gene polymorphisms and inflammatory bowel diseases

... chromosome 10q22q23.1 The SP-A1 gene is telomeric to the SP-A2 and SPD genes: the SP-A2 and SP-D genes are located 36 kb and 130 kb respectively from SP-A1 Both SP-A1 and SPA2 genes have a number of 5′-untranslated ... has not been associated with polymorphisms in TNFα, LTα, TNF receptor II and IL-6 genes [15], nor with polymorphisms in the IL-8 and IL-8 receptor (CXCR-1 and CXCR-2) genes [16] A reported association ... include alleles in the genes encoding TAP2, the CC chemokine receptor 2, the angiotensin-converting enzyme and vitamin D receptor [12] Polymorphisms in the fibronectin gene [13] and the HLA-DPB1*1301...

Ngày tải lên: 12/08/2014, 18:20

... OA, the immune response, and cancer [12] The VDR gene acts as an important regulator of calcium metabolism and bone cell function [13], and it was the first candidate gene to be studied in osteoporosis ... elderly Dutch men and women It can be expected that the same polymorphisms could be important for both knee OA and hand OA, although no association between the VDR genotypes and hand OA was found ... is genetically relatively homogeneous and represents an isolated gene pool, the isolation being caused by linguistic and geographic factors To our knowledge, the association between the VDR gene...

Ngày tải lên: 09/08/2014, 07:20

... Science and Technology in Wuhan City, Hubei province, China Participation was voluntary Detection of mannose-binding lectin gene polymorphisms Polymorphisms in codons 54 and 57 of the MBL gene were ... 60°C for minute and extension at 72°C for minute; and a final elongation at 72°C for minutes The PCR products were digested with the restriction enzymes BanI and MboII for codons 54 and 57, respectively ... cleaved into two bands (of 263 bp and 52 bp), whereas the fragment with a mutant allele showed one band (of 315 bp) For codon 57, a fragment with a wild-type allele showed one band (of 315 bp),...

Ngày tải lên: 09/08/2014, 08:22

... IL-7/IL-7R pathway is independent from and additive with a TNFα-driven pathway This is supported by recent findings demonstrating TNFα-independent IL-7-driven inflammatory and bone-destructive activity ... dynamics, microenvironmental organization and osteolysis Exp Hematol 1996, 24:1521-1529 10 Weitzmann MN, Pacifici R: Estrogen deficiency and bone loss: an inflammatory tale J Clin Invest 2006, 116:1186-1194 ... (receptor activator of nuclear factor kappa B ligand) are crucial mediators in this IL7-driven osteoclast formation [7] Interestingly, in the study of Long and colleagues, TNFα was not tested as an...

Ngày tải lên: 09/08/2014, 10:23

... the present study, we investigated the genetic contribution of FVL, PT G20210A and ACE-ins/del gene polymorphisms to Table Factor V Leiden, PT G20210A, and ACE-ins/del Genotype Frequencies in ... circulating thrombin generation [9] Regarding surgical outcomes, however, Völzke et al found no association between FVL and glycoprotein IIIa PlA1/PlA2 gene polymorphisms and mid-term mortality ... Renin-angiotensin system and haemostasis gene polymorphisms and outcome after coronary artery bypass graft surgery Int J Cardiol 2005, 98:133-139 Eifert S, Rasch A, Beiras-Fernandez A, Nollert G,...

Ngày tải lên: 10/08/2014, 09:22

... Chinese] Carcinogenesis Teratogenesis and Mutagenesis 1999, 11:228-230 34 Hu YL, Zhang Qi: Genetic Polymorphisms of CYP1A1 and Susceptibility of Lung Cancer [in Chinese] Chin J Med Genet 1999, 16:26-28 ... MspI and exon7 gene polymorphisms and lung cancer risk, and performed the subgroup analysis stratified by ethnicity, histological types of lung caner, gender and smoking status of case and control ... CYP1A1 MspI gene polymorphism and lung cancer risk for the combined types B and C vs Type A that MspI and exon polymorphisms of CYP1A1 correlated with increased lung cancer susceptibility and there...

