from one to many the singleton and flyweight patterns

... (CNS) From the very beginning, these findings pointed to a possible neuromodulatory role for UII The aim of this review is to provide an overview of the UII system and to describe the recently ... particularly with regard to arousal and sleep Molecular constituents of the UII system Presently, three molecules are known to form the UII system: the UII receptor and the peptides UII and urotensin-related ... brains when monitored with a nonselective UII ⁄ URP immunoassay [17] On the other hand, UII has also been found and sequenced from porcine hypothalamus and purified to advanced degree from human spinal...

Ngày tải lên: 19/02/2014, 07:20

... the ball forward But because the system is too complex to take into account all the factors involved— the speed of the ball, the speed of the wheel, the precise angle at which the ball hits the ... actually “know” and “see” that + = When his tormentor holds up two fingers on one hand and two on the other, for a moment at least Winston is both able to know and to see that they add up to five Orwell ... whole The observer and the observed are one The only way they could be separated is if we could cut a quantum into two parts one part remaining with the measuring apparatus and the other with the...

Ngày tải lên: 09/04/2014, 16:38

... couple together to give a total orbital angular momentum L, and the individual atomic spin angular momenta couple together to give a total spin angular momentum S Finally, L and S couple together, ... Atoms In a simple paramagnet, the atoms not interact with each other, and the ˆ only contributions to the Hamiltonian H come from their interaction with the applied magnetic field H As the atoms ... field H and the direction of the magnetization M of the bar magnet [11] The product pl is the magnetization M of the bar [13] The work done by the torque gives rise to a potential energy U in the...

Ngày tải lên: 04/06/2014, 15:18

... allocated to phone and email contact The final phase of the intervention will involve the PSW 'weaning' the young person from the support of the PSW by encouraging the young person to be proactive ... of the study and made substantial contributions to the study design and the development of the intervention and the study protocols All authors have been involved in drafting the manuscript and ... contacts and supports The young person will be reminded that at the cessation of the study they will no longer be able to rely on the PSW for support One of the aims of the study is to identify...

Ngày tải lên: 11/08/2014, 16:22

... ratio> than the sector to the cone; (5) therefore the circumscribed, too, has to the inscribed a smaller ratio than the sector to the cone [The commentary of Eutocius of Ascalon to the first ... that the on them, too (10) But as the on KE to the on , so the circumscribed to each other;74 (11) and therefore, as the on KM to the on N, so the ... (2) and it will be: as E to A, that is EK to A ,123 (3) the joined from the center to the touchingpoint, that is the radius of the smaller sphere (4) to the perpendicular from the...

Ngày tải lên: 01/11/2013, 10:20

... of the cone E is equal to the bases of the cones Z, H, (6) and they are under the same height, (7) therefore the cone E, that is the sphere (8) is equal to the cones Z, H.253 (9) But the ... to K, K to AM (30) And it is also: as to K, MA to to K, K to AM and AM to A A ;239 (31) therefore also: as To the second theorem Arch 192 Arch 193 And compoundly, as to , A to AE, that is the ... X to X , so KB, BX taken together to K, X to XB.278 to XB,277 (6) dividedly and alternately: as (7) And it was also: as X to XB, KB to BP; (8) therefore as to K, X to XB and KB to BP And therefore...

Ngày tải lên: 01/11/2013, 10:20

... modelling should be used to: • study the costing of aspects of AMR and control of the impact of AMR, in order to transfer the knowledge and capacities from one setting to another and better plan for ... concrete steps to be taken at the clinic and national levels, from the moment a patient presents to the clinic with a persistent gonococcal infection suspected to be due to resistance to cephalosporins ... more thorough determination of the magnitude of the problem is mandated The response of the public health system then includes liaising with the laboratory to identify the proportion of isolates...

Ngày tải lên: 18/02/2014, 15:20

... assessed the accuracy of the coders’ choices in choosing the antecedent utterance using the expert annotator’s annotation as a gold standard Given this, one coder’s accuracy was 92%, whereas the other ... when taking into account the distance of NSUs from their antecedent, the proportion of long distance NSUs in multilogue increases radically: the longer the distance, the higher the proportion ... Ack(nowledgements), and Rejection These are used either in grounding interac- 233 tion, or to affirm/reject propositions.2 The overwhelming adjacency to their antecedent underlines the locality of these interactions...

Ngày tải lên: 08/03/2014, 04:22

... access to the epithelial basal layer and enter the dividing basal cells Having entered the epithelial tissues, the HPV virus enters the nucleus of a basal epithelial cell, where early genes E1 and ... would have exited the cell cycle The late-phase L1 and L2 proteins encapsidate newly synthesized viral genomes and virions are shed from the uppermost layers of the epithelium [19] The induction ... have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work Any republication, referencing or personal use of the...

Ngày tải lên: 08/03/2014, 19:20

... error, the lemma model may prove to be the best predictor of the three The regression models By the end of the parameterisation stage, each text of the corpus has been reduced to a vector comprising ... Because of this, they recommend using the PO model (4) In Equation 4, x is the vector containing the independent variables, αj is the intercept parameter for the jth level and β is the vector of regression ... there is no guarantee the language employed there is the same as the rest of the textbook material (metalinguistic terms and so on can be found there) 4.1 The language model The lexical difficulty...

