fragment growth and the discovery of auy922

fragment based drug discovery and x-ray crystallography

fragment based drug discovery and x-ray crystallography

... chip and ligands are allowed to flow past Ligands that bind to the protein cause changes in the reflectivity properties of the metal that are related to the mass of the ligand and the mass of the ... energy of ligand binding” is normally expressed in kilocalories per mole and the number of heavy atoms refers to the number of non-hydrogen atoms in the ligand Of course, the free energy of ligand ... which they analyzed the binding data of about 150 natural and synthetic ligands to a number of proteins [80] By plotting the binding energy against the number of heavy atoms in the ligand, they...

Ngày tải lên: 29/05/2014, 23:54

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Credit Growth and the Effectiveness of Reserve Requirements and Other Macroprudential Instruments in Latin America pdf

Credit Growth and the Effectiveness of Reserve Requirements and Other Macroprudential Instruments in Latin America pdf

... the motives and use of RRs across the world 4 partly reflects the sectoral and targeted nature of many of these other macroprudential instruments and also their less active use over the cycle ... Colombia, and Peru 24 The cumulative dummy captures changes in the rates of the RRs and therefore, facilitates the comparison of changes to the RR regime across countries However, the variable ... against the wind”: (i) raising RRs during the upswing phase of the cycle to contain excessive credit growth and the associated build up of vulnerabilities and (ii) lowering them during the downswing...

Ngày tải lên: 06/03/2014, 04:21

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Assessing and Managing Rapid Credit Growth and the Role of Supervisory and Prudential Policies docx

Assessing and Managing Rapid Credit Growth and the Role of Supervisory and Prudential Policies docx

... to the borrower, the purpose and use of the loans, their sectoral composition and concentration, the currency denomination, and the maturity and other conditions of the loans In terms of the ... guided by the nature of the risks associated with the nature of the credit growth (see Table for a mapping from various features of the credit growth to different types of risks, and Table for the ... affected by a number of factors, including the openness of the capital account, the degree of euroization of the economies, the adequacy of monetary instruments and the effectiveness of monetary policy...

Ngày tải lên: 06/03/2014, 08:20

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Tài liệu Finance and the Sources of Growth pptx

Tài liệu Finance and the Sources of Growth pptx

... cannot reject the null hypotheses of the appropriateness of the instruments and the assumption of no serial correlation of the differenced error terms The results seem to indicate that there is a ... is the nominal interest rate and p the inflation rate The inflation rate is the average of the current and year-ahead inflation Terms of Trade Old and young dependency ratios are the shares of ... relationship between economic growth and the assortment of economic indicators, we use natural logarithms of the regressors in the regressions of GROWTH, CAPGROWTH, PROD1, PROD2 and PROD3 17 development...

Ngày tải lên: 27/01/2014, 11:20

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Tài liệu Ghost Wave - The Discovery of Cortes Bank and the Biggest Wave on Earth pptx

Tài liệu Ghost Wave - The Discovery of Cortes Bank and the Biggest Wave on Earth pptx

... Island They would then cross another thirty-two miles of ocean to the southern flank of San Clemente Island, a naval base and artillery range populated by unexploded ordnance and a dwindling herd of ... had seen from the air and set a course that soon put them within earshot of what seemed the loneliest bell on the face of the planet The tiny man-made island was laden with guano and inhabited ... breakfast into the deep blue sea The buoys stayed anchored, offering the surfers a point of reference and a measure of relief When the next set of four or five waves broke, they showed that the surf...

Ngày tải lên: 17/02/2014, 05:20

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Tài liệu The Economic Promise of Investing in High-Quality Preschool: Using Early Education to Improve Economic Growth and the Fiscal Sustainability of States and the Nation pptx

Tài liệu The Economic Promise of Investing in High-Quality Preschool: Using Early Education to Improve Economic Growth and the Fiscal Sustainability of States and the Nation pptx

... context, they exceed the percent rate of return suggested for government programs by the Office of Management and Budget; they also exceed the historic real rate of return in the stock market of approximately ... implementation site, and also among families within a single program site.190 The intensity of the services provided, the skills of the home visitors, and the content of the home visiting curriculum ... to meet the needs of working parents Furthermore, states should welcome a diverse set of providers that meet quality standards and the needs of the parents and communities they serve Business...

Ngày tải lên: 20/02/2014, 20:20

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aggarwal and conroy-price discovery in initial public offerings and the role of the lead underwriter

aggarwal and conroy-price discovery in initial public offerings and the role of the lead underwriter

... quoting and trading the stock We use unique quote data with the identity of the market maker to examine the quoting behavior of the lead underwriter during the preopening period; the behavior of other ... Price t The indicative price at time t is taken as the average of the bid quotes and the average of the ask quotes during the 30-second interval If the preopening is efficient, then the slope ... early and others later Besides the preference of the lead underwriter, characteristics of the individual offering also determine the opening time Therefore, we examine whether initial returns ~offer-to-open!...

