from normal to cancer stem cells

... overexpression P63+ basal /stem cells were transformed into AR+ or ARcancer cells but rarely into ChgA+ neuroendocrine cancer cells Conventional human prostate cancer cells include malignant cells of luminal, ... intended to elucidate whether P63 + basal /stem cells can be directly transformed into AR- cancer cells We demonstrated that Hh overexpression initiated malignant transformation of P63+ basal /stem cells ... used the Hh overexpression mouse model to elucidate whether the PCSCs arise from P63+ basal /stem cells and to examine whether these cancer cells can maintain stem cell characteristics after metastasis...

Ngày tải lên: 10/08/2014, 05:21

... between normal stem cells and cancer stem cells can thus be targeted to deplete cancer stem cells without damaging normal stem cells Ovarian tumors The ovaries contain three main types of cells ... target cancer stem cells while sparing normal stem cells Experimental evidence suggests that ovarian cancer stem cells are relatively resistant to conventional chemotherapeutic agents Current cancer ... regeneration, cancer progression and targeting therapies [29,30] In this review we aim to provide insight into the Evidence for the existence of cancer stem cells To assay the cancer stem cells, a...

Ngày tải lên: 20/06/2014, 07:20

... immunohistochemistry, we added more patients so as to amount to 10 patients for each group Patients were divided into those cancer groups according to the WHO classification and by immunohistochemistry ... groups and pathological classification To explore protein markers to distinguish LCNEC from SCLC, we investigated cancer cells prepared by laser microdissection from FFPE sections of LCNEC, SCLC, ... 0.021, respectively) from LCNEC vs SCLC comparisons and thus specific to LCNEC Interestingly, AK1C1, AK1C3, AL1A1, and CD44 have been reported to be biomarkers of cancer stem cells (see Discussion)...

Ngày tải lên: 10/08/2014, 09:22

... normal stem cells strongly suggest that miRNA may be involved in the transformation of normal stem cells into cancer stem cells Therefore, screening for differences in miRNA expression between normal ... hsa-miR-935 SP cells are enriched for markers of HSCs To examine whether SP cells are enriched for characteristics of stem cells compared to the non-SP cells, we further characterized the SP cells from ... somatic stem cells Therefore, markers of normal stem cells are being sought with the expectation that these molecules are also expressed by cancer Page of 10 stem cells, and can be used to identify...

Ngày tải lên: 10/08/2014, 10:20

... likely to be an important gene regulatory factor in cancer cells, even cancer stem cells Another example is miR21, which has been reported to have extensive roles and is expressed in embryonic stem ... isolated tumorigenic breast cancer cells with stem/ progenitor cell properties from a breast cancer cell line, and Huang [17] screened side population (SP) cells from a breast cancer cell line Here, ... developed from × 105 and × 106 MCF-7 cells and from × 103 and × 104 BCSCs 24-well plates on top of irradiated NIH/3T3 feeder cells At day 3, the number of adherent cells increased, and three to five...

Ngày tải lên: 10/08/2014, 10:20

... and Cancer Stem Cells. ” The text is sharply focused as they ponder, “What causes the transformation from normal stem cells to cancer stem cells? ” The authors suggest that cancer stemloid (or stem ... Active in Leukemic Stem Cells to Overcome Drug Resistance 401 Miaorong She and Xilin Chen Chapter 21 Cancer Stem Cells and Chemoresistance Suebwong Chuthapisith Chapter 22 Cancer Stem Cells in Drug ... challenges of clinical practice Cancer Stem Cells Theories and Practice is firmly grounded in the latest results on cancer stem cells (CSCs) from world-class cancer research laboratories, but its twenty-two...

Ngày tải lên: 12/08/2014, 06:20

... transforming normal stem cells to cancer stem cells Adult normal stem cells represent one purported origin of cancer stem cells What causes the transformation from normal stem cells to cancer stem cells? ... insight into potential roles of GIN in the transformation of normal adult stem cells to cancer stem cells Mirura et al obtained cancer progenitor cells from bone marrow derived mesenchymal stem cells ... transformation of normal stem cells into cancer stem cells How does genomic instability contribute to the transformation of normal stem cells? It has been suggested that normal stem cells and their...

Ngày tải lên: 12/08/2014, 06:20

... the stem cell character of glioma stem cells may also contribute to resistance of tumor cells to therapy (FIG 4) First, normal stem cells can assume a quiescent state that is regulated by the stem ... culture is analyzed, the ratios of glioma stem cells to the total bulk cells can greatly vary Another feature that normal stem cells and glioma stem cells share is expression of drug efflux pumps ... progenitor cells, basal/mucous secretory bronchial progenitor cells, and neuroendocrine progenitor cells, which maintain normal homeostasis as well as play roles in repair [3-5] These progenitor cells...

Ngày tải lên: 12/08/2014, 06:20

... www.adultpdf.com Cancer Stem Cells in Lung Cancer: Distinct Differences between Small Cell and Non-Small Cell Lung Carcinomas 133 [90] Li, L., Neaves, W.B (2006) Normal stem cells and cancer stem cells: ... tumorigenic breast cancer cells to chemotherapy J Natl Cancer Inst, 100, 672-679 [16] Li, L., Borodyansky, L., Yang, Y (2009) Genomic instability en route to and from cancer stem cells Cell Cycle, ... chemiluminescence system (ECL, Amersham) This is trial version www.adultpdf.com 124 Cancer Stem Cells Theories and Practice This is trial version www.adultpdf.com Cancer Stem Cells in Lung Cancer: Distinct...