Ngày tải lên: 08/03/2014, 21:20

... agency in the health sector and the only UN agency with the technical and programmatic mandate to address all four components of the comprehensive approach to prevention of mother -to- child transmission ... transmission from a woman living with HIV to her infant; and • Providing appropriate treatment, care and support to mothers living with HIV and their children and families To prevent the transmission ... and progress towards MDGs 4, and At the country level, WHO will provide support to expand and strengthen health information systems to provide effective geographical and populationbased monitoring...

Ngày tải lên: 14/03/2014, 09:20

... Challenge to the Nation to eliminate the suffering and death due to cancer by 2015 I have been extraordinarily pleased with the response of the cancer community and the desire of many to partner ... dietary and physical activity patterns, and other lifestyle factors to further understand how they contribute to cancer prevention as well as to carcinogenesis > Integrate preclinical and clinical ... risk of lung cancer begins to decrease After ten years, the risk drops to one third to one half the level of people who continue to smoke Many of the chemicals in tobacco smoke are also carcinogenic...

Ngày tải lên: 15/03/2014, 00:20

... produced the regulatory structure and activities that led to it The key to understanding the political economy of the S&L crisis is to recognize that the relationship between voter-taxpayers and the ... the agent (a politician or regulator) does not have the same incentives to minimize costs to the economy as the principal (the taxpayer) To act in the taxpayers’ interest and lower costs to the ... Office of the Comptroller of the Currency has over the national banks The regulatory responsibilities of the FSLIC were given to the FDIC, and the FDIC became the sole administrator of the federal...

Ngày tải lên: 22/03/2014, 21:20

... ZIM-1, ZIM-2, and ZIM-3, providing a mechanism for homologous recognition to occur [31,32] These proteins then attach to the nuclear envelope, where they interact with the SUN and KASH domain ... with telomeres on the nucleoplasmic side, and with a dynein protein motor on the cytoplasmic side In this way, telomeres are moved by the driving force generated by the dynein motor on microtubules, ... MRX (Mre11–Rad50–Xrs2) complex, and the 5¢-ends of DNA breaks are resected to expose 3¢-single-strand tails; a RecA-type recombinase, Rad51, then binds to the ssDNA and plays a role in searching...

Ngày tải lên: 29/03/2014, 08:20

... through the people at the root of it, through their social and intellectual biographies, the influences they have had, their inotivations and the spirit in which they undertook their xviii From ... nahire, the historian-philosopher must go to meet those actually doing the science, dive into their culture, follow them in their paths and pilgrimages, understand the web of their community, their ... someone to write the “little tale” of the European and world effort to sequence the yeast genome As I browsed through the archives, I became inore and more convinced that the origins, the size, and...

Ngày tải lên: 08/04/2014, 12:48

... off the tops of the tomatoes; scoop out the centers; add the other ingredients except the shrimps Heat the butter boiling hot; fry the shrimps; then add to the tomatoes; fill the tomatoes with the ... in the onions and cabbage; then put in the meat and the tomatoes; add the seasonings and the water; cook very slowly until the meat is tender; then add the potatoes; when they are done, add the ... STARTING THE TOMATO PLANT CHAPTER In the northern part of West Virginia and in the higher altitudes the tomato seed should be sown from the first to the fifteenth of March, but in the southern part and...

Ngày tải lên: 20/04/2014, 13:47

... force your hand in many mix situations You’ll have to mix from vinyl to CD, to vinyl to CD, and so on, losing the option of mixing from one CD to another, or one vinyl tune to another vinyl tune ... players, and even PCs are the common DJ input devices ߜ A mixer This is used to change the music that comes from the speakers from one input device to the other ߜ Headphones These plug into the mixer ... helps to change the sound from one input to another is the cross-fader As you move the cross-fader from left to right (or reverse), the sound you hear through the speakers gradually changes from one...

Ngày tải lên: 01/06/2014, 01:19

... games, England led by two games to one (with one game drawn), needing only to draw the last match to win back The Ashes they last held almost 20 years ago At the end of the fourth day of the final ... and Jack and then from 10 down to Suppose we shuffle the cards and deal one Shuffling is taken to mean that we have lost track of where all the cards are in the pack, and consequently each one is ... each player tries to assess how likely his hand is to be at the others involved in the game If your hand is weak, you can fold and allow the accumulated bets to be given to your opponent Alternatively,...

Ngày tải lên: 11/06/2014, 01:04

... OSI, PAI; UNAIDS, and WHO In addition, experts were consulted on each topic, both to ensure complete coverage of the topic and to review the evidence included in the analysis Altogether, more than ... related to the evidence in the chapters they were reviewing Other experts were sought out to provide technical detail and understanding; those questions were tailored for their area of expertise and ... and to the outstanding queries of the authors To be included in this review, the SRH interventions had to have an evaluation (either the intervention was part of a study or it was subject to an...

Ngày tải lên: 20/06/2014, 08:20

... components The first of these is the amount equal to the difference between the strike price and the price of the underlying, and it is termed the intrinsic value The second component is the ... a stock purchase 1  The basics of calls For both stocks and futures, the limited loss feature of these calls also acts as a built-in stop-loss order Out-of -the- money, in -the- money and at -the- money ... as their distance from the current price of XYZ increased Many investors purchase these ‘out-of -the- money’ calls, as they are known, because of their lower cost, and because they believe that there...

Ngày tải lên: 20/06/2014, 20:20