... that G/G ofthe PTPN11 gene encoding SHP-2 increased the risk of gastric atrophy among the seropositive subjects [18] The present study examined the association of a polymorphism of Gab1 with gastric ... So, the Gab1 polymorphism was associatedwiththe low risk ofthe infection independent on severe atrophy Although the Gab1 polymorphism prevented H pylori infection, it was associatedwiththe ... had evidence of H pylori infection because ofthe earlier presentation or diagnosis of cancer In summary, the Gab1 A/A was associatedwiththe low risk of H pylori infection while the G/A and...
... surgery but without signs of infection or inflammation Secondly, an evaluation ofthe association ofthe MIF polymorphisms withthe survival of severe sepsis patients was performed Methods The investigation ... preconditions the power ofthe presented results for the -173 G/C SNP and the -794 (CATT)n microsatellite was 98% and 87%, respectively The linkage disequilibrium ofthe two loci was assessed withthe ... in the groups defined by the focus of sepsis it was not Especially in the younger patient group the effect of genetic predisposition might be stronger because ofthe fewer incidences of other...
... myocytes, an effect that is associatedwiththe inhibition of potassium currents [8,9] Coronary vasospasm and acute myocardial infarction (AMI) associatedwiththe use of topical capsaicin patches ... pepper pills support the role of capsaicin in the development of coronary vasospasm through increased sympathetic stimulation Conclusions This is the first report linking the use of cayenne pepper ... one ofthe few cases associatedwith capsaicin Capsaicin, a sympathomimetic agent, may be implicated in the initiation of coronary vasospasm and acute myocardial infarction in the absence of substance...
... modernization associatedwiththe development ofthe knowledge-based economy, the thesis analyses, assesses the situation of human resources for industry of modernization associatedwiththe development of ... modernization associatedwiththe development ofthe knowledge-based economy in the Province of Thua Thien Hue withthe data limited in the period from 1999 to 2012 and the solutions made for the period ... modernization associatedwiththe development ofthe knowledge-based economy on the basis of absorbing the thoughts of C Marx on labor, the previous studies and clarifying the characteristics of human...
... transfer of phVEGF165 [37] The hypothesis that VEGF might have dual functions in the pathogenesis of SSc, with positive effects on the vascular system but with negative effects on the development of ... recruited at the Section of Rheumatology ofthe University of Florence All patients fulfilled the American College of Rheumatology criteria for SSc [16] There were 35 women and eight men with a median ... and the presence of teleangiectasias and other skin ulcers was found Discussion The process of angiogenesis appears to be largely impaired in SSc following the profound disarrangement of the...
... directly to the loss of disc collagen and GAGs The lack of effect on GAG synthesis further validates the importance ofthe degradative component ofthe remodeling cycle in relaxin's modulation of matrix ... tissue In this study we determined the effects of relaxin with or without β-estradiol on the modulation of MMPs, and assessed the contribution of these proteinases to the changes in collagen and glycosaminoglycan ... calculated from the ratio ofthe stained area to the total area in each section The average ofthe 10 values for each half disc was used for analysis Determination of GAG synthesis by 35S radiolabeling...
... topographical loss of cartilage in the different subregions ofthe knee and theassociated risk factors Moreover, the impact ofthe location and rate of cartilage loss on the evolution of OA symptoms ... time as the disease progressed The relationship between the worsening in the WOMAC scores withthe loss of cartilage on the central portion ofthe tibial plateau is intriguing The level of significance ... evidence of OA ofthe affected knee on a radiograph obtained within months ofthe outset ofthe study Finally, patients had to have a minimum joint space width (JSW) ofthe medial compartment of between...
... right ventricle (RV) and the left ventricle (LV) ofthe heart, whereas the IVS in the heart ofthe control group is intact without any damage (Figure 2A) Since acetylation of histones H3 and H4 ... activities through the intervention ofthe transcription of HDAC genes More likely, valproate inhibits HDAC activities directly by binding withthe active site ofthe enzyme as other HDAC inhibitors ... early in the developing heart Withthe development ofthe heart, Tbx5 is asymmetrically expressed in the heart Expression of Tbx5 in the ventricu- Wu et al Journal of Biomedical Science 2010, 17:16...
... the presence ofthe 1100delC variant Discussion None ofthe investigated 91 patients with SCCHN carried the CHK2 1100delC variant The incidence of 1100delC in the population ofthe state NorthrhineWestphalia ... patients, they did not detect any truncating mutation Therefore, we were able to confirm these results Nevertheless, they found the missense I157T mutation in 4.1% ofthe cases In this study, the incidence ... week) The remaining patients were mostly heavy smokers and drinkers Sequence analysis of exon 10 ofthe CHK2 gene was performed for all patients However, none ofthe patients showed the presence of...
