from molecular nutrition to nutritional systems biology

... Prototypical examples of multisite phosphorylation in signal transduction and cell-cycle regulation (A) Receptor proteins Binding of a high-affinity ligand to the T-cell receptor (TCR) leads to ... strategy, ATP is added to the enzyme–substrate complex, together with an inhibitor that can trap the free enzyme [27] In a distributive mechanism, the inhibitor traps the free enzyme, stopping the reaction ... phosphoinositol-3-kinase ⁄ Akt pathway and the cAMP pathway Any phosphorylation is enough to trigger dissociation of BAD from the anti-apoptotic protein Bcl-XL, inhibiting the pro-apoptotic activity...

Ngày tải lên: 18/02/2014, 08:20

... THE SEROTONIN RECEPTORS THE RECEPTORS KIM A NEVE, SERIES EDITOR The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics, EDITED BY Bryan L Roth, 2006 The Adrenergic Receptors: ... extracellular amino-terminus, and From: The Receptors: The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics Edited by: B L Roth © Humana Press Inc., Totowa, NJ Kroeze and Roth an ... encoding the serotonin 1c receptor Science 1988;241:558–564 Kroeze WK, Kristiansen K, and Roth BL Molecular biology of serotonin receptors structure and function at the molecular level Curr Top Med Chem...

Ngày tải lên: 29/03/2014, 13:20

... Chemical Kinetics From Molecular Structure to Chemical Reactivity This page intentionally left blank Prelims.qxd 12/22/2006 10:42 AM Page iii Chemical Kinetics From Molecular Structure to Chemical ... the term molecularity for what we would call today reaction order (the power to which a concentration of a component enters into the rate equation) When referring to the actual concept of molecularity, ... determines the energy necessary to convert from one structure into another, that is, for a chemical reaction to occur In the passage from a reactant well, or valley, to that of products, there is...

Ngày tải lên: 01/04/2014, 10:29

... leukaemia From systems to networks biology Talks related to networks biology covered a large portion of the meeting Among many different types of biological networks discussed were gene regulatory ... Functional genomics and systems biology S Ivakhno Table Overview of the topics covered in the meeting report according to systems biology applications, types of high-throughput ... the regulatory network uses different regulatory hubs [22] Functional genomics and systems biology Networks derived from synthetic genetic interactions and RNAi screens Other approaches to the construction...

Ngày tải lên: 30/03/2014, 09:20

... mathematical abstractions applied to biology, and in particular systems biology Symmetry and symmetry breaking play a prominent role in developmental biology, from bilaterians to radially symmetric organisms ... introduction to group theory, then review applications to the genetic code, and the cell cycle The last section explores ideas expanding group theory into contemporary molecular systems biology Introduction ... (or not) to take place and for the cell to settle to some stable attractor In some cases more than one nucleus was added to a cell in another state For example two G1 nuclei were added to a cell...

Ngày tải lên: 13/08/2014, 16:20

... transferred to the mycobacteriology laboratory for culture, while the other undergoes fixation for histological evaluation Microscopic aspects: Organ involvement by TB leads to an inflammatory reaction ... of microbiological laboratory techniques is to isolate and identify causative organisms as well as to test antimicrobial susceptibility The contribution of microbiology to the diagnosis of TB depends ... technology that to date has yet to be improved: the so-called radiometric growth detection systems The main limitation of this new technology was the need to work with radioactive isotopes, a major...

Ngày tải lên: 14/06/2016, 18:50

... 7.6.0.324, R2008a) with the software packages systems biology toolbox2 and the sbpd Extension Package as described in [34] Both matlab and systems biology toolbox2 are necessary for the performance ... Glob Optim 39, 197–219 34 Schmidt H & Jirstrand M (2006) Systems Biology Toolbox for MATLAB: a computational platform for research in systems biology Bioinformatics 22, 514– 515 35 Tang X, Ruffner ... significantly from 0.13 ± 0.04 to 2.25 ± 0.6 lmolÆg)1 FW after days of cold exposure (P < 0.01), and was about twice as high as in C24, which showed an increase from 0.09 ± 0.02 to 0.96 ± 0.39...

