... crossing the blood? ? ?brain barrier Here, improvement of the current in vitro models of the BBB may further improve the predictive value of in vitro experiments, Cocultures of brain endothelial cells ... successful therapy of brain diseases The BBB is constituted by the specialized endothelium of the brain microvessels that preserves brain homeostasis by restricting the influx of a variety of compounds, ... gabapentin, and baclofen [13] For a detailed review of carrier-mediated transport at the BBB, see [14] Figure Proposed mechanisms of transport across the blood? ? ?brain barrier The blood brain barrier consists
Ngày tải lên: 04/12/2022, 16:38
... to the endothelium so that the marginal zone of the postcapillary venule lumen lacks blood cells traveling in the bloodstream (dark streaks) Note the extensive leakage of Evans blue from the ... role of ICAM-1 in the pathogenesis of severe P falciparum malaria and the binding of P falciparum iRBC to the endothelium is generally accepted [59,61,153–159] However, comparison of the endothelial ... consequences for the physiology of the brain First, PLOS Pathogens | www.plospathogens.org the overall hypoperfusion of the brain, enhanced by inadequate contact between RBCs and the endothelium, likely
Ngày tải lên: 02/11/2022, 10:38
Dynamic analysis of the mesenchymal-epithelial transition of blood-brain barrier forming glia in Drosophila
... for the uniform insertion of SJs and thus the insulating function of the barrier To our knowledge, this is the first dynamic in vivo analysis of all stages in the formation of a secondary epithelium ... in the occasional loss of individual SPG cells (Yu et al., 2005) The first stage of BBB formation is the migration of SPG onto the surface of the nerve cord The timing of this migration is unaffected ... the surrounding hemolymph In addition, the barrier selectively regulates the uptake of nutrients from and the release of waste products to the hemolymph The barrier is established by subperineurial
Ngày tải lên: 24/11/2022, 17:56
functional coupling of human microphysiology systems intestine liver kidney proximal tubule blood brain barrier and skeletal muscle
... collection (D) The blood- brain barrier with NVU is constructed in a membrane-separated, two-chambered microfluidic device The brain- derived endothelial vascular compartment is perfused at the influx ... taken of the effluent from the kidney proximal tubule module and from the vascular and brain sides of the NVU for MS analysis metabolism in the human intestine module; b) polarized transport of ... transport of fexofenadine into the apical and basolateral compartments These findings are consistent with the transport and metabolism of terfenadine and the metabolite fexofenadine in the human
Ngày tải lên: 04/12/2022, 10:32
COGNITIVE FUNCTIONS OF THE BRAIN: PERCEPTION, ATTENTION AND MEMORY
... processing different kinds of sensory information Some of these modules take the form of sensory maps, mapping some aspect of the world across part of the brain? ??s surface These different modules ... of the shoe reconstructed by the brain of the person is the percept Another example would be a telephone ringing The ringing of the telephone is the distal stimulus The sound stimulating a person’s ... with the other sense in unexpected ways Smell is also the most primal of the senses It has been the discussion of being the sense that drives the most basic of human survival skills as it being the
Ngày tải lên: 02/05/2024, 23:54
co - planar stereotaxic atlas of the human brain - j. talairach, p. tournoux (thieme)
... Anterosuperior view of brain Example of the diversity of form of the gyri and sulci of two hemi- spheres of one brain Note also the secondary folds of the fissure of Rolando of the left hemisphere and ... with the advance of ana- tomoradiologic correlations The right and left hemispheres of the reconstructed brain show the extent of variability of the sulci and gyri in the two hemispheres of the ... Space The general course of these fibers is influenced by the meanderings of the cortex and the spatial distribution of the interconnected cortical regions Cortical Areas The topography of the
Ngày tải lên: 12/05/2014, 16:51
Báo cáo y học: "On the functions of the h subunit of eukaryotic initiation factor 3 in late stages of translation initiation" potx