Ngày tải lên: 10/08/2014, 10:21

... proteins and cell cycle regulators thereby affecting not only inflammatory gene expression but cell proliferation and survival [19,20] NF-B-induced lysine residue-specific histone acetylation (K8 and ... function and that pro -inflammatory cytokines are key factors in the pathogenesis of Crohn’s disease (CD) Activation of nuclear factor kappa B (NF-B), which is involved in pro -inflammatory cytokine gene ... acetylation patterns between TH1 and TH2 cells [48,49] Acetylation of K8 and K12 is associated with the upregulation of inflammatory genes [28] In the DSS model of colitis, H4 K8 and K12 were highly acetylated...

Ngày tải lên: 11/08/2014, 03:20

... proteins and cell cycle regulators thereby affecting not only inflammatory gene expression but cell proliferation and survival [19,20] NF-B-induced lysine residue-specific histone acetylation (K8 and ... function and that pro -inflammatory cytokines are key factors in the pathogenesis of Crohn’s disease (CD) Activation of nuclear factor kappa B (NF-B), which is involved in pro -inflammatory cytokine gene ... acetylation patterns between TH1 and TH2 cells [48,49] Acetylation of K8 and K12 is associated with the upregulation of inflammatory genes [28] In the DSS model of colitis, H4 K8 and K12 were highly acetylated...

Ngày tải lên: 11/08/2014, 06:22

... disorders [3], anxiety disorders [4-6], and schizophrenia [7] Whereas imaging genetics has generally relied on exploration of candidate gene effects, gene discovery has generally been accomplished through ... Environmental and genetic modifiers have been studied in behavioral and psychiatric genetics studies of traumatic stress and PTSD [12,15,16,96], but GxE remains to be investigated in imaging genetics ... clarify links between genetic variation and disease phenotypes Associations found with imaging genetics may guide further exploration and confirmation using conventional candidate gene associations...

Ngày tải lên: 11/08/2014, 15:22

... [21-34] IL18 gene is located on chromosome 11q22.2-22.3 [35] and several polymorphisms within the IL18 promoter gene have been associated with different inflammatory and autoimmune diseases [36-43] ... Danish [21], French [60], and Swiss [61], and IL-6 promoter and eNOS polymorphisms, in Italians [24,28] This evidence may indicate a Page of high reproducibility of the genetic associations with ... our understanding of the pathogenesis of autoimmune diseases may be to establish the presence of shared mechanisms that may lead to a variety of very different complex autoimmune diseases Taking...

Ngày tải lên: 12/08/2014, 12:20

... findings and publication bias, as well as heterogeneity in genetic and environmental modifiers of specific gene/ disease associations We evaluated here only a small number of selected genes and of ... population genetics data analysis Genetics & Biometry Laboratory, University of Geneva, Switzerland 2000 Rosenwasser LJ, Borish L: Genetics of atopy and asthma: the rationale behind promoter-based candidate ... of Roads and Transport, the Cantons Basel-Stadt, Basel-Land, Geneva, Zurich, Ticino, Aargau, Luzern, the Swiss Lung League and the Lung League of Ticino, Zurich and Basel Stadt/Basel Landschaft...

Ngày tải lên: 13/08/2014, 13:22

... combination of medical treatment and surgery, with a final visual acuity of 40% in the affected eye [1] The only case of Lyme disease affected a 31 year-old farmer and his ocular manifestations...

Ngày tải lên: 03/11/2012, 11:11

... to pulmonary TB; (2) TLR2 gene polymorphisms may predispose patients with pulmonary TB to presenting with systemic symptoms or pleural involvement; and (3) TLR2 gene polymorphisms may influence ... products by using a sequencer (ABI Prism®3100 Genetic Analyzer; Applied Biosystems, USA) and Gene Scan analysis software T, -15607 A>G, 1350 T>C, and 2258 G>A polymorphisms by direct sequencing",1,0,1,0,0pc,0pc,0pc,0pc>Genotyping ... carrier and Del/Del genotype, and 92.3% between patients with the 1350 T carrier and CC genotype, using the standard t test formulations with a simple adjustment to the sample sizes in our study and...

Ngày tải lên: 06/03/2014, 04:20

... other proteins and molecules (Fig 2) Oncogenesis, Inflammatory and Parasitic Tropical Diseases of the Lung Figure The binding of specific ligands to the receptor activates EGFR and generates a signal ... DM, et al Randomized phase II trial comparing bevacizumab plus carboplatin and paclitax‐ 25 26 Oncogenesis, Inflammatory and Parasitic Tropical Diseases of the Lung el with carboplatin and paclitaxel ... transgene, consist‐ 35 36 Oncogenesis, Inflammatory and Parasitic Tropical Diseases of the Lung ing of a target gene behind a tet-responsive promoter (tetO7) vector, e.g pTRE-Tight (2nd generation...

