gene set and pathway based analysis for cancer omics

báo cáo khoa học: "Gene-expression and network-based analysis reveals a novel role for hsa-mir-9 and drug control over the p38 network in Glioblastoma Multiforme progression" ppsx

báo cáo khoa học: "Gene-expression and network-based analysis reveals a novel role for hsa-mir-9 and drug control over the p38 network in Glioblastoma Multiforme progression" ppsx

... Gene- expression and network -based analysis reveals a novel role for hsa-mir-9 and drug control over the p38 network in Glioblastoma Multiforme progression Rotem Ben-Hamo1 and Sol Efroni1,* ... molecular and clinical data sets with a set of computational algorithms we were able to identify a gene- gene and gene- microRNA network that significantly stratifies patient prognosis By combining gene- expression ... Database [12] Gene- expression analysis Pathway Consistency and Pathway Activity metrics were calculated according to [11] and [20] These measures treat the pathway as a network of interactions and give...

Ngày tải lên: 11/08/2014, 12:21

26 278 0
báo cáo hóa học:" Gene Expression and Pathway Analysis of Ovarian Cancer Cells Selected for Resistance to Cisplatin, Paclitaxel, or Doxorubicin" docx

báo cáo hóa học:" Gene Expression and Pathway Analysis of Ovarian Cancer Cells Selected for Resistance to Cisplatin, Paclitaxel, or Doxorubicin" docx

... changes in a large number of genes and pathways, we wondered whether pathway analysis may help us identify “dominant” pathways for each drug resistance phenotype Using pathway analysis, we were indeed ... 3C) Pathway enrichment analysis of these genes revealed that the most significantly enriched pathway was “fatty acid metabolism and oxidation” (4 genes were part of this pathway) Certain genes ... ovarian cancer cell lines To identify genes and pathways important in the development of drug resistance, we performed gene expression profiling analysis on the OV90 drug sensitive cell line and...

Ngày tải lên: 20/06/2014, 08:20

28 384 0
Báo cáo y học: " Patient-oriented gene set analysis for cancer mutation data" pptx

Báo cáo y học: " Patient-oriented gene set analysis for cancer mutation data" pptx

... of gene set sizes and probabilities: For example, there were 260 sets containing between 20 and 30 genes, 124 sets containing between 75 and 125 genes, and 23 sets containing between 225 and ... the genes in a specific gene set to get a binary gene set statistic, which is one if the gene set is altered in the patient and zero if it is not We then obtain a statistic for each gene set ... these gene sets using hypothetical genes To generate realistic genes we sampled nucleotide compositions and sequencing coverage from the real genes in [4] For each of the spiked-in sets and each...

Ngày tải lên: 09/08/2014, 22:23

10 191 0
Báo cáo y học: " Patient-oriented gene set analysis for cancer mutation data" pps

Báo cáo y học: " Patient-oriented gene set analysis for cancer mutation data" pps

... of gene set sizes and probabilities: For example, there were 260 sets containing between 20 and 30 genes, 124 sets containing between 75 and 125 genes, and 23 sets containing between 225 and ... the genes in a specific gene set to get a binary gene set statistic, which is one if the gene set is altered in the patient and zero if it is not We then obtain a statistic for each gene set ... these gene sets using hypothetical genes To generate realistic genes we sampled nucleotide compositions and sequencing coverage from the real genes in [4] For each of the spiked-in sets and each...

Ngày tải lên: 09/08/2014, 22:23

10 264 0
Báo cáo khoa học: Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 ppt

Báo cáo khoa học: Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 ppt

... target genes encoding regulators of immune and inammatory responses and also genes involved in apoptosis and cell proliferation [36] In this paper, we report the results of cell -based, in vitro and ... this NF-jB signaling pathway should be tested not just in vitro and cell based but also simulated in silico Combining this method of analysis (in vitro, cell -based and in silico analysis) will facilitate ... performed using the same protocol as that described for the Tris HCl MgCl2 and Hepes MgCl2 MnCl2 assay Kinetic analysis For two substrate prole analysis, initial velocity studies were performed...

Ngày tải lên: 16/03/2014, 11:20

13 475 0
Báo cáo sinh học: "A microsatellite-based analysis for the detection of selection on BTA1 and BTA20 in northern Eurasian cattle (Bos taurus) populations" doc

Báo cáo sinh học: "A microsatellite-based analysis for the detection of selection on BTA1 and BTA20 in northern Eurasian cattle (Bos taurus) populations" doc

... Software for Genetic Data Analysis Genetics and Biometry Laboratory, University of Geneva, Geneva 2000 41 Slatkin M: A measure of population subdivision based on microsatellite allele frequencies Genetics ... Haploview: analysis and visualization of LD and haplotype maps Bioinformatics 2005, 21:263-265 43 Raymond M, Rousset F: Genepop (version1.2): population genetics software for exact tests and ecumenicism ... starting assumptions For each pair of populations (i, j), and for all loci, we calculated F i and Fj (Fi and F j are the populationspecific divergence; for details see [7,49]) and generated the expected...

