forests and decentralization in switzerland a sampling

... principle, the sampling, extraction and GC analysis should be made at low temperature, in a gastight state and in a short time This method is applicable to other biomedical specimens and drinks/foods ... transformation in rats J Pharm Sci 74:780–782 10) Kielbasa WB, Bauer JA, Fung HL (1999) Analysis of isobutyl nitrite inhalant in rat and human blood: application for pharmacokinetic investigations J Chromatogr ... concentration of an alkyl nitrite on the horizontal axis and peak area on the vertical axis The concentration of the analyte in a specimen is calculated using the calibration curve i Assessment and some...

Ngày tải lên: 18/10/2013, 00:15

... GC/MS analysis for DAEMS in serum (a) a total ion chromatogram (TIC) and a mass chromatogram; (b) an EI mass spectrum of DAEMS; (c) a CI mass spectrum of DAEMS Poisoning case, and toxic and fatal ... concentrations of DAEMS are spiked into blank serum specimens containing a fixed amount of DAEMO (IS) each and extracted as described before Since the base peaks of DAEMS and DAEMO (IS) equally appear ... GC/MS analysis for EMPA in serum (a) a TIC and mass chromatograms; (b) an EI mass spectrum of the t-BDMS derivative of EMPA; (c) a CI mass spectrum of the same derivative of EMPA data of animals According...

Ngày tải lên: 18/10/2013, 00:15

... 188 Cannabinoids and their metabolites GC analysis of cannabinoids in plant specimensa Reagents and their preparation • • • Extraction and purification of cannabinoids [3]: Cannabis sativa L is ... Yokoyama M, Okada Y, Suzuki K (1992) Determination of cannabinoids in cannabis oil by capillary gas chromatography Eisei Kagaku 38:471–475 (in Japanese with an English abstract) 5) Watanabe K, Yamaki ... construct a calibration curve with cannabinoid concentration on the horizontal axis and with peak area ratio of a cannabinoid to IS on the vertical axis GC analysis of cannabinoids in plant specimens...

Ngày tải lên: 24/10/2013, 19:15

... Main metabolic pathways of morphine, heroin and codeine The thick and thin arrows show the main and minor metabolic pathways, respectively ⊡ Figure 3.1 196 Morphine and its analogues GC and ... Hasegawa M, Maseda C, Kagawa M et al (1992) Morphine and codeine being contained in poppy seeds and poppy seed-containing foods Eisei Kagaku 38:192–195 (in Japanese with an English abstract) 11) ... morphine, codeine and tetrahydropapaveroline in Parkinsonian patient undergoing L-3,4-dihydroxyphenylalanine therapy: a possible biosynthetic pathway of morphine from L-3,4-dihydroxyphenylalanine...

Ngày tải lên: 24/10/2013, 19:15

... normal cyanosis headache, dyspnea, tachypnea, tachycardia and hypertension mental derangement, listlessness and metabolic acidosis coma, convulsive attack and hypotension death A poisoning case ... oxidation of nitrite into nitrate and the same extractions as those for nitrate A calibration curve for nitrite using blank specimens and IS is also prepared for quantitation in the same way Assessment ... [4] An unidentified male was found naked from the waist up in a park at about 10:00 p m.; he was suffering from some difficulty in breathing He was sent to a nearby clinic and diagnosed as exsiccosis;...

Ngày tải lên: 24/10/2013, 19:15

... 285, 290 alternative specimens Amanita neoovoidea 480 Amanita pantherina 469 Amanita phalloides 469 Amanita verna 469, 474 Amanita virosa 469, 473 amanitin 473, 477, 479 amido-type local anesthetic ... 635 inorganic nitrite 649 inorganic poisons 637 interface 40 International Normalized Ratio 605 intratracheal contents 168 intratracheal gas 161, 162 in vitro interval 218 iodoplatinate reagent ... absorbance of cuvette B at 630 nm is read using cuvette A as reference, and this reading is A1 After allowing cuvette D to stand for 10 min, the absorbance at 630 nm is read using cuvette C as...

Ngày tải lên: 24/10/2013, 19:15

... vitro interval (period between sampling and analysis) are variable; the hydrolytic rate of cocaine shows great variation Usually, the metabolism, metabolite accumulation and excretion for cocaine ... Significance and problems of doping tests and toxin analysis Nipponrinsho 57:361–363 (in Japanese) 10) Sander R, Ryser MA, Lamoreaux TC et al (1985) An epidemic of cocaine associated deaths in Utah ... Japan the number of such cases is limited The author et al experienced a fatal cocaine poisoning case and measured concentrations of cocaine and its metabolites in body fluids and various organs...

