarian Tissues and Cancer Cell lines 4.3.3 Inhibition of Ovarian Cancer Cell Attachment and ... carcinogenesis and demonstrates that each effect and response occurs is possibly tissue specific 1.2.1 Exposure of Estrogen and the Risk of Ovarian Cancer Ovarian cancer is the sixth most common cancer ... Glands 5.3 Human UO-44 and Ovarian Cancers 5.3.1 Estrogen-regulated Proteins as Potential New Markers for Ovarian Cancers 5.3.2 HuUO-44 – A Protein Involved in Ovarian Cancer Cell Adhesion and...
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Genes involved in colon cancer development and progression
Ngày tải lên :
07/10/2015, 10:02
... suppressor genes associated with colon cancer has been strongly tested and confirmed There is thus a great need to identify other candidate metastasis suppressor genes associated with colon cancer ... HDAC1 and HDAC2, in colorectal cancer The hypothesis to be tested was that HDAC1 and HDAC2 may be differentially expressed in colon cancer and may hence play an important role in the pathogenesis ... second most common cancer in both gender groups, second only to lung and breast cancers in the male and female groups respectively Combining the data in the two gender groups, colon cancer tops the...
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Báo cáo y học: "Application of Small Angle X-ray Scattering (SAXS) for Differentiation between Normal and Cancerous Breast Tissue"
Ngày tải lên :
02/11/2012, 11:08
... are 0.33, 0.36, 0.46 and 0.4 nm for carcinoma, fibrocystic changes, adipose and fibroglandular tissues respectively Comparison of the measured signatures between the fresh and frozen tissues is ... materials and body tissues Med Phys 1987; 14 (4): 1811-1816 Lewis RA, Rogers KD, Hall CJ, Towns-Andrews E, Slawson S, Evan A, Pinder SE, Ellis IO, Boggis CRM, Hufton AP and Dance DR Breast cancer ... between normal and tumor breast tissues Furthermore, it is possible to differentiate between fibrocystic changes and carcinoma using this parameter The difference between adipose and tumors is...
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Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor
Ngày tải lên :
25/10/2013, 21:20
... frequent types of cancer diagnosed in the United States in decreasing incidence are breast cancer, prostate cancer, lung cancer and colon cancer; yet lung cancer is the deadliest form of cancer in the ... identification of classes of yeast cyclins (Clns in G1 and Clbs in G2) that control Cdc28 and classes of vertebrate cyclins (D- and E-type cyclins in G1 and A -and B-type cyclins in G2/M) that control a family ... 1997; Zachariae and Nasmyth 1999) These studies and others demonstrated the universality of the cell Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor 231 cycle, and strongly suggested...
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Tài liệu The Early Detection Research Network: Investing in Translational Research on Biomarkers of Early Cancer and Cancer Risk docx
Ngày tải lên :
14/02/2014, 21:20
... cancers, gastrointestinal and other associated cancers, lung and upper aerodigestive cancers and prostate and urologic cancers, each have biomarkers in prevalidation and validation phases in which ... Texas M D Anderson Cancer Center Colorectal and Other Gastrointestinal Cancers 35 Colorectal Cancer Colon cancer is the third most frequently diagnosed cancer in the United States and the third ... sequences and other biomarkers have been identified as promising biomarkers for bladder and prostate cancers; and mutations and deletions in mitochondrial DNA were detected in prostate and other cancers...
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Tài liệu Pesticide Residues in Food and Cancer Risk: A Critical Analysis pdf
Ngày tải lên :
14/02/2014, 22:20
... bioassays and are carcinogenic (Gold et al., 1997b) Dehydroepiandrosterone (DHEA) and DHEA sulfate are the major secretion products of adrenal glands in humans and are precursors of androgenic and ... proliferation and carcinogenesis Drug Metab Rev 30, 339357 Cohen, S M., and Ellwein, L B (1991) Genetic errors, cell proliferation, and carcinogenesis Cancer Res 51, 64936505 Cohen, S M., and Lawson, ... DIVISION IN MUTAGENESIS AND CARCINOGENESIS What might explain the high proportion of chemicals that are carcinogenic when tested in rodent cancer bioassays (Table 38.3)? In standard cancer tests,...
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Tài liệu The Diet and Cancer Connection ppt
Ngày tải lên :
15/02/2014, 04:20
... with cancer of the mouth, larynx, pharynx and esophagus, and heavy beer drinking is associated with cancer of the rectum Cancer can develop anywhere along the gastrointestinal tract, but colon cancer ... Nutrition and Health, stomach cancer has been found among populations who eat lots of pickled vegetables (Japan), salted fish (Norway) and smoked trout and mutton (Ireland) Esophageal cancer is ... certain types of cancer, especially if you drink and smoke Choose high-fiber foods Besides fresh fruits and vegetables, add more whole grain breads and cereals and legumes (dried peas and beans) to...
