from epidemiology to molecular mechanisms
Báo cáo y học: " From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development" potx
Ngày tải lên :
12/08/2014, 18:20
... seems to be a negative regulator of Hh signalling [27], and a member of SOCS (suppressor of cytokine signalling)-box WD proteins, SWip1, which is one of the earliest markers to respond to Shh ... Candidates for the answer to this question are morphogens and growth factors Morphogens are defined as molecules that diffuse away from their source and give positional information to surrounding cells ... Hh to Ptc, the inhibitory effect on Smo is released, leading to the dissociation of the microtubule complex Ci cleavage is prevented and Ci activates the transcription of target genes Respiratory...
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Tài liệu Báo cáo khoa học: Multisite protein phosphorylation – from molecular mechanisms to kinetic models pdf
Ngày tải lên :
18/02/2014, 08:20
... Prototypical examples of multisite phosphorylation in signal transduction and cell-cycle regulation (A) Receptor proteins Binding of a high-affinity ligand to the T-cell receptor (TCR) leads to ... strategy, ATP is added to the enzyme–substrate complex, together with an inhibitor that can trap the free enzyme [27] In a distributive mechanism, the inhibitor traps the free enzyme, stopping the reaction ... sequential mechanisms becomes more pronounced when the number of phosphorylation sites is large In addition to these intramolecular mechanisms, competition between several substrates for access to the...
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Báo cáo khoa học: Weak oligomerization of low-molecular-weight protein tyrosine phosphatase is conserved from mammals to bacteria pot
Ngày tải lên :
16/03/2014, 02:20
... Hydrogens were added to the dimer using a program from the WHAT IF server (http://swift.cmbi.ru.nl/servers/html/index.html) ˚ The atomic element radius was assigned to be 3.3 A and ˚ the atomic distance ... cysteines confer a peculiar redox regulation to low molecular weight protein tyrosine phosphatase in response to platelet-derived growth factor receptor stimulation J Biol Chem 276, 33478–33487 ... This work was partially supported by funds from the Spanish Ministry of Education (BIO2007-63458 to MP) J.B is a recipient of a predoctoral fellowship from the Spanish Ministerio de ´ Education...
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Báo cáo khoa học: Differing molecular mechanisms appear to underlie early toxicity of prefibrillar HypF-N aggregates to different cell types potx
Ngày tải lên :
16/03/2014, 13:20
... solutes from the matrix, mitochondrial swelling, release of proapoptotic factors such as cytochrome c and AIF, and activation of procaspase 2, and Cytochrome c, in complex with the cytosolic factor ... of cytochrome c from the mitochondria to the cytosol However, cytochrome c release was much higher and decreased rapidly in IMR90 cells, whereas in Hend cells it increased progressively up to 24 ... aggregates and ⁄ or to sustain apoptosis [14] In IMR90 cells exposed to HypF-N aggregates for h intracellular ATP was significantly decreased (to 65% with respect to control cells exposed to the same...
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chemical bonding and molecular geometry from lewis to electron densities mar 2001
Ngày tải lên :
11/06/2014, 10:09
... corresponding to the lone pairs on the sulfur atom and torodial charge concentrations on each chlorine atom (see also Figure 7.5) Top left: The Lewis Struclure Top right: The VESPR model Bottom left: Contour ... one hydrogen atom to form the molecule HCl, is also said to have a valence of 1, while an oxygen atom, which forms bonds with two hydrogen atoms to give the molecule H20, is said to have a valence ... negative charge, added to the appropriate atoms (Box 1.3) In 1932 Pauling introduced the term eIectronegativity to describe the power of an atom in a molecule to attract electrons to itself In general,...
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Báo cáo hóa học: " Research Article Neural Mechanisms of Motion Detection, Integration, and Segregation: From Biology to Artificial Image Processing Systems" docx
Ngày tải lên :
21/06/2014, 09:20
... Reentrant mechanisms for modulatory signal enhancement together with subsequent feature competition using center-surround mechanisms for activity normalization implement a framework to bias the ... input currents If we take into account excitatory and inhibitory synaptic inputs that are delivered by fast chemical synapses, then the respective synaptic currents need to be incorporated in the ... interaction from higher model areas to modulate the initial activation from the filtering stage This mechanism implements a linking strategy in which the feeding input is required to drive the...