Ngày tải lên: 29/10/2013, 01:15

... concentration in the horizontal axis and peak area ratio of pentazocine to IS in the vertical axis The peak area ratio of a test specimen is applied to the calibration curve to obtain its pentazocine ... plasma by high performance liquid chromatography Pharmazie 46:464–465 8) Seno H, Kumazawa T, Ishii A et al (2000) Determination of pentazocine in human whole blood and urine by gas chromatography/surface ... (17) 285 (9) Poisoning case, and toxic and fatal concentrations A 17-year-old female [11] ingested about 100 tablets of pentazocine (total amount estimated, 2.5 g) and fell into unconsciousness...

Ngày tải lên: 29/10/2013, 02:15

... 108–109 (in Japanese) 2) The Pharmaceutical Society of Japan (ed) (1992) Standard Methods of Chemical Analysis in Poisoning – With Commentary – Nanzando, Tokyo, p 43 and p 151 (in Japanese) 3) ... blood and urine, because its amount to be ingested is as small as about 10 µg and LSD is rapidly metabolized in human bodies As metabolites of LSD, 2-oxo-LSD, 3-, 13- and 14-hydroxy-LSDs and an ... obtained for purification by LC under an ultraviolet light For a piece of paper, which is suspected to contain LSD, the drug is extracted by adding % tartaric acid aqueous solution and by shaking...

Ngày tải lên: 08/11/2013, 01:15

... urinary MDAs recommended by the Substance Abuse and Mental Health Services Administration (SAMHSA) is 250 ng/mL Symptoms, and toxic and fatal concentrations MDMA causes increased catecholamine ... derivatization method J Chromatogr 467:227–235 24) Tsuchihashi H, Nakajima K, Nishikawa M et al (1991) Determination of methamphetamine and amphetamine in urine by headspace gas chromatography/mass ... MDEA=3,4-methylenedioxyethylamphetamine; MA=methamphetamine; AP=amphetamine 235 236 3,4-Methylenedioxyamphetamines ⊡ Figure 7.5 Mass spectra of TFA-derivatives of MDMA, MDA, HMMA and HMA extracted from an MDMA addict’s urine Detailed...

Ngày tải lên: 08/11/2013, 01:15

... responding verbally; the levels of serum creatinin kinase and aspartate aminotransferase were more than 100-times the normal limits On hospital day 2, he became rigid, diaphoretic and had a temperature ... Lee LF, Halzhauer LB et al (2001) Analysis of urine samples in cases of alleged sexual assault: case history In: Salamore SJ (ed) Benzodiazepines and GHB: Detection and Pharmacology Humana Press, ... brain [3], and is an agonist of GABAB receptors [4–8] GHB was first synthesized in 1960 and used as an anaesthetic adjuvant or induction agent [9] This application is still in use in Europe In...

Ngày tải lên: 08/11/2013, 01:15

... Louis, MO, USA) Pure powder of perazine and clospirazine was donated by Mitsubishi Welpharma, Osaka, Japan; that of flupentixol by Takeda Chem Ind Ltd., Osaka, Japan; that of thioproperazine by Shionogi ... LC/MS analysis [8] See [8] Reagents and their preparation i Reagents Prochlorperazine, trifluoperazine, perphenazine, fluphenazine, propericiazine and thioridazine can be purchased from Sigma (St ... concentration on the horizontal axis and of peak area ratio of a drug to IS on the vertical axis The above peak area ratio obtained from a specimen is applied to the calibration curve to obtain its...

Ngày tải lên: 15/12/2013, 12:15

... haloperidol in total (combined amount for both children); both were brought to a hospital in the comatose state and showed bradycardia, hypotension and sinus arrhythmia Mannitol was injected into ... diphenhydramine was injected into her intravenously; she recovered days after admission For the male baby, similar treatments, such as intravenous injection of mannitol and diphenhydramine, were carried ... Poisoning cases, and toxic and fatal concentrations ⊡ Figure 2.3 HPLC-DAD chromatograms for the authentic haloperidol (HP) and reduced haloperidol (RHP) (100 ng/mL each) (A) and for a serum extract...

Ngày tải lên: 15/12/2013, 12:15

... antidepressants can Poisoning cases, and toxic and fatal concentrations ⊡ Table 3.2 RI values and mass spectra of tricyclic and tetracyclic antidepressants Name amitriptyline amoxapine carbamazepine ... concentrations of tricyclic and tetracyclic antidepressants Compound amitriptyline amoxapine carbamazepine clomipramine desipramine dosulepin imipramine lofepramine maprotiline mianserin nortriptyline ... antidepressants and carbamazepine obtained by HPLC-UV A: carbamazepine, B: desipramine, C: maprotiline, D: nortriptyline, E: amoxapine, F: setiptiline, G: mianserin, H: imipramine, I: amitriptyline, J:...

