functions of the blood brain barrier
Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt
... investigate the effect of antibody-mediated C5a-blockade on preventing the development of encephalopathy in experimental sepsis We hypothesised that blockade of C5a would reverse the dysfunction of the ... Under physiological conditions, the BBB maintains the cerebral micro-environment by tightly regulating the passage of molecules into and out of the brain to protect the brain from microorganisms and ... J: The influence of cytokines on the integrity of the blood- brain barrier in vitro J Neuroimmunol 1996, 64:37-43 55 Papadopoulos MC, Davies DC, Moss RF, Tighe D, Bennett ED: Pathophysiology of...
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báo cáo hóa học: " Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF" potx
... entry into the brain because of blood- brain barrier (BBB) efflux transporters so that the brain serves as a reservoir for HIV-1 [2] and a source for viral escape [3] Therefore, HIV-1 in the brain ... blood- brain barrier to various sized molecules Am J Physiology 1985, 248:H712-H718 Chou S, Dix RD: Viral infections and the blood- brain barrier In Implications of the Blood- Brain Barrier and ... transcellular transport of HIV-1 across the blood- brain barrier (BBB) through the activation of p38 mitogen-activated protein kinase (MAPK) signaling in brain microvascular endothelial cells (BMECs)...
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Application of biologically active micelles in drug delivery across the blood brain barrier
... although 12% of all drugs are active in the CNS, only 8% of them are active in the brain for the treatment of diseases or disorders (Lipinski, 2000) The BBB lies between the blood flow and the brain ... in the central nervous system (CNS) is to overcome the barrier preventing the drugs moving from blood circulation into the brain parenchyma The limited penetration of drugs through the blood brain ... parenchyma The blood brain barrier (BBB) lies between the blood flow and the brain parenchyma The BBB prohibits most foreign molecules entering from the blood to brain, including CNS drugs The limited...
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Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain
... History and Anatomy of the Blood Brain Barrier 1.1.2 Functions of the Blood Brain Barrier 1.1.3 Clinical Significance of the Blood Brain Barrier 1.2 METHODS TO OVERCOME THE BLOOD BRAIN BARRIER 1.3 NANOPARTICLES ... the presence of glutathione, likely via cotransport, is required [13] 1.1.2 Functions of the Blood Brain Barrier The main function of the blood brain barrier is to protect the brain The BBB serves ... endothelial cell Fig The BBB as a selective sieve With these two functions of the blood brain barrier, the brain capillaries allow the passage of oxygen and other essential chemicals and shield the...
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the blood – brain barrier
... junctions of the blood- brain barrier Cell Mol Neurobiol 20, 57–74 68 Brightman, M W., and Tao-Cheng, J H (1993) Tight junctions of brain endothelium and epithelium In The Blood- Brain Barrier Cellular ... through the diaphragm and the costal cartilages left of the sternum up to the level of the clavicle A transverse cut is made in the diaphragm The heart is then grasped using the index and thumb of the ... The large apparent work capability of the blood- brain barrier: A study of mitochondrial content of capillary endothelial cells in brain and other tissues of the rat Ann Neurol 1, 409–417 175 Claudio,...
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báo cáo hóa học:" Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells" docx
... the blood- brain barrier Journal of Controlled Release 2005, 108:84-96 Poduslo JF, Curran GL: Polyamine modification increases the permeability of proteins at the blood- nerve and blood- brain barriers ... other charged nanoparticles [66-69] across the barrier may be from direct charge induced damage to endothelial cells of the barrier and disruption of the barrier Our proposed mechanism for the ... of the bloodbrain tumor barrier; in addition, we validated the importance of prolonged nanoparticle blood half-life for the effective accumulation of nanoparticles within brain tumor cells Therefore,...
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báo cáo hóa học:" Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors" ppt
... compared the permeability of the BTB of RG-2 gliomas grown within the brain, the orthotopic site, to that of the BTB of RG-2 gliomas grown outside the brain in the temporalis skeletal muscle, the ... characterize the differences in the permeability of the BTB of a malignant brain tumor to that of the BTB of a peripheral solid tumor, and to define the upper limit of pore size within the BTB of the ... ectopic site, the permeability of the BTB of the breast cancer tumor growing in the brain is lower than the BTB of the original tumor in breast tissue, the orthotopic site[5] The brain tissue...
