from the rationale to human applications

... within normal human breast tissue, showing comparable results to those observed in the mouse The percentage of cells which were able to efflux the dye and form the SP varied from 0.2% to 1% to 5% (Alvi ... been shown to exert their effects through ligand-activated steroid receptors in the mammary epithelium Approximately 10%–15% of the cells within the epithelium coexpress oestrogen receptor alpha ... cells from this subpopulation had the ability to produce the normal heterogeneous structure of the gland, suggesting that these cell markers are not sufficient to completely mark the SC (Shackleton...

Ngày tải lên: 15/03/2014, 09:20

... similar to each other than either is to the 5-HT2B receptors The 5-HT6 receptors are more similar to the 5-HT2 receptors than the other classes The 5-HT4 receptors are most similar to the 5-HT6/5-HT2 ... THE SEROTONIN RECEPTORS THE RECEPTORS KIM A NEVE, SERIES EDITOR The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics, EDITED BY Bryan L Roth, 2006 The Adrenergic Receptors: ... extracellular amino-terminus, and From: The Receptors: The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics Edited by: B L Roth © Humana Press Inc., Totowa, NJ Kroeze and Roth an...

Ngày tải lên: 29/03/2014, 13:20

... also be detrimental The aim of this study was to explore the mechanisms responsible for the shunt from the COX to the 5-LO pathway in human OA osteoblasts We also examined the implication of both ... FLAP in the production of LTB4 in these cells and the factors that might modulate their expression We also sought to determine whether there was a relationship between PGE2 levels and either IL-10 ... expression levels, the Ct values were converted to numbers of molecules and the values for each sample were calculated as the ratio of the number of molecules of the target gene to the number of molecules...

Ngày tải lên: 09/08/2014, 08:23

... through the snow into a frozen pond Let the kids piece the story together 28 pull a rhino hoax 55 abscond in a suitcase hop a train Cut large notches in ends of suitcases Cover the holes ... some play at a concert Dive into the ar  s of m a hottie in the crowd Cruise the merchandise table to pick up a memento of the show—or of when you first met “Bump into” that special someone during ... iron in the groom’s pocket wards off evil spirits Just the two of you in town? Grab a witness off the street A rip in the veil brings good luck The pieces of a broken glass symbolize the many...

Ngày tải lên: 15/01/2014, 12:15

... form, sector or location, are to have the potential to grow and develop so as to contribute to the overall goal To survive in the new competitive environment, no enterprise can afford to stand ... are able to absorb them and profit from them Ensuring the existence of these conditions is the aim of innovation policy, the subject of this Communication 1.2 Need for the Communication The European ... up the results in the private sector The increased emphasis on the private sector in its double role of technology user and “translator” of market needs into research problems has led to the...

Ngày tải lên: 16/01/2014, 16:33

... of the room Well, then, the room is the heavens, the table is the earth, and the moon is yourself." And they would go away delighted So, then the moon displays invariably the same face to the ... opposed to the other Happily for these citizens, so useful to their country, a distance of from fifty to sixty miles separated them from one another, and they had never yet met Which of these two ... seconds, and the period is too brief for the resistance of the medium to be regarded otherwise than as insignificant Proceding, then, to the attraction of the earth, that is, the weight of the shell,...

Ngày tải lên: 17/02/2014, 04:20

... States and the United Nations bring different capabilities to the process Neither is likely to succeed without the other Both have much to learn not just from their own experience but also from that ... Nation-Building: From the Congo to Iraq Following the loss of 18 U.S soldiers in Somalia in 1993, the United States took great precautions through the rest of the decade to avoid casualties The United ... administrators • the uneven quality of military components • the even greater unevenness of police and civil administrators xviii The UN’s Role in Nation-Building: From the Congo to Iraq • the United...

Ngày tải lên: 18/02/2014, 00:20

... 2.1 The Right to Life and Human Dignity 2.2 Human Dignity and the General Personality Right (a) The Right to Free Fulfilment of the Personality (b) The General Freedom of Action (c) The Right to ... or even to define them under the sole term of ‘revolution.’ Indeed, one of the difficulties of understanding the changes is reflected in the lack of one satisfactory term to label them.2 The people ... and Southern Europe With their experience and knowledge of post-totalitarian democracies, they turned to post-communist systems, probably eager to test their hypotheses and to extend their empirical...

Ngày tải lên: 18/02/2014, 11:20

... marginal Right now there is no way to tell if there will be either the changes in the composition of the economy or in the role of schooling What we know from the past is that when the how, what, ... in the 21st Century The 20th century was the education century For the first time in human history the majority of the world’s population learned to read and write (Cohen and Bloom, 2005) The ... inculcating the organizational attributes of the factory “Attempts to reform British and American society from the 1830s on in what we now label the Victorian era were a monumental success The impact...

