gene i implicated to the pathogenesis of autoimmune renal diseases
Báo cáo y học: "Insights in to the pathogenesis of axial spondyloarthropathy based on gene expression profiles" ppt
Ngày tải lên :
09/08/2014, 14:22
... been implicated in SpA adds to the credibility of gene expression microarray analysis as a technique to identify causal factors in this disease SLPI has not previously been implicated in the pathogenesis ... identified a number of novel and intriguing potential contributors to SpA Gene expression microarray may elucidate pathogenesis, facilitate diagnostic specificity, correlate with pharmacologic ... analysis in silico Use of a primary dataset and an independent validation dataset provides additional robustness Utilizing a false discovery rate calculation limits the possibility of false positives...
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Báo cáo y học: "Incidence of Ocular Zoonoses referred to the Inflammatory and Autoimmune Ocular Diseases Service of the University of Parma - Italy"
Ngày tải lên :
03/11/2012, 11:11
... [1] The only case of Lyme disease affected a 31 year-old farmer and his ocular manifestations are described in the specific section Figure 1: Geographical location of the province of Parma (Italy) ... Int J Med Sci 2009, 119 this case the patient had a panuveitis, which recovered only after a combination of medical treatment and surgery, with a final visual acuity of 40% in the affected ... References Mora P, Vecchi M, Barbera L, Toscani M, Orsoni JG Use of systemic cyclosporin A in a case of severe Toxocara uveitis J Infect 2006; 52:159-161 http://www.medsci.org ...
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Tài liệu Báo cáo khoa học: A single amino acid substitution of Leu130Ile in snake DNases I contributes to the acquisition of thermal stability A clue to the molecular evolutionary mechanism from cold-blooded to warm-blooded vertebrates docx
Ngày tải lên :
20/02/2014, 23:20
... suggested to be a critical factor in the initiation of human and rat SLE [12,40], the acquisition of thermally stable characteristics during DNase I evolution may provide a clue to the etiology of SLE ... characterization, including determination of thermal stabilities, of reptilian DNases I is required, not only to elucidate the molecular evolutional aspect of the DNase I family but also to address the ... both E quadrivirgata and E climacophora DNase I was substituted In comparison with the susceptibility of each wild-type enzyme to G-actin, the susceptibility of the E quadrivirgata (Ile67Val) enzyme...
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Báo cáo y học: "Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases" ppt
Ngày tải lên :
09/08/2014, 08:23
... significantly higher arthritis scores (Figure 5a) Histological investigation of the joints showed sig- nificantly severe cell infiltration in the hIL-32β group of mice (Figure 5b) In this way, hIL-32β ... expressed in the synovial tissues of rheumatoid arthritis patients (a) In situ hybridization of the synovial tissues from rheumapatients toid arthritis (RA) patients IL-32β was expressed in the synovial-infiltrated ... activators of T cells and important cytokines in the pathogenesis of autoimmune diseases CD4+ T cells increased IL-32 expression in response to IL-12 + IL18 and IL-23 stimulation (Figure 1d) In...
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Báo cáo y học: "Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline"
Ngày tải lên :
03/11/2012, 10:01
... responsibility towards future generations, difficulties of distinction between gene therapy and genetic enhancement, and the spectre of eugenics [1, 2, 3] Thus, human germline genetic modification is ... centrifugation to displace the obscuring cytoplasmic material such that the pronuclei become visible Similarly, the pronuclei in ovine zygotes are very difficult to visualise, due to sharing a very similar ... attributed to the fortuitous removal or inhibition of IF(s) [43] Seminal fluid reportedly contains an inhibitory factor (IF-1) that appears to actively block the binding of exogenous DNA to sperm...
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Tài liệu Báo cáo khoa học: Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation ppt
Ngày tải lên :
19/02/2014, 06:20
... Mapping of transcription initiation sites in the human DNASE1 gene To identify the transcription initiation sites of DNASE1 in pancreas, 5¢-RACE based on RNA ligasemediated and oligo-capping ... responsible for tissue-specific distribution of DNase I enzyme activity and ligation with the GeneRacer RNA oligo cDNA was synthesized by using Superscript III and the DNASE1specific primer DN+254, the ... regulation of human DNASE1 may provide clues to the mechanisms underlying ischemia-induced elevation of DNase I activity in vivo Here, we describe the identification of a novel transcription starting...
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Báo cáo y học: "Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration" ppt
Ngày tải lên :
09/08/2014, 14:20
... Panayi GS: Dysregulation of the in vivo production of interleukin-1 receptor antagonist in patients with rheumatoid arthritis pathogenetic implications Arthritis Rheum 1995, 38:642-648 Sive JI, ... NP cells This is consistent with the changes identified in the degeneration of the IVD, which include an upregulation in type I collagen protein in the NP region [20] The results of this study ... suggestion that TNF-α is involved in the early onset of degeneration, stimulating and driving the IL-1β signalling, as is thought to occur in articular cartilage and osteoarthritis If TNFα is involved...
