gene environment interactions in environmental lung diseases
báo cáo khoa học: " Simulating gene-environment interactions in complex human diseases" pdf
Ngày tải lên :
11/08/2014, 12:20
... models, a special set of high-order gene- gene interaction models in which genes influence disease risk only through interactions with other genes, without any main effects Applicability of the simulation ... surrounding genetic markers, so more sophisticated simulation methods are needed to simulate linked markers using genetically related individuals Existing approaches include: resampling from existing ... simulate gene- environment interactions in complex diseases BMC Bioinformatics 2010, 11:8 Isohanni M, Oja H, Moilanen I, Rantakallio P, Koiranen M: The relation between teenage smoking and drinking,...
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Báo cáo khoa học: Nature, nurture and neurology: gene–environment interactions in neurodegenerative disease docx
Ngày tải lên :
16/03/2014, 19:20
... variability in brain ageing and associated cognitive 2355 Gene environment interactions in neurodegenerative disease decline in all human populations, forming a template on which specific disease gene ... Hannan Gene environment interactions in neurodegenerative disease Table Environmental in uences on neurodegenerative disease AD, Alzheimer’s disease; HD, Huntington’s disease; PD, Parkinson’s ... threefold, indicating increased capacity for injury-associated plastic changes in the enriched cortex [38] Environmental enrichment also causes molecular changes in the developing brain Enriching animals...
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Báo cáo y học: "Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking" potx
Ngày tải lên :
09/08/2014, 10:23
... polymorphism interacts with heavy cigarette smoking in a multiplicative manner These findings contribute to the growing understanding of how genetic and environmental factors interact in RA pathogenesis, ... in controls and 14% in cases) In analyses involving CTLA-4 and PADI-4, we assessed the risk for RA in dominant, additive, and recessive models Gene- environment and gene- gene interactions We conducted ... Toes RE, Huizinga TW, Klareskog L, Alfredsson L: Gene- gene and gene- environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis Am J Hum Genet 2007,...
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Báo cáo y học: " A model of gene-gene and gene-environment interactions and its implications for targeting environmental " doc
Ngày tải lên :
13/08/2014, 16:21
... factors in determining a trait However, analysis of twin data is usually limited by the assumptions made in the classical twin study [15], including that: (i) there are no gene- gene interactions ... (for example, lung cancer); (ii) the complexity of gene- gene and gene- environment interactions and/or lack of knowledge of environmental factors (for example, schizophrenia) Targeting environmental/ lifestyle ... be avoided if an environmental intervention (such as a lifestyle change or reduction in exposure) succeeds in moving everyone in the 'high environmental risk group' to the 'low environmental risk'...
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Báo cáo y học: " Angiogenesis in Interstitial Lung Diseases: a pathogenetic hallmark or a bystander?" potx
Ngày tải lên :
12/08/2014, 16:20
... protein, GRO: Growth related genes, IP-10:IFN-γ-inducible protein 10, ITAC: IFN-γ-inducible T-cell a chemoattractant, MIG: Monocyte Induced by interferon gamma-protein, NAP: Neutrophil activating ... in interstitial lung diseases (Table 1) Molecules that originally promote angiogenesis include members of the CXC chemokine family, characteristically heparin binding proteins which on structural ... chemokine described to inhibit aberrant angiogenesis Furthermore, the angiostatic ELR- members of the CXC chemokine family include the interferon (IFN)-γ inducible protein (IP)-10/ CXCL10, monokine...
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Báo cáo y học: "Protein interactions in human genetic diseases" doc
Ngày tải lên :
14/08/2014, 08:20
... alanine scanning energetics experiments in protein binding [21] as a 'gold-standard' test set (see Materials and methods) In such an alanine scan, residues in the binding interface of a protein ... explained by the overrepresentation of homo -interactions in the structural templates set: 70% of all distinct protein pairs in iPfam are homo -interactions, which is in accordance with recent findings ... clustering in MPZ mutations Brain 2004, 127:371-384 Finn RD, Marshall M, Bateman A: iPfam: visualization of proteinprotein interactions in PDB at domain and amino acid resolutions Bioinformatics...
