function structure and biological activity of their derivatives

... the structure of peptide cER consists of two b-turns, located at the N- and C-termini A comparison of the b-turn structure of cER with the similar region in the crystal structure of rat and human ... bonds between NH of Thr5 and CO of Arg2, as well as NH of Arg2 and CO of Thr5 Structure of cyclic hexapeptides – cYT peptide The NMR data of the cYT peptide were indicative of its flexible nature ... the peptide and the proximity of amide protons due to compact nature of the structure However, the coupling constant of most of the amide protons was in the range of 6–8 Hz, suggestive of rapidly...

Ngày tải lên: 19/02/2014, 13:20

... Fragments of HSQC and HMBC spectra of compound Labels illustrate assignment of the amide linkage between the amino group of Asp and the carboxyl group of GalA residue E Scheme The structures of oligosaccharides ... present in the products and were identified, and the ratio of structures and was close to : All chemical shifts remained mostly unchanged with the exception of H/C-2 and H/C-3 of the glycerol residue ... Amide linkage between C-6 of residue E and an amino group of the aspartic acid was identified on the basis of the HMBC correlation between H-2 of aspartic acid and C-6 of the GalA E, thus showing...

Ngày tải lên: 19/02/2014, 16:20

... presence of minute amounts of endotoxins The comparison of LPS and MfGl-II in the LAL assay shows, as expected, activity of LPS in the range of down to 10 pgÆmL)1, whereas MfGl-II has only activity ... Bally, M.B (1983) Structural properties of lipids and their functional roles in biological membranes In Membrane Fluidity in Biology: Concepts of Membrane Structure, Vol (Aloia, R.C., ed.), pp ... of unlabeled molecules into the double-labeled liposomes leads to probe dilution and with that to a decrease in the efficiency of FRET: the emission intensity of the donor increases and that of...

Ngày tải lên: 21/02/2014, 00:20

... [19], bone marrow [10] and several other organs [20] However, the main host cells and the target organs of this virus are still undefined The study of the biological functions of TTV is particularly ... interactions, and to find permissive cell lines for further molecular and cell biological studies of this peculiar human virus For this purpose, we have cloned and sequenced the full-length genome of TTV ... SalI double-digestions of the input linear construct yielded three restriction fragments of approximately 2100, 740 and 890 bp with the first enzyme pair, and of 2200, 630 and 890 bp with the latter...

Ngày tải lên: 16/03/2014, 05:20

... influence of nociception on the beating rate of CM measured on day of culture without and with pretreatment with either 0.2 lM of I or II on day and after seeding The basal beating rate of the CM ... down-regulation of the nociceptin/orphanin FQ receptor to be the mechanism of biological activity of compounds I and II The antisense pretreatment remained without any influence on the basal beating rate of ... involvement of nonendocytic mechanisms (Fig 3) On the other hand, energy-dependent and -independent mechanisms contributed differently to the cellular uptake of the naked PNA and of the conjugate...

Ngày tải lên: 23/03/2014, 13:20

... analysis of the calculated structures revealed a short distances between NH of Leu7 and the side chain carboxyl group of the Asp6 residue (< 0.28 nm), and NH of Leu7 residue and C¼O of Leu5 (< ... Characterization of the secondary structure of these two ligands of ODN receptors should provide useful information for the design of potent, stable and selective agonists and antagonists of these receptors ... secondary structure of the cyclic OP analogs by two-dimensional 1H-NMR and molecular dynamic simulation, and we have investigated the biological activity of these analogs by measuring their ability...

Ngày tải lên: 24/03/2014, 04:21

... its N- and C-terminal Ó FEBS 2002 Structure activity relationships of GGN4 analogues (Eur J Biochem 269) 4371 Fig Solution structures of GGN4 analogues Backbone atoms (N, Ca, and C¢) of the finally ... Fig Fluorescence quenching and blue shift Fluorescence emission spectra of NATA (a and b) and D16W-D24)37 GGN4 (c and d) in water (a and c) and in 10 mM SDS micelles (b and d) were measured with ... complete restoration of activity In the present work, we further examined the biological activities of several GGN4 analogue peptides The structural effect and the functional role of the tryptophanyl...

