formation blood brain barrier disruption and serotonin levels in the rat pdf
báo cáo hóa học: " Neuro-Inflammation, Blood-Brain Barrier, Seizures and Autism" pot
Ngày tải lên :
19/06/2014, 22:20
... as well as in inflammation [26] Substances originating in the gut or the brain can trigger mast cells to release mediators that could disrupt the gutblood barrier and blood- brain barrier (BBB), ... 303:1061-1066 51 Theoharides, T C and Konstantinidou, A.: Corticotropin-releasing hormone and the bloodbrain -barrier Front Biosci 2007, 12:1615-1628 52 Rehni, A K., Singh, T G., Singh, N., and Arora, ... R., Tutor, D., and Theoharides, T C.: Corticotropin-releasing hormone (CRH) and brain mast cells regulate blood- brain- barrier permeability induced by acute stress J Pharmacol Exp Ther 2002, 303:1061-1066...
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Báo cáo khoa học: "Protective and therapeutic effects of an extract mixture of alder tree, labiate herb, milk thistle green bean-rice bran fermentation, and turnip against ethanol-induced toxicity in the rat" pdf
Ngày tải lên :
07/08/2014, 20:23
... significance, but did indicate a trend The yogurt treatment did not reduce the levels of AST or total bilirubin similar to the results of the commercial drug On the other hand, the ALT levels in the herbal ... acclimatized for one week prior to the experiment The procedures involving the animals and their care were carried out according to the Guidelines for the Care and Use of Laboratory Animals of Seoul National ... processed in an alcohol-xylene series, embedded in paraffin wax, and sectioned at µm The sections were stained with hematoxylin and eosin The sections were graded for the degree of fatty change, inflammation...
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Báo cáo y học: "Silencing CD36 gene expression results in the inhibition of latent-TGF-β1 activation and suppression of silica-induced lung fibrosis in the rat" pdf
Ngày tải lên :
12/08/2014, 14:20
... Lv-shCD36-NC in physiological saline, was instilled into the lungs using a 14-gauge needle inserted into the trachea through the epiglottis of the larynx The site of surgery was sutured and the rats ... draft the manuscript LL participated in the animal instillation and in the histological and immunohistochemical experiments JC initiated the project, participated in the design of the study and in ... manuscript) In the current study, a rat silicosis model was generated by intratracheal instillation, and the inhibitory effects of Lv-shCD36 on the activation of LTGF-β1 and the resulting antifibrotic...
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Báo cáo y học: "Alterations of alveolar type II cells and intraalveolar surfactant after bronchoalveolar lavage and perfluorocarbon ventilation. An electron microscopical and stereological study in the rat lung" pdf
Ngày tải lên :
12/08/2014, 15:20
... not alter the incorporation of acetate and choline into the lung and synthesis of lecithin seemed not different between conventional and liquid ventilation [24] In preterm rabbits [25] and preterm ... Healthy in the volume of lamellar bodies per cell with a subsequent decrease in the intracellular surfactant content per lung (Tab 3) Taking the qualitative findings and the stereological data on intraalveolar ... concerning the quantitative changes in the intraalveolar and intracellular surfactant composition Intraalveolar perfluorocarbons prevent end-expiratory alveolar collapse and thus, improve the BAL induced...
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Báo cáo y học: "Evaluation of the effects of a VEGFR-2 inhibitor compound on alanine aminotransferase gene expression and enzymatic activity in the rat liver" pdf
Ngày tải lên :
13/08/2014, 13:20
... of drugs and toxins may help in understanding the potential localization of hepatic diseases and carcinomas within the liver Understanding these regional effects is critical in the interpretation ... Kalamazoo, MI) for 15 minutes To help permeabilize tissue, sections were incubated in Proteinase K (Dako) for 20 minutes The remaining steps including equilibration and end labeling reaction were ... elicited an increased in hepatic ALT mRNA levels Additionally, regional differences among the lobes of the liver were observed in AG28262 treated rats The largest increase in ALT mRNA was in the caudate...
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báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
Ngày tải lên :
19/06/2014, 22:20
... Anandamide inhibits VCAM-1 induced by TMEV in brain endothelial cells by CB1 receptors The endothelial blood brain barrier protects the CNS from the changing environment in both physiologic and ... activity [18-22] A diminished number of leukocyte infiltrates into the CNS has been shown to occur in the EAE model by administering the synthetic cannabinoid WIN 5,212-2 [23] In the TMEVIDD model ... intracellular trafficking [9] Increasing evidence suggests the involvement of the ECS in both the inflammatory and the neurodegenerative processes associated to MS and other neurodegenerative diseases...