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Báo cáo sinh học: "Effects of data structure on the estimation of covariance functions to describe genotype by environment interactions in a reaction norm model" potx
Ngày tải lên :
14/08/2014, 13:22
... analysed trait showed that genetic variances increase with increasing herd level of the trait [1, 8] In order to simulate mainly increasing genetic variance across environments, 99% of simulated ... Mendelian Sampling term was simulated dependent on the environment, to ensure that it explained half of the total genetic variance in each given environment The breeding value in a specific environment ... methods for breeding value prediction that either (1) ignore environmental sensitivity or (2) ignore re-ranking by correcting only for heterogeneity of variances [9] In international breeding value...
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Báo cáo sinh học: "Genotype by environment interactions in relation to growth traits in slow growing chickens" ppsx
Ngày tải lên :
14/08/2014, 13:22
... in environment A than in B Expression of the genetic potential was therefore better in A than in B, with the effects originating from the environment lower, and heritability higher in A than in ... heritable in S than in C, and for K, more heritable in SC than in E In the second and third situations, both genetic and residual variances were higher in environment B than in A, suggesting the ... three environments, traits measured in C, S, and E were treated as distinct (e.g for BRY we G × E interactions in slow-growing chickens 519 distinguished BRYC , BRYS , and BRYE , subscripts indicating...
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Nanotechnology Consequences for Human Health the Environment (Issues in Environmental Science and Technology)
Ngày tải lên :
02/03/2016, 20:27
... Pollution and Health 11 Environmental Impact of Power Generation 12 Endocrine Disrupting Chemicals 13 Chemistry in the Marine Environment 14 Causes and Environmental Implications of Increased UV-B Radiation ... Initiative, bringing the total investment since the NNI was established in 2001 to over $6.5 billion and nearly tripling the annual investment of the first year of the Initiative.7 With this investment ... active in nanomaterials for many years continue to invest heavily in new products, and in Japan and China there has been a very significant growth in investment in this whole area that will inevitably...
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business and environmental risks spatial interactions between environmental hazards and social vulnerabilities in ibero-america
Ngày tải lên :
29/05/2014, 23:42
... London since 2006 Since 2009 he is one of the global coordinators of GIN (Greening of Industry Network) – an international network which promotes the integration of environmental issues in firms, ... Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) To all those living in ‘hot-spots’ and suffering the consequences of the problems outlined in ... developmental problems can, and indeed should, be tackled separately is deeply ingrained in a still dominant Introduction mindset that invokes the existence of trade-offs between environmental and social...
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Báo cáo lâm nghiệp: "Genetic variation and genotype by environment interactions of juvenile wood chemical properties in Pinus taeda " pps
Ngày tải lên :
07/08/2014, 16:20
... within site), γ is the vector of random-effects parameters including general combining ability (GCA) for female and male, specific combining ability (SCA), GCA by site interaction, SCA by site interaction, ... essentially no site by general combining ability interactions for α-cellulose for juvenile and transition wood, mainly because of zero general combining ability by site interaction variances The ... using a t distribution with n-2 degrees of freedom The magnitudes of genotype by environment interactions were estimated by analyzing combined sites under the general linear mixed model given Genetic...
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Báo cáo toán học: "How to include organ interactions in models of the root system architecture? The concept of endogenous environment " potx
Ngày tải lên :
08/08/2014, 14:22
... specifying that each node can develop roots during a given time (age) window Regarding branching of existing roots, a very common process occurring in almost all root systems is acropetal branching, ... [13] in the case of root systems INCLUSION OF SUB-MODELS FOR DESCRIBING THE SOIL-ROOT INTERACTIONS Since the soil is a very heterogeneous medium, and it is well known that this heterogeneity in ... which occur in a large range of growing conditions, and lead to highly determined topological structures Thus, they are worth formalising through morphogenetic rules, Modelling root interactions...
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Báo cáo y học: "Host gene expression profiling in influenza A virus-infected lung epithelial (A549) cells: a comparative analysis between highly pathogenic and modified H5N1 viruses" ppt
Ngày tải lên :
12/08/2014, 01:21
... GO:0019221~cytokine-mediated signaling pathway down regulated genes at different time point post infection Contrastingly, genes coding for ribosomal proteins and other proteins involved in protein translation ... S1 Genes involved in chemokine & cytokine mediated signaling in highly-pathogenic and RG modified H5N1 infected A549 cell lines (16 h post infection time point) Red arrow indicates expression in ... Figure S2 Genes involved in p53 signaling pathway in highly-pathogenic and RG modified H5N1 infected A549 cell lines (16 h post infection time point) Red arrow indicates expression in highly-pathogenic...