Ngày tải lên: 14/02/2014, 22:20

... corresponding to the nt sequences of the cDNA from positions 28–48 and 867–885, respectively The amplified fragment was ligated into the pcDNA3.1 (+) vector (Invitrogen) to construct the expression vector ... 14657111 to K K and 12357003 to T Y.) and grants from the Japan Science Society 2001 to K M (JSS-12-153), Uehara Memorial Foundation 2002 to H T and Daiwa Securities Health Foundation to K K References ... evolutionary stage from reptiles to birds after deletion of Ser205 from the enzymes of amphibians as they evolved into reptiles Thermal stability of the enzyme might be evaluated as one of the factors that...

Ngày tải lên: 20/02/2014, 23:20

... prologue to the field for newcomers, as well as an update to those already active in the field Sydney Brenner from the MRC Molecular Biology Laboratory in Cambridge opened the field of C elegans biology ... impressive field is going MicroRNAs: From Basics to Disease Biology is mainly intended for readers in the fields of molecular cell biology, genomics, biotechnology and molecular medicine This book may ... incorporated into an Argonaute containing silencing complex (RISC) (Du and Zamore, 2005) From this * Author to whom correspondence should be addressed MicroRNAs: From Basic Science to Disease Biology, ...

Ngày tải lên: 06/03/2014, 09:21

... Neuropilin: From Nervous System to Vascular and Tumor Biology Neuropilin: From Nervous System to Vascular and Tumor Biology Edited by Dominique Bagnard, Ph.D Maître ... addition to nervous systems, NRP is also expressed in endothelial cells12,20 and function as a coreceptor for the vascular endothelial growth factor (VEGF) receptor, VEGFR2 (Flk-1/KDR), to mediate ... (B, D) into embryonic chick olfactory neurons Labeled axons are visualized by alkaline phosphatase histochemistry in wholemounted brains In each of (A, B), trajectories of olfactory axons from four...

Ngày tải lên: 14/03/2014, 21:20

... estimated to bind to proteins or to be taken up into stores (Kamishima and McCarron, 1996) Despite this, opening of Ca2+ channels causes [Ca2+]i to rise to micromolar levels This is suYcient to activate ... Growth factors Vascular growth factors are potent chemoattractants and mitogens Factors such as platelet-derived growth factor (PDGF) and basic Wbroblast growth factor (bFGF) are thought to play ... diastole and adds little to systolic pressure but tends to increase early diastolic pressure The former eVect keeps pulse pressure to a minimum and the latter may be important with regard to coronary...

Ngày tải lên: 22/03/2014, 20:21

... peptides, extending from P3 to P4¢ and from P3 to P3¢, respectively The analogs NC-p1 and p1-p6 extended from P5 to P5¢, while p6pol-PR extended from P5 to P6¢ because lysine was added to provide greater ... average B-factors ranged from 8.0 A2 at the higher res˚ at the lower resolutions for protein olutions to 22.4 A ˚ main chain atoms, and 10.6–29.9 A2 for protein side chain and inhibitor atoms Alternate ... in space group P21212 and were refined to R-factors of 0.12–0.18, including solvent molecules, and anisotropic B-factors The resolu˚ tion ranged from 1.10 to 1.60 A The complex ˚ PRV82A–p2-NC was...

Ngày tải lên: 30/03/2014, 20:20

... of internal molecular motion (e.g., torsion- FROM MOLECULAR STRUCTURE TOWARDS BIOLOGY 17 al motions of atomic groupings about specified axes), besides the overall rigid-body motion, from analysis ... function and centered at an atomic position The Fourier coefficients of FROM MOLECULAR STRUCTURE TOWARDS BIOLOGY 19 the various functions are then added to the free-atom form factors with variable population ... the transition from chemistry to biology to take place in small steps While ribozymes, relics from that ancient RNA world, attest to the emergence of the DNARNA-protein world from the RNA world,...

