gain of function mutation of gpib ix v
Báo cáo Y học: A novel gain-of-function mutation of the integrin a2 VWFA domain docx
Ngày tải lên :
08/03/2014, 22:20
... that binding of these ligands to a2 VWFA domain occurs at the same site as collagen I and probably by the same mechanism DISCUSSION We report a novel gain- of- function mutation of the a2 VWFA domain ... for the development of potent a2b1 antagonists In conclusion, we have generated a mutant form of the a2 VWFA domain which shows a gain- of- function, and which may result in the promotion of the open ... a2 VWFA domain The binding of JA203 to eight of the nine chimeras was similar to that of wild-type VWFA domain, but no binding to the chimera covering helix a3 was seen (Fig 6) The E318W mutation...
- 9
- 471
- 0
Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
Ngày tải lên :
14/02/2014, 18:20
... true for frameshift mutations, even though recurrent mutations eventually will prevail here also as the overall number of mutations increases Of the residues affected by missense mutations, proline ... 30 missense mutations in the BTK SH2 domain have been described in patients with XLA, and the effects of these mutations have been analyzed in a large number of in vitro and in vivo studies [45] ... present, no definitive cure or vaccine Therefore, the development of novel antiviral drugs should be a priority Notably, the tools of modern molecular biology have enabled the design of nucleic acid...
- 10
- 926
- 0
Báo cáo khoa học: Biosynthesis of platelet glycoprotein V expressed as a single subunit or in association with GPIb-IX doc
Ngày tải lên :
23/03/2014, 13:20
... mAbs V. 1 and V. 5 against GPV, ALMA.12 against GPIba, ALMA.16 against GPIX and RAM.1 against GPIbb, were developed in our laboratory [19] CHO cell lines CHO-K1 and CHO-DUK (deficient in dihydrofolate ... previously for CHO /GPIb IX cells [18,22] (Fig 4C) Analysis of the supernatants revealed no secreted forms of GPV (data not shown), while the mature GPV in K562 /GPIb V IX cells was sensitive to ... cotransfected with GPV and GPIb- IX (A) CHO cells stably transfected with GPV, GPIba, GPIb and GPIX were analysed for surface expression of GPV by flow cytometry A positive GPV signal was observed with approximately...
- 7
- 363
- 0
Báo cáo y học: " Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in miceg" pdf
Ngày tải lên :
11/08/2014, 03:20
... mice with loss of function mutation in TLR4 fed either LF diet (3.2 vs 3.1 g/d/mouse) or TF diet (2.3 vs 2.6 g/day/mouse) Visceral fat (fat pad), liver, and cecum morphologies of WT and TLR4 ... respectively Mice with loss of function mutation in TLR4 had significantly higher total serum cholesterol compared to WT mice regardless of the diet type they received (P < 0.01) Mice with loss of function ... University School of Medicine, Atlanta, GA 30322, USA 2Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA 3Division...
- 7
- 272
- 0
Báo cáo y học: "Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice" docx
Ngày tải lên :
11/08/2014, 06:22
... mice with loss of function mutation in TLR4 fed either LF diet (3.2 vs 3.1 g/d/mouse) or TF diet (2.3 vs 2.6 g/day/mouse) Visceral fat (fat pad), liver, and cecum morphologies of WT and TLR4 ... respectively Mice with loss of function mutation in TLR4 had significantly higher total serum cholesterol compared to WT mice regardless of the diet type they received (P < 0.01) Mice with loss of function ... University School of Medicine, Atlanta, GA 30322, USA 2Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA 3Division...
- 7
- 238
- 0
báo cáo khoa học: " pax1-1 partially suppresses gain-of-function mutations in Arabidopsis AXR3/IAA17" pdf
Ngày tải lên :
12/08/2014, 05:20
... abaxial (ventral) surfaces, and the transition from the juvenile to the adult phase of vegetative development is marked by the onset of trichome production on the abaxial surfaces of the leaves [46] ... suggestive of auxin resistance, but others are not Analysis of the loss of function phenotypes of individual Aux/IAAs and ARFs demonstrates that the network is very robust with significant functional ... leaf vein pattern in Arabidopsis Plant Physiology 1999, 121:1179-1190 Thimann KV, Skoog F: On the inhibition of bud development and other functions of growth substance in Vicia faba Proceedings of...
- 13
- 155
- 0
Báo cáo y học: "Gain of a 500-fold sensitivity on an intravital MR Contrast Agent based on an endohedral Gadolinium-Cluster-Fullerene-Conjugate: A new chance in cancer diagnostics"
Ngày tải lên :
26/10/2012, 09:07
... Imaging Invest Radiol 2006; 41: 332-8 Bolskar RD, Benedetto AF, Husebo LO, et al First soluble M@C-60 derivatives provide enhanced access to metallofullerenes and permit in vivo evaluation of Gd@C-60[C(COOH)(2)](10) ... Journal of the American Chemical Society 2003; 125: 5471-8 Bolskar RD, Benedetto AF, Husebo LO, et al First soluble M@C60 derivatives provide enhanced access to metallofullerenes and permit in vivo ... reactivity and avoidance of stereomutation Org Lett 2003; 5: 975-7 41 Waldeck W, Wiessler M, Ehemann V, et al TMZ-BioShuttle a reformulated temozolomide Int J Med Sci 2008; 5: 273-84 42 Vives E,...
