gene environment interaction in complex diseases asthma as an illustrative case

... simulate gene- environment interactions in complex diseases BMC Bioinformatics 2010, 11:8 Isohanni M, Oja H, Moilanen I, Rantakallio P, Koiranen M: The relation between teenage smoking and drinking, ... whole-genome association and population-based linkage analyses Am J Hum Genet 2007, 81:559-575 doi:10.1186/gm142 Cite this article as: Peng B: Simulating gene- environment interactions in complex human diseases ... gene- environment interactions using a combined case- only and case- control approach Am J Epidemiol 2009, 169:497-504 Wang T, Ho G, Ye K, Strickler H, Elston RC: A partial least-square approach for modeling gene- gene...

Ngày tải lên: 11/08/2014, 12:20

... mapping in humans while retaining the advantages of animal experiments Relevance of findings made in animal models It is sometimes argued that findings made in animals are not necessarily relevant ... both human and animal genetics have benefits: human genetics in its certain relevance and relatively fast identification procedure; and animal genetics in its ability to limit complexity and so ... causative gene remains As in the tale of the tortoise and the hare, human genetics has been regarded as fast but unreliable, whereas animal genetics is slow and laborious but likely to find the gene...

Ngày tải lên: 09/08/2014, 01:22

... and A J Hannan changes in response to enrichment include increases of greater than threefold, indicating increased capacity for injury-associated plastic changes in the enriched cortex [38] Environmental ... Gene environment interactions in neurodegenerative disease with predominantly genetic causes, such as Huntington’s disease (HD) and other trinucleotide repeat expansion disorders, as well as ... causing HD: an expanded CAG repeat in the gene encoding a protein that came to be known as huntingtin [5] Normal individuals have 10–34 CAG repeats in this gene 2348 T L Spires and A J Hannan Individuals...

Ngày tải lên: 16/03/2014, 19:20

... characteristics XGZ was involved in the FE-SEM, EDX, and IMVS analyses of TiO2 films and TN- and ATN-doped TiO2 films J-YP participated in the preparation of TN and ATN, and in the analyses of XRD and FE-SEM ... photoelectrode-based DSSCs was 4.74%; it was increased to 6.13% after adding wt.% ATN into TiO2 films The electron lifetime of DSSCs with ATN increased from 0.29 to 0.34 s and that electron recombination was ... prepared titanium dioxide nanofibers by electrospinning J Nanosci Nanotechnol 2010, 10:3402-3405 17 Li D, Xia Y: Fabrication of titania nanofibers by electrospinning Nano Lett 2003, 3:555560 18 Ding...

Ngày tải lên: 20/06/2014, 20:20

... financialisation manifests in the expansion of the banking, wealthmanagement and insurance sectors, as well as the broadening and deepening of capital markets The personal finance market is an ... finance requires that individuals internalise an ethos of financial risk-taking (Martin 2002) The mass media have played a large role in glorifying the 17 culture of financial risk-taking, as ... Concomitant with the rise of “financial infotainment” was an explosion in advertising for financial products targeted at the retail investor (293) For individuals to participate in this new financial...

Ngày tải lên: 30/09/2015, 10:13

... financialisation manifests in the expansion of the banking, wealthmanagement and insurance sectors, as well as the broadening and deepening of capital markets The personal finance market is an ... finance requires that individuals internalise an ethos of financial risk-taking (Martin 2002) The mass media have played a large role in glorifying the 17 culture of financial risk-taking, as ... Concomitant with the rise of “financial infotainment” was an explosion in advertising for financial products targeted at the retail investor (293) For individuals to participate in this new financial...

Ngày tải lên: 03/10/2015, 21:56

... financialisation manifests in the expansion of the banking, wealthmanagement and insurance sectors, as well as the broadening and deepening of capital markets The personal finance market is an ... finance requires that individuals internalise an ethos of financial risk-taking (Martin 2002) The mass media have played a large role in glorifying the 17 culture of financial risk-taking, as ... Concomitant with the rise of “financial infotainment” was an explosion in advertising for financial products targeted at the retail investor (293) For individuals to participate in this new financial...

Ngày tải lên: 04/10/2015, 07:59

... to interact with Calp1 This indicates the presence of a calpain binding site in the C-terminal domain of smooth muscle a-actinin Involvement of the C-terminal domain of ask in Calp1 binding In ... implicated in the interface linking calpain to skeletal muscle a-actinin Colocalization of microcalpain and a-actinin in myogenic cells Calpains and a-actinin were previously located in Z-disks [44], and ... the interaction was conducted in the presence of mM calcium (and E64 as calpain inhibitor), a tenfold increase in affinity [Kd(+Ca2+) ¼ 0.05 ± 0.01 lM] was observed (Fig 2C, Calpain 1–a-actinin interaction...

Ngày tải lên: 07/03/2014, 21:20

... overexpressed in MS Immunohistochemistry confirmed this finding, and 5-lipoxygenase staining was mainly detected in cells resembling macrophages and monocytes The authors point out that 5-lipoxygenase ... S, Ingegnoli F, Chang S-YP, Alexander H, Massa M, Pistorio A, Martini A, Pitzalis C, Sinigaglia F, Rogge L: Increased expression of α(1,3)-fucosyltransferase-VII (FucT-VII) and P-selectin binding ... disease The role of Fc receptors in EAE was studied by comparing the severity of disease in Fc receptor-deficient and wild-type mice Acute disease was less severe and chronic disease was absent in...

