gene environment interaction and the metabolic syndrome

... in Asian 68 populations on the association between the metabolic syndrome and ischemic heart disease 4.2 The role of central obesity in the definition the metabolic syndrome 74 4.3 Study 4: Disordered ... increase in the risk of CVD in the Singapore population Over half of the CVD events occurring in our population are attributable to the metabolic syndrome We further show that the metabolic syndrome ... to defining the burden of disease associated with the metabolic syndrome, these studies cast important light on some of the pathways involved in the pathophysiology of the metabolic syndrome 8 ...

Ngày tải lên: 12/09/2015, 10:42

... two of the components of the metabolic syndrome (high TG and hypertension), but not any of the other components (low HDL, obesity, and glucose intolerance) or the presence of the metabolic syndrome ... hypertension [11,12], and central obesity [11]: these may collectively contribute to the development of the metabolic syndrome [13,14] and atherosclerosis [15,16] The metabolic syndrome, first described ... the draft of the manuscript GDK contributed substantially to the conception and design of the project and to the revision of the draft of the manuscript All authors read and approved the final manuscript...

Ngày tải lên: 09/08/2014, 01:22

... two of the components of the metabolic syndrome (high TG and hypertension), but not any of the other components (low HDL, obesity, and glucose intolerance) or the presence of the metabolic syndrome ... hypertension [11,12], and central obesity [11]: these may collectively contribute to the development of the metabolic syndrome [13,14] and atherosclerosis [15,16] The metabolic syndrome, first described ... the draft of the manuscript GDK contributed substantially to the conception and design of the project and to the revision of the draft of the manuscript All authors read and approved the final manuscript...

Ngày tải lên: 09/08/2014, 13:22

... [11]) Mutation in the Clock gene leads to metabolic syndrome in mice [12], and in humans Clock polymorphisms have been associated with obesity and metabolic syndrome [13,14] Cellular metabolic states ... drinking on the same day In the laboratory, a nurse recorded how these instructions had been followed and then took the blood samples The samples were centrifuged at the examination site and placed ... hypertension and of Per2 with blood glucose levels Together these earlier findings and those of ours emphasize the importance of the circadian system and its core genes in regulation of blood pressure, and...

Ngày tải lên: 10/08/2014, 09:20

Ngày tải lên: 06/08/2014, 19:21

... andand the presence ofmetabolic syndrome according to the definition used used * P < 0.05 EGIR The relationship between methotrexate use the presence of the the metabolic syndrome according to the ... patients The prevalence of the MetS increased with age up until the seventh decade and fell off thereafter, and was similar in males and females (P = 0.429; Table 3) Associations of the metabolic syndrome ... that seen in the general population, with the IDF criteria reporting the highest and the EGIR criteria the lowest rates We also demonstrate for the first time that, irrespective of the definition...

Ngày tải lên: 09/08/2014, 14:22

... definitions from the metabolic syndrome The previous work evaluated this difference and did not analyze the relative weight of each component of the metabolic syndrome The importance of the current ... OR and AS have participated in the design of the study, performed the statistical analyses and drafted the paper SB and IS conceived the study, participated in its design and coordination and ... to draft and review the manuscript TF, TC and OKB helped in the data organization and retrieval, English editing and final draft preparation All of the authors have read and approved the final...

Ngày tải lên: 11/08/2014, 03:20

... definitions from the metabolic syndrome The previous work evaluated this difference and did not analyze the relative weight of each component of the metabolic syndrome The importance of the current ... OR and AS have participated in the design of the study, performed the statistical analyses and drafted the paper SB and IS conceived the study, participated in its design and coordination and ... to draft and review the manuscript TF, TC and OKB helped in the data organization and retrieval, English editing and final draft preparation All of the authors have read and approved the final...

Ngày tải lên: 11/08/2014, 06:22

... (29), (30) and (31) However, in the absence of prior knowledge about the form of the genetic model, the presence or absence of gene- environment interactions, and the validity of the 'equal environments' ... File Gene- gene and gene- environment interaction model Contains the Visual Basic macro (Twincal), input and output datasheets and charts used to calculate the solutions described in the text The ... perfectly known and are either environmental or genetic Retention of these assumptions here may be problematic and could limit the applicability of the results Nevertheless, all the other questionable...

Ngày tải lên: 13/08/2014, 16:21

... effects on the amount and type of social interaction that takes place The benefits of the Internet in terms of increased communication are clear, with people connected across the globe In the past, ... That said, there is no doubt in my mind that this has had negative impacts on social interaction People, especially the younger generation, spend hours of their time online, chatting and on forums ... certainly not the same as real interaction with human beings and does not involve the same skills It is important that children have and maintain real friendships in order to develop their own interpersonal...