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Molecular mechanisms underlying the pathogenesis of nasal polyposis and its response to steroid treatment
Ngày tải lên :
10/09/2015, 15:49
... 1994] 1.4.6 Molecular and chemical mediators The molecular and chemical mediators (e.g., peptides, proteins, amines, or lipids) released from the inflammatory/structural cells contribute to the complicated ... cells S aureus produces a large variety of enterotoxins, including S aureus enterotoxins (SEs) A to E, G to I, and TSST-1 (toxic shock syndrome toxin-1), which act as superantigen function and ... enterotoxin A Staphylococcus aureus enterotoxin B Staphylococcus aureus enterotoxin C Staphylococcus aureus enterotoxin D Staphylococcus aureus enterotoxin E Staphylococcus aureus enterotoxin...
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Dendritic cells respond differently to live and killed bacteria molecular mechanisms of pathogen recognition by dendritic cells and implications for vaccine development
Ngày tải lên :
14/09/2015, 08:24
... include: adaptor 19 molecule myeloid differentiation factor 88 (MyD88), IL-1 receptor-associated kinase (IRAK), TNF receptor-associated factor (TRAF) 6, mitogen-activated protein (MAP) kinases, Toll-interacting ... subsequent degradation Upon released from its inhibitor, NF-B moves from the cytoplasmic region to the nucleus where it binds to the promoters of genes of several cytokines, chemokines, and adhesion ... IRAKs (IL-1-receptorassociated kinases) and TRAF6 (tumour-necrosis-factor-receptor-associated factor 6), and leads to the activation of the IKK complex (inhibitor of nuclear factor-B (IB)- kinase...
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Cambridge.University.Press.Allegories.of.Union.in.Irish.and.English.Writing.1790-1870.Politics.History.and.the.Family.from.Edgeworth.to.Arnold.Oct.2000.pdf
Ngày tải lên :
21/09/2012, 10:39
... means as monotonously monolithic and insensitive to historical change as Eagleton’s work in particular may make it seem By paying close attention to rhetorical matters, and especially to the concrete ... the modernizing imperial family of man I attend to narrative structure, and to the kind of stories that get told and retold about the Irish, so as to reveal both the regularity of English colonial ... that to equate the Euroconquest of Africa with heterosexual rape is to engage rhetorically in a version of the act they liberally claim to condemn Similarly, Heaney’s poem aims to demystify, to...
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Cambridge.University.Press.Debating.Design.From.Darwin.to.DNA.Nov.2007.pdf
Ngày tải lên :
21/09/2012, 10:46
... 21:7 Michael Ruse linked to the popular ideology of the day – progress, from blob to vertebrate, from ape to human, from primitive to civilized, from savage to Englishman From what Spencer termed ... and mathematics from Bristol University, an M.A in philosophy from McMaster University, and his Ph.D from Bristol University He was full professor of philosophy at Guelph from 1974 to 2000 Dr Ruse ... professors and 1,500 students from 1989 to 1993 He also served as the director of the Texas A&M University Polymer Technology Center from 1986 to 1990 and from 1994 to 2000 He has received more...
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John.Wiley.And.Sons.Marketing.Insights.From.A.To.Z.eBook-LiB.pdf
Ngày tải lên :
21/09/2012, 17:33
... your company also has to raise money from investors As a result you need to know how to market to investors You also want to attract talent to your company So you need to develop a value proposition ... is to watch your competitors, it is more important to obsess on your customers Customers, not competitors, determine who wins the war Most markets are plagued by too many fishermen going after too ... Wharton School of Business “Here is anything and everything you need to know about where marketing stands today and where it’s going tomorrow You can plunge into this tour de force at any point from...
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Apress.Beginning.Ajax.with.PHP.From.Novice.to.Professional
Ngày tải lên :
15/11/2012, 14:19
... Ajax can be used together to design some basic tools that are quite new to Internet applications but have been accessible to desktop applications for ages The ability to make a call to the server ... start to get into the meat and potatoes of the XMLHttpRequest object This is the method you use to open a connection to a particular file on the server It is where you pass in the method to open ... a request to the server, you need to confirm a few basic functionalitybased questions First off, you need to decide what page (or script) you want to connect to, and then what area to load the...
