general aspects of dendritic cell biology functions and clinical application

... Biology and chemistry of b-secretase (BACE-1) C E Hunt and A J Turner A B Fig Processing of APP to form Ab peptides (A) Schematic diagram of the alternative processing pathways of APP ... full details) (B) Sites of cleavage of APP by b- and c-secretases to form Ab peptides The sites of the juxtamembrane and intramembrane cleavages of transmembrane APP by b- and c-secretases, respectively, ... Modulation of oligomeric state and hence activity of the enzyme Modulation of protein–protein interactions affecting localization and ⁄ or activity Modulation of lipid environment of the enzyme...

Ngày tải lên: 07/03/2014, 00:20

... Circulating monocyte and dendritic cell subset frequencies in sepsis patients Frequencies of circulating monocyte and dendritic cell subsets in Circulating monocyte and dendritic cell subset frequencies ... using a standardized assay as described in Materials and methods, and is given as HLA-DR antibodies per cell (Ab /cell) (b) For plasmacytoid dendritic cells (PDCs) and myeloid dendritic cells (MDCs), ... circulating monocyte and dendritic cell subsets in patients with sepsis at baseline and at day 28 compared with healthy controls Monocyte and dendritic cell subsets were stained and gated as described...

Ngày tải lên: 13/08/2014, 18:22

... index of embodied quality in different types and vintages of labor, fixed once and for all and independent of levels of K, would be very restrictive and is not necessary at this level of aggregation ... survey and exposition of such an approach 90 EDUCATION AND PRODUCTION FUNCTIONS sional version of such an approach.16 Each person is thought of as consisting of one unit of raw labor and some ... production functions and of the problems associated with the measurement of such variables and with the specification and estimation of models that use them It soon became clear that some of the...

Ngày tải lên: 06/03/2014, 21:20

... three cases of governance of the biotechnology sector: Finland and Sweden, the USA and the UK, and Australia The aim is to integrate research on innovation systems (the dynamics of firms and economic ... production and consumptions systems, and the political and regulatory arrangements, of Fordism with emerging post-Fordist modes of development (Boyer and Durand 1997; Hirsch 1991; Hollingsworth and ... particular Finland and to some extent Sweden; the second by the US and the UK, and the third by Australia Biotechnology governance in Sweden and Finland The Scandinavian system of bio-industrial...

Ngày tải lên: 13/03/2014, 21:59

... Rehabilitation and Research Centre, University of Oulu, FIN-, Finland Axel Urhausen Institute of Sports and Preventitive Medicine, Department of Clinical Medicine, University of Saarland, D-, Saarbruecken, ... of Jyvọskylọ, FIN-, Finland Timo Sọppọlọ National Public Health Institute, Helsinki, FIN-, Finland Timo Takala Department of Biology of Physical Activity, University of Jyvọskylọ, FIN-, Finland ... of Anatomy, University of Kuopio, FIN-, Finland Jan Henriksson Department of Physiology and Pharmacology, Karolinska Institute, University of Stockholm, SE, Sweden Nils Hjeltness Department of...

Ngày tải lên: 15/03/2014, 09:20

... island republic of great wealth and uncertain international status And across the narrow barrier of the Taiwan Strait, these two powers—the People’s Republic of China (PRC) and the Republic of ... island republic of great wealth and uncertain international status And across the narrow barrier of the Taiwan Strait, these two powers—the People’s Republic of China (PRC) and the Republic of ... rapidly and completely • The deployment of hundreds or thousands of conventionally armed and highly accurate ballistic and cruise missiles that could greatly endanger the operability of Taiwan’s...

Ngày tải lên: 15/03/2014, 15:20

... results of Hecke and Weil for the case of GL2 in both the classical and representation theoretic contexts Jacquet xF==, Converse Theorems for GL, and application to liftings and Langlands [30] ... about II As we shall see, the proof of this theorem essentially follows that of Hecke and Weil and Jacquet-Langlands It is of course valid for n = as well For applications, it is desirable to ... The proof of Theorem 2.1 essentially follows the lead of Hecke, Weil, and Jacquet-Langlands It is based on the integral representations of Lfunctions, Fourier expansions, Mellin inversion, and finally...