Ngày tải lên: 20/02/2014, 20:20

... and the preparations for the European Food Agency EFSA were on the way All these factors, most of them in the state of flux, had to be taken into account They were however all dominated by the ... have at the beginning an idea of the current state of the art of the sector and the main developments along the food chain at the moment During the next 10 years, the European food sector will ... consumer science The overriding theme of the project is the need to focus on the end consumer as the most important element in the food chain, and to re-construct the single elements of the food production...

Ngày tải lên: 22/02/2014, 05:20

... urge them to persevere, to remain united, not to relax in their determination, and to strive with all their might to extend the scope of their meritorious activities I will continue to pray for them ... Bolton’s question as to whether the Guardian has given any instructions to the friends as to the best way to make their investments secure during the coming world crisis; I am instructed to inform ... are these words to the present state of mankind! Ours then is the duty and privilege to labour, by day, by night, amidst the storm and stress of these troublous days, that we may quicken the...

Ngày tải lên: 06/03/2014, 12:21

... ready for the next step: high-end home theater The transition to 4K home theater Just as the history of movie theater design is a story of ever greater engagement, so is the history of home theater ... distances You can think of the classic theater as a long rectangle with the screen on the short side Seating distances ranged from PH in the back to 2.7 PH in the front While today’s audiences might ... floor” auditorium gave way to “stadium seating.” It’s as if we had turned the classic theater 90 degrees, placing the screen on the long side of the rectangle In this new era, the back of the room...

Ngày tải lên: 07/03/2014, 14:20

... When the guns got to the top of the rise, they must go at a trot to their positions, the sooner to get the horses from under fire Twenty or thirty steps brought us to the top of the sharp little ... described by Swinton, the admirable historian of the "Army of the Potomac." (Swinton's "Army of the Potomac," p 443): "Finally," he says, "the column (Warren's) emerged from the woods into a clearing, ... and there After a while he felt a hard lump, which ought not to be there The doctor wondered what it could be then feeling about, he found another hard lump, and then another, and another Then the...

Ngày tải lên: 08/03/2014, 13:20

Ngày tải lên: 08/03/2014, 18:18

... affect to the extent of the intensity of the exposure and the degree of susceptibility to the disease or the intrinsic factors that modi‐ fy the form in which the child's bodily tissues respond to ... application to the clinic There are four sections in the book The first section is about the hypothesis on the etiology of ALL; two chapters were selected at this point The model for identifying the ... factors and susceptibility to the disease [4] The theories con‐ cerning the origin of this illness have been focussed fundamentally on the B-cell precursors of ALL [1] The most important of these...

Ngày tải lên: 17/03/2014, 12:20

... COMMUNICATION FROM THE COMMISSION TO THE EUROPEAN PARLIAMENT AND THE COUNCIL A Roadmap towards a Banking Union INTRODUCTION Over the past four years, the EU has responded decisively to the economic ... policy to the real economy throughout the Euro Area The Commission has therefore called2 for a banking union to place the banking sector on a more sound footing and restore confidence in the Euro ... COMPLETING THE BANKING UNION As set out by the Commission11 before the June 2012 European Council and in the report of the Presidents of the European Council, the Commission, the Eurogroup and the European...

Ngày tải lên: 29/03/2014, 08:20

... of the SBA The decision to increase the period of public consultations launched by the Commission from eight to twelve weeks from 2012 onwards should give more time to stakeholders to consult their ... for them to delay accounting for VAT until they receive payment from their customers5 The Directive to combat late payment adopted by the Council in January 2011 requires public authorities to ... generate costs to the extent that they discourage entrepreneurs from expanding their business to other Member States Therefore, the Commission will propose a single set of rules for computing the corporate...

Ngày tải lên: 29/03/2014, 18:20

... thus strengthening the integrity of the internal market, linking the East with the West and the North with the South, and EN EN creating real territorial cohesion to the benefit of all The budget ... money delivering on our commitments to help the poorest in the world If we face tough times at the moment, they face the toughest of times all of the time The theme of solidarity is enshrined throughout ... helps them to find another job as rapidly as possible The amounts which are needed vary from year to year, that is why the Commission is proposing to keep the EGF outside the financial framework The...

Ngày tải lên: 29/03/2014, 18:20

... with the rest of the story Into this little town comes the sad news that the leader of the world proletariat, Lenin, has died This is the time for the workers to show their redoubled commitment to ... Even the camp of the innovators was deeply divided They disagreed with one another on issues such as whether a film should tell a story, whether there should be professional actors, how the actors ... common people They sent thousands of agitators to the villages in order to explain their pro­ gramme to the peasants; they took control of the press and made sure that it was only their interpretation...

Ngày tải lên: 30/03/2014, 14:20

... the one hand many of the divinities of the poets were themselves identified with components of the world such as the sea or the earth, while on the other the Ionians appear to have regarded their ... of a theory of the nature of the soul, and in particular of the view that the soul is akin to the world as a whole, and therefore to be explained via the application of the same mathematical conceptions ... At the end of the seventh century the Greeks began, for the first time, to produce monumental sculpture in stone There can be no doubt, from analysis of the proportions of these statues, that the...

Ngày tải lên: 05/06/2014, 11:30