functional and clinical relevance of chondroitin sulfate proteoglycan 4

... 44 Proteoglycans 45 1.9.1 Heparan sulfate proteoglycans 48 1.9.2 Chondroitin sulfate proteoglycan .49 1.9.2.1 1.10 CSPG signalling mechanisms 51 Aims of current ... kinase Chondroitin- 4- sulfatase Chondroitin- 6-sulfatase Chondroitinase ABC Conditioned medium Central nervous system Chondroitin sulfate Chondroitin sulfate glycosaminoglycans Chondroitin sulfate proteoglycans ... 1 74 Figure 4. 4 CSPG and the stem cell niche 181 List of Tables Table 1.1 Composition of glycosaminoglycan chains and their modifications 46 Table 3.1 Summary of gene profiling...

Ngày tải lên: 12/09/2015, 21:26

... Gelatinases A and B Methods Enzymol 248 , 47 0 48 4 39 Nagase, H., Itoh, Y & Binner, S (19 94) Interaction of alpha 2-macroglobulin with matrix metalloproteinases and its use for identification of their ... Arrowheads show the 74/ 76 kDa doublet and 80 and 85 kDa forms of gelatinase in the CaCl2 treated material (B) The amount of TIMP-1 used was (lane 3), 10 (lane 4) and 20 nM (lane 5) In (A) and (B), at ... mechanisms of the precursors of matrix metalloproteinases 1, and Matrix Suppl 1, 237– 244 18 Liotta, L.A & Stetler-Stevenson, W.G (1991) Tumor invasion and metastasis: an imbalance of positive and negative...

Ngày tải lên: 17/03/2014, 10:20

... http://arthritis-research.com/content/9/5/221 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 B and L by cytokines in synovial fibroblast-like cells Br J Rheumatol 1997, 36:735- 743 Kaneko M, Tomita T, Nakase ... metalloproteinases and tissue inhibitors of metalloproteinases in ankylosing spondylitis: MMP-3 is a reproducibly sensitive and specific biomarker of disease activity Rheumatology (Oxford) 2006, 45 :41 4 -42 0 Vandooren ... transcription of cathepsin B [40 -42 ] The location of cathepsin B appeared to be restricted to synovial cells attached to cartilage and bone at sites of RA joint erosion [43 ] Accumulation of active...

Ngày tải lên: 09/08/2014, 10:21

... IQR CNS92 04 AIEOP CNS99 04 ALL PATIENTS 1.8 1.9 6.3 6.8 1.3-2.5 1 .4- 2 .4 4.3-11.3 5.0-11.5 Sex Female 28 (52%) 30 (36%) 18 (43 %) 23 (47 %) 99 (43 %) Male 26 (48 %) 54 ( 64% ) 24 (57%) 26 (53%) 130 (57%) ... (CNS99 04) through 67% (AIEOP) and 74% (SFOP) to 95% (CNS92 04) The clinical characteristics of children whose tumors were reviewed on this study are provided in Table and are representative of those ... 24: 4 34- 440 27 Ridley L, Rahman R, Brundler MA, Ellison D, Lowe J, Robson K, Prebble E, Luckett I, Gilbertson RJ, Parkes S, Rand V, Coyle B, Grundy RG: Multifactorial analysis of predictors of...

Ngày tải lên: 11/08/2014, 07:21

... (16.7) 0.66 0.55 Mycophenolate mofetil 44 ( 84. 6) (15 .4) 14 (31.8) (12.5) 0 .41 0.39 Basiliximab 46 (88.5) (11.5) 14 (30 .4) (16.7) 0.66 0.55 Tacrolimus 48 (92.3) (7.7) 14 (29.2) (25.0) 1.00 0.86 (3.8) ... Steroids 28 (53.8) 24 (46 .2) (17.9) (8.3) 0 .43 0 .47 Cyclosporinb 46 (88.5) (11.5) (15.2) (0) 0.58 - Mycophenolate mofetilb 44 ( 84. 6) (15 .4) (15.9) (0) 0.58 - Basiliximabb 46 (88.5) (11.5) (15.2) ... Tracheotomy 46 (88.5) (11.5) (8.7) (50.0) 0.03 5.75 Reintubation 37 (71.1) 15 (28.9) (10.8) (20.0) 0 .40 1.85 Reanimation 44 ( 84. 6) (15 .4) (11 .4) (25.0) 0.29 2.20 Cardiomyopathyb 48 (92.3) (7.7) ( 14. 6)...

