from proof of concept to therapeutic perspectives

... seeking to offset the impact of their carbon emissions ITTO 2005b Page 16 of 140 FINAL 06 August 2007 Forest-Backed Bonds Proof of Concept Study Forum for the Future & EnviroMarket The Forestry Sector ... both investor and operator Page of 140 FINAL 06 August 2007 Forest-Backed Bonds Proof of Concept Study • Forum for the Future & EnviroMarket Investment liquidity - Lack of ability to easily buy ... limit of 10% to 75% (FAO 2005) and a basal-area Page 15 of 140 FINAL 06 August 2007 Forest-Backed Bonds Proof of Concept Study Forum for the Future & EnviroMarket weighted mean vegetation height of...

Ngày tải lên: 06/03/2014, 08:20

... further reduced to four Newtons, his ability to isolate his fingers again diminished but improved after further training with this amount of assistance from 36 to 38 degrees Proof of concept testing ... hemisphere [2] Proof of concept testing methods We conducted a series of trials to establish the safety and viability of this system for the rehabilitation of hand and arm dysfunction due to stroke ... functional therapeutic outcomes for the arm and hand post-stroke These concepts have led to the development of the Virtual Piano Trainer This paper will provide a proof of concept of whether...

Ngày tải lên: 19/06/2014, 08:20

... Importance of cumulative exposure to elevated cholesterol and blood pressure in development of atherosclerotic coronary artery disease in systemic lupus erythematosus: a prospective proof- of- concept ... University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada The University of Melbourne ... objective was to compare measures of cumulative exposure with remote and recent values for each of total cholesterol (TC), systolic (SBP) and diastolic (DBP) blood pressure in terms of ability to quantify...

Ngày tải lên: 12/08/2014, 18:20

... requirement of the patient as the disease process evolves in response to treatment or as a result of healing The goal of this proof- of- concept study is to explore the feasibility of supplementing ... variable of interest are identified The idea is to provide the values of these predictor variables from the index patient to the model, and a predicted range of fluid requirement is obtained from ... problem domain to test the feasibility of the concept A software application is envisioned that builds a model consisting of patients that are similar to an index patient in terms of age, gender,...

Ngày tải lên: 13/08/2014, 11:23

... biomarkers from thousands of genes could be a great challenge Here we performed a proof- of- concept study by selecting a handful of biomarker genes to develop a practical assay with the aid of RD computational ... interrogation of mechanism(s) underlying cellular responses to toxicants Toxicology 181–182: 555–563 Bartosiewicz M, Penn S, Buckpitt A (2001) Applications of gene arrays in environmental toxicology: ... expression of essentially all of the selected genes in the seven pathways while lindane up-regulated the expression of most of these genes Similarly, TCDD downregulated the expression of most of genes...

Ngày tải lên: 23/09/2015, 14:47

... the catchment of Addis Ababa The PMTCT programme data were obtained from routine monthly reports from 2004 to 2009 and from published antenatal HIV surveillance reports from 2003 to 2009 Data ... decline from 10.0% in 2004 to 4.5% in 2009 There were five antenatal surveillance sites from 2003 to 2007 in Addis Ababa and they increased to seven by 2009 Four rounds of surveillance data from ... training to minimize gaps due to staff turnover need to be emphasized Use of summary reports and the lack of cost effectiveness analysis would be some major limitations of the study However, to ensure...

Ngày tải lên: 15/03/2014, 10:20

... PERIOD OF TRANSITION: FROM NICOLAS OF CUSA TO DESCARTES Nicolas of Cusa The Revival of Ancient Philosophy and the Opposition to it The Italian Philosophy of Nature Philosophy of the State and of ... between Plato and Aristotle"), of Bessarion (Adversus Calumniatorem Platonis, 1469, in answer to the Comparatio Aristotelis et Platonis, 1464, an attack by the Aristotelian, George of Trebizond, ... for its object to promote by means of lectures the investigation of nature on the basis of atomism, and, at the same time, to free it from the reproach of leading to atheism and to show its harmony...