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Tài liệu Changing patterns of cardiovascular diseases and cancer mortality in Portugal, 1980--2010 docx
Ngày tải lên :
15/02/2014, 04:20
... mortality and YLL, and the transition towards cancer In more recent years, the highest burdens of disease came from cancers in men and from cardiovascular diseases in women Keywords Cancer, Cardiovascular ... rates and numbers of deaths were performed for all ages and by age groups (0–14, 15–34, 35–54, 55–74 and ≥75 years) The YLL due to premature mortality for each cause (CVD and cancer) , gender and ... 1980 and 2010, the burden of CVD was much higher compared to cancer and, in 2010, CVD were responsible for 10,000 deaths more than cancers Among men, the YLL from cancer increased between 1980 and...
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Tài liệu What Lung Cancer Patients Need to Know About Bone Health: A Publication of The Bone and Cancer Foundation pdf
Ngày tải lên :
15/02/2014, 05:20
... (noncancerous) or malignant (cancerous) Vertebra: The bony segments that make up the spinal column The mission of The Bone and Cancer Foundation is to: • Provide information to cancer patients and ... information can be found in the Bone and Cancer Foundation publication “Osteonecrosis of the Jaw – Information for Cancer Patients” available online at www.boneandcancerfoundation.org or by calling ... percent of people with lung cancer will have their cancer spread, or metastasize, to bone When lung cancer metastasizes, tumor cells from the original cancer break off and travel through the blood...
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Tài liệu Trans Care Medical issues: Trans people and cancer ppt
Ngày tải lên :
15/02/2014, 05:20
... for skin cancer, colon cancer, and lung cancer is the same for women and men (trans or not) Trans people should have the same screening as anyone else for these kinds of cancers Some cancer protocols ... detection and treatment of cancer The rest of this booklet focuses on trans-specific protocols for cancer screening Trans-Specific Cancer Screening Recommendations The earlier cancer is detected and ... spread Cancer of the uterus” usually refers to cancer of the lining of the uterus (endometrium) Endometrial cancer is the fourth most common type of cancer in BC and is the most common cancer...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt
Ngày tải lên :
16/02/2014, 09:20
... to ERBB3 and ERBB4 NRG1 and NRG2 bind to both ERBB3 and ERBB4, whereas NRG3 and NRG4 only bind to ERBB4 [3] Although these ligands show redundancy, heparinbinding-EGF is the only ligand whose ... 3-kinase, and thus is a preferred dimerization partner EGFR and cancer EGFR overexpression and cancer EGFR is expressed in a variety of human tumors, including those in the lung, head and neck, ... relatively low, being 33, 24 and 28%, respectively regulin and epigen); (b) those that bind to EGFR and ERBB4 (including betacellulin, heparin-binding EGF and epiregulin); and (c) neuregulin (NRG)...
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Tài liệu Báo cáo khoa học: Comparison of membrane fraction proteomic profiles of normal and cancerous human colorectal tissues with gel-assisted digestion and iTRAQ labeling mass spectrometry pptx
Ngày tải lên :
16/02/2014, 15:20
... because of their low concentration and high hydrophobicity New tools and strategies are needed so that membrane fractions from cancer cells can be screened for candidate biomarkers In this study, ... of colorectal tumorigenesis to identify specific protein markers for early colorectal cancer detection and diagnosis or as potential therapeutic targets VDAC1, annexin A2 and Keratin variant have ... Overexpression of CLDN3, HLA-A1, TAPBP and SLC25A4 in colorectal cancer has not been prominently reported, and there is interest in developing these proteins as diagnostic and prognostic markers for this...
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Tài liệu Báo cáo khoa học: Cytokinin oxidase/dehydrogenase genes in barley and wheat docx
Ngày tải lên :
19/02/2014, 16:20
... overexpressing HvCKX genes To investigate whether the cloned genes code for active CKX enzymes, we overexpressed HvCKX2 and HvCKX3 in Arabidopsis and tobacco The cDNAs and, for HvCKX2, also the genomic clone, ... to amplify genomic sequences of HvCKX genes with HvCKX2r, HvCKX3r, and HvCKX23f primers Amplified DNA was cloned into the pDRIVE vector and sequenced The same primers, with Asp718 and XbaI overhangs, ... Hordeum and Triticum, as well as report on the cloning of the first two CKX genes of barley and demonstrate functionality for one of them in transgenic tobacco and Arabidopsis plants Materials and...
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