... The differences in expressionof these miRNA expression between adult cells and hES cells and between adult cells and EB were significant (P < 0.05) Of note, theexpression levels of let-7b and ... between theexpression levels of hES upregulated miRNAs andthe levels of their predicted targets The predicted targets for each miRNA were downloaded from miRNAMap2.0 [44] and their expression ... Journal of Translational Medicine 2009, 7:20 we calculated the correlation coefficients between miRNA expression levels and randomly-selected non-target genes ofthe same number In general, the expression...
... shown to regulate theexpressionof FOS and JUN family genes in the rat brain [58-60], the effect of typical APs and atypical APs on these genes in the liver have not been reported The superoxide ... that thegeneexpression changes are quite robust in the postmortem liver tissues This may be due to the direct and profound effects of APs on geneexpression in the liver as compared to the confounding ... geneexpressionand a subset of those genes are associated with stress responses in the liver Thus, the genes andthe pathways identified in the current study may provide important clues to the...
... collagen I and collagen III in the mesenchymal tissue ofthe saline control group The expressions of collagen I and collagen III ofthe silica+LvshCD36 group were weaker than those ofthe silica and ... inhibit theexpressionofthe collagen I and III in lung To further observe the degree of fibrosis, immunohistochemical examination of collagen I and III was performed in the lung tissue The results ... (Stage I) and tiny collagen fibers in the lung of rats in the silica+Lv-shCD36 group Compared to the silica andthe silica+Lv-shCD36-NC groups, the number of nodules in the lungs of rats in the silica+Lv-shCD36...
... TFs and putative, as yet uncharacterized regulators We analyzed the history of each ofthe global regulators, andof a sample of each ofthe other types of regulators (see Figure and Materials and ... two operons, andthe proximity of these regulators to their regulated genes suggests that HGT might be involved in theevolutionof these regulatory relationships [14] Furthermore, these neighbor ... theory [35,36] More precisely, we imagine that the genes themselves andthe regulatory relationship between them benefit the host, but the proximity itself may not be of benefit to the host and...
... profiling Gene- expression profiling is the simultaneous measurement ofthe amount of mRNAs of all the genes, which are transcribed from the genome, in the cell At any moment, not all the genes are ... this case, the variances ofthe classes are pooled to compute the standard error, s2 and s2 denote the variance ofthe two classes respectively, N1 and N2 denote the sample size ofthe two classes ... many mor ofthe increment depends on the correlation ofthegene with the one ofthe two phenotypes We theref phenotype The enrichment score is the maximum deviation from Moreover, in the permutation...
... the first two structural motifs, and hence the N-terminal domain ofthe protein, just as in the genes for cS and cA–F However, the second half ofthegene has the structure of a b-crystallin gene, ... encoding the two motifs ofthe C-terminal domain The crygn gene is thus a hybrid of b and c crystallin gene structures, apparently an intermediate in theevolutionofthe c-crystallins from the b-crystallins ... different regions ofthe eye Theexpressionof cN in the central regions ofthe lens, fiber cells that were laid down before birth, is consistent with the familiar pattern ofexpressionofthe principally...
... consequence ofthe physical laws of our universe andthe subatomic structure ofthe oxygen atom As we shall see in Chap 2, the existence of oxygen atoms is in turn a necessary result oftheevolutionof ... Thus, the higher the pH value, the lower the proton concentration and therefore the degree of dissociation of water This behavior of water depends strongly on the temperature, the higher the temperature ... the nucleus The number of protons in a nucleus gives its atomic number and its positive charge Add the number of neutrons and you have the atomic mass The nucleus ofthe most common isotope of...
... in nature These are often called white, brown, and pink noise, and all are defined by the relation between the frequency and power (proportional to the square ofthe amplitude) of their components ... videos, and most of what is called art film—is designed to suppress awareness ofthe presentational aspects ofthe film while promoting the narrative The units of film are the act, the sequence, the ... near the film’s end was analyzed as Shot The autocorrelation ofthe length of a Shot with itself (Lag 0) is always 1.0; autocorrelations ofthe length of Shot with the lengths of Shots (Lag 1) and...
... tF > tS, and if CFn are the net cash flows ofthe investment of new entrants, then the expected market value of new entrants will equal the sum of discounted value ofthe investment andthe net ... abandoned wholesale regulation (the case ofthe USA) and some others have shifted from light-handed regulation to heavy-handed regulation with mandatory unbundling ofthe local loop (the case of ... aspects ofthe ladder of investment theory and also refers to papers presenting empirically based analyses ofthe tenability ofthe theory Moreover, the chapter introduces the issue of intermodal...
... in expressionof thousands of genes [9,12,13] Another challenge is that the specificity and sensitivity of a given RNA profiling platform are affected by the abundance and variability ofthe ... measure the amplitude ofthe globin artifact or the amount of noise it introduces We have chosen the standard deviation ofexpression values rather than covariance to quantify the amplitude ofthe genes ... drafting and editing ofthe manuscript SL completed the analysis ofthe protocol selection study, participated in the analysis ofthe SAHA data and participated in the drafting and editing of the...