Ngày tải lên: 09/08/2014, 01:21

... genes’ in target cells and various (normal and disease) tissues requires the use of different cell types in the complex interaction and interplay The synovium can be classified and analyzed as ... proteins and transcripts), in the context of the whole genome While an understanding of genes and proteins continues to be important, the focus should be on ascertaining a system’s structure and ... fish), as well as the interactions that change in the disease state (clinical material and diagnosis) (Fig 1) This information resides neither in the genome nor in individual gene( s)/protein(s),...

Ngày tải lên: 09/08/2014, 01:21

... low (9% in controls and 14% in cases) In analyses involving CTLA-4 and PADI-4, we assessed the risk for RA in dominant, additive, and recessive models Gene- environment and gene- gene interactions ... height (in meters squared), as reported at baseline Alcohol intake was reported at least every years and categorized in grams per day Husband's educational level was assessed in 1992 in NHS and 1999 ... different from ours, in that they did not find a significant interaction between the presence of the PTPN22 polymorphism and smoking in determining RA risk Their gene- smoking interaction analyses used...

Ngày tải lên: 09/08/2014, 10:23

... Glucocorticoids (GCs) are invaluable therapeutic tools in the treatment of many chronic inflammatory diseases, including asthma and RA Recent findings in the study of inflammatory lung diseases demonstrate ... human airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD) In both bronchial biopsies and alveolar macrophages isolated from asthma patients, a significant increase in ... relevant to inflammatory disease is just beginning to be assessed [23] Many of the compounds listed above are in phase I, phase II and phase III clinical trials for the treatment of leukemias and...

Ngày tải lên: 09/08/2014, 11:20

... 1,3- -glucanases and several proteinase inhibitors Early induction of genes encoding chitinases and 1,3- -glucanases is a typical response of plants towards fungal pathogens In the interaction ... amino acid phenylalanine via phenylalanine ammonia-lyase (PAL), and encompass a range of structural classes such as lignins, phenolic acids, flavonoids and stilbenes A key branching point in ... were compiled into one table and using the Arabidopsis as well as RPS-Blast hits an initial classification into the MapMan BINs was achieved This was then checked manually based on the annotations...

Ngày tải lên: 12/08/2014, 03:21

... in CAEBV cases (P ≤ 0.01) and relatively high in EBV-HLH cases The Zp-V1 variant, however, was only found in IM and control cases, while the V4 variant was not detected in any CAEBV cases Co-existence ... control cases Zp-V1 was identified as a novel variant and was detected in 10 IM and health control cases but not in CAEBV and EBV-HLH The absence or low level of ZP-V1 and Zp-V4 in CAEBV and HLH ... variants and EBV subtypes As shown in Table 3, the incidence of co-existence of Zp variants (Figure 2) in HLH (30.4%) and CAEBV (37.5%) cases was higher than for both IM (14.8%) and control cases...

Ngày tải lên: 12/08/2014, 04:20

... epithelial-mesenchymal interaction effects in human cancers Interactions between cancer cells and non-malignant cells in the surrounding microenvironment are important determinants of cancer development and progression ... for investigating the gene expression program in response to heterotypic cell-cell interaction in normal breast and in breast cancer, we examined cells representing the benign and malignant epithelial ... pathway, such as the gene encoding latent transforming growth factor beta binding protein LTBP2 and transforming growth factor induced gene TGFBI, were induced in parallel with the 'myofibroblast response'...

Ngày tải lên: 14/08/2014, 08:20

... 20) Protein ubiquination, actomyosin structure and biogenesis, protein binding, ion binding WDR1 [4p16.1] WD repeat domain (WDR1), transcript variant Actin binding, protein binding, sensory perception ... chromosome Human protein interaction networks A human protein interaction network was generated [4] Briefly, protein interaction data were obtained from the databases BIND [42,43], MINT [44], IntAct ... using genetic programming improves detection and modeling of gene- gene interactions in studies of human diseases BMC Bioinformatics 2003, 4:28 Marinov M, Weeks D: The complexity of linkage analysis...

Ngày tải lên: 14/08/2014, 08:20

... Clinical Center Maribor using the reference standard definition for HF and pulmonary diseases in accordance with the previously cited instruments, including chest X-ray, echocardiographic examination, ... ultrasound examination and Table Test characteristics of ultrasound examination, modified Boston examination, NT-proBNP and combination of ultrasound examination and NT-proBNPa Ultrasound examinationb ... dyspnea and pulmonary-related acute dyspnea (the hospital reference standard for HF and pulmonary diseases: asthma/ COPD) was confirmed by cardiologists and/or intensive care physicians in the...

Ngày tải lên: 14/08/2014, 08:21

... minimising p is the same as maximising the genetic change in environment τ x can be derived also in a more intuitive manner as follows: The intercept of a reaction norm can be defined in any environment ... value in a specified environment and of the optimum selection environment, the environmental variance of slope was increased so that heritability decreased with an increasing distance from the intercept, ... Desired gains in level and slope Keeping the slope constant, as in 2.3.4., is a special case of desired gains for level and/or slope For the general case, a desired ratio, δ, between the change in slope...

Ngày tải lên: 14/08/2014, 13:22

... nitrogen and triglycerides In addition, an enzymatic activity for the following proteins was measured: alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, lactate dehydrogenase, ... of injury - in this case the liver - or when using gene expression data from a surrogate source such as whole blood Another illuminating trend in both liver and blood gene expression data was ... clustering using Ward's minimum variance as the heuristic criteria and Euclidean distance as the similarity metric was performed on all of the animals in the medium dose/6 hour group using the...

Ngày tải lên: 14/08/2014, 20:22