gene therapy in heart failure forthcoming therapies
DEVICE THERAPY FOR HEART FAILURE WHAT’S NEW IN 2008
... Pathophysiology of heart failure, illustrated by Venn diagram 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 Cardiac Resynchronization Therapy* in Patients With Severe Systolic Heart Failure ... resynchronization therapy (CRT) with or without an ICD is indicated for the treatment of New York Heart Association (NYHA) functional Class III or ambulatory Class IV heart failure symptoms on ... 2008 Guidelines Heart Failure I IIa IIb III For patients with LVEF less than or equal to 35% with NYHA functional Class I or II symptoms who are receiving optimal recommended medical therapy and...
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Báo cáo y học: "Different effect of exercise on left ventricular diastolic time and interventricular dyssynchrony in heart failure patients with and without left bundle branch block"
... lack of increase in LV dyssynchrony during dobutamine stress in patients with wide QRS duration (20) In contrast, Kurita et al reported on an increased mechanical dyssynchrony during pacing–induced ... pacing–induced tachycardia in patients with normal QRS duration (21) A remarkable increase in intra-LV dyssynchrony was also demonstrated during pharmacological stress in systolic heart failure patients ... rest or during exercise or the exercise-related increase in EDVI and the corresponding LDT values were found in both IDCM subgroups Results Systolic and diastolic time intervals The clinical characteristics...
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gene therapy in cardiovascular disease
... generating increased collateral flow But documented clinical success in reducing angina scores and improving myocardial perfusion in otherwise untreatable patients has been observed In a porcine ... cardiovascular gene therapy Hum Gene Therapy 10:3031–3044, 1999 Mann MJ, Gibbons GH, Tsao PS Cell cycle inhibition preserves endothelial function in genetically engineered rabbit vein grafts J Clin Invest ... 200 GENE THERAPY IN CARDIOVASCULAR DISEASE Mann MJ, Whittemore AD, Donaldson MC Preliminary clinical experience with genetic engineering of human vein grafts: Evidence for target gene inhibition...
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gene therapy in the treatment of cancer
... molecules in the interleukin family, which have similar effects and have also been studied, including interleukin (IL-4), interleukin (IL-7), and interleukin 12 (IL-12) IL-12 is a heterodimer consisting ... translational initiation site or a splicing site on the gene (Fig 10.4) This binding represents an antigene approach that would inhibit genetic information flow (DNA–RNA–protein) The antigene approach ... Lipofection 250 GENE THERAPY IN THE TREATMENT OF CANCER now in development Such inhibition results not only in growth inhibition in vitro but also results in growth inhibition of tumors in animal models...
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Chapter 065. Gene Therapy in Clinical Medicine (Part 1) doc
... Main Viral Vectors Features Retroviral Lentiviral Adenoviral AAV Hum Foamy Vir advantages gene transfer in gene transfer in effective dividing cells in few gene expre transduced transducing inflammatory ... steps in which the donated DNA enters the target cell and begins expression is referred to as transduction Gene delivery can take place in vivo, in which the vector is directly injected into the ... inflammatory in both div tissues various tissues responses, and nondiv nonpathogenic cells Main disadvantages Theoretical Might risk of insertional induce mutagenesis (occurred in oncogenesis some...
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Chapter 065. Gene Therapy in Clinical Medicine (Part 2) pdf
... from J Gene Med New Jersey, Wiley, 2006.) Gene Transfer for Genetic Disease Gene transfer strategies for genetic disease generally involve gene addition therapy This approach most commonly involves ... using integrating vectors in hematopoietic cells must include a plan for monitoring sites of insertion and clonal proliferation Strategies to overcome this complication have included employing ... "suicide" gene cassette in the vector, so that errant clones can be quickly ablated; or using "insulator" elements in the cassette, which can limit the activation of genes surrounding the insertion...
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Chapter 065. Gene Therapy in Clinical Medicine (Part 3) docx
... by mutations in several different genes; ~15% of cases of LCA are due to a mutation in a gene, RPE65, encoding a retinal pigment epithelial protein In dogs with a null mutation in RPE65, sight ... knockdown of VEGF Gene Therapy for Cancer The majority of clinical gene transfer experience has been in subjects with cancer (Fig 65-1) As a general rule, a feature that distinguishes gene therapies ... and will likely be tested in upcoming trials Administration of an AAV vector expressing factor IX to the liver in humans with hemophilia resulted in therapeutic circulating levels at the highest...
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Chapter 065. Gene Therapy in Clinical Medicine (Part 4) ppt
... with immune-enhancing genes encoding cytokines, chemokines, or co-stimulatory molecules Sustained clinical responses provide evidence that the transduced cells can act as a vaccine In a related approach, ... transduced with genes encoding a T cell receptor–like molecule, with a tumor antigen–binding domain fused to an intracellular signaling domain to allow T cell activation, thereby converting normal ... particular value in treating minimal residual disease after other anticancer modalities Gene transfer strategies have also been developed for inhibiting tumor angiogenesis These have included constitutive...
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Chapter 065. Gene Therapy in Clinical Medicine (Part 5) ppt
... recombinant proteins are recent examples Gene therapeutics, which entered clinical testing in the early 1990s, are well along in the course of development, and are likely to become increasingly ... Taking History from Subjects Enrolled in Gene Transfer Studies Elements of History for Subjects Enrolled in Gene Transfer Trials What vector was administered? Is it predominantly integrating ... manuscript Further Readings Hacein-Bey-Abina S et al: LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-XI Science 302:415, 2003 [PMID: 14564000] Lin E, Nemunaitis...