... viability andgeneexpression over time In summary, we conducted a detailed study ofthe effects of weak DC on viability, geneexpressionand morphology of B subtilis The data suggest that the ions and ... DC The genes are listed in the order ofgene names A full list of induced genes can be found in the Additional File (Supplemental Data) The experiment was done in duplicate andthe average expression ... DC The genes are listed in the order ofgene names A full list of repressed genes can be found in the Additional File (Supplemental Data) The experiment was done in duplicate andthe average expression...
... tF > tS, and if CFn are the net cash flows ofthe investment of new entrants, then the expected market value of new entrants will equal the sum of discounted value ofthe investment andthe net ... abandoned wholesale regulation (the case ofthe USA) and some others have shifted from light-handed regulation to heavy-handed regulation with mandatory unbundling ofthe local loop (the case of ... aspects ofthe ladder of investment theory and also refers to papers presenting empirically based analyses ofthe tenability ofthe theory Moreover, the chapter introduces the issue of intermodal...
... taxa to the Strongylida are members ofthe Rhabditina, including C elegans, and both are grouped in Clade V ofthe Nematoda, on the basis of small subunit rRNA sequence analysis [48] The set of 742 ... we have addressed the question of whether secreted proteins of parasitic nematodes show accelerated evolution, and our results indicate that this is the case The predominance of predicted secreted ... categories of genes which are prominent in other nematode parasites, such as the five clusters encoding homologs of Ancylostoma secreted protein [2], five clusters of C-type and S-type lectins [55] and...
... result of increased biosynthesis and reduced catabolism, the sensitivity to the hormone may decrease as a result of reduced expressionofthe receptor GA biosynthesis genes ofthe GA 20-oxidase and ... (Table 3) Expressionof organ identity and patterning genes Ofthe genes representing the developmental processes, key floral and fruit patterning genes were examined for their expression profiles ... the final floral landmark as well as the first fruit landmark (Table and 2) At the time of anthesis, the anther lobes dehisced to release the pollen, which after landing on the receptive stigma,...
... x-axis represents the log2 oftheexpression ratios between 137F and B6 The y-axis represents the log2 oftheexpression ratio between either 44H and B6, or 97C and B6 As expected, there is a highly ... summary ofthe modes of regulation encountered in the IRCSs and their parent strains A summary ofthe modes of regulation encountered in the IRCSs and their parent strains Blue marks the B6 chromosome ... fashion in the IRCSs (class 3) - in this case the dysregulation between B6 and SEG on the one hand and B6 andthe IRCSs on the other hand is associated with a strong correlation between gene expression...
... facilitated by the TATA box [42-44] Thus, a TATA box could increase the extent of re-initiation, thereby amplifying geneexpression Notably, the binding ofthe PIC to the TATA box andthe binding of transcription ... nucleosome positioning, and changes in the number of repeats affect the density and positioning of nucleosomes in the critical part ofthe promoter [52] Expression divergence by cis and trans mutations ... genes is enriched with plasma membrane genes and, in general, genes that interact with the cell environment [7] (Figure 2) These genes are needed to cope with changes in the environment and their...
... similar in the peripheral blood and in the parotid gland These results suggest an important role for VL chain gene usage in the immune activation of B cells within the parotid gland ofthe pSS patient ... CD5, further supporting the hypothesis of homing and activation of specific B cells in the glands B cell malignancies and Sjögren’s syndrome In contrast to the focal sialadenitis ofthe minor ... pathology of SS This process seems to be tightly regulated at least in part by chemokines andthe local expressionof their receptors Chemokines andtheexpressionof chemokine receptors by the inflamed...
... understanding ofthe roles of these co-repressor complexes and thereafter their roles in disease In summary cigarette smoke exposure reduced HDAC2 activity andtheexpressionof mSin3a and Mi-2α ... alteration of both the formation and targeting of these complexes Consequently, an oxidant-mediated reduction in the protein expressionof Mi-2α and mSin3a and increased protein expressionof Mi2β may ... in its design and prepared the manuscript CSS designed and ran the in vivo model KFC participated in the study design and preparation ofthe manuscript IMA and PAK conceived ofthe study, participated...
... understanding ofthe roles of these co-repressor complexes and thereafter their roles in disease In summary cigarette smoke exposure reduced HDAC2 activity andtheexpressionof mSin3a and Mi-2α ... alteration of both the formation and targeting of these complexes Consequently, an oxidant-mediated reduction in the protein expressionof Mi-2α and mSin3a and increased protein expressionof Mi2β may ... in its design and prepared the manuscript CSS designed and ran the in vivo model KFC participated in the study design and preparation ofthe manuscript IMA and PAK conceived ofthe study, participated...