Ngày tải lên: 14/08/2014, 13:21

14 506 0
Tài liệu Onomatopoeia in Spoken and Written English: Corpus- and Usage-based Analysis pot

Tài liệu Onomatopoeia in Spoken and Written English: Corpus- and Usage-based Analysis pot

... dissertation I am grateful to him for instilling in me a deep respect for the data, for sharing his wisdom, and for making me realize the attractiveness of studying languages and linguistics I also owe ... the grammatical and semantic characteristics of onomatopoeia The former includes Kloe (1977), Kaida et al (1985) and Taylor (2006), and the latter Schourup (1993) and Tamori and Schourup (1999) ... (documents, reports, etc.) / Learned and scientific writings / General fiction / Mystery and detective fiction / Science fiction / Adventure and Western fiction / Romance and love story / Humor) This...

Ngày tải lên: 24/02/2014, 18:20

219 701 1
LabelMe: a database and web-based tool for image annotation pdf

LabelMe: a database and web-based tool for image annotation pdf

... Comparison with existing datasets for object detection and recognition We compare the LabelMe dataset against four annotated datasets currently used for object detection and recognition: Caltech-101 ... Note that for applications where it is important to have uniform prior distribitions of object locations and sizes, we suggest cropping and rescaling each image randomly Extending the dataset We ... where object and part polygons have high overlap The object-part score for a candidate label is NO,P /(NP + α ) where NO,P and NP are the number of images in IO,P and IP respectively and α is a...

Ngày tải lên: 07/03/2014, 23:20

33 515 1
Báo cáo khoa học: "Combining Trigram-based and Feature-based Methods for Context-Sensitive Spelling Correction" docx

Báo cáo khoa học: "Combining Trigram-based and Feature-based Methods for Context-Sensitive Spelling Correction" docx

... methods, which are based on word trigrams This method also has the advantage that training can be done once and for all, and quite manageably, for all confusion sets; new confusion sets can be added ... occurred, and just guesses based on the priors Table shows the performance of the baseline method for the 18 confusion sets Trigrams Mays, Damerau, and Mercer (1991) proposed a word-trigram method for ... 71.5 71.5 Table 1: Performance of the baseline method for 18 confusion sets "Train" and "Test" give the number of occurrences of any word in the confusion set in the training and test corpora "Most...

Ngày tải lên: 23/03/2014, 20:21

8 249 0
Tutorial Final and Construction Stage Analysis for a Cable-Stayed Bridge potx

Tutorial Final and Construction Stage Analysis for a Cable-Stayed Bridge potx

... Condition Setting To perform the final stage analysis for the cable-stayed bridge, open a new file and save it as ‘cable stayed’, and start modeling Assign ‘m’ for length unit and ‘kN’ for force ... classified into forward analysis and backward analysis, based on the analysis sequence Forward analysis reflects the real construction sequence Whereas backward analysis is performed from the ... entered for the cables using Display Fig 30 Unit Pretension Loads entered for Cables 32 FINAL AND CONSTRUCTION STAGE ANALYSIS FOR CABLE-STAYED BRIDGES Perform Structural Analysis Perform static analysis...

Ngày tải lên: 24/03/2014, 06:20

68 504 1
math - functional and structural tensor analysis for engineers - brannon

math - functional and structural tensor analysis for engineers - brannon

... Henry Thoreau Matrix Analysis (and some matrix calculus) Tensor analysis is neither a subset nor a superset of matrix analysis — tensor analysis complements matrix analysis For the purpose of this ... tensor, and matrix analysis are subsets of a more general area of study called functional analysis One purpose of this book is to specialize several overly-general results from functional analysis ... reproduced for profit DRAF September 4, 2003 5:24 pm Introduction Rebec FUNCTIONAL AND STRUCTURED TENSOR ANALYSIS FOR ENGINEERS: a casual (intuition -based) introduction to vector and tensor analysis...

Ngày tải lên: 31/03/2014, 16:19

323 928 0
Báo cáo khoa học: "Complementing Word Net with Roget''''s and Corpus-based Thesauri for Information Retrieval" pdf

Báo cáo khoa học: "Complementing Word Net with Roget''''s and Corpus-based Thesauri for Information Retrieval" pdf

... file This information has been collected from the Wall Street Journal corpus and uses part of the corpus for training and the rest for testing Also, it has separate lists for such information as ... using only the corpus -based syntactic-relationbased thesaurus, expansion using only the corpusbased co-occurrence -based thesaurus, and expansion using combined thesauri For each method we also ... publication Mark A Stairmand 1997 Textual context analysis for information retrieval In Proceedings of the 20th Annual International A CM-SIGIR Conference on Research and Development in Information Retrieval,...