Ngày tải lên: 30/08/2016, 02:23

... Lane 1, DevSP; lane 2, DevSP and DevR K182G mutant protein; and lane 3, DevSP and WT DevR protein The top panel represents the phosphorimage and the bottom panel the Coomassie stained gel (B) ... footprints and their profiles shows that the C8 mutation in the P box abolished the binding of DevR to both the P and S boxes at 0.5 lm protein concentration From DNase I footprinting and EMSA results, ... (Table 2) and 30 lg of RNA from aerobic and standing cultures (twice using two separate lots of RNA) The reactions were run alongside the sequence ladder generated using the same primer and M tuberculosis...

Ngày tải lên: 22/03/2014, 16:20

... of the gene resulted in disappearance of the oscillation Thus, we hypothesized that, in yeast, the metabolic oscillator drives other oscillators via the interaction of Gts1p and GAPDH1, but the ... vector, and the resulting plasmids, named pUCTDH1, pUCTDH2 and pUCTDH3, were digested to remove the promoters and 5¢ halves of the TDH genes The remaining fragments containing the 3¢ halves of the ... coupled to the metabolic oscillation Deletion of GTS1 resulted in the loss of the fluctuations in the synthesis of trehalose and cAMP [26], leading to the disappearance of the oscillations These results...

Ngày tải lên: 31/03/2014, 21:21

... similar in the peripheral blood and in the parotid gland These results suggest an important role for VL chain gene usage in the immune activation of B cells within the parotid gland of the pSS patient ... in the glands B cell malignancies and Sjögren’s syndrome In contrast to the focal sialadenitis of the minor (labial) salivary glands, the lymphocytic lesions of the major salivary glands often ... and the local expression of their receptors Chemokines and the expression of chemokine receptors by the inflamed tissue as well as by lymphocytes are therefore likely to be of importance in the...

Ngày tải lên: 09/08/2014, 01:21

... discuss the evidence on the relationships between TB and DM, and the possible mechanisms through which this link may be caused, we then discuss the link between antiretroviral therapy (ART), metabolic ... and precursor to DM), increased levels of cholesterol and triglycerides, lipodystrophy, and the onset or complication of diabetes[18,60] HIV, Metabolic Syndrome, and Heart Disease Metabolic Syndrome ... recent years there was a lack of good evidence on the strength and nature of the association between TB and DM At present recognition of the association between diabetes and TB is low The link goes...

Ngày tải lên: 11/08/2014, 14:21

... stable by themselves and must be strengthened by the combination of other interactions or by multimerization (for examples within the replicative complex of MeV see [54]) In further support of the ... [Θ]1 and [Θ]2 correspond to the measured mean ellipticity values per residue, n1 and n2 to the number of residues for each of the two proteins, and R to the excess molar ratio of protein The experimental ... added to the resin and incubation was carried out for one additional hour The flow-through, containing the unretained fraction, and the resin were recovered and analyzed by SDSPAGE The NTAIL-XD...

Ngày tải lên: 12/08/2014, 04:21

... template These PCR products were then gel purified To fuse the Igκ and FLAG to the N-terminal of εSG, the PCR product containing the Igκ , FLAG and a small portion of ε-SG ECD was mixed together ... together with the PCR products of the deletions and another round of PCR was performed using P14 and the respective primers P16, 17 and 18 to obtain the final constructs as shown in Figure The sequences ... Verification of the interaction between ε-SG and Erk2p- In order to verify the possible interaction between ε-SG and Erk2p, three approaches were employed The first was to establish their endogenous interaction...

Ngày tải lên: 05/10/2015, 21:24

... Canada and the Arctic marine environment The United States and the Arctic marine environment Australia and the Antarctic marine environment The United States and the Antarctic marine environment ... between the marine environment and the land environment This is scarcely surprising, given that the greatest impact on the marine environment comes not from the use of the sea but from the use of the ... America and the Law of the Sea’, in L M Alexander (ed.), The Law of the Sea: A New Geneva Conference Proceedings of the 6th Annual Conference of the Law of the Sea Institute, Kingston, Rhode Island,...

Ngày tải lên: 21/09/2012, 10:58

... resources and needs as a component of the syndrome The arrival of the MET brings a critical care environment to the bedside In a sense, when an MET syndrome develops, it could be argued that both the ... power due to the large variance in outcome incidence and wide standard deviation and the lower-than-expected incidence of the outcome measures under investigation Given the incidence and variance ... ‘placebo’ Cluster randomisation of hospitals requires large numbers of centres Before -and- after studies lack rigour and generalisability they are In the words of the slogan of the American Society...

Ngày tải lên: 25/10/2012, 10:35

... either of the polar regions, and have been leaders in the development of Arctic and Antarctic law and policy Australia, the chief initiator of the Antarctic Environmental Protocol, asserts the ... boundary.35 The OCSLA provided for orderly leasing of these lands, while ensuring protection of the environment and that the federal government received fair market value for the land and for mineral ... Department of the Interior, the Department of State, the Department of Transportation and the Environmental Protection Agency.43 Canada and the United States in protecting the Arctic marine environment: ...

Ngày tải lên: 01/11/2013, 09:20