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Báo cáo y học: " Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients" pdf
... transgene expression in the joint was high [48], but interestingly the transgene expression also increased with joint inflammation [49] Clinical efficacy of local gene therapy with recombinant ... activity in murine collagen-induced arthritis Gene Ther 2003, 10:19501960 Yin G, Liu W, An P, Li P, Ding I, Planelles V, Schwarz EM, Min W: Endostatin gene transfer inhibits joint angiogenesis ... of proinflammatory cytokines, thereby reducing their circulating levels and abolishing a sensitizing effect on naïve joints A conflicting finding was the protection of the ipsilateral hind paw...
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Báo cáo y học: "The 3rd International Meeting on Gene Therapy in Rheumatology and Orthopaedics" pot
... in the meeting, Haim Burstein (Targeted Genetics Inc., Seattle, WA, USA) described the first human clinical trial using AAV in arthritis gene therapy John Mountz (University of Alabama, Birmingham, ... experiments in horses in which allogeneic chondrocytes were transduced with equine insulin-like growth factor-1 or human bone morphogenetic protein (BMP)-7, incorporated into a fibrin clot, and ... methods for delivering proteins efficiently into cells by attaching protein transduction domains to their amino-termini One such protein transduction domain is derived from the TAT protein of HIV; Jeffrey...
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THE ROLE OF SURGERY IN HEART FAILURE - part 2 pps
... who have heart failure worldwide Heart failure is primarily a disease of the elderly, and the prevalence of chronic heart failure increases with advancing age Currently, chronic heart failure ... chronic shortage of donor hearts Currently, the mainstay of heart failure treatment is pharmacologic and includes angiotensin converting enzyme inhibitors, angiotensin receptor blockers, b-adrenergic ... diastolic heart failure ranges from 5% to 15%, and admission rate for recurrent heart failure is 50% within the first months [1–4] The remaining 50% to 70% of patients present with systolic heart failure...
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THE ROLE OF SURGERY IN HEART FAILURE - part 3 pptx
... Heart Failure Clin (2007) 139–157 Surgery for Heart Failure: Now Something for Everyone? Stephen Westaby, MS, PhD, FRCS* Oxford Heart Centre, John Radcliffe Hospital, Headington Oxford, ... better understanding of the anatomy and pathophysiology of heart failure The failing heart beats at more than 120,000 beats per day, pumping more than 6,000 L of blood against an increased systemic ... This procedure was the landmark beginning of cardiac pacing (Fig 1) For the past 50 years cardiac surgery has been in a continuous state of flux In congenital heart disease palliative techniques...
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THE ROLE OF SURGERY IN HEART FAILURE - part 4 ppsx
... transvalvular gradient [4] Intraoperative myocardial injury remains prevalent in the increasingly elderly surgical population because tolerance to ischemia is reduced in aged myocardium [5] Patients ... coronary bypass and unstable angina to a glycoprotein IIb/IIIa inhibitor or placebo, the 7-day mortality or myocardial infarction rate was 22.3% in almost 700 patients in the control arm [2] A collective ... unit with borderline cardiac index and a blood pressure of 110/70 mm Hg Over the next hours the blood pressure remains acceptable on inotropic support but the urine output dwindles and the ankles...
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THE ROLE OF SURGERY IN HEART FAILURE - part 6 doc
... their rationale in the setting of life-threatening AMI and acute on chronic * Corresponding author New York Presbyterian Hospital, Milstein Hospital Building, Room 7-435, 177 Fort Washington Avenue, ... In the first minute, contractile dysfunction within the ischemic zone results from sarcomere deterioration Active systolic shortening progresses to passive lengthening Within 20 minutes of IRA ... to innovations in pharmacologic treatment, interventional cardiology, as well as techniques in bypass surgery and circulatory support [4] Surgery has played a key role in addressing emergent catastrophes...
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THE ROLE OF SURGERY IN HEART FAILURE - part 8 pdf
... Heart Failure Clin (2007) 211–228 Revascularization in Heart Failure: Coronary Bypass or Percutaneous Coronary Intervention? Sorin V Pusca, MD, John D Puskas, MD* ... Puskas, MD* Emory University School of Medicine, Atlanta, GA, USA Coronary artery disease (CAD) is currently the single most common cause of heart failure in adults [1] The prognosis of patients ... scarring after previous myocardial infarction There is increasing evidence that chronic LV dysfunction resulting from hibernating myocardium in patients who have severe multivessel disease is not...
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THE ROLE OF SURGERY IN HEART FAILURE - part 9 potx
... b Ischemic heart disease is the leading cause of heart failure in North America, accounting for approximately two thirds of heart failure cases [1] Patients who have ischemic heart failure suffer ... The increase in tension plays a key role in activating complex neurohormonal mechanisms, including an increase in angiotensin II, collagen deposition, and degradation through metalloproteinase-1 ... doi:10.1016/j.hfc.2007.05.003 heartfailure.theclinics.com Heart Failure Clin (2007) 237–243 Left Ventricular Restoration: How Important is the Surgical Treatment of Ischemic Heart Failure Trial? Lorenzo...
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THE ROLE OF SURGERY IN HEART FAILURE - PART 2 pdf
... individual patient basis [13] Indeed, it may not be 1551-7136/07/$ - see front matter Ó 2007 Elsevier Inc All rights reserved doi:10.1016/j.hfc.2007.05.005 heartfailure.theclinics.com Heart Failure ... obtain the first results of trials in 2007 Revascularization is not discussed further in this manuscript The initial enthusiasm for skeletal myoblast and stem cell transplantation into the failing ... erythropoietin-stimulating peptides when not due to specific haematinic deficiency may also improve symptoms, although the data are not robust [5] Withdrawal of nonsteroidal anti -in ammatory drugs, including...
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