from bench research to clinical challenges

... functions as high affinity receptor 10 Pulmonary Hypertension – From Bench Research to Clinical Challenges and a cofactor for plasma factors VII/VIIa, the initiator of blood coagulation TF is ... as inositol triphosphate receptor (IP3R), heterodimeric GTP binding protein, Ca2+ Pulmonary Hypertension – From Bench Research to Clinical Challenges ATPase and several transient receptor potential ... Hypertension – From Bench Research to Clinical Challenges Angiolillo DJ, Ueno M, Goto S Basic principles of platelet biology and clinical implications Circ J 2010; 74:597-607 Atkinson C, Stewart S, Upton...

Ngày tải lên: 27/06/2014, 17:20

... potentially self-perpetuating owing to the involvement of a host of redundant factors Such factors include various growth factors, proteases and inflammatory mediators that have been incriminated ... [50] This raises the issue of the relevance of animal models to clinical Dahal et al Respiratory Research 2011, 12:60 http://respiratory -research. com/content/12/1/60 situation in humans The chronic ... anti-human von Willebrand factor antibody (vWF, dilution 1:900, Dako, Germany) followed by analysis of Dahal et al Respiratory Research 2011, 12:60 http://respiratory -research. com/content/12/1/60...

Ngày tải lên: 12/08/2014, 13:22

... introduced into the ventilator circuit via an adaptor positioned on the inspiratory port of the Fisher and Paykel humidification chamber Thus, NO was mixed with the bias flow gas of the oscillator and ... delivered to the neonate via the inspiratory limb of the ventilator circuit The resulting concentration of the inhaled NO and NO2 was verified in-line by using an electrochemical sensor (Pulmonox, Tofield, ... weaned to discontinuation Ventilatory parameters thereafter were weaned and HFOV was replaced by a conventional ventilator An arterial/alveolar oxygen (a/A) ratio less than 0.22 was used to define...

Ngày tải lên: 12/08/2014, 18:20

... 2) 1.56 (1 to 2) 1.13 (0.5 to 1.5)* Inflammation 2.56 (2 to 3) 2.63 (2.5 to 3) 2.44 (1.5 to 3) Necrosis 2.31 (2 to 3) 2.44 (1.5 to 3) 2.31 (1.5 to 3) Histological score (no injury) to (severe ... Oedema 2.08 (2 to 2.5) 2.08 (2 to 2.5) 0.08 (0 to 0.5) Inflammation 2.42 (2 to 3) 2.17 (1.5 to 2.5) Necrosis 2.42 (2 to 3) 2.00 (1.5 to 2.5) Histological score (no injury) to (severe injury) [26] Page ... studies In contrast to most medical treatments, where results from animal experiments are validated by clinical studies, in this case it was necessary to revert to animal experiments to create standardised...

Ngày tải lên: 13/08/2014, 11:23

... mechanism is referred to as 'homeometric autoregulation' and is postulated to result from stimulation of stretchactivated calcium channels [39], release of positive inotropic substances from the endocardial ... opted to use the difference between systolic arterial pressure and RV systolic pressure, taking into consideration the fact that an important part of right coronary artery flow occurs during systole ... received honoraria for lectures from the manufacturer of iloprost From 2003 to 2004, the Department of Anaesthesiology of the University of Aachen held a research grant from Schering AG, the former...

Ngày tải lên: 13/08/2014, 11:22

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Ngày tải lên: 19/02/2014, 00:20

Ngày tải lên: 09/03/2014, 12:20

... LB -0.297 (-0.345 to -0.249) -0.308 (-0.357 to -0.258) -0.202 (-0.250 to -0.154) -0.223 (-0.273 to -0.173) -0.147 (-0.188 to -0.108) -0.147 (-0.187 to -0.107) 0.962 (0.905 to 1.020) 34 0.936 ...

Ngày tải lên: 18/06/2014, 19:20

... medications that may combine vasodilator and antiproliferative activity include angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and PDE type V inhibitors [5] The use of angiotensin-converting ... inhibitors in SScl to prevent scleroderma renal crisis is well established [11] Studies in animal models have suggested that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers ... approaches depart from the previously dominant strategy for both PAH and RP, which was to achieve symptomatic relief through vasodilatation [6] Calcium channel blockers are now recognised to have a limited...

Ngày tải lên: 09/08/2014, 06:23

... kit (Vector Laboratories, Burlingame, USA) Preliminary experiments indicated that microwaving for 15 in 0.01 M citric acid Wang et al Respiratory Research 2010, 11:36 http://respiratory -research. com/content/11/1/36 ... significant difference from the control group # P < 0.05, significant difference from the smoke-exposed group Wang et al Respiratory Research 2010, 11:36 http://respiratory -research. com/content/11/1/36 ... hypertension; RVSP: right ventricular systolic pressures; TGF-b1: transforming growth factor-b1 Wang et al Respiratory Research 2010, 11:36 http://respiratory -research. com/content/11/1/36 Acknowledgements...

Ngày tải lên: 12/08/2014, 11:21

... [47,52] To date, there are few studies about the role of p27kip1 on hypoxic pulmonary hypertension More work need to be done to Xu et al Respiratory Research 2010, 11:182 http://respiratory -research. com/content/11/1/182 ... difference from the hypoxia group #P < 0.05, significant difference from the normoxia group Values are expressed as mean ± SD (n = 3) Xu et al Respiratory Research 2010, 11:182 http://respiratory -research. com/content/11/1/182 ... Respiratory Research 2010, 11:182 http://respiratory -research. com/content/11/1/182 Laboratory Animals (Publication No 85-23, revised 1985) Male Sprague-Dawley rats (body weight 180-230 g) from...