Ngày tải lên: 31/03/2014, 21:20

8 263 0
Báo cáo y học: "Construction of a high-resolution genetic linkage map and comparative genome analysis for the reef-building coral Acropora millepora" ppt

Báo cáo y học: "Construction of a high-resolution genetic linkage map and comparative genome analysis for the reef-building coral Acropora millepora" ppt

... EM and MVM performed the cross and larval rearing SW and LZ conducted DNA preparation, SNP and microsatellite genotyping, and linkage analysis EM conducted comparative genome analysis SW, EM and ... complex traits [12,13] A genetic linkage map, especially gene- based, is also an excellent platform for comparative genome studies Recent comparative genome analyses based on genetic maps have already ... cnidarians such as corals are phylogenetically basal in the phylum Cnidaria, and have proven to be particularly informative for understanding the evolution of metazoan genetic and developmental complexity...

Ngày tải lên: 09/08/2014, 20:20

17 269 0
báo cáo khoa học: " Social networks, work and network-based resources for the management of long-term conditions: a framework and study protocol for developing self-care support" potx

báo cáo khoa học: " Social networks, work and network-based resources for the management of long-term conditions: a framework and study protocol for developing self-care support" potx

... include the formal and informal, visible and invisible work that is involved in the engagement, sense-making, and appraisal of illnessrelated practices; they are done both individually and collectively, ... reviews [20,21] (one on information -based interventions and the other on social networks) The evidence from our review of informationbased interventions indicates that informational strategies that ... details Health Sciences Research Group, and Collaboration for Leadership in Applied Health Research and Care (CLAHRC) for Greater Manchester, School for Community Based Medicine, University of Manchester,...

Ngày tải lên: 10/08/2014, 10:23

7 332 0
Báo cáo y học: "Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma" pdf

Báo cáo y học: "Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma" pdf

... control E6-E7 gene expression and are necessary for episomal virus production [10] Specific viral genes (E6 and E7) from HPV types 16, 18, and 33 act as oncogenes [14,15] Recentaly, a second-generation ... accurate and consistent study for OSMF and OSCC, in which viral integration and the expression of viral oncogenes (E6 and E7) have been shown [8] HPV detection in potentially malignant and malignant ... Sidransky D: Evidence for a causal association between human papillomavirus and a subset of head and neck cancers J Natl Cancer Inst 2000, 92(9):709-20 Kreimer AR, Clifford GM, Boyle P, Franceschi...

Ngày tải lên: 12/08/2014, 01:22

10 454 0
Báo cáo y học: " Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy" pps

Báo cáo y học: " Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy" pps

... keywords including ‘dietary agents’, cancer , ‘prostate cancer , ‘brain cancer , ‘pancreatic cancer , ‘colorectal cancer , cancer stem cells’, cancer prevention’, cancer therapy’, ‘chemotherapy’, ... AI PcBra1 cells from localized prostate cancer and metastatic and androgen-dependent (AD) LNCaP and AI C4-2B, DU145 and PC3 prostate cancer cells in vitro and in vivo, without any toxic effect ... dasatinib-induced inhibition of growth and transformation of colon cancer cells Int J Cancer 2011, 128:951-961 Kesmodel SB, Spitz FR: Gene therapy for cancer and metastatic disease Expert Rev Mol...

Ngày tải lên: 13/08/2014, 14:20

19 434 0
Báo cáo sinh học: " Equivalence of multibreed animal models and hierarchical Bayes analysis for maternally influenced traits" potx

Báo cáo sinh học: " Equivalence of multibreed animal models and hierarchical Bayes analysis for maternally influenced traits" potx

... term in and  aS (2) stands for the covariance between genotypic values for the parents of the individual, and can be developed further by expanding to the previous generation Under this formulation, ... fitted to an experimental Angus × Hereford data set, and for the first time estimates of the full set of genetic (co)variance components described by Cantet and Fernando [2] in a maternal animal model ... priori values for the genetic (co)variance components 2 for each source of variability Moreover, S e p and S e o represent prior values for the maternal permanent environmental variance and the white-noise...

Ngày tải lên: 14/08/2014, 13:21

12 392 0
Chemical and pharmacological studies of ardisia elliptica antiplatelet, anticoagulant activities and multivariate data analysis for drug discovery

Chemical and pharmacological studies of ardisia elliptica antiplatelet, anticoagulant activities and multivariate data analysis for drug discovery

... Metabolomics 42 1.3.1 Metabolomics for quality control of medicinal plants 44 1.3.2 Metabolomics and analysis of pharmacological effects 45 1.3.3 Using metabolomics for drug ... the leaves of the plant and fractionated HPLC and GC-MS were used for the analysis of the extract and fractions Platelet aggregation assay was performed on the extract and fractions using a platelet ... initiation, propagation and fibrin formation (Rang et al., 2003; Weitz and Bates, 2005) The initiation step can occur by two pathways, the intrinsic pathway and the extrinsic pathway (Figure 1.1)...

Ngày tải lên: 10/09/2015, 08:25

213 558 0
w