... profile is associatedwiththe cumulative effect over time ofthe characteristics of an organisation The recognition of these variables will assist the process of clinical differentiation of ... that the “frenetic” profile is highly associatedwiththe number of hours per week dedicated to work, that the “underchallenged” profile is related withthe type of occupation and that the “worn-out” ... “Length of service” in the organisation showed a direct linear association withthe “worn-out” type, to the extent that the longer the Page 10 of 13 service, the greater the likelihood of having...
... of polymorphisms ofthe IL-8 gene on the risk of IPF We genotyped and compared the frequencies of three SNPs ofthe IL-8 genes in 237 subjects with IPF and 456 normal controls and evaluated their ... analysis of a case-control study determined that the IL8 rs4073T>A and rs2227307T>G SNPs from the promoter region are associatedwith development of IPF The frequencies ofthe minor allele ofthe ... and normal healthy subjects in the UK [16] These study reported no association ofthe SNPs of IL8 withthe risk of pulmonary fibrosis The Page of Figure Comparison of luciferase activity between...
... by performing this type of examination The Page of results ofthe scan are available within 30 of radio tracer injection and the technique can be performed at the bedside with portable nuclear ... order to measure the impact of altering the use ofthe brain death determination protocol at the University of Pennsylvania Medical Center, in an attempt to decrease the time between the first examination ... quite prominent in those with brain death, allowing definition ofthe contours ofthe head in such subjects (Fig 2) For each patient in group I, the specific timing ofthe first and second brain...
... requires the placement ofthe tube in the esophagus to the level ofthe xiphoid and confirming the position with a chest roentgenogram If the position is acceptable (midline), the tube is then advanced ... feeding These smaller tubes decreased the risk of ulceration ofthe nose, pharynx and stomach associatedwiththe larger-bored and more rigid type [11] However, it was not long after the narrow-bore ... identification of all cases To place the risks associatedwith feeding tube placement into perspective, the probability of pneumothorax with central line insertion is in the 1-2% range [4,5] Therefore,...
... included the use of official or official treated water on the farm compared to the use of non-official untreated water, storing manure on the farm at any time of year, and the presence of other domestic ... for the colonization of broiler flocks with Campylobacter Farm-level factors associatedwith an increased risk of colonization include: the presence of other animals on the farm [13,20-23]; the ... (i.e the practice of shipping all flocks on the farm within the span of a few days, with all houses remaining empty for a period of time) was not a significant predictor in any ofthe models The...
... http://www.actavetscand.com/content/53/1/22 Page of Model validation was preformed according to Hosmer and Lemeshow [7] The fit ofthe model was evaluated withthe Hosmer-Lemeshow goodness -of- fit test withthe data partitioned ... by others we would like to make the recommendations to vaccinate twice if the dog is of a larger breed Conclusions The probability of success of rabies vaccinations of dogs depends on type of ... reduce the Table Distribution of potential risk factors associatedwiththe success (antibody titres ≥ 0.5 IU/ml) of rabies vaccination in dogs (n = 6,789) Variable Type of vaccine Level Number of...
... hospital, seven of whom were not evaluable because of death soon after initiation of APC Ofthe 34 remaining patients, nine had major bleeding episodes The clinical characteristics of these 34 patients ... independently associatedwiththe risk of a bleeding event (P = 0.02, odds ratio = 23.5, 95% confidence interval = 1.75–315) Ofthe five patients with ALD who had bleeding episodes, four died within ... excluded from the major clinical trials of APC, it may be prudent to withhold therapy with APC from all patients with ALD until data from trials that include these patients, or further postmarketing...
... the incidence of severe brain injury There were no statistical differences ofthe ISS or the incidence of severe thoracic injury between the two groups In the emergency room, administration of ... slope of mHLA-DR of less than 1.2 was independently associatedwiththe risk of developing sepsis, a finding that reflects the possible pivotal role of immune dysfunction in the increased risk of ... participated with AC in the interpretation of all data, and contributed to the writing ofthe paper BA and GMo helped to design the study, participated with AC in the interpretation of all data,...
... determination of this putative pathway ofthe development of anemia is of clinical importance Therefore, we explored the correlation between IL-6 and hepcidin, and the subsequent rate of Hb decrease ... addition, in these patients the presence of different comorbidities and the severity ofthe disease could have influenced the development of anemia However, we were not able to express these variables ... drafting the manuscript MT collected demographic and SIRS data, built the database and collected the blood samples JGH revised the manuscript and participated in the design ofthe study DWS revised the...