Ngày tải lên: 23/04/2014, 16:09

20 361 0
Three essays on the credit growth and banking structure of Central and Eastern European countries

Three essays on the credit growth and banking structure of Central and Eastern European countries

... in the credit growth of the CEE countries This chapter of the thesis has the following structure The following section provides the characteristics of the transition in the CEE countries, and the ... strand of theory, the credit line at the CEE subsidiaries may decline if the financial situation of the parent bank and/ or the macroeconomic conditions in the home country worsens On the other ... comprised of 18 parent banks and their 41 CEE subsidiaries The results indicate that the size of the parent bank matters for the growth of credit: CEE banks can increase their credit line further as the...

Ngày tải lên: 03/06/2014, 02:21

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Flow and the Psychology of Discovery and Invention

Flow and the Psychology of Discovery and Invention

... none of these considerations bears in the least on the theory of relativity, they were all very much part of how the media portrayed Einstein and it is these traits rather than the profundity of ... del Duomo, the board that supervised the building of the cathedral, but their plans were found unpersuasive The Opera was made up of the political and business leaders of the city, and their personal ... helpless, at the mercy of cold, hunger, wild beasts, and one another They had no idea how to explain the great forces they saw around them the rising and setting of the sun, the wheeling stars, the alternating...

Ngày tải lên: 04/07/2014, 15:17

405 237 0
Dissertation for doctor of philosophy in agriculture study on the growth and development ability of some imported soybean varieties and cultivation techniques for prospect variety in thai nguyen

Dissertation for doctor of philosophy in agriculture study on the growth and development ability of some imported soybean varieties and cultivation techniques for prospect variety in thai nguyen

... development of planting area, yield, output and marketing 3.2 Results of assessing growth and development of the imported varieties of soybean in Thai Nguyen 3.2.1 Results of assessing growth and development ... height, LAI and the level of Bean pyramid and Lima bean podborer The yield components and yield gradually increased from the treatment (20 kg N/ha) and reached the peak in treatment and then gradually ... appendices 27 and 31) In winter, both the EY and the AY increased basing on the raise of density from Treatment to treatment (45 plants/m2), but then reduced even though the raise of density The EY...

Ngày tải lên: 14/07/2014, 13:23

26 376 0
Báo cáo sinh học: "Of mice and men: phylogenetic footprinting aids the discovery of regulatory elements." doc

Báo cáo sinh học: "Of mice and men: phylogenetic footprinting aids the discovery of regulatory elements." doc

... the scientific community Users of ConSite can either provide an existing alignment of two orthologous sequences or input just the sequences alone and the program will generate the alignment The ... alignment of orthologous sequences; then, automated computer programs were developed to assist the process In this issue of Journal of Biology, Lenhard, Sandelin and colleagues describe their most ... positions in the two aligned sequences, are selected and reported in the output The remainder of the sites, which are not conserved between the two species, are considered to be false positives and are...

Ngày tải lên: 06/08/2014, 18:20

4 341 0
Báo cáo lâm nghiệp: "Evaluation of the growth and health status of selected clone mixtures in comparison with ordinary planting stock" docx

Báo cáo lâm nghiệp: "Evaluation of the growth and health status of selected clone mixtures in comparison with ordinary planting stock" docx

... further growing was performed on the basis of the complex evaluation of parent trees (the health status was the main criterion, and both the individuals with intensive growth dynamics and the ... RESULTS Comparison of the growth of parent trees and clones of the 1st and 2nd generation Research plots were evaluated in the intervals of several years So data acquired in plantations of different ... locations The results of field surveys showed the same relations in height and diameter growth among the studied clones in generative mother plantations and clone plantations of the 1st and 2nd...

Ngày tải lên: 07/08/2014, 03:22

9 299 0
Báo cáo lâm nghiệp: " Effects of ectomycorrhizal inoculation and the type of substrate on mycorrhization, growth and nutrition of containerised Pinus pinea L. seedlings produced in a commercial nursery" docx

Báo cáo lâm nghiệp: " Effects of ectomycorrhizal inoculation and the type of substrate on mycorrhization, growth and nutrition of containerised Pinus pinea L. seedlings produced in a commercial nursery" docx

... enhancing the photosynthetic capacity [11] and by increasing the uptake of water and nutrients, and their accumulation in the seedling tissues [3, 8] Environmental conditions marked by the Mediterranean ... prevented the formation of mycorrhizas The relatively high pH value (7.7) of the substrate could have reduced the efficacy of all fungi tested Since most of them are acidophilous, both the germination ... required by the fungus [11, 35] The lack of stimulation of seedlings growth by the fungi could also be influenced by nursery practices like the fertilisation levels, the type of substrate, or the container...