Ngày tải lên: 16/03/2014, 03:20

... et al.: Pilot proof of concept clinical trials of Stochastic Targeted (STAR) glycemic control Annals of Intensive Care 2011 1:38 Submit your manuscript to a journal and benefit from: Convenient ... of Intensive Care 2011, 1:38 http://www.annalsofintensivecare.com/content/1/1/38 Page of 12 Number of patients with cTIB cutoff >= 0.80 Num patients 2 Days on STAR % of patients with cTIB cutoff ... intervention and the system model of Equations (1)(6) to yield a range of BG outcomes of differing likelihood Note that the stochastic model shown is for a 1-hour interval, the 2- to 3-hour interval models...

Ngày tải lên: 20/06/2014, 23:20

... stained slides on a scale from to (ranging from stained cartilage to fully destained cartilage) Cartilage damage was scored from to (ranging from unaffected cartilage to maximum chondrocyte death ... dose-escalating, proof- of- concept study in patients with RA – the first of its kind in humans The study's primary objective was to investigate safety and tolerability; therefore, it was not powered to investigate ... and leads to total destruction of the joint within to 10 days, controlateral joints or joints receiving control 3T3 cells not exhibit signs of inflammation Application of ACZ885 intraperitoneally...

Ngày tải lên: 09/08/2014, 10:23

... method From patient 2, a total of 15 SGS were obtained from the plasma sample 16 days after initiation of IVIG treatment (2.PLd16); 23 SGS from the supernatant at baseline (2.BL); and 38 SGS from ... used to treat autoimmune and inflammatory diseases Its effects are complex and involve modulation of expression and function of Fc receptors; interference with complement activation and the cytokine ... magnitude of the viral increase in plasma and the size of the latent HIV1 pool, together with findings from SGS of the gag region, indicate that HIV-1 in plasma originated from the pool of latently-infected...

Ngày tải lên: 10/08/2014, 05:21

... conformed to the policies established by the Code of Ethics of the World Medical Association (Declaration of Helsinki) and ethics approval was obtained from the Doctoral Commission of the University of ... part of the definition of homelessness), makes difficult to attribute to personality disorders, valued in general, the presence of psychosocial disorders Something similar happens in the case of ... because of the possible variables in community treatment [18] In this study, our aim was to investigate which factors (psychosocial or personality disorders) are more important contributors to treatment...

Ngày tải lên: 11/08/2014, 16:21

... consumption; VE: expiratory minute ˙ volume; VLCO2: amount of CO2 exhaled from the lungs per unit of time; ˙ VMCO2: amount of CO2 removed from the circulation via membrane oxygenator per unit of time Acknowledgements ... setup WMZ and FI contributed to the conceptual design of the study, to the interpretation of data, and to manuscript writing and editing WMZ and FI contributed equally to this study All authors ... limit of this assay was approximately μM sulfide in plasma Calculation of carbon dioxide production  Total VCO was monitored continuously and was calculated as the sum of CO2 exhaled from the...

Ngày tải lên: 14/08/2014, 07:21

... members of the inhibitor of apoptosis family (cIAP-1, XIAP and survivin, which directly bind to and inhibit caspases), was strikingly reduced Dr Brigitte Mueller-Hilke (University of Rostock, Germany) ... will be transferred into CIA mice to ameliorate the autoimmune process On the basis of the previous finding of a differential impact of Th1 and Th2 cells on the function of bone marrow-derived ... http://arthritis-research.com/content/6/4/155 either T helper (Th) or Th2 effector cells The goals of this arm of EUROME are to identify genes and pathways involved in this differentiation of DCs and to set up an ex vivo–in vivo cell therapy...