Ngày tải lên: 31/03/2014, 09:20

... H of 5BI to C=O of Glu 81, C2 =O of 5BI to NH of Leu 83 and N1’ -H of 5BI to C=O of Leu 83 Glu81 and Leu 83 are also known as gk+1 and gk+3 amino acid residues respectively because they are and ... of isoindigos without compromising biological activity 1.5 Biological properties of functionalized isoindigos 1.5.1 Mode of action of meisoindigo Meisoindigo is the most widely investigated of ... Effect of 6-4 on the different phases of the cell cycle of K562 cells……… 123 Table 5-5 Effect of 4-5 on the different phases of the cell cycle of K562 cells…….… .125 Table 5-6: Distribution of normal,...

Ngày tải lên: 10/09/2015, 08:38

... later The structures of A and B are shown in Fig 2, which revealed that the molecular structures of A and B are similar and also symmetric to our satisfaction Selected bond lengths ( and bond ... cross-section values of s of the compounds A and B are 386 and 418 GM (1 GM ¼ 10À50 cm4 s photonÀ1 moleculeÀ1) in DMF solution, respectively 3.4 Cytotoxicity assay and biological images of two-photon ... 0.1701 1.028 Gof on F2 314 G Xu et al / Dyes and Pigments 101 (2014) 312e317 Fig Molecular structure of A and B showing 50% probability displacement 3.2 Linear absorption spectra and single-photon...

Ngày tải lên: 01/07/2014, 13:22

... (or both) of the above-mentioned processes may be relevant to moult control, we first investigated the biological activity of MIH and CHH during precisely timed stages of the moult cycle of Carcinus ... MIH content of the SG, relative to CHH, during late premoult Expression patterns of MIH and CHH in the X-organ during the moult cycle Expression patterns of mRNA levels of both MIH and CHH were ... investigated levels of MIH and CHH peptides in the sinus gland and levels of transcripts in XO neurones during the moult cycle, to see whether significant events, such as up- or down-regulation of transcription...

Ngày tải lên: 21/02/2014, 00:20

... spectra and minimal nutrient combinations Both strategies allow for a quantification of functional properties of metabolic networks These are used to identify groups of organisms with similar functions ... engineering Specific biological questions were in focus of three articles: Andorf et al investigated a systems biological hypothesis towards explaining heterosis on the scale of metabolite partial ... heterozygote crossings and make further predictions regarding expected heterosis effects if very different lines are crossed Ebenhoeh and Handorf describe two functional classifications of genome-scale...

Ngày tải lên: 22/06/2014, 00:20

... absorbance in the presence of the sample and H2 O2 , A0 is the absorbance of the control in the absence of the sample and H2 O2 , and A is the absorbance only in the presence of the H2 O2 2.6 Nuclear ... International Journal of Biological Macromolecules 47 (2010) 271–275 273 Fig FTIR spectra of polysaccharide TMP-A dent’s t-test and one-way analysis of variance Values of P < 0.05 were considered ... analysis 3.2 Structure elucidation of TMP-A The intensity of bands around 3408.22 cm−1 in the IR spectrum (Fig 1) was due to the hydroxyl stretching vibration of the polysaccharide and as expected...

Ngày tải lên: 28/06/2014, 11:20

... was directed to the proximal third of the tail The tip of the tail of the mice was individually 718 Table G Mariappan et al Analgesic activity of benzimidazole derivatives on mice by using tail-flick ... showed profound analgesic activity The rest of the compounds 3a, 3b, 3c, 3e and 3f showed moderate activity when compared with the control 3.4 Screening of anti-inflammatory activity From the Table ... most of the tested compounds showed significant results in comparison with standard diclofenac sodium Amongst all the compounds, 3b, 3d, 3f, 3g and 3i showed potent anti-inflammatory activity and...

Ngày tải lên: 02/09/2015, 13:45

... friends and family for their unwavering support during these four years i TABLE OF CONTENTS TABLE OF CONTENTS ii SUMMARY iv LIST OF TABLES vi LIST OF FIGURES vii LIST OF SCHEMES ix LIST OF ABBREVIATIONS ... synthesis of analogs of pepticinnamin and curacin A.75,76 Today the synthesis of a library of compounds based on a natural product scaffold is commonplace for the optimization of the biological and ... rapamycin and fumagillin.11-14 Figure 2.1 Examples of conjugated polyenes with biological activity 30 In 2006, Capon and co-workers published a report on the isolation and structure elucidation of several...

