forehead is the reach too short how wide should the pedicle be should i delay the procedure for safety
Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
Ngày tải lên :
14/02/2014, 19:20
... binding core regions for the v-KIND–MAP2 interaction and showed that the MAP2 binding core is not only critical for targeting of v-KIND to neuronal dendrites, but also is indispensable for the ... protein kinase regulatory subunit RII binding domain, the central domain (CD) and the microtubule-binding domain (Fig 3A) To determine the v-KIND-binding region in MAP2, we first divided MAP2 into ... -MAP2 Input IB: -GFP GST-CD2 (CBB stain) Fig Residues 456–487 within the v-KIND KIND2 domain contain the MAP2-binding core site (A) Division of the KIND2 domain (456–620) into five subregions: KIND2-1...
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Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt
Ngày tải lên :
06/03/2014, 09:22
... efficiently kill invading microorganisms [4,5] The signaling mechanisms that elicit expression of antimicrobial peptides are best understood in Drosophila melanogaster In this species, the Toll pathway ... with ’Ã’ The predicted secretion signal peptide is underlined The proteolytic activation site is indicated with i The N-terminal sequence, determined by Edman degradation, of the activated form ... conservative substitutions by ’:’ below the sequences The P1 residue at the activation cleavage site is shown in bold, and the scissile bond is indicated by an arrow Absolutely conserved cysteines...
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Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf
Ngày tải lên :
06/03/2014, 11:20
... an important role in the stabilization of the two conformers The two His residues, His334 and His356, may both participate in stabilization of the polar interactions Thus, His334, situated on the ... between the charged side chains of the minidomain residues The minidomain is indeed enriched in polar and charged residues, and the main structural difference between the two conformers is in the ... Therefore, one hypothesis is that the protonation state of the His356 side chain could be crucial for protein folding and for the stabilization of the conformers At pH values above its pKa, the imidazole...
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Báo cáo khoa học: Structure and function of the 3-carboxy-cis,cis-muconate lactonizing enzyme from the protocatechuate degradative pathway of Agrobacterium radiobacter S2 pdf
Ngày tải lên :
30/03/2014, 10:20
... Rmerge ¼ Si ŒIi – I æŒ ⁄ S I æ, where I is an individual intensity measurement and I æ is the average intensity for this reflection with summation over all data b R-factor is defined as Si Fobs ... active site is identical in both enzymes and therefore is unlikely to contribute to this difference in specificity There are no changes in the active site, but there are a few changes in the region ... with isocitrate as a negative control, in order to determine the nature of the inhibition Surprisingly, both citrate and isocitrate acted as noncompetitive inhibitors (Fig 3), lowering the Vmax...
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structure and function of the arabic verb
Ngày tải lên :
03/04/2014, 12:48
... Sibawayhi Thus, this tome is for Arabists and Semitists as well as general linguists, who should always be interested in broadening their linguistic horizons and getting involved with non-Indo-European ... Arabic verb, (ii) the mixing of various historical eras of the Arabic language, and (iii) the absolute lack of authentic texts It is our strong belief that, with the current state of linguistic theory, ... interest in the notion of Modality in linguistics during the second half of the century illustrates the independent directions of these two disciplines Having established that communication is the...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 1 pps
Ngày tải lên :
11/08/2014, 06:21
... clinical auditory discipline The book also provides basic information about the auditory system in a form that is suitable for the scientist who does basic research on the auditory system The ... Is Temporal or Place Code the Basis for Discrimination of Frequency? 112 5.1 Temporal Hypothesis for Frequency Discrimination of Complex Sounds 112 5.2 Place Hypothesis for Frequency Discrimination ... further analysis in the auditory nervous system This analysis consists primarily of separating sounds into bands of frequencies before they are coded in the discharge pattern of individual auditory...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 2 ppsx
Ngày tải lên :
11/08/2014, 06:21