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Báo cáo y học: " Characterization of variants in the promoter of BZLF1 gene of EBV in nonmalignant EBV-associated diseases in Chinese children" docx
Ngày tải lên :
12/08/2014, 04:20
... found in all infection categories, except a relatively rare diseaseCAEBV, indicating that it was the primary variant of EBV circulating in China The Zp-V3 variant was the dominant genotype in CAEBV ... superinfection by multiple strains of EBV, especially the presence of the Zp-V3 variant, may be a contributing factor in the development of severe EBV infections in children Thus, these findings ... variants and EBV infection in the China children population In this study, statistical analysis determined that differences in the distribution of Zp variants were significant in the four patient...
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Báo cáo y học: " Expression, regulation and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseases" pptx
Ngày tải lên :
12/08/2014, 11:21
... elastase in CF lungs could decrease mCD14 and thereby reduce the mCD14 amount to be cleaved by LPS and shedded into the airway environment; (iii) the intrinsic genetic mutation in the CFTR gene might ... mCD14 in pediatric lung diseases has not been defined Therefore, we quantified sCD14 and mCD14 levels in peripheral blood and BALF of children with infectious and non-infectious pediatric lung ... after 40 hours of incubation was protease-independent since PMSF did not inhibit CpG-induced sCD14 release by PBMCs After 40 hours of incubation, LPS and CpGs cooperated in the induction of sCD14...
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Báo cáo y học: " A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: a staged highthroughput biophysical screening" pps
Ngày tải lên :
12/08/2014, 13:22
... with a class of 143-3 proteins and, moreover, competitively inhibit the binding of phosphorylated cofilin to 14-3-3 proteins Using SPR-based evaluation of protein interactions, we found that ... the highest binding affinity for the g isoform of 14-3-3 proteins (Figure 1B) Hence, we focused on pHSP20-14-3-3 g protein interactions in human ASM as a potential molecular target against excessive ... protein was subjected to two-step GST-His tag affinity purification according to manufacturer’s instructions (Sigma-Aldrich Inc., St Louis, MO; Qiagen Inc., Valencia, CA) Fractions containing...
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Báo cáo y học: " Claudins in lung diseases" ppt
Ngày tải lên :
12/08/2014, 13:22
... Expression of claudins in lung cells has been compiled in Table Claudins in embryonic development of the lung Claudins are involved in embryogenesis and organogenesis and changes in their expression ... claudin 1, and mRNA and protein expression and an increase in claudin mRNA in alveolar epithelial cells resulting in an increased leakiness of tight junctions in the lung [27] Additionally, inflammatory ... [29] Interestingly, claudin 15 knockout mice develop a megaintestine [30] In organogenesis, claudin expression is turned off in cells taking part in epitheliomesenchymal transition [31] In embryonic...
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Báo cáo y học: "Silencing CD36 gene expression results in the inhibition of latent-TGF-β1 activation and suppression of silica-induced lung fibrosis in the rat" pdf
Ngày tải lên :
12/08/2014, 14:20
... [14] Determination of hydroxyproline content The lung samples were measured for hydroxyproline content using a hydroxyproline kit from Nanjing Jian Cheng Institute (China) following instructions ... HE and vG staining for histopathologic changes in rat lungs (× HE and vG staining for histopathologic changes in rat lungs (× 400) (A) days after instillation; (B) 21 days after instillation; ... revealed using a 3, 3'-diaminobenzidine tetrahydrochloride Substrate Kit (Beijing Zhongshan Golden Bridge Biotechnology Ltd., China) The sections were counterstained with hematoxylin for min, rinsed...
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Báo cáo y học: " Global gene expression patterns in the post-pneumonectomy lung of adult mice" ppt
Ngày tải lên :
12/08/2014, 14:20
... compensatory lung regeneration from the remaining lung lobes [4], in part through neoalveolarization within the existing parenchyma [5] This regenerative process is characterized by restoration of lung ... contain, based on a Pvalue that indicates the likelihood of the genes in a network being found together due to chance A score of indicates a in 100 chance that the focus genes of interest were linked ... transcription factors in lung in the early phase of postpneumonectomy lung growth Am J Physiol Lung Cell Mol Physiol 2001, 281:L1138-49 Gilbert KA, Rannels DE: Increased lung inflation induces gene expression...
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