... α-subunits, and two transactivating domains, namely the amino-terminal transactivating domain and the carboxylterminal transactivating domain (C-TAD) The C-TAD has been shown to interact with ... encapsulating tenosynovium and from joint synovium, and we found that oxygen in invasive tenosynovium was 43% lower than in matched joint synovium, and 28% lower than in matched encapsulating tenosynovium ... series examines the evidence for hypoxia in inflammatory and destructive joint disease, and discusses the interplay between alterations in oxygen tension, vascularity and inflammatory signalling pathways...
Ngày tải lên: 09/08/2014, 01:22
... α-subunits, and two transactivating domains, namely the amino-terminal transactivating domain and the carboxylterminal transactivating domain (C-TAD) The C-TAD has been shown to interact with ... encapsulating tenosynovium and from joint synovium, and we found that oxygen in invasive tenosynovium was 43% lower than in matched joint synovium, and 28% lower than in matched encapsulating tenosynovium ... series examines the evidence for hypoxia in inflammatory and destructive joint disease, and discusses the interplay between alterations in oxygen tension, vascularity and inflammatory signalling pathways...
Ngày tải lên: 09/08/2014, 13:22
Báo cáo y học: " Serum Interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study" pps
... demonstrated that inflammatory cytokines increase early after AKI as serum interleukin-6 (IL-6) and keratinocyte-derived cytokine (KC, the murine analogue of interleukin-8) were increased by hours ... consecutive children undergoing CPB surgery were considered for study; 29 were excluded for nephrotoxin use Acute kidney injury (AKI) was defined by a 50% or greater increase in serum creatinine within ... messages • The proinflammatory cytokines IL-6 and IL-8 are increased early (at hours) in patients with AKI due to CPB • Other serum cytokines, including IL-18, are not increased in patients with...
Ngày tải lên: 13/08/2014, 16:21
Báo cáo y học: "Controversies concerning the diagnosis and treatment of bipolar disorder in children" ppsx
... bipolar disorder showing a proportional increase in minority youth with this diagnosis from 1997 to 2006 (23% increase in African-American and other minorities and corresponding drop in white youth) ... appear in distinct and sustained episodes–not as chronic or rapidly cycling As Klein put it, episodicity is a sine qua non of BP Stage Tightening the definition of BP and beginning to define a new ... harder in children than in adults Younger persons can have difficulty noticing and describing symptoms and providing accurate accounts of time of onset and duration of symptoms (although children...
Ngày tải lên: 13/08/2014, 18:21
Báo cáo y học: "Impact of the Kenya post-election crisis on clinic attendance and medication adherence for HIV-infected children in western Kenya"
... independent variables were selected from the domains of demographic, household, and clinical care information, including child's age, sex, tribe, and in which clinic the child received care In ... by involving additional investigators in reviewing the recordings and field notes and in confirming or disconfirming the codes and the subsequent themes Data triangulation was used by comparing ... Medicine and Moi Teaching and Referral Hospital (Eldoret, Kenya) and the Institutional Review Board of the Indiana University School of Medicine (Indianapolis, Indiana) Informed consent was obtained...
Ngày tải lên: 25/10/2012, 10:31
Báo cáo y học: "Refractive Status and Prevalence of Refractive Errors in Suburban School-age Children"
... attention paid to children' s vision and refractions in Western China In order to obtain the refractive status in school-age children in Western China, we selected Yongchuan District, Chongqing, a representative ... of myopia in urban and rural children in mainland China Optom Vis Sci 2009; 86: 40-44 18 National Bureau of Statistics of China China statistical yearbook 2003 [in Chinese] Beijing: China Statistics ... Refractive error in children in a rural population in India Invest Ophthalmol Vis Sci 2002;4: 615-622 14 Dandona R, Dandona L, Naduvilath TJ, Srinivas M, McCarty CA, Rao GN Refractive Errors in an urban...
Ngày tải lên: 25/10/2012, 11:40
Tài liệu Seropositivity for celiac disease in children and adolescents with short stature doc
... Signs and symptoms Occasional abdominal pain, difficulty gaining weight and height Prior history of anemia Difficulty gaining weight and height Prior history of anemia Frequent abdominal pain, ... villi in the small intestine, causing an inadequate absorption of nutrients The disease has a varied spectrum of presentations, ranging from the classic form (chronic diarrhea, abdominal pain and ... stature, and abdominal pains)(35) Celiac disease is a cause of short stature that should not be forgotten, particularly in deprived populations, and must be borne in mind during diagnostic investigations...