... (reprinted from Shaw, 1974, with permission from the American Institute of Physics) 3.3 Physical Basis for Directional Hearing The physical basis for directional hearing in the horizontal plane is ... depends on their intensity has implications for theories about the physiologic basis for discrimination of frequency and it explains the one-half octave shift in noise induced hearing loss (see ... of reproducibility (Fig 2.16) [95] The variations in the impedance obtained in different individuals are therefore a result of permanent individual differences This individual variation has several...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 4 potx
Ngày tải lên :
11/08/2014, 06:21
... frequency is discriminated Frequency discrimination is a prominent feature of hearing and its physiologic basis has been studied extensively because it is assumed to play an important role in discrimination ... to explain the physiologic basis for discrimination of frequency One hypothesis, the place principle, claims that frequency discrimination is based on the frequency selectivity of the basilar membrane ... selectivity of the basilar membrane is the basis for the place principle of frequency discrimination Coding of the temporal pattern of sounds in the discharge pattern of auditory nerve fibers is the...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 6 pot
Ngày tải lên :
11/08/2014, 06:21
... The horizontal line is a line between the two ears and it is also the time axis The vertical axis is a line between the middle of that line and the vertex The origin of the vectors is the latency ... stimulus intensities, practically only peak V is discernible For diagnosis of disorders of the auditory nervous system (or for excluding such disorders) the ABR is commonly elicited by click simulation ... on the forehead at the hairline and the mastoid on the side where the stimuli were applied The upper recording is shown with vertex positivity as an upward deflection, the middle curve is the...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 7 pot
Ngày tải lên :
11/08/2014, 06:21
... discrimination Impairment of speech discrimination from injuries to the auditory nerve is less predicable from the elevation in hearing threshold Speech discrimination is typically more impaired ... may impair discrimination of speech of high intensity However, the high sound intensities (above 90 dB SPL) where speech discrimination without a functioning acoustic reflex becomes impaired ... attention because it is involved in a common disorder known as otitis media with effusion (OME), which is an inflammation of the lining of middle-ear cavity, the mastoid cell system and the Eustachian...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 8 docx
Ngày tải lên :
11/08/2014, 06:21
... approximately kHz Individual variation is a characteristic feature of all forms of hearing impairment including NIHL, but the reason for this individual variation in acquired hearing loss from similar ... of these substances varies widely among individuals and it is different in different animal species There is evidence that older individuals have a higher susceptibility and individuals with diseases ... is interesting that an ototoxic antibiotic, neomycin, that is not allowed for systemic administration because of its ototoxicity is approved for local administration including in the ear Evidence...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 9 pdf
Ngày tải lên :
11/08/2014, 06:21
... The similarity between the basis for trichromatic color discrimination and the vocoder is thus obvious To illustrate how frequency discrimination in the auditory system can be achieved by using ... likewise may be accompanied by tinnitus Tinnitus is frequent in individuals who have noise induced hearing loss or other causes of impaired hearing but there is no direct correlation between the the ... [177] It has been hypothesized that 5-HT (serotonin) may be involved in the disorder [188] Lyme disease is another disorder that often is accompanied by hyperacusis (and tinnitus) Autism is also...
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Báo cáo y học: "Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the protein" ppsx
Ngày tải lên :
14/08/2014, 14:21
... of proteins within these groups to be tissue-specific or ubiquitous The assignment process is described in Figure Results Comparing expression patterns within different tissues For each tissue ... analysis of the assignments The sequences assignments file in the used in Phyletic assignments the proteins used in in analysis Click proteins proteins proteinsthe inanalysis analysis tionalhere ... assignments of analysis in the analysis analysis FuncFunctional File usedof of thethe proteins analysis analysis Phyletic Additionalforof of the proteins usedused used thethe The sequences the the...