Ngày tải lên: 15/12/2013, 12:15

... 4-hydroxytriazolam, α-hydroxytriazolam and alprazolam (IS) A 100-ng aliquot each of triazolam, 4-hydroxytriazolam and α-hydroxytriazolam and 50 ng of alprazolam were added to mL blood plasma Toxic and ... oxazolam, cloxazolam, mexazolam, flutazolam and haloxazolam having oxazolo rings in their structures [1] In such cases, the relatively low injection temperature and the use of a wide-bore capillary ... fludiazepam, flurazepam, prazepam, flutoprazepam, dipotassium clorazepate, medazepam, chlordiazepoxide, flunitrazepam, alprazolam, midazolam, etizolam and brotizolam for both blood and urine The detection...

Ngày tải lên: 15/12/2013, 12:15

... biological materials by gas chromatography and gas chromatography-mass spectrometry A fatal poisoning by ingestion of a drug containing acetaminophen, ethenzamide and bromvaleryurea Jpn J Legal Med ... allylisopropylacetylurea in serum and urine by high-performance liquid chromatography with a multiwavelength UV detector and thin-layer chromatography J Anal Toxicol 15:123–125 5) Tanaka E, Nakamura T, Nagashima A ... bromide and urea: g of 2-bromohexanoyl bromide (Aldrich, Milwaukee, WI, USA) and an equimolar amount of urea are placed in a 100 mL volume eggplant-shaped glass flask and warmed in a water bath to...

Ngày tải lên: 15/12/2013, 12:15

... (estimated) female was found dead on a bed of a hotel In her room, tablets of Vegetamin (a combined drug containing, phenobarbital, promethazine and Survived and fatal poisoning cases chlorpromazine) ... barbiturates Action type long-acting Compound barbital phenobarbital phenobarbital sodium metharbital Intermediate amobarbital acting amobarbital sodium short-acting pentobarbital calcium pentobarbital ... times and detection limits for main barbiturates measured by HPLC Compound barbital allobarbital metharbital phenobarbital cyclobarbital pentobarbital hexobarbital amobarbital secobarbital thiopental...

Ngày tải lên: 15/12/2013, 12:15

... chlorpheniramine and its metabolites didemethylchlorpheniramine and demethylchlorpheniramine is described Reagents and their preparation • • • Chlorpheniramine maleate and brompheniramine maleate are ... Greenblatt DJ, Scavone JM et al (1986) Pharmacokinetics of diphenhydramine and demethylated metabolite following intravenous and oral administration J Clin Pharmacol 26:529–533 3) Hattori H, Yamamoto ... E, Yamasaki S, Iizuka Y et al (1992) The optical resolution of racemic chlorpheniramine and its stereoselective pharmacokinetics in rat plasma J Pharm Pharmacol 44:44–47 14) Sakamoto T (ed and...

Ngày tải lên: 15/12/2013, 12:15

... drugs in plasma J Chromatogr 416:293–302 9) Shinozuka T, Nakajima R, Takei S et al (1999) Simultaneous analysis of propionic acid analgesic and antipyretic drugs in human plasma by gas chromatography ... analgesics and antipyretics, the 115th Annual Meeting of the Pharmaceutical Society of Japan, the data of the Public Health Council Pharmaceutical Society of Japan, Tokyo, pp 81–86 (in Japanese) 3) Shinozuka ... of urine or serum (plasma) is mixed well with 0.1 mL phosphoric acid and 0.5 mL of purified water and poured into an Oasis®MAX cartridge, which had been activated by passing mL methanol and mL...

Ngày tải lên: 15/12/2013, 12:15

... • • APAP (Eastmann, Rochester, NY, USA) and APAP metabolites a (APAP-glucuronide, catechol 3-hydroxyaminophen, APAP-N-sulfate, 3-cysteinyl APAP, 3-methoxy APAP and APAP-3-mercapturic acid) are ... IS: internal standard (theophylline) (20 µg/mL, 5.1 min) HPLC analysis of APAP and its metabolites in urine HPLC analysis of APAP and its metabolites in urine [4] Reagents and their preparation ... determination of acetaminophen in plasma after propacetamol administration: application to pharmacokinetic studies J Pharm Biomed Anal 20:327–334 18) Brunner LJ, Bai S (1999) Simple and rapid assay...

Ngày tải lên: 15/12/2013, 12:15