Ngày tải lên: 12/02/2014, 19:20
Tài liệu Sport and Physical Activity in Children with Congenital Heart Disease ppt
... surgery/interventions (including ablations) 1.1 Without remaining findings (complete correction) 1.2 With minimal findings 1.3 With clinically significant findings 1.4 After palliative interventions: ... function and hemodynamic findings under exertion BOX Findings after cardiac surgery and/ or interventions Minor remaining findings (1.2) – Scar after ventriculotomy – Incomplete right bundle branch ... forms of exercise and games in childhood Types of exercise with a high dynamic/low static component Running, skipping, jumping, cycling, swimming, inline skating, skateboarding, running games, ball...
Ngày tải lên: 12/02/2014, 19:20
Tài liệu Báo cáo khoa học: Glycation of low-density lipoprotein results in the time-dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages docx
... Ne-carboxymethyl-lysines and Ne-carboxyethyl-lysines and pentosidine) being known to accumulate with age on tissue proteins, and at an increased rate in LDL and atherosclerotic lesions in people with ... (1994) Binding and modification of proteins by methylglyoxal under physiological conditions A kinetic and mechanistic study with Nalpha-acetylarginine, Nalpha-acetylcysteine, and Nalpha-acetyllysine, ... mLÆmin)1) The flow rate was increased by mLÆmin)1 every 10 min, and the monocyte cell fractions collected with flow rates of 15, 16, 17, 18 and, finally, 40 mLÆmin)1 were collected and combined...
Ngày tải lên: 19/02/2014, 02:20
Tài liệu Review of essential medicine priorities in ear, nose and throat conditions in children doc
... The Royal Children s Hospital Clinical Practice Guidelines combines advice for “rhinosinusitis”, defined as “inflammation of the epithelial lining in the paranasal sinuses” and noting that this ... Guidelines Clearinghouse Cincinnati Children' s Hospital Medical Center Evidence-based care guideline for management of acute bacterial sinusitis in children 1-18 years of age Cincinnati (OH): Cincinnati ... and Clinical Immunology.41,42 Both are intended for adult and paediatric application The following advice is offered in relation to rhinitis: • “Saline douching reduced symptoms in children and...
Ngày tải lên: 19/02/2014, 08:20
Tài liệu Báo cáo khoa học: The crystal structure of coenzyme B12-dependent glycerol dehydratase in complex with cobalamin and propane-1,2-diol pptx
... gel [44], two bands appeared upon protein staining, and only the upper one stained upon activity staining (data not shown) The Mr values for the upper and lower bands were 220 000 and 200 000, ... (green) and K+ (cyan) are shown in ball-andstick models Cobalamin, pink (B) Residues hydrogen-bonded to cobalamin The residues interacting with cobalamin from distances ˚ ˚ shorter by 0.1 A and longer ... dehydratase [9] In addition, aG and bG are longer by one amino acid than aD in the N-terminal and by three than bD in the C-terminal, respectively In the final structure, all residues of the a chain (Met1–Glu555),...
Ngày tải lên: 21/02/2014, 03:20
Pompe disease in children and adults: natural course, disease severity and impact on daily life docx
... 291 France5 Other (via Erasmus MC) Total Including patients from Belgium; 2including patient from New Zealand; 3including patient from Denmark, patients from Switzerland and from Austria; 4including ... 4including patient from Taiwan; 5patients recruited both via patient organization and Institut de Myologie (Paris); 62 patients from Greece, from Luxembourg, from Switzerland, from Italy and from ... a starting point The Self Care scale included items such as combing hair, washing oneself, and putting on clothes The mobility scale included items such as moving inside the house, climbing stairs,...
Ngày tải lên: 05/03/2014, 10:20
IDSA Clinical Practice Guideline for Acute Bacterial Rhinosinusitis in Children and Adults pot
... is active against most strains of H in uenzae and M catarrhalis, whereas clindamycin is active against most S pneumoniae including some penicillinintermediate and resistant strains (85% susceptible ... are inactive [95, 136, 137] Oral cephalosporins including cefpodoxime and cefdinir are inactive against penicillin-resistant S pneumoniae [136, 138] Intravenous ceftriaxone and cefotaxime remain ... eradication and pharmacodynamic endpoints in the antimicrobial treatment of ABRS, by inserting an indwelling catheter into the maxillary sinus This allowed serial sinus aspirate sampling IDSA Guideline...
