gene environment interaction and obesity
Báo cáo y học: " A model of gene-gene and gene-environment interactions and its implications for targeting environmental " doc
Ngày tải lên :
13/08/2014, 16:21
... and of quantifying gene-gene and gene -environment interactions: see, for example, [11-14] A 'top-down' approach instead considers risks at the population level using twin and family studies and ... low genotypic risk categories (rg and rog); (b) high and low environmental risk categories (re and roe); (c) four categories based on combined genotypic and environmental risk re = γRge + (1-γ) ... (29), (30) and (31) and using the definition of the gene -environment interaction factor (Equation (28)) gives: RSD = cSD and (66) Zero γ0 (where R00 = 0) γneg = γminge (where PAFEge = and Rge =...
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Báo cáo khoa học: Nature, nurture and neurology: gene–environment interactions in neurodegenerative disease docx
Ngày tải lên :
16/03/2014, 19:20
... 2351 Gene environment interactions in neurodegenerative disease T L Spires and A J Hannan A B long as control mice, and environmental enrichment completely rescued this deficit At this age, environmental ... accurate animal models and appropriate environmental manipulations will allow us to experimentally explore gene environment interactions in the healthy and diseased states, and the associated relationships ... examination of gene environment interactions, despite the fact that virtually all medical disorders involve both genetic and environmental factors The vast majority of the many thousands of different...
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Báo cáo khoa học: K182G substitution in DevR or C8G mutation in the Dev box impairs protein–DNA interaction and abrogates DevR-mediated gene induction in Mycobacterium tuberculosis doc
Ngày tải lên :
22/03/2014, 16:20
... H-bonding interactions with the O6 and N7 atoms of G13 (complementary to the conserved C8 base on the sense strand) and the N7 atom of A12 (complementary to the conserved T9 base on the sense strand ... of protein and DNA (in a half-site of the primary binding motif), we highlight the singular importance of G13– Lys182 and partial importance of A12–Lys182 interaction for DevR binding and function ... Phosphorylation of WT and K182G mutant DevR proteins with DevS201P (phosphorylated cytoplasmic domain of DevS) Lane 1, DevSP; lane 2, DevSP and DevR K182G mutant protein; and lane 3, DevSP and WT DevR...
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Báo cáo y học: "Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking" potx
Ngày tải lên :
09/08/2014, 10:23
... (9% in controls and 14% in cases) In analyses involving CTLA-4 and PADI-4, we assessed the risk for RA in dominant, additive, and recessive models Gene -environment and gene-gene interactions We ... assessments for gene -environment interactions by testing for both additive and multiplicative interactions For additive interactions, we calculated the attributable proportion due to interaction using ... significant additive and multiplicative gene -environment interactions between heavy cigarette smoking and the presence of the PTPN22 T allele (additive interaction: P = 0.0006; multiplicative interaction: ...
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Báo cáo sinh học: "Genotype by environment interaction for adult body weights of shrimp Penaeus vannamei when grown at low and high densities" ppt
Ngày tải lên :
14/08/2014, 13:21
... and sire origin, and their interaction with density were not significant (P > 0.05) The covariate age (and age-squared) and the fixed effects of sex and density, as well as their interaction, were ... their standard errors The different heritabilities across environments were caused by different additive genetic and environmental variances occurring at each environment for growth: a larger environmental ... from USA to Brazil and into different Asian countries [7] Between and within different countries, shrimp is cultured in a large variety of environmental and culture conditions and selective breeding...
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Cambridge.University.Press.Protecting.the.Polar.Marine.Environment.Law.and.Policy.for.Pollution.Prevention.Jan.2001.pdf
Ngày tải lên :
21/09/2012, 10:58
... Australia, Canada and the United States Donald R Rothwell and Christopher C Joyner Canada and the Arctic marine environment The United States and the Arctic marine environment Australia and the Antarctic ... Management and Marine Regional Building’, Ocean and Coastal Management, Vol 24, 1994, pp 17–38; and B A Boczeck, ‘Global and Regional Approaches to the Protection and Preservation of the Marine Environment , ... marine environment and the land environment This is scarcely surprising, given that the greatest impact on the marine environment comes not from the use of the sea but from the use of the land Defining...
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Báo cáo y học: "Low socio-economic status, smoking, mental stress and obesity predict obstructive symptoms in women, but only smoking also predicts subsequent experience of poor health"
Ngày tải lên :
31/10/2012, 15:34
... physically examined and interviewed by physicians and research nurses Information concerning education and socio-economic group was obtained by questionnaire, which was sent out beforehand Data on smoking ... linear regression model including VC, FEV1 and PEF and individual heights The other “standard” confounding factors for lung function measurements, gender and age, were not controlled for as the ... 1.2-8.9 and OR 4.6, 95% CI 1.6-13.3) and in relation to smoking status A significant trend was obstructive symptoms in 2000-2001 (OR 3.7, 95% CI found between smoking status and lower lung 1.8-8.0 and...