... translatability of the AtbZip11 leader in the eif3h mutantFigure 2 uORF2b contributes to poor translatability of the AtbZip11 leader in the eif3h mutant. (a) Schematic of the arrangement of uORFs in the ... by comparing the activity of the associated firefly (Fluc) reporter gene with the activity of the Renilla luciferase (Rluc) reference gene, which is expressed under the control of the cauliflower ... consistent with the low level of the truncated eIF3h protein detected in the eif3h-1 allele [19]. The defects in the eif3h-1 mutant may be a consequence of both the reduced expression level and the truncation
Ngày tải lên: 14/08/2014, 20:22
DUAL FUNCTIONS OF THE PROTEIN MGTE IN PSEUDOMONAS AERUGINOSA
... deletion of the gene encoding the protein MgtE from P aeruginosa increases the cytotoxicity of biofilms, although it does not impact biofilm... with the hypothesis that the magnesium ... of Science Barbara M. Coffey 07/12/2011 DUAL FUNCTIONS OF THE PROTEIN MGTE IN PSEUDOMONAS AERUGINOSA A Thesis Submitted to the Faculty of Purdue University by Barbara M. Coffey ... bacteria, they are nevertheless highly destructive to the host The decreased cytotoxicity of the bacteria in biofilms is one of the adaptations that allows them to persist Previous
Ngày tải lên: 24/08/2014, 11:35
Molecular and cellular functions of the alternatively spliced isoforms of GDNF receptor complex in neuronal differentiation
... Franklin Neither this thesis, nor the man I am today, would be possible without the heroic effort of Professor Too Heng-Phon, whose philosophy of mentoring is a true embodiment of the quote. Professor ... CELLULAR FUNCTIONS OF THE ALTERNATIVELY SPLICED ISOFORMS OF GDNF RECEPTOR COMPLEX IN NEURONAL DIFFERENTIATION ZHOU LIHAN B.Sc. (Hons.), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... SUMMARY IX LIST OF FIGURES AND TABLES XII LIST OF ABBREVIATIONS XV CHAPTER INTRODUCTION 16 1.1 Motivations of the study 16 1.2 Organization of the thesis 17 1.3 List of related publications
Ngày tải lên: 09/09/2015, 10:13
Functions of the dynamin like protein VPS1 in actin organization in saccharomyces cerevisiae
... phosphorylation of the Pan1p/Sla1p/End3p complex by Prk1p is one of the important mechanisms by which the organization and functions of the actin cytoskeleton are regulated. INTRODUCTION The rapid ... in yeast are the cortical patches and the cytoplasmic cables, both of which display a conspicuous pattern of dynamics during the cell cycle. The pattern of cellular distribution of these actin ... the loss of the Epsin functions results in a block in RME (Chen et al., 1998) These lines of evidence suggest that epsin, together with Eps15, is an accessory protein of the
Ngày tải lên: 16/09/2015, 15:54
PUBLIC FUNCTIONS OF THE SQUARES IN THE CENTRAL AREA OF HOCHIMINH CITY VO THANH TUYEN, TẠP CHÍ ĐẠI HỌC THỦ DẦU MỘT, SỐ 1(40),2019,TR.103-112
... structure To understand the public space functions of the square, the article analyzes and evaluates the current use of the square in the center of Ho Chi Minh City Specifically, the squares such as ... the previous one in 1965 on the order of the Saigon authorities to "build a symbol of the regime at the park or the square" (Minh Tri, 2017) After 1975, it was renamed to mark the martyrdom of ... inscription denoting the end of the Republic of Vietnam (the turtle and the memorial stone was destroyed in 1976) In 1972, the government of Nguyen Van Thieu abandoned the statues of French soldiers,
Ngày tải lên: 20/12/2019, 17:22
Public functions of the squares in the central area of Ho Chi Minh city
... structure To understand the public space functions of the square, the article analyzes and evaluates the current use of the square in the center of Ho Chi Minh City Specifically, the squares such as ... the previous one in 1965 on the order of the Saigon authorities to "build a symbol of the regime at the park or the square" (Minh Tri, 2017) After 1975, it was renamed to mark the martyrdom of ... inscription denoting the end of the Republic of Vietnam (the turtle and the memorial stone was destroyed in 1976) In 1972, the government of Nguyen Van Thieu abandoned the statues of French soldiers,
Ngày tải lên: 12/01/2020, 22:21
báo cáo hóa học: " Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF" potx
... entry into the brain because of blood- brain barrier (BBB) efflux transporters so that the brain serves as a reservoir for HIV-1 [2] and a source for viral escape [3] Therefore, HIV-1 in the brain ... blood- brain barrier to various sized molecules Am J Physiology 1985, 248:H712-H718 Chou S, Dix RD: Viral infections and the blood- brain barrier In Implications of the Blood- Brain Barrier and ... transcellular transport of HIV-1 across the blood- brain barrier (BBB) through the activation of p38 mitogen-activated protein kinase (MAPK) signaling in brain microvascular endothelial cells (BMECs)...