Ngày tải lên: 10/09/2015, 15:49

... Structures and inhibition values of 2-1 164 Table 4.2 Structures and inhibition values of 3-17 165 Table 4.3 Structures and inhibition values of 2-2 165 Table 4.4 Structures and inhibition values of ... values of 3-38 and 3-45 166 Table 4.5 Structures and inhibition values of 3-28 and 3-29 167 vii LIST OF FIGURES Figure 1.1 Three key elements of solid-phase synthesis Figure 1.2 Structure of various ... substitution of resin 3-12 Reaction of 3-12 with primary amines under basic condition Figure 3.5 Structure and yields of 3-17 obtained from solid phase synthesis 87 Figure 3.6 Structure and yields of 2-1c...

Ngày tải lên: 14/09/2015, 08:25

... prices “over and beyond” what such changes imply for the path of aggregate demand and inflation (Borio and Lowe 2002, Cecchetti et al 2000) Proponents of this policy emphasise that episodes of financial ... precision of the estimates, we thus follow Goodhart and Bean (2004) and Kohn (2006) discuss the implications of lags for the use of monetary policy in the face of asset price bubbles Sutton (2002) and ... for Denmark, Switzerland, Spain, Finland, France, Germany, Ireland, Italy, the Netherlands, Norway and the UK, a threemonth Treasury bill rate for Belgium, Sweden and the US, and a three-month commercial...

Ngày tải lên: 24/10/2012, 09:40

... (511) and (440) These planes are indications of the presence of a spinel cubic structure The diffraction lines corresponding to a cubic, spinel-type and crystalline phase provides clear evidence of ... increasing magnetic moment per formula of Ni1-xCoxFe2O4 and equivalently, an enhancement of magnetization [7].The dependence of saturation magnetization Ms as a function of Co2+ concentration is shown ... high coercivity of materials, the second term can take part of several tens percent of HC and the last one whereas can only reach several hundreds of gauss Thus, the increasing of Co-concentration...

Ngày tải lên: 13/02/2014, 04:20

... determinants of corporate share ownership structures.4 The literature emphasizes the roles of customs, social norms, and law and legal systems in shaping the structure of property rights and their governance ... Journal of Accounting and Economics 11, 143-81 Demsetz, H., 1964 The exchange and enforcement of property rights Journal of Law and Economics 3, 1-44 Demsetz, H and K Lehn, 1985 The structure of ownership: ... Department of Finance, School of Business and Management, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong c Department of Accounting, School of Business and Management,...

Ngày tải lên: 18/02/2014, 01:20

... attributed to bH of Ala12 and NH of Val15, and aH of Pro13 and NH of Val15 Ó FEBS 2004 Structural study of internal fusion peptide of ASLV (Eur J Biochem 271) 4733 Conformational alteration of IFP–wt ... mixing activity of IFP–wt Fig Membrane binding and insertion depth of IFP–wt probed by NBD fluorescence (A) Lipid binding of NBD-IFP–wt at pH 7.4 and 37 °C Increased intensity and the blue-shift of ... and internal FPs, in the hope of improving our understanding of the role of fusion peptides in the fusion event Structure and membrane interaction of IFP–wt Binding of IFP–wt to lipid vesicles...

Ngày tải lên: 19/02/2014, 16:20

... about 84% of all sugar structures The structures of the N-glycans of nLyc e and their molecular percentages are presentec in Table The peptide analysis of nLyc e identified 21 peptides of the natural ... of 50 kDa would suggest that we had purified the truncated isoform Cloning of the cDNA of two isoforms of tomato b-fructofuranosidase and recombinant expression in E coli For protein expression ... superimposable and clearly showed the existence of secondary structures (not shown) Comparison of IgE-reactivities of the purified natural and recombinant Lyc e HIC-purified natural and electroeluted...

Ngày tải lên: 21/02/2014, 00:20