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EXPRESSION AND FUNCTION OF THE PRL FAMILY OF PROTEIN TYROSINE PHOSPHATASE
Ngày tải lên :
24/08/2014, 11:44
... chosen for in situ hybridization (ISH) and/ or immunohistochemical (IHC) analysis In situ hybridization Non-isotopic ISH was performed using FITClabeled oligonucleotide probes specific for PRL1 ... embryonic kidney HPLC High Performance Liquid Chromatography Hr Hour ISH In situ hybridization IUPUI Indiana University-Purdue University Indianapolis JNK c-Jun-N-terminal kinase Ka Dissociation ... attributed I certify that all copyrighted material incorporated into this thesis/dissertation is in compliance with the United States’ copyright law and that I have received written permission...
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Regulation and function of the novel candidate tumor suppressor gene dlec1 in the HCT116 colorectal cancer cell line
Ngày tải lên :
16/10/2015, 15:37
... Alteration of these genes are responsible for self-sufficiency in growth signals , insensitivity to negative growth signaling, tissue invasion and metastasis, induction of angiogenesis and evasion ... categories including the following: repression of genes that are essential for the continuing of the cell cycle; coupling the cell cycle to DNA damage to inhibit cell division or initiate apoptosis; ... obtaining written informed consent from patients This study was approved by the Institutional Review Board, National University of Singapore, Singapore 4.15 Statistical analysis In the Real-time...
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Tài liệu Body Size: The Structure and Function of Aquatic Ecosystems pptx
Ngày tải lên :
17/02/2014, 19:20
... (Ophiuroids, Holothurians & Crinoids) Amphiura filiformis4 Comaster multifidus Cucumaria miniata1 Fluorometra serratissima1 Oligometra serripinna Ophiopholis aculeata Ophiopteris antipodium Ophiothrix ... Therefore, against the theoretical argument that invasibility (the ability to invade a population) is a more realistic measure of fitness than r or LRS, is the practical one that invasibility is ... National Center for Ecological Analysis and Synthesis, Santa Barbara JAMES F GILLOOLY University of Florida, Gainesville Introduction Body size is the single most important axis of biodiversity...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
Ngày tải lên :
18/02/2014, 16:20
... concluded before, the C-terminal segment of helix III, which is involved in the DNA recognition process, displays higher mobility than the preceding moiety, and Arg53 within the recognition helix appears ... implication for DNA binding that may be envisaged from the available conformational options within the recognition helix [2–4,7–9] is that the latter helix, firmly oriented within the helix–turn–helix ... and helix II, and a broad distribution of se, with a weighted average around 1.5 ns, like helix II Again as with helix II, some side chains in this part of the recognition helix (residues 45,...
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Tài liệu Báo cáo khoa học: Expression and function of Noxo1c, an alternative splicing form of the NADPH oxidase organizer 1 doc
Ngày tải lên :
19/02/2014, 06:20
... PX-mediated binding to phosphoinositides is involved in, but not absolutely required for, Nox3 activity This is in contrast with the observation that the PX domain by itself is essential for Nox3 ... activation (Fig 8C) The partial dependence on the lipid-binding activity may explain why Noxo1c with a weak but significant lipid-binding activity (Fig 5) is equivalent to Noxo1b in Nox3 activation ... phospholipid-binding activity of Noxo1c may be impaired In this context, it should be noted that Noxo1c contains the five-amino-acid insertion in the PX domain (Fig 1) To determine the effect of the insertion,...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
Ngày tải lên :
19/02/2014, 12:20
... nonoverlapping binding sites as only ImI competes with a-BTX binding [35] Thus, ImII may act in a noncompetitive manner The example of ImII shows that it is important to distinguish competitive from ... same binding site [35] The proline residue in position 6, which is conserved in all other a-conotoxins, appears to be the major determinant of the abilities of ImI and ImII to interact with a-BTX ... properties of the channel In situ hybridization and immunohistochemistry data show overlapping distributions for a variety of subunits, and electrophysiological and other functional studies in native...
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