Ngày tải lên: 31/03/2014, 16:26

... down-regulation of groups of miR at hours of maturation with sustained low expression throughout the rest of maturation and up-regulation of other groups of miR at hours of maturation and sustained ... gene [23] and is functionally important in B cell, T cell and macrophage biology miR-155 is up-regulated in B cells exposed to antigen, in T cells stimulated by Tolllike receptor ligand and in macrophages ... attracting cytokines CCL22 and CXCL12 [22] These Treg cells can counter the effects of Th1 responses by cytotoxic T cells, Th1 cells, and NK cells In contrast, we found that LPS and IFN-g maturated...

Ngày tải lên: 18/06/2014, 16:20

... some definitions and basic results of almost periodic functions, Stepanov almost periodic functions, pseudo-almost periodic functions, and Stepanov-like pseudo-almost periodic functions for more ... of Chinese Ministry of Education, the NSF of Jiangxi Province of China, the Youth Foundation of Jiangxi Provincial Education Department GJJ09456 , and the Youth Foundation of Jiangxi Normal University ... Analysis Theory, Methods & Applications, vol 73, no 5, pp 1426–1438, 2010 H.-S Ding, J Liang, and T.-J Xiao, “Some properties of Stepanov-like almost automorphic functions and applications to abstract...

Ngày tải lên: 21/06/2014, 05:20

... follows from Cases 1–4 and the proof of Theorem 3.4 is completed Applications In this section, we establish some inequalities by use of Theorems 3.1, 3.2 and 3.4 and the theory of majorization Theorem ... D Anderson, M K Vamanamurthy, and M Vuorinen, “Generalized convexity and inequalities,” Journal of Mathematical Analysis and Applications, vol 335, no 2, pp 1294–1308, 2007 18 A W Marshall and ... Inequalities: Theory of Majorization and Its Applications, vol 143 of Mathematics in Science and Engineering, Academic Press, New York, NY, USA, 1979 19 S.-H Wu, “Generalization and sharpness of the power...

Ngày tải lên: 22/06/2014, 02:20

... (Ms), dendritic cells (DCs), mast cells (MCs)] and their counterparts in the adaptive immune cells [e.g., T and B cells, and subpopulations (cytotoxic T cells, Th1, Th2, Treg)], vasculature and ... Chronic Diseases and Cancer Cell and Molecular Biology, Immunology and Clinical Bases inflammation is a common denominator in the genesis and manifestation of a wide range of age-associated ... Inflammation, Chronic Diseases and Cancer Cell and Molecular Biology, Immunology and Clinical Bases combating viruses and bacteria CMI that mediates through NKs and/ or cytotoxic T cells (CTs) is essential...

Ngày tải lên: 28/06/2014, 11:20

... results of Hecke and Weil for the case of GL2 in both the classical and representation theoretic contexts Jacquet xF==, Converse Theorems for GL, and application to liftings and Langlands [30] ... about II As we shall see, the proof of this theorem essentially follows that of Hecke and Weil and Jacquet-Langlands It is of course valid for n = as well For applications, it is desirable to ... The proof of Theorem 2.1 essentially follows the lead of Hecke, Weil, and Jacquet-Langlands It is based on the integral representations of Lfunctions, Fourier expansions, Mellin inversion, and finally...

Ngày tải lên: 06/07/2014, 15:22

... Sources of Stem Cells for Tissue Repair Different types of stem cells include embryonic stem (ES) cells, umbilical cord blood stem cells, organ-specific somatic stem cells (e.g., neural stem cells ... to the desired cell types before transplantation The study of human ES cells has been controversial, and their use in clinical applications would be unacceptable to some patients and physicians ... number of generic problems must be overcome for the development of successful clinical applications These include development of methods for reliably generating large numbers of specific cell types,...