Ngày tải lên: 12/08/2014, 13:22

... nonviral method to transfer genes into human hematopoietic stem and progenitor cells Stem Cells Dev 2006, 15(2):278-85 Yu and Hales Respiratory Research 2011, 12:21 http://respiratory -research. com/content/12/1/21 ... Respiratory Research 2011, 12:21 http://respiratory -research. com/content/12/1/21 progenitor cells [10] Karshovska and co-workers found that neointima formation and smooth muscle progenitor cell ... hematopoietic progenitor cells These data on c-kit expression together with the result from GFP expression demonstrated that CXCR4 knock down by shRNA decreased bone marrow-derived progenitor...

Ngày tải lên: 12/08/2014, 13:22

... biomarker to assess DNA oxidative damage and oxidative stress [22] Wang et al Respiratory Research 2011, 12:26 http://respiratory -research. com/content/12/1/26 Page of Figure Representative photomicrographs ... RV -dP/dt (D) *P < 0.05, **P < 0.01 Wang et al Respiratory Research 2011, 12:26 http://respiratory -research. com/content/12/1/26 inflammatory cells infiltrated the lung tissue However, all of ... according to the manufacturer’s instructions Levels of 8-OHdG in serum and lung tissue were measured with ELISA kits Protein concentration Wang et al Respiratory Research 2011, 12:26 http://respiratory -research. com/content/12/1/26...

Ngày tải lên: 12/08/2014, 13:22

... body tissues to an inflammatory insult are triggered and modulated by cytokines Most relevant to the topic at Di Paola et al Respiratory Research 2011, 12:41 http://respiratory -research. com/content/12/1/41 ... in lung tissues obtained from sham-operated mice (A and E, respectively) Densitometry analysis of immunocytochemistry photographs (n = photos from each sample collected from all mice in each experimental ... observed in lung tissues obtained from sham-operated mice (A) Densitometry analysis of immunohistochemistry photographs (n = photos from each sample collected from all mice in each experimental...

Ngày tải lên: 12/08/2014, 13:22

... Respiratory Research 2011, 12:87 http://respiratory -research. com/content/12/1/87 receptor types located on PASMCs cause a potent vasoconstriction and proliferation of PASMCs [9] The ET-B receptors ... [3,25,26] A series of clinical studies were performed with sitaxentan, named the Sitaxentan to Relieve Kosanovic et al Respiratory Research 2011, 12:87 http://respiratory -research. com/content/12/1/87 ... Respiratory Research 2011, 12:87 http://respiratory -research. com/content/12/1/87 a) c) Page of 13 b) d) Figure Effect of TBC3711 on pulmonary artery acceleration time (ACT), cardiac output (CO), total...

Ngày tải lên: 12/08/2014, 13:22

... Apoptosis Regulation of Autophagy: Co-Regulators of Autophagy and Apoptosis Regulation of Autophagy: Chaperone-Mediated Autophagy Regulation of Autophagy: Co-Regulators of Autophagy and Apoptosis ... Co-Regulators of Autophagy and Apoptosis B-cell CLL/lymphoma BCL2 NM_000633 0.000727 Regulation of Autophagy: Co-Regulators of Autophagy and Apoptosis Regulation of Autophagy: Co-Regulators of Autophagy ... of Autophagy: Co-Regulators of Autophagy and Apoptosis Co-Regulators of Autophagy and the Cell Cycle Interferon, gamma IFNG NM_000619 0.017749 Regulation of Autophagy: Co-Regulators of Autophagy...

Ngày tải lên: 12/08/2014, 14:20

... from IL-6-/- and IL-6+/+ mice exposed to hypoxia for weeks (d) *P < 0.05 compared to IL-6+/+ mice exposed to hypoxia for weeks Page of 13 (page number not for citation purposes) Respiratory Research ... antiinflammatory effects of IL-6 IL-6 suppressed the generation of the proinflammatory cytokines IL-1 and TNF in macrophages exposed to lipopolysaccharide and attenuated the inflammatory response to intratracheally ... immunostaining is visible in vessel walls from the animal exposed to hypoxia (arrows) IL-6R and gp-130 RNA expression in total lung tissue from IL-6+/+ mice exposed to hypoxia (d) Each point is the mean...

Ngày tải lên: 12/08/2014, 14:20

... citation purposes) http://respiratory -research. com/content/10/1/110 Table 1: Patient details (Continued) Respiratory Research 2009, 10:110 http://respiratory -research. com/content/10/1/110 Table ... immunohistochemical http://respiratory -research. com/content/10/1/110 findings We have consequently minimized the effect of confounding factors on the immunohistochemical data by applying strict protocols ... citation purposes) Respiratory Research 2009, 10:110 http://respiratory -research. com/content/10/1/110 Figure B) eNOS, (C and D) iNOS, (E and hypertension (A, C, E) and from control patients of...

Ngày tải lên: 12/08/2014, 14:20

... immunized vs tolerated; ANOVA with Bonferroni test was employed to statistical analysis The results are reported as cells/mm2 Velosa et al Respiratory Research 2010, 11:1 http://respiratory -research. com/content/11/1/1 ... CAPPesq of the Clinical Board of the School of Medicine, University of Sóo Paulo, as stated in Protocol of Research number 268/05 Collagenous Fibers Histomorphometric Analysis To characterize ... for each slide after Velosa et al Respiratory Research 2010, 11:1 http://respiratory -research. com/content/11/1/1 Page of 10 enhancing the contrast up to a point at which the fibers were easily...

Ngày tải lên: 12/08/2014, 14:20