Ngày tải lên: 12/08/2014, 06:20

... linked to the activation of stem cell signaling pathways in cancer stem cells This dysregulation of cancer stem cells leads to disease initiation, development, progression, metastasis, resistance to ... MB cancer stem cells maintenance The origins of MB are intrinsically linked to the cerebellum development and MB tumor initiating cells can originate from progenitor cells and neuronal stem cells ... dysregulation of cancer stem cells 5.4 miR-29a Recent research has found that miR-29a plays a vital role in cancer stem cells It has been shown that miR-29a is highly expressed in hematopoietic stem cells...

Ngày tải lên: 12/08/2014, 06:20

... review this issue with depth Stem cells and cancer stem cell theory Stem Cells In order to understand cancer stem cells a brief description of normal adult stem cells and the environment in which ... cancer stem cells (CSC) or cancer stem- like cells or, better, tumour-initiating cells (TICs) The terminology, while not too important, may be misleading though, since the term cancer stem cells ... www.adultpdf.com 380 Cancer Stem Cells Theories and Practice Normal adult stem cells (SCs) are cells with the ability to continually repopulate the tissues that comprise the organ system in which they...

Ngày tải lên: 12/08/2014, 06:20

... insights into this process The inclusion of cancer stem cells into models of clonal evolution leads to the prediction that in cancers which contain stem cells, clonal evolution of stem cells may ... (the stem cells) we can see that for any size of tumour, because of the much smaller number of stem cells, clonal evolution is predicted to be faster in stem cells compared to non -stem cells What ... into the cell of origin in breast cancer and breast cancer stem cells Asia Pac J Clin Oncol 2010, 6:89-97 12 Shackleton M, Quintana E, Fearon ER, Morrison SJ: Heterogeneity in cancer: cancer stem...

Ngày tải lên: 13/08/2014, 16:20

... as were the progenitor cells from cancer and normal cultures Functional annotation of the cancer stem cell signature We used annotation data from the Gene Ontology (GO) [17] to identify key functional ... PTL (µM) Figure PTL induces apoptosis in primitive cancer cells PTL induces apoptosis in primitive cancer cells Percent viability of prostate cancer cells and cells from a patient with BPH treated ... significantly elevated expression in stem cells (Welch t test, p < 0.035) Comparison of the expression patterns from normal stem cells with those from malignant stem cells (Gleason score >7) identified...

Ngày tải lên: 14/08/2014, 08:21

... VEGF-R2-positive cells induced from undifferentiated mouse embryonic stem (ES) cells can differentiate into both VE-cadherin-positive endothelial cells (ECs) and αSMA-positive mural cells (MCs), ... derived from human ES cells could serve as a source for vasculogenesis in order to contribute to therapeutic neovascularization and to neuroprotection in the ischemic brain human embryonic stem cells ... the transplanted vascular cells derived from human ES cells (HES-3) Characterization of the transplanted vascular cells derived from human ES cells (HES-3) A, Flow cytometric analysis of VE-cadherin...

Ngày tải lên: 18/06/2014, 15:20

... mesenchymal stem cells: feasibility and safety from monkey to human Stem Cells Dev,2006,15(3):349-357 Devine SM, Bartholomew AM, Mahmud N, et al Mesenchymal stem cells are capable of homing to the ... Autologous hematopoietic stem cell transplantation in autoimmune diseases Expert Rev Hematol,2009 Dec;2(6):699-715 12 Rosato E, Pisarri S, Salsano F Current strategies for the treatment of autoimmune ... transplantation of stem cells, it is very important to observe the survival and curative effects of transplanted stem cells Traditional immunohistochemical method can easily identify the transplanted cells...

Ngày tải lên: 25/10/2012, 11:18

... these genes in progenitor cells or cells that have yet to express the genes at physiologically relevant levels [11] Chromatin structure modifications in uncommitted progenitor cells have also been ... differentiation of murine embryonic stem cells PCR analysis of DNase I treated and reverse-transcribed total RNA extracted from differentiating embryonic stem cells at the indicated time points ... and normalized the data to those obtained from the neuronal necdin gene (Fig 4) The data show that RNA Pol II is recruited to HS2 but not to the b-globin gene at day in undifferentiated ES cells...

Ngày tải lên: 07/03/2014, 12:20

... detect cancer very early, when some cells start going abnormal and transform into cancer cells The immune system might be the best weapon against cancer, since immune defense is programmed to recognize ... PR receptors are weak prognostic indicators and should not be used to determine whether to treat a patient with adjuvant therapy Newer guidelines from a Oncogene and Cancer – From Bench to Clinic ... guidelines) is to monitor response to therapy in the metastatic breast cancer setting Candidate Protein Biomarkers with possible clinical application in breast cancer i Topo2-alpha (Topo2) DNA topoisomerase...

Ngày tải lên: 16/03/2014, 21:20

... novo cancer) seemed to be more common in Asian than in other populations Although most cases of colorectal cancer are thought to arise from a sequence of adenoma to carcinoma, evidence from Asia, ... reports from Asia and Africa, as compared to the Western reports * Corresponding Author 12 Colorectal Cancer – From Prevention to Patient Care The definition of ‘Young adults’ varies, to a small ... Pernazza, Vito Pende and Igor Monsellato VII Preface When a patient are presented with symptoms that eventually lead to a diagnosis of colorectal cancer, it is the clinician who ultimately has to deliver...

Ngày tải lên: 17/03/2014, 02:20