Ngày tải lên: 13/08/2014, 10:20

... in 62 out of 82 patients with COPD (sensitivity of 76%), out of 23 patients with asthma (13%) and in out of 101 (3%) of patients with congestive heart failure [6] In a larger study of 157 patients, ... patients, the same investigators demonstrated presence of Hoover's sign in 71 patients (45 % of study population), and in 36%, 43 % and 76% respectively of patients with mild, moderate or severe COPD [3] ... molecular/structural basis of the Hoover's sign and explain how it could be utilized in the bedside and emergent management of severe airway disease Clinical presentation of Hoover's sign Case Report...

Ngày tải lên: 13/08/2014, 13:22

... journal of the American Association for the Study of Liver Diseases (AASLD), and of Current Hepatitis Reports, and a member of the Editorial Board of the Journal of Hepatology and of the Journal of ... genotypes and (B), and genotypes 4, and (C) Int J Med Sci 2006, HCV genotypes and Patients infected with HCV genotypes or have a 70%-80% likelihood of an SVR with a low dose of ribavirin and only 24 ... for a total of 48 weeks The virological response must be assessed by means of a sensitive HCV RNA assay (lower limit of detection of 50 IU/ml or less) at the end of therapy and 24 weeks later...

Ngày tải lên: 02/11/2012, 09:56

... B and C virus infection and risk of hepatocellular carcinoma in cirrhosis Cancer 19 94; 74: 244 2-8 31 Tsai JF, Jeng JE, Ho MS, Chang WY et al Effect of hepatitis C and B virus infection on risk of ... difficulties of managing hepatitis B infection Hence, further research and understanding in this sector may bring exciting new information and better understanding of the natural history of HBV and supplement ... activity, and with or without HBeAg seroreversion Clinical Spectrum of HBV Infection Primary Infection –Subclinical Infection and Acute hepatitis B Majority of HBV infection in children are subclinical...

Ngày tải lên: 02/11/2012, 11:17

Ngày tải lên: 03/11/2012, 11:11

... 0. 246 a = c = 90 b = 90.9 501.72 0.062 (0.192) 17.2 (5.7) 98.0 (92.7) 186 775 26 200 3.1 (2.9) 18.1 0.2 14 0. 244 18.1 16.2, 16.5 21.8, 56.0 26.5 18.3 16 .4, 16.3 34. 2, 43 .2 25.6 0.007 1 .43 9 2xog ... studies of the structure and binding sites of enzymes Inhibitor binding to ribonucleases J Mol Biol 45 , 49 1511 33 Ui N (1971) Isoelectric points and conformation of proteins I Effect of urea ... [44 ], and diadenosine 5Â,5ÂÂ,5ÂÂÂ-PÂ,PÂÂ,PÂÂÂ triphosphate (Ap3A) [17] Solution NMR studies have shown that the C3Â-endo puckering is a predominant state for unbound furanose rings [44 ,45 ] O4Â-endo...

Ngày tải lên: 14/02/2014, 22:20

... pp.6 54- 712 ISBN-10: 0 543 873021 Ulvike A, Vollset SE, Hoff G & Ueland PM (2008) Coffee consumption and circulating Bvitamins in healthy middle-aged men and women Clinical Chemistry, Vol. 54, No.9, ... Homocysteine and vascular disease Lancet, Vol.3 54, No.9176, (1999), pp 40 7 -41 3, ISSN: 0 140 -6736 Hultberg B, Andersson A & Sterner G (1993) Plasma homocysteine in renal failure Clinical Nephrology, Vol .40 , ... pathology of homocysteinemia: implications for pathogenesis of arteriosclerosis American Journal of Pathology, Vol.56, (1969), pp 111-128, ISSN: 0002 944 0 32 Pathophysiology and Clinical Aspects of...