Ngày tải lên: 09/08/2014, 01:23

... NA 0.60 (subtentorial vs supratentorial) 0.72 (0.40-1.29) 0.28 (supratentorial and subtentorial vs supratentorial ) 1.40 (0.96-2.05) 0.75 (supratentorial and subtentorial vs subtentorial 1.93 (1.1-2.53) ... neurologic symptoms at diagnosis of brain involvement, number of BMs, and type of treatment were independent prognostic factors for survival (Table 5) To assess whether the availability of resources ... sex, primary tumor, date of initial diagnosis of primary cancer, date of radiographic diagnosis of BMs, number and location of BMs, neurologic symptoms, presence/absence of extracranial disease,...

Ngày tải lên: 10/08/2014, 10:20

... has a longer shelf life in storage, and second, the fruit of this tomato could be left on the plant until optimally ripe Because of these attributes, FlavR Saver tomatoes are sold for premium prices ... development of green revolution crop plants and of faster growing, higher yielding forest trees; (3) improvements in the postharvest storage and handling of crops; (4) the use of plant hormones to improve ... of plant cells in shaker or bioreactor cultures, low rates of synthesis of desired products, and synthesis of compounds not present in intact plants In fact, it was discovered in the course of...

Ngày tải lên: 25/10/2013, 05:20

... needless to remark can in no possible way be traced to the effects of rowing, we come to the consideration of those diseases of the respiratory and the circulatory systems (in other words of the ... Three of those from whom I have not received letters belong to the University of Oxford, and one is a graduate of Cambridge To each of them I have addressed several communications, but hitherto ... proportion of the deaths is due to diseases of those organs which might be expected to suffer from muscular exercise carried to excess, it will be allowable to examine somewhat critically into the...

Ngày tải lên: 14/02/2014, 21:20

... not be able to discover the identity of the beneficiary of the account and will be unable to meet their “know your customer” obligation The combination of market access and obscurity of ownership ... characterized by the high mobility of funds and the rapid development of new payment tools To secure the benefits of the international financial system, we, the Finance Ministers of the G-7 countries, must ... authorities to identify beneficial owners We welcome the OECD’s forthcoming review of this subject d Stolen Assets: International money laundering has often been used by government officials to assist...

Ngày tải lên: 17/02/2014, 21:20

... autograph collectors, the trip was eventless In Tetschen, at the border, I was relieved of the bother of customs officials through the kindness of an Austrian officer It was the lasting grief of ... leaving a tail of smoke behind him I had to stop him in his attempt to reach safety, so, in spite of his wrecked motor, I had to attack him again About 200 meters inside our positions I overtook him, ... Bölcke is to report at once to the Commander-in-Chief of the Aerial Division He is to be at the disposal of the Commander-in-Chief of the Army." My joy was great, for I expected to be sent to the...

Ngày tải lên: 18/02/2014, 09:20

... degree of channeling of fructose 1,6-bisphosphate (Fru1,6P2) to CO2 (99 ± 16% of the flux from Fru1,6P2 channeled, P ¼ 0.005) This result requires that all of the downstream steps from Fru1,6P2 to ... recall from the Results that the CO2 evolved from [14C]glucose was strictly proportional to the total uptake of glucose Thus, we can use CO2 evolved as a reliable proxy for the total uptake To facilitate ... 14CO2 from [14C]glucose as the result of coincubation of [14C]glucose and [12C]intermediate is proportional to ‘B’ as defined above Likewise the amount of [14C]Fru6P converted to 14CO2 from exogenous...

Ngày tải lên: 19/02/2014, 18:20

... of pitching, so he returned to his hometown of Trenton for a midnight raid Years later he told the story to an African American newspaper, the Cleveland Gazette: By luck I happened to think of ... fascinating, often forgotten world of black baseball’s first historian, Sol White Baseball history owes much to the efforts of Sol White and to Malloy himself In his essay “The Birth of the Cuban ... coverage of a trip the Cuban Giants made to Boston On October 15, 1887 their Boston correspondent wrote: Mr F P Thompson, formerly of Philadelphia, but now of the Hotel Vendome [in Boston], organized...

Ngày tải lên: 21/02/2014, 06:20