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Tài liệu The Practical Guide: Identification, Evaluation, and Treatment of Overweight and Obesity in Adults pdf
Ngày tải lên :
14/02/2014, 09:20
... Aerobics Research; and Dr Van S Hubbard, National Institute of Diabetes and Digestive and Kidney Diseases The Practical Guide Identification, Evaluation, and Treatment of Overweight and Obesity in Adults ... Overweight and Obesity .5 Treatment Guidelines Assessment and Classification of Overweight and Obesity Assessment of Risk Status 11 Evaluation and Treatment ... Study of Obesity (NAASO) and the National Heart, Lung, and Blood Institute (NHLBI) It is based on the Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity...
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Tài liệu Báo cáo khoa học: SREBPs: protein interaction and SREBPs Ryuichiro Sato doc
Ngày tải lên :
18/02/2014, 13:20
... interaction with importin-b [6] In the nucleus, SREBPs detach from importin-b, and their transcription factor activities are regulated through interaction with a variety of nuclear proteins Interaction ... mitochondrial biogenesis and FEBS Journal 276 (2009) 622–627 ª 2008 The Author Journal compilation ª 2008 FEBS 623 Protein interaction and SREBPs R Sato respiration, and modulates hepatic gluconeogenesis ... Rbx1, and one of a family of F-box proteins, Fbw7 [17] Glycogen synthase kinase-3b phosphorylates serine and ⁄ or threonine residues near the ubiquitination site in SREBP-1 and SREBP-2, and SREBP...
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Tài liệu Báo cáo khoa học: Globin gene family evolution and functional diversification in annelids ppt
Ngày tải lên :
19/02/2014, 02:20
... typical molecular features: Lys-A9, Trp-B10 and also a deletion of three residues between the A and B helices, and a deletion of one residue between the F and G helices Moreover, the two residues ... Asp-A4, Trp-A16, Phe-B10 and LeuB13 Furthermore, it shows an insertion of three residues between the A and B helices, an insertion of one residue between the F and G helices, and a three-residue motif ... Ar marina A2 and B2 extracellular globins (accession numbers AJ880690 and AJ880691, respectively) and myoglobin MbIIa (accession number AJ880692), the extracellular A1, B1a, B1b and B1c globin...
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Tài liệu Obesity guidance on the prevention, identification, assessment and management of overweight and obesity in adults and children ppt
Ngày tải lên :
21/02/2014, 11:20
... overweight or obesity (including assessment and agreement of goals and actions) should be made in partnership with the child and family, and be tailored to the needs and preferences of the child and the ... activity • psychosocial distress and lifestyle, environmental, social and family factors – including family history of overweight and obesity and comorbidities • willingness and motivation to change ... comorbidities • lifestyle – diet and physical activity • environmental, social and family factors that may contribute to overweight and obesity and the success of treatment • growth and pubertal status 1.2.3.10...
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Tài liệu Báo cáo Y học: Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins doc
Ngày tải lên :
22/02/2014, 07:20
... different roles in the activation and repression of transcription [9] In our hands, Sp1 generated a single band and Sp3 generated two bands in EMSAs (two of three bands migrated to the same position; ... to the manufacturer’s protocol Cell culture, transfections and assays of promoter activity Mouse NIH3T3 and F9 cells and human HeLa and 293 cells were grown in Dulbecco’s modified Eagle’s medium ... against Sp1, Sp3 and AP-2 (Fig 3A) The retarded band designed B1 was shifted even further upon addition of antibodies against Sp1 (lane 3), while the retarded bands corresponding to B2 and B3 were...
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THE ARTS CHILD POLICY CIVIL JUSTICE EDUCATION ENERGY AND ENVIRONMENT HEALTH AND HEALTH CARE docx
Ngày tải lên :
06/03/2014, 09:21
... posting of RAND documents to a non-RAND website is prohibited RAND documents are protected under copyright law For information on reprint and linking permissions, please visit the R AND permissions ... adaptation and counteradaptation between the insurgents and the COIN force; rather, these were macro-level and sea-change phases Paul, Clarke, and Grill, 2010 8 Victory Has a Thousand Fathers: ... corresponded with government and military statements and helped generate and sustain credibility and legitimacy The conflict reached a stalemate in the late 1980s and was ultimately resolved through...