- 11
- 655
- 0
Báo cáo khoa học: Gain of structure and IgE epitopes by eukaryotic expression of the major Timothy grass pollen allergen, Phl p 1 pdf
Ngày tải lên :
16/03/2014, 18:20
... maintenance of important T cell epitopes of a given allergen and simultaneously preserves sequences relevant for the induction of protective antibody responses [36] Controlled reduction of the fold of ... candidates for a novel form of specific immunotherapy J Clin Invest 99, 1673–1681 32 Hayek B, Vangelista L, Pastore A, Sperr WR, Valent P, Vrtala S, Niederberger V, Twardosz A, Kraft D & Valenta R (1998) ... disruption of native structure by fragmentation has led to a strong reduction of the IgE binding capacity and allergenic activity of the major birch pollen allergen, Bet v [31], the cross-reactive calcium-binding...
- 11
- 355
- 0
Báo cáo y học: "Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics" pdf
Ngày tải lên :
09/08/2014, 08:23
... however, the presence of myofibroblasts persists, leading to overproduction of extracellular matrix, and eventually to loss of function of the organ [16] This accumulation of extracellular matrix ... been suggested that mutations in genes involved in the control of cell-cycle and survival, like that encoding p53, are involved in the deranged behaviour of FLSs in RA synovium The changes that ... involved in acquisition of patient material and immunohistochemistry GvdP was involved in conception of the study and participated in the design of the study CL was involved in conception of...
- 10
- 424
- 0
Analysis of type IX collagen in zebrafish axial development
Ngày tải lên :
15/09/2015, 22:06
... expression of twhh Table 4.1 Overview of expression profile of various chains of collagen IX in different vertebrate systems 120 155 xi List of Abbreviations LIST OF ABBREVIATIONS ATP BCIP bFGF bHLH ... role of individual components of the ECM in these events is not fully understood To reveal the xvii Summary functional role of colIXα2 in precursors of axial structures, translation of colIXα2 ... gene expression involving photomediated activation of caged mRNA (Ando et al., 2001) have also been developed Besides gain- of- function analyses by transgenic approaches, loss -of- function analyses...
- 236
- 172
- 0
Báo cáo hóa học: " A Sigma-Delta ADC with Decimation and Gain Control Function for a Bluetooth Receiver in 130 nm Digital CMOS" pdf
Ngày tải lên :
22/06/2014, 22:20
... and Networking High gain mode Csh VDDA LG Vb1 CM HG N2 Cs N2 N1 Vb2 + + Vb2 I np I nm Vb3 Figure 7: Gain control in the FIR filter OutP Input OutM N1 Vb3 Vb4 VSSA 600 Noise (uVrms ) 500 Figure ... implementation of the sampling network, but, for the sake of clarity at this point, it does not include the gain control function Since the supply voltage is 1.58 V, that is, above 1.4 V of the nominal ... realized as regular NMOS devices with nominal VT = 600 mV The key role of the FIR filter is to provide enough noise suppression around Fs /2 The signal at the input of the ADC is naturally band-limited...
- 8
- 280
- 0
Báo cáo y học: " Mutation Analysis of hCDC4 in AML Cells Identifies a New Intronic Polymorphis"
Ngày tải lên :
31/10/2012, 16:49
... (A) Overview depicting the common exons – 11 and the three transcript variants (TV) of exon of the hCDC4 gene Arrows mark the position of the detected mutation in the 5’ UTR of Exon 1-TV3 and ... of the hCDC4 gene may not play a pivotal role in the pathogenesis of AML This supplements studies which have discovered hCDC4 mutations in subsets of solid tumors and implies that mutations of ... derived from patients with AML revealed one heterozygous mutation in the untranslated region of transcript variant of exon in form of a T > C exchange A mutation of the hCDC4 gene at this location...
- 4
- 393
- 0
Báo cáo y học: "Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects"
Ngày tải lên :
03/11/2012, 09:49
... risk of CVD in patients with MTHFR mutation [26] The tHcy level is strongly dependent on the folate and vitamin B12 status of each individual [27,11,28] Plasma tHcy may be increased in cases of ... correlation between elevated plasma homocysteine, MTHFR mutation and CIT [32,33] while others gave equivocal results [34,35] No data are available about the frequency of the MTHFR mutation and its ... important determinant of plasma homocysteine is the folate intake [46,47] Several previous reports illustrated the positive effect of folate intake on the reduction of plasma tHcy level and subsequent...