Ngày tải lên: 05/03/2014, 10:20
Extent of Dental Disease in Children Has Not Decreased, and Millions Are Estimated to Have Untreated Tooth Decay pptx
... and II contain more information on our NHANES and MEPS analyses Finally, we obtained information on oral health and the Medicaid population from CDC and from dental associations and experts including ... health insurance, and uninsured children The group of children with private insurance included both children with dental coverage and children without dental coverage,6 while the group of uninsured ... dental care from his Medicaid managed care organization, Deamonte’s family had experienced significant difficulties in obtaining needed dental care, including finding a dentist in their Maryland neighborhood...
Ngày tải lên: 14/03/2014, 09:20
Management of invasive meningococcal disease in children and young people pdf
... guideline in individual hospitals, units and practices, and to monitor compliance This may be done by a variety of means including patient-specific reminders, continuing education and training, and ... symptoms and signs may be indistinguishable from intercurrent and self limiting viral infection.4 The majority of deaths continue to occur in the first 24 hours, frequently before the institution ... protein is a frequently measured acute phase protein and may be useful diagnostically in helping to distinguish bacterial from viral infection, it has poor sensitivity and specificity in predicting...
Ngày tải lên: 14/03/2014, 09:20
Priorities for Investments in Children and Families in Caddo and Bossier Parishes doc
... counseling curricula or life preconception - Smaller group skills training for settings and children and interconception personalized youth health and teachers - Educating and Public schools instruction ... forward in implementing interventions in their focus areas of health, education, and poverty 17 Findings We now present findings from analyses of data that provide information about the needs and ... suggesting data sources, and providing other ongoing input during the project We thank Stacy Fitzsimmons for administrative assistance during the project, and Lance Tan for assistance in preparing...
Ngày tải lên: 16/03/2014, 03:20
Báo cáo khóa học: Phospholipase C, protein kinase C, Ca 2+ /calmodulin-dependent protein kinase II, and redox state are involved in epigallocatechin gallate-induced phospholipase D activation in human astroglioma cells ppt
... protein kinase C, Ca2+/calmodulin -dependent protein kinase II, and tyrosine phosphorylation are involved in carbachol-induced phospholipase D activation in Chinese hamster ovary cells expressing ... not involved [23,24] To determine whether PLC activity or G-protein-mediated signaling was involved in EGCG-induced PLD activation in U87 cells, we examined the effects of pertussis toxin and ... activation is dependent on Ca2+ and possibly involves the Ca2+-activated protein kinase, CaM kinase II (Fig 9D) These data suggest that EGCG activates PKC-a in U87 cells Involvement of PKC in EGCG-induced...
Ngày tải lên: 16/03/2014, 16:20
New ESPGHAN guidelines for the diagnosis of Coeliac Disease in Children and Adolescents pptx
... gluten and related prolamines in genetically (mainly HLA) susceptible individuals characterized by a combination of: • gluten dependent clinical manifestations • anti-tissue transglutaminase ... • Change in clinical paradigm Definitions of coeliac disease New diagnostic guidelines Algorithms Interlaken ESPGHAN criteria (1979) Small intestinal biopsy: villous atrophy Gluten free diet ... Towards a new definition of coeliac disease Chronic Multi-organ Small intestinal inflammation Transglutaminase-related ESPGHAN working group, 2011 Suggestion: New definition an immune-mediated...
Ngày tải lên: 22/03/2014, 09:20
Guidance on Cancer Services - Improving Outcomes in Children and Young People with Cancer pptx
... cancer in children and young people 39 • information for parents/carers and families • training and education for staff in all care settings in which chemotherapy is given • Improving Outcomes in Children ... years and 213.9 per million in those aged 15–24 years Cancers in children and young people show a characteristic pattern of incidence that changes with increasing age Leukaemia, and brain and spinal ... tumours, including cytogenetics and molecular genetics Imaging Timely access to appropriately skilled diagnostic imaging, including nuclear medicine, is essential in evaluating children and young...
Ngày tải lên: 22/03/2014, 16:21
Báo cáo khoa học: Okadaic acid induces DNA fragmentation via caspase-3-dependent and caspase-3-independent pathways in Chinese hamster ovary (CHO)-K1 cells pot
... may play an important role in inducing DNA fragmentation OA induces caspase -dependent and caspase-independent DNA fragmentation in the presence of caspase-3 We next examined whether the activation ... not involving DEVDase activity; caspase-3 -dependent and other caspase activation-independent pathways not involving DEVDase activity; and other caspase activation -dependent pathways involving ... DNA fragmentation in caspase-3) ⁄ ) cells, but not in CHO-K1 cells, suggesting that caspase-3 is involved in OA-induced DNA fragmentation independently from DEVDase activity, and that DEVDase...
Ngày tải lên: 22/03/2014, 21:20