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Báo cáo y học: "New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model" potx
Ngày tải lên :
12/08/2014, 14:22
... necrosis of bone marrow (asterisk), H&E staining, I, V, IX ×20; II, VI, X ×40; III, VII, XI ×100; IV, VIII, XII ×200, dotted square chosen to be magnified (b) Photomicrographs showing apoptosis of ... 0.05 These criteria resulted in the identification of 51 genes with significant modulation in G2 compared with G1 and six genes with significant modulation for G3 to G2 (Tables and 3) They also identified ... Page of 12 Figure Histology findings in placebo and steroid-induced ANFH rats (a) Photomicrographs showing histological findings in placebo- (I- IV) and steroid-treated WKY rats (V-VIII & IX-XII)...
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Báo cáo y học: "Bench-to-bedside review: Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis" ppsx
Ngày tải lên :
12/08/2014, 19:21
... Pendurthi UR: Mechanism of antithrombin III inhibition of factor VIIa/tissue factor activity on cell surfaces comparison with tissue factor pathway inhibitor/factor Xa-induced inhibition of factor VIIa/tissue ... [2,22,23] In addition to inhibition of fibrin formation, APC also promotes fibrinolysis in vitro by inhibiting two important inhibitors of plasmin generation, namely PAI-1 [18,54] and TAFI [56–58] This ... activator inhibitors of fibrinolysis [54], including plasminogen activator inhibitor (PAI)-1 and PAI-2 [16,54,56–58] Intravascular fibrinolysis is principally mediated by the actions of tissuetype...
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Báo cáo y học: "Prior mucosal exposure to heterologous cells alters the pathogenesis of cell-associated mucosal feline immunodeficiency virus challenge" docx
Ngày tải lên :
13/08/2014, 01:20
... a crucial role in immunopathogenesis of many viral infections including herpes simplex virus (HSV), hepatitis C virus (HCV), Friend virus and lentiviruses including FIV [53-58] These studies suggest ... consistent with findings that intact stimulating cells are required for efficacious production of antiHIV activity [66] Whether this is due to conformational interactions, interaction with secondary ... Source of Human Immunodeficiency Virus in Semen The Journal of Infectious Diseases 1997, 176:960-968 Jeng C, English R, Childers T, Tompkins M, Tompkins W: Evidence for CD8+ antiviral activity in...
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Báo cáo y học: " Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complex" pps
Ngày tải lên :
13/08/2014, 13:20
... [33] Differential inhibitory effects of KCREB and A-CREB were observed (Fig 4A, lanes 3–6) In light of this, we quantitated and compared the inhibitory activities of dominant negative proteins ... utilizes different domains to target different cellular factors We also found that multiple bZIP transcription factors including the newly-identified LZIP are involved in Tax activation of HTLV -I ... A-ATF4, AFos and A-LZIP might non-specifically inhibit transcription Functional significance of the HTLV -I TATAA element to transcriptional activation by Tax In the course of our analyses, we...
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Molecular mechanisms underlying the pathogenesis of nasal polyposis and its response to steroid treatment
Ngày tải lên :
10/09/2015, 15:49
... (iv) the infiltration of eosinophils and concentration of total IgE in tissues were also significantly increased in samples with the presence of specific IgE to enterotoxins Moreover, there is ... oncogene homolog mitogen-activated protein kinases mitogen-activated protein kinase kinase major basic protein major histocompatibility complex class II macrophage migration inhibitory factor ... differentiation of bone marrow progenitors into functionally 12 mature cells; (ii) rolling, adhesion and migration through the endothelium; (iii) chemotaxis, activation and survival within the tissue...
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Part i organic reactions in non conventional solvents part II new approach to the formation of bishomoallylic alcohols synthesis of (r) sulcatol
Ngày tải lên :
16/09/2015, 15:54
... Application of Mannich bases and their derivatives in medicine Hence, the versatility of the Mannich reaction, along with the remarkable possibilities of exploiting the reactivity of Mannich bases in ... asymmetric Mannich-type reaction in ionic liquids Firstly, we investigated the effect of different ionic liquids on the asymmetric Mannich-type reaction using InCl3 Four different ionic liquids were ... liquid, 15 Cl 14 Scheme The newly designed ionic liquid 15 Summary vii Part II: New Approach to the Formation of Bishomoallylic Alcohols – Synthesis of (R)-Sulcatol The regioselectivitives of...