Ngày tải lên: 19/02/2014, 23:20

... Promoted Uses 142 12.3 Products Available 142 12 .4 Pharmacologic/Toxicologic Effects 143 12 .4. 1 Endocrine Effects 143 12 .4. 2 Neurologic Effects 144 12 .4. 3 Cardiovascular Effects 144 12 .4. 4 Hematologic ... and/ Traditional Uses 53 4. 2 Current Promoted Uses 53 4. 3 Products Available 54 4 .4 Pharmacologic/Toxicologic Effects 54 4 .4. 1 Central Nervous System Effects 54 4 .4. 2 Musculoskeletal Effects 59 4. 4.3 Reproduction ... Use 43 3.3 Products Available 43 3 .4 Pharmacologic/Toxicologic Effects 44 3 .4. 1 Nervous System Effects 44 3 .4. 2 Cardiovascular Effects 46 3 .4. 3 Carcinogenicity/Mutagenicity/Teratogenicity 46 3 .4. 4...

Ngày tải lên: 06/03/2014, 14:20

... diagnostic method of TB was detection of Mycobacterium tuberculosis in the sputum on 1353 (56.3%) of patients, diagnosis by means of clinical and radiological findings on 346 ( 14. 4%) of patients, ... world population and the wider disparity of income, more and more people are falling into 2 94 (12.2) 46 (1.9) 10 (0 .4) (0.3) (0.29) (0.25) (0.2) (0.08) (0. 04) (0. 04) (0. 04) (0. 04) poverty, whichever ... Number of patients 191 1 14 42 28 20 15 11 7 (%) 7. 94 5.17 1.9 1.27 0.9 0.68 0 .49 0.36 0.31 0.31 0.27 0.22 0.13 0.09 0. 04 Table Clinical presentation of tuberculosis in the study group Clinical...

Ngày tải lên: 15/03/2014, 03:20

... Rehabilitation and Research Centre, University of Oulu, FIN-, Finland Axel Urhausen Institute of Sports and Preventitive Medicine, Department of Clinical Medicine, University of Saarland, D-, Saarbruecken, ... 135 80 60 (63a) 12 1 .4 1.3 48 >(22-) 27; exercise >1.0 45 >(22-) 27; exercise >1.0 43 (47 a) 43 (45 a) *Hypertrophic index (%) = septum + LV thickness (mm)/LVED diameter (mm) Functional adaptations ... of Anatomy, University of Kuopio, FIN-, Finland Jan Henriksson Department of Physiology and Pharmacology, Karolinska Institute, University of Stockholm, SE, Sweden Nils Hjeltness Department of...

Ngày tải lên: 15/03/2014, 09:20

... 2.86 4. 10 3.70 G 3.01 2.79 3.93 G 10.01 10.86 8 .40 T 4. 66 7.66 3 .49 A 5.28 4. 82 4. 90 C 4. 65 4. 90 4. 27 G 4. 16 4. 56 4. 64 A 1 .40 2.06 1.81 C 2.16 1.98 2. 84 A 9.13 9.98 7. 74 G 3 .44 6.13 2.53 G 4. 57 4. 27 ... 13 .45 11 .41 10.61 0.017 0. 042 0.155 ± 0.10 ± 0.33 ± 0.51 7.31 6.53 6.56 < 0.01 0.2 14 0. 745 ± 0.15 ± 0. 24 ± 0.39 40 .03 44 .15 41 .98 0.001 < 0.001 0.002 ± 0.11 ± 0.12 ± 0.01 T 3. 34 ± 0.25 2 .42 ± ... 0.062 0. 042 0.038 0.023 0.017 0.013 0.013 0.011 0.062 0.3 84 Frequency )0.218 0.791 0.301 )0. 046 )4. 632 )5 .43 9 )1.271 0.280 )0.097 )4. 748 )0.727 )1.6 04 – Coefficent Cases and controls 0 .40 8 0.5 34 0.538...