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THE EUROPEAN ENVIRONMENT: STATE AND OUTLOOK 2010 pot
Ngày tải lên :
06/03/2014, 16:20
... mitigation Land use Land use Soil Nature protection and biodiversity Marine and coastal environment Waste Consumption and environment Assessment of global megatrends Material resources and waste ... urban environment European Environment Agency, Copenhagen EEA, 2010o The European environment — state and outlook 2010: land use European Environment Agency, Copenhagen EEA, 2010p The European environment ... different sources and activities is crucial to understanding and limiting the harm such emissions may cause to human health and the environment Emissions of a range of air pollutants and greenhouse...
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ENVIRONMENT SCIENCE AND POLICY FOR SUSTAINABLE DEVELOPMENT: GREEN MARKETING docx
Ngày tải lên :
06/03/2014, 21:20
... Council’s “Leadership in Energy and Environmental Design” (LEED) provides a rigorous rating system and green building checklist that are rapidly becoming the standard for environmentally sensitive ... their personal needs and the environment. 56 When introducing its Renewal brand, Rayovac positioned the reusable alkaline batteries as a solution for heavy battery users and the environment with concurrent ... value and providing substantive environmental benefits Often, consumers don’t have the expertise or ability to verify green products’ environmental and consumer values, creating misperceptions and...
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Báo cáo khoa học: Identification of yeast aspartyl aminopeptidase gene by purifying and characterizing its product from yeast cells potx
Ngày tải lên :
07/03/2014, 12:20
... fractionation, and chromatography Mono Q chromatography was used to separate aspartyl aminopeptidase activity into three major peaks (Fig 1) The first and second peaks were pooled as fraction I and II, ... activity in Mono Q fractions I and II using a Superose column (s, d) Activity of fractions I and II, respectively (B, C) Results of SDS ⁄ PAGE analysis of fractions I and II Lane numbers correspond ... bacteria and eukaryotes [6] We selected 12 of these and aligned their sequences using the clustal_x program [7] (Table 3) This revealed three conserved His residues, two conserved Glu residues, and...
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Clinical Practice Guidelines for the Management of Overweight and Obesity in Adults ppt
Ngày tải lên :
08/03/2014, 14:20
... evidence-based guidance for assessing and managing overweight and obesity in Australia They also highlight important health concerns associated with overweight and obesity and, through the provision of ... examining energy intake and expenditure to determine how energy imbalance has occurred; and considering the nature of the environment and personal and other factors to understand why it has occurred ... Overweight and Obesity in Adults II EVIDENCE-BASED STATEMENTS AND RECOMMENDATIONS Evidence-based statements Evidence level Obesity in childhood and adolescence is a risk factor for obesity later...
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Weight Management and Obesity Resource List pdf
Ngày tải lên :
08/03/2014, 14:20
... http://www.cdc.gov/nccdphp/dnpa /obesity/ defining.htm Description: Discusses obesity and obesity measures while detailing dangers and risks Defines overweight and obesity for adults, children and teens Obesity Information ... Defines overweight and obesity, and identifies possible causes of each, who is at risk, treatment, prevention, and more Trends, Statistics, and Costs Overweight and Obesity: Causes and Consequences ... http://www .obesity. org/resources-for/your-weight-anddiabetes.htm • Obesity and Cancer: http://www .obesity. org/resources-for/cancer -and- obesity. htm • Childhood Overweight: http://www .obesity. org/resources-for/childhoodoverweight.htm • Obesity, ...
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Human Pharmaceuticals in the Environment: Current and Future Perspectives pot
Ngày tải lên :
16/03/2014, 22:20
... on Human Pharmaceuticals in the Environment Bryan W Brooks, Jason P Berninger, Alejandro J Ramirez, and Duane B Huggett Background Human interaction with the environment remains one of the most ... global trade and digital communications, energy security, natural resource scarcities, climatic changes and environmental quality, emerging diseases and public health, biodiversity and habitat ... et al [15], Ternes [16], and Daughton and Ternes [17] Citation information from Web of Knowledge Pharmaceuticals and Personal Care Products (PPCP) in the environment and by doing so coined the...
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Gene Therapy - Tools and Potential Applications by Francisco Martin Molina Contributors ppt
Ngày tải lên :
17/03/2014, 21:20
... Nanoparticles for Drug and Gene Delivery to Cells and Tissue Advanced Drug Delivery Reviews 2003;55(3) 329347 [25] Shive MS, Anderson JM Biodegradation and Biocompatibility of PLA and PLGA Mi crospheres ... silencing Materials and methods 2.1 DNA constructs pGL3-Control and pCMV-luc were purchased from Stratagene (Techno-Path, Limerick, Ire land) and Promega (Medical Supply Co., Dublin, Ireland) respectively ... as a vehicle for drug and protein de livery [23,24] Biodegradable PLA and PLGA particles are biocompatible and have the ca pacity to protect pDNA from nuclease degradation and increase pDNA stability...
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