- 12
- 519
- 0
Tài liệu Enumeration of Kinematic Structures According to Function P2 doc
Ngày tải lên :
17/12/2013, 13:15
... bipartite if every vertex of V1 is connected to every vertex of V2 by one edge A complete bipartite is denoted by Ki,j , where i is the number of vertices in V1 and j the number of vertices in V2 Figure ... (v2 + v3 + v4 + · · · + vm ) − ( 2v2 + 3v3 + 4v4 + · · · ) = 3v − 2e , (2.10) which can be written as v2 = 3v − 2e + (v4 + 2v5 + · · · + vm ) (2.11) Equation (2.11) implies that the number of ... two, v3 the number of vertices of degree three, etc It follows that vi = v2 + v3 + v4 + · · · + vm = v , (2.8) i where m denotes the maximal degree of a vertex Since each edge has two end vertices...
- 26
- 379
- 0
Tài liệu Enumeration of Kinematic Structures According to Function P3 pptx
Ngày tải lên :
17/12/2013, 13:15
... matrix form There are several methods of matrix representation as described in Chapter Perhaps, the most frequently used method is the link-to-link form of adjacency matrix Other methods of representation, ... adjacency matrix of the spur-gear set shown in Figure 3.2 is given by 1 1 A= (3.2) 1 1 The matrix representation given by Equation (3.2) provides no distinction for the types of joint ... study of the nature of connection among various links of a kinematic chain is called the structural analysis or topological analysis To facilitate the analysis, several methods of representation of...
- 18
- 406
- 0
Tài liệu Enumeration of Kinematic Structures According to Function P4 ppt
Ngày tải lên :
17/12/2013, 13:15
... Number of vertices Number of edges Number of vertices of degree i Degree of vertex i Number of independent loops Total number of loops (L + 1) Number of loops with i edges Symbol v e vi di L ... and n5 = (or in terms of a graph there are vertices of degree two, vertex of degree three, vertices of degree four, and vertices of degree five) has a vertex degree listing of “4132.” Example 4.10 ... vertices of a graph are said to be similar if they are contained in the same cycle of a permutation of a vertex-induced group of automorphisms In the above example, vertices and are similar Vertices...
- 35
- 361
- 0
Tài liệu Enumeration of Kinematic Structures According to Function P7 doc
Ngày tải lên :
17/12/2013, 13:15
... number of degrees of freedom, number of independent loops, and vertex degree listing Table 7.1 Classification of Epicyclic Gear Trains Degrees of Freedom No of Loops No of Links No of Joints No of ... nonisomorphic graphs in terms of the number of degrees of freedom and the number of independent loops Appendix F provides an atlas of labeled graphs and typical functional schematics of nonfractionated ... or arm of a gear pair We note that a vertex in the graph of an EGT may serve as the transfer vertex for more than one fundamental circuit From a mechanical point of view, any vertex having only...
- 33
- 365
- 0
Tài liệu Enumeration of Kinematic Structures According to Function P8 pdf
Ngày tải lên :
26/12/2013, 00:16
... and b provide graphical representations of the two types of distribution The total number of vertices in each level is given in Table 8.3 Table 8.3 Partition of Six Vertices into Two Levels Classification ... second level vertices that are connected to a common first level vertex by thin edges of the same label form a family By definition, vertices of different families are connected to lower level vertices ... into Two Levels No of Vertices Type Level 1 2 3 4 Level 1 2 3 S3 Connect all the first level vertices to the root by thin edges of the same label S4 Partition the second level vertices into as many...
- 41
- 387
- 0
Tài liệu Enumeration of Kinematic Structures According to Function P9 doc
Ngày tải lên :
26/12/2013, 00:16
... of three-dof joints For example, type 201 limb has two one-dof, zero two-dof, and one three-dof joints, whereas type 120 limb consists of one one-dof, two two-dof, and zero three-dof joints The ... (9.8) Solving Equation (9.7) for positive integers of Ck in terms of the number of degrees of freedom, subject to the constraint imposed by Equation (9.8), we obtain all feasible limb connectivity ... Table 9.1 Each connectivity listing given in Table 9.1 represents a family of parallel manipulators for which the number of limbs is equal to the number of degrees of freedom of the manipulator,...
- 27
- 410
- 0
Tài liệu Enumeration of Kinematic Structures According to Function P10 ppt
Ngày tải lên :
26/12/2013, 00:16
... Since both 2x3 and are even numbers, x2 must be an even number Let x2 assume the values of 0, 2, and 4, one at a time, and solve Equation (A.8) for x3 Once x3 is found, we solve Equation (A.6) for ... s are nonnegative integers, the constants ki s are positive integers, and n > m Furthermore, the solutions to the system of equations are subject to a constraint that all the variables xi , for ... DISCARD THE SOLUTION IF x(n) ≥ 0, SAVE THE SOLUTION NEXT In−1 NEXT I3 NEXT I2 NEXT I1 A.2 Solving m Equations in n Unknowns Next, we consider a system of m linear equations in n unknowns:...
- 4
- 318
- 0