Ngày tải lên: 08/08/2014, 00:22

6 510 0
Báo cáo lâm nghiệp: "Effects of light intensity on the growth and energy balance of photosystem II electron transport in Quercus alba " potx

Báo cáo lâm nghiệp: "Effects of light intensity on the growth and energy balance of photosystem II electron transport in Quercus alba " potx

... before the start of the experiment and, unlike seedlings growing under FL and LS, only a small portion of the leaves actually initiated their growth after the start of the experiment The significant ... MS (p ≤ 0.011) at the 60th day into the experiment and FL > HS/ MS (p < 0.005) and LS > HS (p < 0.067) at the end of the experiment At the end of the experiment, total biomass and each biomass ... their first growth flush and about 80% initiated their second growth flush during the three-week transplant acclimation time before the start of the experiment The optimized soil moisture and nutrient...

Ngày tải lên: 08/08/2014, 00:22

8 531 0
Báo cáo lâm nghiệp:"Growth and biomass partitioning of Fagus sylvatica L. and Quercus robur L. seedlings in response to shading and small changes in the R/FR-ratio of radiation" pot

Báo cáo lâm nghiệp:"Growth and biomass partitioning of Fagus sylvatica L. and Quercus robur L. seedlings in response to shading and small changes in the R/FR-ratio of radiation" pot

... respectively)) and the dry mass of the main stem (DMshoot) at the end of the experiment, the dry mass of the main stem at the start of the experiment and after 50 days was estimated using the following ... particular the ratio of the red components of radiation to those of the far red (R/FR-ratio) is altered below the crowns of the canopy trees due to the selective absorption of light by their leaves ... (product of branch length and the square of the diameter at branch base (in cm respectively)) and the dry mass of the branch (DMbranch) that was calculated using the branches of a quarter of total...

Ngày tải lên: 08/08/2014, 01:21

9 341 0
Báo cáo khoa học: "Effects of irrigation and nitrogen fertiliser on the growth and nutrient relations of Prunus avium L and ’Colt’ (Prunus avium x Prunus pseudocerasus) in the nursery and after transplantation" doc

Báo cáo khoa học: "Effects of irrigation and nitrogen fertiliser on the growth and nutrient relations of Prunus avium L and ’Colt’ (Prunus avium x Prunus pseudocerasus) in the nursery and after transplantation" doc

... 1976) and a further 40-50 kg N The soil at -1 -1 year be deposited from the may atmosphere in southern and eastern England (Goulding, 1990) The total uptake of N into the shoots and leaves of the ... ence Early in the season the concentrations of N and Ca in the stems and shoots of ’Colt’ were greater than in P avium From May until the end of July the concentration of K, Mg and Mn were significantly ... that each of the degrees of freedom of the variety x nitrogen interaction and of the irrigation x nitrogen and variety x irrigation x nitrogen interactions was confounded in or of the replicates...

Ngày tải lên: 08/08/2014, 19:21

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Báo cáo lâm nghiệp: "Response of shoot growth and gas exchange of Picea abies clones to rain acidity and the addition of ions" ppt

Báo cáo lâm nghiệp: "Response of shoot growth and gas exchange of Picea abies clones to rain acidity and the addition of ions" ppt

... differences between the pH treatments = = acidity and the addition of the ionic mix- ture The effect of acidic rain on the Gn of clone 1019 seemed to depend upon envi- ronmental and/ or ecophysiological ... interaction of pH x ions x d was found The Newman Keuls test was not significant at P

Ngày tải lên: 09/08/2014, 04:20

4 181 0
Báo cáo lâm nghiệp: "Effect of soil temperature upon the root growth and mycorrhizal formation of white spruce (Picea glauca (Moench) Voss) seedlings grown in controlled environments" doc

Báo cáo lâm nghiệp: "Effect of soil temperature upon the root growth and mycorrhizal formation of white spruce (Picea glauca (Moench) Voss) seedlings grown in controlled environments" doc

... inoculation and tem- maintained out -of- doors before the first trials; were stored at 2°C in darkness for the period Dec 87-May 88, a common B.C practice; and had recently completed the 2nd yr growth ... flush in July 88 The growth chambers were programmed for 14 h daily photoperiods with a constant air temperature of 20°C and soil temperatures of 3, 10 and 17°C Seedling caliper and shoot length ... Alberta Environment, RRTAC pp 32-45 status of Lavender D.P (1988) Characterization and manipulation of the physiological quality of planting stock Proceedings of the Tenth North American Forest Biology...

Ngày tải lên: 09/08/2014, 04:20

4 176 0
Báo cáo y học: "The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies" pptx

Báo cáo y học: "The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies" pptx

... activities The residual cost (Table 1) is the difference between the cost of null hypothesis and the total cost The larger the difference between the cost of the null hypothesis and total cost, the ... %Y, the percentage of known actives in the hit list (recall); Ht, the number of hits retrieved; D, the number of compounds in the Page of 13 database; E, the enrichment of the concentration of ... decamethonium [10] and donepezil [19] extend to the mouth of the gorge, the opening of the hydrophobic pocket Page of 13 The drug discovery process is both time-consuming and expensive [20] yet...

Ngày tải lên: 10/08/2014, 05:21

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