Ngày tải lên: 15/03/2014, 10:20

... 2202 320 320 HPA I HPA I 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 p.I94Sa c.592_613del22 p.R252W p.L48Sa p.L48Sa p.L48Sa p.A403Va c.165delT c.165delT c.165delT ... p.L213P p.R 243 X p.E280K p.Y414Ca c.1055delG Unknown 630 48 40 1210 640 2117 242 2 54 986 393 550 28 74 1186 700 1210 2 148 605 1270 1815 1512 142 8 1180 1936 2529 1936 1089 1230 327 540 340 280 45 0 385 ... catalysis and processing FEBS Lett 505, 44 544 8 Function and structure of PAH human variants 40 Andersen OA, Stokka AJ, Flatmark T & Hough E (2003) 2.0 A resolution crystal structures of the ternary...

Ngày tải lên: 16/03/2014, 01:20

... 79 :45 4 45 8 Dunsmuir RA and Gallacher G (2003) Microwave sterilization of femoral head allograft J Clin Microbiol 41 (10) :47 55 47 57 Fitzpatrick JA, Kwoa-Paul J, and Massey K (1978) Sterilization of ... Validation and Routine Control (20 04) 44 3 Appendix The IAEA Program on Radiation and Tissue Banking — Public Awareness Strategies for Tissue Banks (2002) 501 Index 545 FA March 19, 2007 14: 26 b478 Radiation ... bacteria by means of microwave heating J Clin Eng 3 :44 47 Hartman FW and Logrippo GA (1957) Betapropiolactone in sterilization of vaccines, tissue grafts, and plasma J Am Med Assoc 1 64( 3):258–260...

Ngày tải lên: 22/03/2014, 20:21

... 6.0 Fe(II)-HbIV Met-HbIV Fe(II)-HbI Met-HbI 40 40 40 40 40 < < < < < 3.00 1.20 1.80 3.00 5 .40 25.80 22.80 24. 60 24. 00 26 .40 (2 .45 3 (1.575 (0.929 (1.8 84 (1.207 ± ± ± ± ± 0.002) 0.010) 0.010) 0.010) ... explained by the reaction of oxoferrylHb with H2O2 with the production of met-Hb and oxygen instead of superoxide anion [8] Our data performed, at pH 5 .4, in the presence of H2O2 and guaiacol (as reductant) ... HbI and HbIV: iron(II)-HbI and met-HbI induce a 23.2 and 50.1% reduction of the peak intensity, respectively, when compared with the peak of the buffer Iron(II)-HbIV and metHbIV induce a 35.8 and...

Ngày tải lên: 23/03/2014, 12:20

... AZT, and reached  38% of the normal level in U937CD and 35% in MOLT4CD cells on day 15 In H2O2-treated cells, the level of ATP declined similarly On day 25, U937CD and MOLT4CD contained 45 and 48 % ... L (19 94) Mechanisms of endotoxin-induced haem oxygenase mRNA accumulation in mouse liver: synergism by glutathione depletion and protection by N-acetylcysteine Biochem J 3 04, 47 7 48 3 14 Anderson, ... activation of the NF-jB transcription factor and HIV-1 EMBO J 10, 2 247 –2258 10 Kurata S.-I (19 94) Potential of azidothimidine to activate the HIV-1 promoter J Biol Chem 269, 245 53– 245 56 11 Kurata,...

Ngày tải lên: 24/03/2014, 04:21

... 303 1 94 216 237 2 94 13–13.9 1 94 228 247 301 202 223 243 338 14 14. 9 220 237 253 322 2 14 237 252 322 15–15.9 222 244 2 64 320 208 239 2 54 322 16–16.9 244 262 278 343 218 241 258 3 34 17–17.9 246 267 ... 285 347 220 241 2 64 350 Data from Frisancho AR New norms of upper limb fat and muscle areas for assessment of nutritional status Am J Clin Nutr 34: 2 540 –2 545 , 1981 With permission management, and ... Pediatr 1 24: 244 – 249 , 19 94 103 Sturman JA, Gaull G, and Raiha NC Absence of cystathionase in the human fetal liver: is cysteine essential Science 169: 74 76, 1970 1 04 Sunehag A, Gustafsson J, and Ewald...

Ngày tải lên: 28/03/2014, 22:20