Ngày tải lên: 19/06/2014, 22:20
Application of biologically active micelles in drug delivery across the blood brain barrier
... although 12% of all drugs are active in the CNS, only 8% of them are active in the brain for the treatment of diseases or disorders (Lipinski, 2000) The BBB lies between the blood flow and the brain ... in the central nervous system (CNS) is to overcome the barrier preventing the drugs moving from blood circulation into the brain parenchyma The limited penetration of drugs through the blood brain ... parenchyma The blood brain barrier (BBB) lies between the blood flow and the brain parenchyma The BBB prohibits most foreign molecules entering from the blood to brain, including CNS drugs The limited...
Ngày tải lên: 11/09/2015, 09:10
Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain
... History and Anatomy of the Blood Brain Barrier 1.1.2 Functions of the Blood Brain Barrier 1.1.3 Clinical Significance of the Blood Brain Barrier 1.2 METHODS TO OVERCOME THE BLOOD BRAIN BARRIER 1.3 NANOPARTICLES ... the presence of glutathione, likely via cotransport, is required [13] 1.1.2 Functions of the Blood Brain Barrier The main function of the blood brain barrier is to protect the brain The BBB serves ... endothelial cell Fig The BBB as a selective sieve With these two functions of the blood brain barrier, the brain capillaries allow the passage of oxygen and other essential chemicals and shield the...
Ngày tải lên: 26/11/2015, 22:48
the blood – brain barrier
... junctions of the blood- brain barrier Cell Mol Neurobiol 20, 57–74 68 Brightman, M W., and Tao-Cheng, J H (1993) Tight junctions of brain endothelium and epithelium In The Blood- Brain Barrier Cellular ... through the diaphragm and the costal cartilages left of the sternum up to the level of the clavicle A transverse cut is made in the diaphragm The heart is then grasped using the index and thumb of the ... The large apparent work capability of the blood- brain barrier: A study of mitochondrial content of capillary endothelial cells in brain and other tissues of the rat Ann Neurol 1, 409–417 175 Claudio,...
Ngày tải lên: 11/04/2014, 10:34
báo cáo hóa học:" Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells" docx
... the blood- brain barrier Journal of Controlled Release 2005, 108:84-96 Poduslo JF, Curran GL: Polyamine modification increases the permeability of proteins at the blood- nerve and blood- brain barriers ... other charged nanoparticles [66-69] across the barrier may be from direct charge induced damage to endothelial cells of the barrier and disruption of the barrier Our proposed mechanism for the ... of the bloodbrain tumor barrier; in addition, we validated the importance of prolonged nanoparticle blood half-life for the effective accumulation of nanoparticles within brain tumor cells Therefore,...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors" ppt
... compared the permeability of the BTB of RG-2 gliomas grown within the brain, the orthotopic site, to that of the BTB of RG-2 gliomas grown outside the brain in the temporalis skeletal muscle, the ... characterize the differences in the permeability of the BTB of a malignant brain tumor to that of the BTB of a peripheral solid tumor, and to define the upper limit of pore size within the BTB of the ... ectopic site, the permeability of the BTB of the breast cancer tumor growing in the brain is lower than the BTB of the original tumor in breast tissue, the orthotopic site[5] The brain tissue...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
... whether the effect of AEA on the adhesion of leukocytes interferes on leukocyte transmigration through the BBB model As expected TMEV-infection of brain endothelial cells increased the number of ... phenol-red-free DMEM the top and the bottom of the filter, 400 μl of 10% FBS/phenolred-free DMEM and 200 μl of 0.45% albumin conjugated to Evan’s blue dye were added to the bottom and the top of the well, ... immunohistochemistry, in the brains of sham animals in both type of mice, Cnr1+/+ or Cnr1-/- The intracranial injection of TMEV induced the expression of VCAM-1 in the ipsilateral cerebral cortex surrounding blood...
Ngày tải lên: 19/06/2014, 22:20
Tài liệu Histology of the Blood Normal and Pathological pptx
... of the blood 23 Coagulability of the blood 24 Separation of the serum 24 Resistance of the red corpuscles 25 THE MORPHOLOGY OF THE BLOOD 27 A METHODS OF INVESTIGATION 29 [alpha] Preparation of ... for besides the estimation of the specific gravity of the total blood, they have carried out that of one at least of its constituents, either of the corpuscles or of the serum The red blood corpuscles ... increase of the lymphocytes of the blood; Frọnkel like Uskoff regards it as the emigration of the young forms of the white blood corpuscles into the blood He concludes logically from the diminution of...
Ngày tải lên: 17/02/2014, 22:20