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báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
... whether the effect of AEA on the adhesion of leukocytes interferes on leukocyte transmigration through the BBB model As expected TMEV-infection of brain endothelial cells increased the number of ... phenol-red-free DMEM the top and the bottom of the filter, 400 μl of 10% FBS/phenolred-free DMEM and 200 μl of 0.45% albumin conjugated to Evan’s blue dye were added to the bottom and the top of the well, ... immunohistochemistry, in the brains of sham animals in both type of mice, Cnr1+/+ or Cnr1-/- The intracranial injection of TMEV induced the expression of VCAM-1 in the ipsilateral cerebral cortex surrounding blood...
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Báo cáo y học: "Effect of magnesium sulfate administration on blood–brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study" ppt
... intra-abdominal sepsis, the cultures of brain specimens taken after the experiment were all sterile (data not shown) One of the major pitfalls in the interpretation of the data was the difficulty of establishing ... reaches the brain site it interacts with the endothelial cells forming the BBB and inhibits their activation [4,24,25] To our knowledge, the present data are the first to show the positive effects of ... of the BBB and the role of a permeability defect in the formation of cerebral edema using other models of cerebral damage [18-20] In our previous experimental study we evaluated the effects of...
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Tài liệu Histology of the Blood Normal and Pathological pptx
... of the blood 23 Coagulability of the blood 24 Separation of the serum 24 Resistance of the red corpuscles 25 THE MORPHOLOGY OF THE BLOOD 27 A METHODS OF INVESTIGATION 29 [alpha] Preparation of ... for besides the estimation of the specific gravity of the total blood, they have carried out that of one at least of its constituents, either of the corpuscles or of the serum The red blood corpuscles ... increase of the lymphocytes of the blood; Frọnkel like Uskoff regards it as the emigration of the young forms of the white blood corpuscles into the blood He concludes logically from the diminution of...
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Đề tài " Prescribing symmetric functions of the eigenvalues of the Ricci tensor " pdf
... give the proof of the second inequality of (6.1): Theorem 6.5 Near xk ∈ Σ0 , the function w satisfies w(x) ≤ log ρ(x) + C (6.12) Proof As in the preceding proofs, the argument is complicated by the ... obtain a global bound: max wi ≤ C n M The next result summarizes the properties of the limit w = limi wi Recall from the proof of Theorem 3.5 the definition of the tensor: Sg = Ric − 2δσ1 (Ag )g ... of the σk -Yamabe problem Moreover, the set of all such solutions is compact 478 MATTHEW J GURSKY AND JEFF A VIACLOVSKY We note that the proof of Theorem 1.1 does not rely on the Liouville theorem...
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Báo cáo khoa học: Identification and characterization of plasma kallikrein–kinin system inhibitors from salivary glands of the blood-sucking insect Triatoma infestans pptx
... widely distributed in saliva of other blood- sucking arthropods and whether they prevent the release of bradykinin during blood- feeding by a mechanism similar to that of hamadarin In this study, ... HK The fact that these three unrelated blood- sucking arthropods share such similar bioactive substances as major components of the saliva emphasizes the biological importance of inhibition of the ... respectively To study the phylogeny of these triafestins, the amino acid sequences of triafestins and ve salivary lipocalins of triatomine bugs were aligned by the clustalw protocol The alignment data...
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Báo cáo khoa học: Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis doc
... in vitro wound healing Ratios of the percentage of fluorescent cells in the wound area to the percentage of fluorescent cells in nonwound regions of the monolayer on the same extracellular matrix ... constructs The extent of increased apoptosis among DP9-expressing cells was similar to the extent of the adhesion deficit This concordance of apoptosis and adhesion suggests that one may cause the other ... the RGD motif Interestingly, even without STS treatment there were increases of about 20–25% in the percentages of apoptotic cells in the cell subpopulations that were overexpressing any of the...