Ngày tải lên: 07/07/2014, 01:20

... transplantation of a variety of different cell types, including ES cells, bone marrow stem cells, endothelial stem cells, and adipose stem cells Bone marrow stem cells in particular have been examined in clinical ... Stem Cell Approaches Ischemic Heart Disease and Cardiomyocyte Regeneration Because of the high prevalence of ischemic heart disease, extensive efforts have been devoted to cell replacement of cardiomyocytes ... heart disease; and (3) stimulation of endogenous stem cells to facilitate repair—e.g., administration of appropriate growth factors to amplify numbers of endogenous stem/progenitor cells or direct...

Ngày tải lên: 07/07/2014, 01:20

... marrow and adipose stem cells into neural stem cells, and vice versa, has been reported, and clinical trials of such cells have begun for a number of neurologic disorders Clinical trials of a conditionally ... strategy Potential sources of stem cells include endogenous liver stem cells (such as oval cells), ES cells, bone marrow cells, and umbilical cord blood cells Although a series of studies in humans ... demyelination, and both ES cells and marrow-derived stem cells are able to facilitate remyelination after experimental spinal cord injury Clinical trials of marrow-derived stem cells have already begun, and...

Ngày tải lên: 07/07/2014, 01:20

... stem cell based therapies are at a very early stage of development, and perfection of techniques for clinical transplantation of predictable, wellcharacterized cells will be a difficult and lengthy ... Essentials of Stem Cell Biology San Diego, Elsevier Academic Press, 2006 Mimeault M et al: Stem cells: A revolution in therapeutics-recent advances in stem cell biology and their therapeutic applications ... implantation of mechanical devices, neuroscience and cognitive research, in vitro fertilization, and prenatal genetic testing From these and other precedents, we learn the importance of understanding and...

Ngày tải lên: 07/07/2014, 01:20

... plots), and to determine the precision frames of their determination In this contribution, we discuss only two of such parameters – total and mean values of the stand quantitative variable, and the ... diameter and height, quality of the bottom third of the stem (A, B, C), stem damage (yes, no), and in the case of the beech also the age and growth area (flysch) In the outputs of the Slovak NFIM, aggregated ... small-sized wood in an area of 1 m2 as a function of the tree species and average small-sized wood diameter, and if necessary, 479 measuring tool, with precision of 1 cm The volume of small-sized deadwood...

Ngày tải lên: 07/08/2014, 04:20

... lack of objectiveness and incoherency of opinions and attitudes of the respondents, possibly caused by ignorance and misinformation brought about by school education (and education in general) and ... environmental and/ or social forest functions No significant difference between the opinions of forest visitors from large cities and from rural areas was determined Importance of realization of forest functions ... Mts in the north of CR), a highland area (Pasecká skála in the Czech-Moravian Highlands in the central part of CR) and a lowland forest (Knížecí les in the south-eastern part of CR by the Svratka...

Ngày tải lên: 07/08/2014, 10:21

... immunogenic cell death and DCs [9] Immunogenic cell death is characterized by expression of calreticulin (CRT) and then heat shock proteins (HSPs), HSP70 and HSP90 on the cell surface, and the release of ... TCLs is removal of the solid cellular debris by centrifugation after repeated cycles of freezing and thawing of target tumor cells [19,26,27] Page of 15 The protective effect of DCs pulsed with ... method [35] B16 cells were trypsinized and suspended at a of density of × 106 cells/ml, then μl BATDA labeling agent was added to each ml of cells for 15 minutes at 37°C After labeling, cells were...

Ngày tải lên: 10/08/2014, 05:21

... peptides of Tbx18 (SC-17869 p) and Wt1 (SC192 p) were used to tested the specificity of Tbx18 and Wt1 Results Expression of Tbx18 and Wt1 in heart Tbx18 and Wt1 were expressed in the proepicardium and ... for the Care and Use of Laboratory Animals of the National Institutes of Health The protocol was approved by the Committee on the Ethics of Animal Experiments of the University of Minnesota (Permit ... by expression of Tbx18 and Wt1 due to their cardiomyogenic potential [7,8], and great expectations rasied in the field of cardiac regeneration being relevant to epicardial cells and the transcription...

Ngày tải lên: 10/08/2014, 10:20