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báo cáo hóa học: " Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF" potx
Ngày tải lên :
19/06/2014, 22:20
... of blood- brain barrier to various sized molecules Am J Physiology 1985, 248:H712-H718 Chou S, Dix RD: Viral infections and the blood- brain barrier In Implications of the Blood- Brain Barrier and ... diffusing from the luminal to abluminal (influx) chamber and was calculated from the initial level of radioactivity in the loading chamber and final level of radioactivity in the collecting chamber: ... BMECs into the abluminal chamber are also involved in the LPS-induced increase in HIV-1 transport, we added antibodies to IL-6 or GM-CSF to the abluminal chamber Neither antibody in the abluminal...
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Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt
Ngày tải lên :
13/08/2014, 15:21
... cells, relaying into the brain inflammatory response and jeopardising the functional integrity of the BBB [55-57] In the present study, we found that, during experimental sepsis, the antibody-mediated ... described to reduce the LPS-induced activation in the paraventricular nucleus and the central amygdala [81] Thus, as we are beginning to gain novel insights into the crucial role of C5a in the development ... inflammation-mediated dysfunction of the blood- brain barrier (BBB), thus allowing neurotoxic mediators to extravasate from the peripheral circulation into the subarachnoid space or into the brain...
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Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain
Ngày tải lên :
26/11/2015, 22:48
... ONE: INTRODUCTION 1.1 BLOOD BRAIN BARRIER 1.1.1 History and Anatomy of the Blood Brain Barrier 1.1.2 Functions of the Blood Brain Barrier 1.1.3 Clinical Significance of the Blood Brain Barrier ... 2.2 BRAIN CANCER AND OTHER BRAIN DISEASES A brain tumor is a mass of unnecessary cells growing in the brain [94] There are two basic kinds of brain tumors: primary brain tumors and metastatic brain ... of the Blood Brain Barrier The main function of the blood brain barrier is to protect the brain The BBB serves as an impermeable wall to prevent the entry of agents from outside of the brain...
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the blood – brain barrier
Ngày tải lên :
11/04/2014, 10:34
... each Infiltration Blocks are then placed in the final resin mixture and propylene oxide in a 1Ϻ1 ratio for at least h and in a 2Ϻ1 ratio for 36 h Place cork stoppers on the tubes containing the ... depending on the number of blocks being cut b Retract both the coarse and fine stage advances c Mount the chuck containing the block into its holder in the machine and tighten the screw holding ... links cadherins to the actin-based cytoskeleton and to other signaling components γ-catenin is related to β-catenin and can substitute for it in the cadherin-catenin complex Catenins are, thereby,...
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Hình thái và chức năng của hàng rào máu não (blood brain barrier)
Ngày tải lên :
19/07/2014, 20:48
... tế bào chất gắn với ß-catenin plakoglobin, đến chu kỳ lại gắn α-catenin, α-actinin vinculin, mục đích làm ổn định phức hợp vùng dính Dải bịt Lòng mạch Phức hợp protein Khoảng gian bào Màng tế ... trúc phân tử Occludin[12] 22 4.2.3.Claudin Claudin có vị trí màng tế bào giống occludin đồng đẳng occludin Claudin protein có trọng lượng phân tử 20-24 kDa Có 24 đồng đẳng claudin phát động vật ... cầu CD11b/CD18 integrins ICAM-1, iC3b, Bạch cầu đơn nhân, đa fibrinogen nhân , lympho iC3b Bạch cầu đơn nhân, (Mac-1) CD11c/CD18 integrins đa nhân VLA-4 integrins VCAM-1 fibronectin Tất cả, trừ...
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Báo cáo y học: "Effect of magnesium sulfate administration on blood–brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study" ppt
Ngày tải lên :
12/08/2014, 20:20
... leads to the formation of brain edema in septic rats Magnesium administration attenuated the increased BBB permeability and caused a reduction in brain edema formation in our rat model of intraperitoneal ... sepsis-induced rats were significantly less than the sham-operated rats, indicating the formation of brain edema after the induction of sepsis (Table 3) Brain tissue SG measurements in the magnesiumtreated ... of magnesium administration on brain edema and blood brain barrier breakdown after experimental traumatic brain injury in rats J Neurosurg Anesthesiol 2003, 15:119-125 Heath DL, Vink R: Neuroprotective...
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Application of biologically active micelles in drug delivery across the blood brain barrier
Ngày tải lên :
11/09/2015, 09:10
... predominantly affects the meninges surrounding the brain and the spinal cord is called meningitis The infection of the brain tissue is called encephalitis If both brain and meninges are affected, the ... parenchyma The blood brain barrier (BBB) lies between the blood flow and the brain parenchyma The BBB prohibits most foreign molecules entering from the blood to brain, including CNS drugs The limited ... the drug can INTRODUCTION reaches the sites of infection in the body, and how quickly the body can eliminate the drug During the clinical application, the biggest obstacle in the antibiotic therapy...