Ngày tải lên: 03/04/2014, 12:14

... al.: A systems biology approach to analyse leaf carbohydrate metabolism in Arabidopsis thaliana EURASIP Journal on Bioinformatics and Systems Biology 2011 2011:2 Abbreviations Frc: fructose; Glc: ... properties and functions Phytochemistry 68R(6):709–731 (2007) H Schmidt, M Jirstrand, Systems biology toolbox for MATLAB: a computational platform for research in systems biology Bioinformatics 22(4):514–515 ... [10] PCA identifies the principal axes of a set of vectors We applied a PCA to the set of vectors of logarithmic parameters that resulted from the convergent identification runs For this purpose,...

Ngày tải lên: 21/06/2014, 03:20

... input-output vectors The model was trained to reproduce these predefined inputoutput pairs, which can be interpreted as some kind of crucial regulatory reply (regulatory step) to cope with a special ... and Systems Biology regulatory architecture of the network model to reproduce four predefined input-output patterns Hence, for our conceptual model, regulatory interactions could be deduced from ... given for each genotype from a molecular network perspective together with two hypotheses and their predictions, for which we were able to find the first supporting evidence from the literature and...

Ngày tải lên: 22/06/2014, 00:20

... change from IEC 61131 to IEC 61499 for the system integrators as well as for the system distributer Because of that it was possible to copy the source code for the INIT and REQ algorithm from the ... this and to use the two events Start and Stop of the new function block instead This makes it possible to have the ECCinitialstate always activated and to associate one successor with the stopping ... block into one algorithm, but it is better to separate the source code according to rule 3.1 in different algorithms By doing this, the algorithms are shorter, easier to validate, and better to understand,...

Ngày tải lên: 22/06/2014, 19:20

... descriptors index Index of all molecular descriptors calculated (only six used in main text) Additional file 5: Table of molecular descriptors values The values for all the molecular descriptors ... connector matrices and thus be amenable to the CRIT framework The derivation of the connector matrix can be trivial such as mapping transcription factors to their binding sites or splice sites to ... applied CRIT to a well characterized system Estrogen receptor (ER) activation is one of the primary molecular features used to differentiate breast cancer subtypes through immunohistochemical staining...

Ngày tải lên: 09/08/2014, 22:24

... degree to which genetic effects on ADHD symptoms are stable from ages to using quantitative genetic techniques In addition to this analysis, we have studied previously reported ADHD risk alleles to ... according to the Hollingshead Four Factor Index (1975) ranged from low to upper middle class (range = 20.5-66; M = 50.9, SD = 14.1) Zygosity was determined via DNA analysis using DNA obtained from ... deficit hyperactivity disorder symptoms from age to 3: A quantitative and molecular genetic investigation BMC Psychiatry 2010 10:102 Submit your next manuscript to BioMed Central and take full advantage...

Ngày tải lên: 11/08/2014, 16:22

... first steps towards understanding macromolecular complexes Pocklington et al [12] have used a systematic approach to integrating the vast amounts Genome Biology 2006, 7:214 http://genomebiology.com/2006/7/4/214 ... complex proteins could also be linked to psychiatric and neurological disorders: 18% to schizophrenia, 12% to mental retardation, 6.5% to bipolar disorder and 7.5% to depressive illness These results ... experiments performed with a wide-range of protocols Thus, it is possible that NMDA receptor complex proteins are more likely to be linked to older topics with more literature For example, more...

Ngày tải lên: 14/08/2014, 16:21

... gene -to- gene regulatory network IEEE/ ACM Trans Comput Biol 2005, 2:254-261 Halobacterium research at the institute for systems biology [http://halo.systemsbiology.net] Cytoscape [http://cytoscape.org] ... regulators) To these 72 potential regulators were added 10 environmental factors for a total of 82 possible predictors for the 1,934 genes with significant signal in the data set In addition to ... terminology, the influencing factors, X, are referred to as regressors or predictors, whereas Genome Biology 2006, 7:R36 http://genomebiology.com/2006/7/5/R36 Genome Biology 2006, the functions Z...

Ngày tải lên: 14/08/2014, 16:21