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Beginning.Ajax.with.PHP.From.Novice.to.Professional_Lee.Babin_Apress_2007
Ngày tải lên :
15/11/2012, 14:21
... Ajax can be used together to design some basic tools that are quite new to Internet applications but have been accessible to desktop applications for ages The ability to make a call to the server ... start to get into the meat and potatoes of the XMLHttpRequest object This is the method you use to open a connection to a particular file on the server It is where you pass in the method to open ... a request to the server, you need to confirm a few basic functionalitybased questions First off, you need to decide what page (or script) you want to connect to, and then what area to load the...
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English Proverbs from A to Z
Ngày tải lên :
18/06/2013, 01:26
... advise others to Prevention is better than cure It is easier to prevent something from happening than to repair the damage or cure the disease later Pride comes before a fall Don't be too self-confident ... valuable and should not be wasted To err is human, to forgive divine It is human nature to make mistakes, therefore one should forgive Too many cooks spoil the broth If too many people are involved ... another You should be helpful to someone who helps you One of these days is none of these days 'One of these days' remains vague One today is worth two tomorrow What you have today is better than what...
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Lesson plan 11 (basic) (from 1 to 16)
Ngày tải lên :
08/07/2013, 01:25
... simple present to tell apart story to make the story loving and near the true more, however it is always used to express in telling story, telling a film, a play or an event of history Work in ... work Calls some to give answers and give reasons about trying to convince them Eg: Would you like to come to the party? Give some expression to convince friends to come We would love to hve you in ... answering the qs + to bring a plate (to bring food to share with others) Asks the sts to work in pairs , + convince sb to sth: Have sts based on the questions in task and examples to the same + budget...
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EVALUATION OF THE REAL SITUATION OF IMPORT ACTIVITIES OF VIETNAM ENERGY DEVELOPMENT SUPPORT JOINT STOCK COMPANY FROM 2009 TO 2011. PROBLEMS AND SOLUTIONS.
Ngày tải lên :
24/07/2013, 09:11
... 2.2.1.3 Competitors For a business, competitors include current competitors and potential competitors Enterprises must study the current competitors and potential competitors to find out their ... mandatory documents within five days of the arrival of the goods to have the goods released from customs' custody Second, importers must file documents for duty assessment If importers want to store ... they operate in 2.2.2 Internal factors In contrast to external factors, internal factors are factors that businesses themselves can control and adjust In order to raise efficiency of import activities,...
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Techical analysis from a to z
Ngày tải lên :
13/08/2013, 15:59
... 24 Introduction, Indicators - Technical Analysis from A to Z 01/09/1999 INTRODUCTION - Indicators Indicators An indicator is a mathematical calculation that can be applied to a security's price ... http://www.ics.forth.gr/~asidirop/AsidiropSoft/TechnicalAnalysis2/free/taaz/intindicators.html Page 28 Introduction, Market Indicators - Technical Analysis from A to Z 01/09/1999 INTRODUCTION - Market Indicators Market Indicators All of the technical analysis tools discussed ... http://www.ics.forth.gr/~asidirop/AsidiropSoft/TechnicalAnalysis2/free/taaz/terminology.html Page Technical Analysis from A to Z 01/09/1999 TO LEARN MORE Investors share a common desire they want to learn more If you'd like to receive a list of additional learning material...
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Beginning GIMP from novice to professional 2nd edtion
Ngày tải lên :
14/08/2013, 11:42
... active tool; if the active tool corresponds to one of the tool buttons, that button will appear “pressed,” as with the Paintbrush tool in Figure 1-1 You can resize the Toolbox to taste, and the tool ... besides clicking a Toolbox button There’s the Tools dialog, accessed from the Toolbox as File ➤ Dialogs ➤ Tools or from any image window as Dialogs ➤ Tools It lists every tool GIMP has (not all ... the Toolbox) You can control which tools show up as buttons in the Toolbox by clicking the “eye” icon next to each tool in the Tools dialog, and you can change their order by dragging tools to...
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