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Báo cáo y học: " High blood pressure, antihypertensive medication and lung function in a general adult population"
Ngày tải lên :
25/10/2012, 10:45
... The clinical examinations and interviews were performed at the same day Overall, the KORA F4 study was conducted between 2006 and 2008 The investigations were carried out in accordance with the ... expiratory lung function manoeuvres in order to obtain a minimum of two acceptable and reproducible values Before the tests the examiner demonstrated the correct performance of the manoeuvres and ... manoeuvres and then the individuals were supervised throughout the tests According to the ATS recommendations [17] the tests were performed in a sitting position and with wearing noseclips The best...
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Báo cáo y học: "Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Diseas"
Ngày tải lên :
25/10/2012, 10:51
... know, there is no study examining serum Cd levels in CAD in the literature We have found that serum Cd levels were significantly decreased in CAD Therefore, the significance of this finding should ... important in preventing the peroxidation of LDL and this action could be paramount in the prevention of atherosclerosis As lypophilic molecules, vitamin E and beta-carotene are incorporated into the ... assessed the association between iron status and CAD risk but the results have been inconsistent (8,9) The aim of the present study was to investigate the changes occurring in the serum level zinc...
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Báo cáo y học: "Comparative study of serum Na+ and K+ levels in senile cataract patients and normal individuals"
Ngày tải lên :
03/11/2012, 09:49
... groups were both examined by an expert ophthalmologist and routine ophthalmic examinations including visual acuity determination, slit lamp examination, ophthalmoloscopy and intraocular pressure ... for the control group Then a fasting-state blood sample was obtained from both case & control group and sent to the laboratory Serum Na+, K+ levels were measured with flam photometry method by the ... of these ions leads to cation imbalance in lens which in turn results in cataract formation [36] Hence alteration in cation concentration of aqueous humor which is attributed to alterations in...
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Tài liệu Báo cáo khoa học: Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the ABC drug transporter, MDR1 Cyclosporin A can lower serum and liver globotriaosyl ceramide levels in the Fabry mouse model doc
Ngày tải lên :
19/02/2014, 07:20
... endothelial staining in Fabry mouse; (C, D) lung – epithelial cell staining increased in Fabry mouse; (E, F) brain microvascular endothelial staining in Fabry mouse Magnification ·16 no VT1 staining of ... staining of normal brain (Fig 7F) In Fabry brain, extensive staining of the microvasculature is evident (Fig 7E) The arachnoid membrane surrounding the brain is extensively stained in Fabry but not ... & van Deemter L (1996) P-Glycoprotein in the blood brain barrier of mice in uences the brain penetration and pharmacological activity of many drugs J Clin Invest 97, 2517–2524 Ichikawa S, Sakiyama...
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Báo cáo khoa học: Post-ischemic brain damage: pathophysiology and role of inflammatory mediators ppt
Ngày tải lên :
07/03/2014, 03:20
... against focal cerebral ischemia in mice J Cereb Blood Flow Metab 21, 1430–1435 Minami M & Satoh M (2003) Chemokines and their receptors in the brain: pathophysiological roles in ischemic brain injury ... injured parenchyma, as demonstrated both in animal models [11,12] and in stroke patients [13–15] Within hours after the ischemic insult, increased levels of cytokines and chemokines enhance the ... accumulate in the capillaries, further impairing cerebral blood flow, or may extravasate into the brain parenchyma where they release neurotoxic substances, including 14 pro -in ammatory cytokines,...
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Báo cáo khóa học: Disruption of the interaction between the Rieske iron–sulfur protein and cytochrome b in the yeast bc1 complex owing to a human disease-associated mutation within cytochrome b potx
Ngày tải lên :
07/03/2014, 15:20
... that interfacial protein–protein interactions between the hinge region of ISP and the extramembranous cd2 helix of cytochrome b are important for maintaining the structure of the hinge region and, ... the ISP or change in the EPR signal It was suggested that the mutation impeded the unwinding of the short stretch of the 310 helix located in the tether region necessary for the movement of the ... in pink, and the hinge region of the ISP is shown in white the integration or stability of the ISP within the bc1 complex In order to investigate its effect on the bc1 complex, we introduced this...
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Báo cáo khoa học: Soluble recombinant CD69 receptors optimized to have an exceptional physical and chemical stability display prolonged circulation and remain intact in the blood of mice doc
Ngày tải lên :
16/03/2014, 04:20
... After the initial dilution caused by binding and retaining in the tissues, the blood level of these proteins stabilized within h, and then remained nearly unchanged for up to 24 h after injection ... with the concomitant increase in the molar extinction coefficient of the protein, and thus the increase in absorbance in the aromatic region Shortly thereafter, a gradual unfolding of the protein ... constant, and the spectra were taken in several time intervals (indicated on the right) (D) FTIR spectrum of CD69 protein in the region of the amide I and II bands (the full line) The dash–dot line...
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