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Charity Law & Social Policy National and International Perspectives on the Functions of the Law Relating to Charities pptx
... The Advancement of Animal Welfare The Promotion of the Efficiency of the Armed Forces of the Crown, or of the Efficiency of the Police, Fire and ... relieving the State of the cost of equivalent service provision The Charitable Organisation The infinite variety of not-for-profit organisations together represent the collective moral strength of a ... gift The duty resting on trustees to honour the terms of their trust and ensure that the objects of the charity prevail has always been seen as the primary means whereby the integrity of the donor’s...
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báo cáo hóa học: " Neuro-Inflammation, Blood-Brain Barrier, Seizures and Autism" pot
... Erickson, M A.: The blood- brain barrier and immune function and dysfunction Neurobiol.Dis 2010, 37:26-32 44 Quan, N.: Immune-to -brain signaling: how important are the blood- brain barrierindependent ... VEGF), some of which increase the expression of vascular endothelial cell adhesion molecules (VCAMs) and permit exit of circulating lymphocytes in the brain Focal brain inflammation could then contribute ... mast cells to release mediators that could disrupt the gutblood barrier and blood- brain barrier (BBB), thus contributing to the pathogenesis of autism [27] Many mediators, such as IL-6 [28], can...
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báo cáo hóa học:" Multiple functions of the von Willebrand Factor A domain in matrilins: secretion, assembly, and proteolysis" ppt
... site of matn-1 To further test this hypothesis, we determined whether the presence of the inhibitors of matrix proteases affected the proteolytic processing of matn-1 The presence of mM EDTA in the ... shown that the number of the EGF repeats does not affect the assembly of matrilins [4] In this study, we investigate whether the presence or absence of the vWF A domain adjacent to the coiled-coil ... Interestingly, all of these MED-causing mutations are located in the β strands in the center of the vWF A domain, which are important for the folding of the protein structure [13] It suggests that the secretion...
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báo cáo hóa học:" Research Article On Multiple Interpolation Functions of the q-Genocchi Polynomials" pptx
... 4.8 By comparing the coefficients of both sides of tm /m! in the above, we have the following theorem 12 Journal of Inequalities and Applications Theorem 4.3 Let r, y ∈ Z Then one has k r y ... note that Genocchi zeta functions are entire functions in the whole complex s-plane see 14–16 Journal of Inequalities and Applications Various kinds of the q-analogue of the Genocchi numbers and ... In 14 , Kim defined new generating functions of q-Genocchi, q-Euler polynomials and their interpolation functions In this paper, we give another definition of the multiple Hurwitz type q-zeta function...
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WHEN THINGS GO WRONG – DISEASES AND DISORDERS OF THE HUMAN BRAIN docx
... volumes of the head and medial surface of the hippocampus and the dorsal and ventral surfaces of the amygdala Volumes of these subregions declined with age in the GTS group but not in controls, so the ... College of Medicine, Philadelphia, USA Introduction The prefrontal cortex (PFC) is part of the frontal lobes lying just behind the forehead and is one of the most important areas in the brain This brain ... development of more effective intervention strategies to treat or prevent these disorders The functions of the PFC are defined by its extensive connections with limbic system The limbic system of the brain...
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Hình thái và chức năng của hàng rào máu não (blood brain barrier)
... dụ: nhồi máu não, xuất huyết não chấn thương sọ não ), có chứng tượng mở hàng rào máu não (Brain- Blood Barrier opening) bù trừ có tính chọn lọc phá hủy mặt cấu trúc giải phẫu cách đơn (Lee et ... trúc phức tạp tinh vi, chúng nối vùng đỉnh khe liên tế bào biểu mô với hàng rào nội mô (endothelial barrier) Chúng có chức “dây kéo” (zipper) nhằm liên kết màng tế bào vùng đỉnh (apical membrane) ... nhân, đa nhân, lympho 5.2.Các bệnh thần kinh tác động lên hàng rào máu não 5.2.1.Phù não (Brain edema) Theo Klatzo, phù não phân thành hai loại khác khác dựa vào đặc điểm hình thái chúng 34 -...
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