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Báo cáo y học molecular approaches to the analysis of deformed wing virus replication and pathogenesis in the honey bee, apis mellifera
Ngày tải lên :
20/12/2015, 08:30
... could provide important insight into the complexity of virus replication strategies leading to disease pathogenesis To gain a better understanding of active sites of DWV replication in infected ... there is lack of information on quantification of virus replicative intermediates and differentiation of positive and negative-strand DWV RNA in the different tissues of infected bees, which could ... of the digestive tract was likely the primary site of the DWV infection via food-borne transmission, with the virus spreading to secondary sites from the digestive tract The presence of positive-strands,...
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the situation of teaching speaking skill to the students of pre intermediate level of proficiency at peoples police college i problems and some suggested techniques and activities
Ngày tải lên :
25/12/2015, 17:24
... English proficiency is one among the main factors affecting their participation in classroom speaking activities Lack of motivation of communicative competence Motivation related to success in ... speaking skills with a view to help the students improve their speaking competence The specific objectives of the study are: To investigate the current situation of teaching English speaking skill ... English Proficiency at the PPCI and some suggested techniques and activities which help them improve the quality of their teaching The study of difficulties, recommendations of other language skills...
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Cambridge.University.Press.An.Introduction.to.the.Philosophy.of.Mind.Jan.2000.pdf
Ngày tải lên :
21/09/2012, 10:39
... than it is in any other field of rational inquiry and it is unfair to criticise metaphysics for failing to deliver what no other discipline – not even mathematics – is expected to deliver Nor is ... domain of empirical scientific inquiry before presuming to offer philosophical reflections about it A scientific theory of vision, say, is neither a rival to nor a substitute for a philosophical ... actions and events Intentionality The individuation of actions Intentionality again Trying and willing Volitionism versus its rivals Freedom of the will Motives, reasons and causes Conclusions...
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A study on the techniques for the improvement to the teaching of oral skills in light of communicative english language teaching for junior high school teachers in quang ngai province part 1
Ngày tải lên :
07/11/2012, 14:41
... given to help them improve their teaching of oral skills The specific aims are: - To investigate the current performance of English teaching and learning in JHSs in Quang Ngai province - To find ... been filled in to guide their listening Students listen and fill in the rest in note form Example: Listen to the weather forecast and fill in the blanks with the information in the text (TIÊNG ... to apply the communicative approach to their teaching The rest still reveal their limitations in language knowledge and are not used to applying the communicative approach to their teaching They...
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A study on the techniques for the improvement to the teaching of oral skills in light of communicative english language teaching for junior high school teachers in quang ngai province part 2
Ngày tải lên :
07/11/2012, 14:41
... VIET NAM NATIONAL UNIVERSITY, HANOI COLLEGE OF FOREIGN LANGUAGES POST GRADUATE STUDIES DEPARTMENT TRẦN QUỐC VIỆT A STUDY ON THE TECHNIQUES FOR THE IMPROVEMENT TO THE TEACHING OF ORAL SKILLS IN ... SKILLS IN LIGHT OF COMMUNICATIVE ENGLISH LANGUAGE TEACHING FOR JUNIOR HIGH SCHOOL TEACHERS IN QUẢNG NG I PROVINCE (NGHIÊN CỨU CÁC THỦ THUẬT NÂNG CAO VIỆC DẠY KỸ NĂNG NGHE N I TIẾNG ANH THEO ĐƯỜNG ... CAO VIỆC DẠY KỸ NĂNG NGHE N I TIẾNG ANH THEO ĐƯỜNG HƯỚNG GIAO TIẾP CHO GIÁO VIÊN TRUNG HỌC CƠ SỞ T I TỈNH QUẢNG NG I) M.A.THESIS HA NOI-2007 ...
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A study on the techniques for the improvement to the teaching of oral skills in light of communicative english language teaching for junior high school teachers in quang ngai province part 3
Ngày tải lên :
07/11/2012, 14:41
... their valuable lectures And their knowledge, their thoughtfulness as well as their sympathy I will always appreciate For the accomplishment of this study, I wish to show my sincere thanks to ... for their attention and encouragement I am appreciative of all those who have kindly advised and helped me during the period of my study at College of Foreign Languages, VNU-Hanoi Finally, I wish ... Appendix .41 iv ACKNOWLEDGEMENTS First of all, I would like to express my deep gratitude to all my teachers at College of Foreign Languages, Vietnam National University-Hanoi for their...
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Learning JavaScript A Hands-On Guide to the Fundamentals of Modern JavaScript
Ngày tải lên :
03/01/2013, 15:51
... cached This way of applying styles is also very difficult to maintain and reuse on a site because everything is customized and tied to the element to which it is attached Inline CSS is fairly important ... the onclick attribute in Listing 1.1.5 They accomplish the same outcome of waiting (listening) for the user to click the link before executing the function you defined Moving forward with this ... see this quite a bit, where inline CSS is all but dead in the wild One of the most common applications of inline JavaScript is adding a click behavior to an element “Click” is a JavaScript event...
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