Ngày tải lên: 23/03/2014, 14:20

... Figure Reduced proinflammatory gene expression in C/EBPb-/- mixed glial cultures Expression of pro -inflammatory (NOS2, IL-1b, IL-6 and TNFa) and anti -inflammatory (IL-4 and TGFb1) genes in C/EBPb+/+ ... proinflammatory gene profiles and neurotoxicity in glial cultures from C/EBPb-null mice Our results show for the first time that absence of C/EBPb attenuates proinflammatory gene expression and ... pro -inflammatory genes studied but not affect mRNA levels of the anti -inflammatory genes IL-4 and TGFb1 Absence of C/EBPb results in significant decreases in LPS-induced expression of NOS2 and...

Ngày tải lên: 19/06/2014, 22:20

... Chadee Chapter Pathogenesis of Inflammatory Bowel Diseases Yutao Yan Part Chapter 111 Advances in Diagnosis of Inflammatory Bowel Disease 135 The Role of Imaging in Inflammatory Bowel Disease Evaluation ... Yaozong Yuan and Shihu Jiang Part Management of Inflammatory Bowel Disease 247 Chapter 14 The Role of Diet, Prebiotic and Probiotic in the Development and Management of Inflammatory Bowel Diseases ... differentiation of T cells and the production and release of proinflammatory cytokines During the course of inflammatory bowel disease and experimental colitis, some prostanoids are released and subsequently...

Ngày tải lên: 27/06/2014, 13:20

... pteronyssinus and D farinae), cat dander, dog dander, horse dander, timothy grass, cladosporium, silver birch, olive, mugwort and nettle Blood samples were allowed to stand and coagulate in Gel and Clot ... association studies: gene- based analysis and replication Am J Hum Genet 2004, 75:353-362 Ober C, Hoffjan S: Asthma genetics 2006: the long and winding road to gene discovery Genes Immun 2006, 7:95-100 ... Nonetheless, epigenetic modifications provide additional instructions on how, where, and when the genetic information will be used (gene expression) These epigenetic changes generally involve...

Ngày tải lên: 08/08/2014, 21:20

... CT60 polymorphisms and chronic inflammatory arthropathies in Northern Ireland Exp Mol Pathol 2006, 80:141-146 Hadj Kacem H, Bellassoued M, Bougacha-Elleuch N, Abid M, Ayadi H: CTLA-4 gene polymorphisms ... cohort, 27% of patients were anti-SSA and anti-SSB negative, 35% had anti-SSA only and 38% had both anti-SSA and anti-SSB All patients and controls were Caucasians and provided informed consent Genotyping ... statistical analysis and drafted the manuscript PL and DC supervised genotyping and contributed to DNA samples collection MA and CC performed genotyping NC performed PHASE analyses EH, XP, and JS contributed...

Ngày tải lên: 09/08/2014, 10:20

... less (p = 0.005) Gene polymorphisms and occurrence of cardiac adverse events (Table 4) Out of seven polymorphisms, the following single gene polymorphisms showed significant results and therefore, ... Cardiothoracic Surgery 2009, 4:46 Additional file Investigated genes, their polymorphisms and function, primer and primer sequences Polymorphisms in genes coding for apolipoprotein E (APOE) [4,8], hepatic ... only 50 and 0% carriers of these variants were free from recurrent symptoms after 10 and 15 years, respectively However, a simple gene risk profile constructed out of randomly chosen polymorphisms...

Ngày tải lên: 10/08/2014, 10:20

... Mi-2//NuRD complex and gene regulation Oncogene 2007, 26:5433-5438 Silverstein RA, Ekwall K: Sin3: a flexible regulator of global gene expression and genome stability Current Genetics 2005, 47:1-17 ... in HDAC-2 activity, Mi-2α and mSin3a are likely to impair the physiological regulation of pro -inflammatory gene expression and may contribute to a chronic enhanced inflammatory response seen ... GR and HDAC [21,26] Both Mi-2 and mSin3a are critical components of transcriptional corepressor complexes and changes in their expression may lead to the alteration of both the formation and...

Ngày tải lên: 11/08/2014, 03:20