for the mode of action in animals sufficient

... between animals and humans? NO Implications of kinetic and dynamic data for dose –response 26 1.Weight of Evidence for the Mode of Action in Animals • Introduction, Postulated Mode( s) of Action ... Sustained Toxicity Regenerative Cell Proliferation Tumour Development 30 1.Is the Weight of Evidence – for the Mode of Action in Animals Sufficient? • Introduction, Proposed Mode( s) of Action, ... we conclude? What are limitations? 27 1.Is the Weight of Evidence – for the Mode of Action in Animals Sufficient? • Introduction, Proposed Mode( s) of Action, Key Events – Proposed MOA(s) would...

Ngày tải lên: 15/04/2015, 09:16

... 6), the similar outcomes from the two analyses reinforce the overall conclusions while providing further insights into the impact of patient characteristics on dose response The key finding of the ... marker of disease severity, was the key covariate The impact of baseline FEV on the dose response in the absence of any model-based interpretation is shown in figure The figure shows the individual ... each of the comparators included in this analysis The most striking feature of the plot is that the response to indacaterol at the plateau exceeds the response of all comparators In other words,...

Ngày tải lên: 12/08/2014, 13:22

... essential for the continued existence of Hz-2V, since the development of the sterile, agonadal condition in all infected moths would lead to the extinction of the insect host, and the possibly the virus ... carrier of Hz-2V Conclusions The evolution of Hz-2V infection in H zea has resulted in the ability of the virus to produce two different types of infections in the insects that enable the virus ... participated in the design of the study, carried out the work with the insects, coordinated the project and assisted in the molecular analysis and drafting of the manuscript JPB conceived the study,...

Ngày tải lên: 18/06/2014, 22:20

... essential for the continued existence of Hz-2V, since the development of the sterile, agonadal condition in all infected moths would lead to the extinction of the insect host, and the possibly the virus ... carrier of Hz-2V Conclusions The evolution of Hz-2V infection in H zea has resulted in the ability of the virus to produce two different types of infections in the insects that enable the virus ... participated in the design of the study, carried out the work with the insects, coordinated the project and assisted in the molecular analysis and drafting of the manuscript JPB conceived the study,...

Ngày tải lên: 20/06/2014, 04:20

... quarter of non-smokers in a national sample of 43,732 adults in the US report exposure to ETS [47] Interestingly, such spread of exposure is occurring in the face of enacted laws banning smoking in ... use to incorporate various sources of information about exposure to ETS in order to differentiate between meaningful gradients of exposure for the purpose of the analysis On the other hand, the ... as well as other countries in the Eastern Mediterranean region (EMR) are experiencing an alarming increase in the popularity of waterpipe smoking [17,18] Although this form of smoking is generally...

Ngày tải lên: 12/08/2014, 18:21

... that for all solid tumors The linear model was not converging, all other models could be fitted Table Results of the fit to the Hodgkin data for the different dose-response models for sarcoma induction ... determining the location and dose to the origin of the tumor In this work another method was used by assuming certain shapes of dose-response curves based on model assumptions The free model ... Page 10 of 21 Table Results of the fits to the Hodgkin data for the different dose-response models for carcinoma induction Site Linear (Eq.6) b† All solid CV nc Full model (Eq.7) a* No fractionation...

Ngày tải lên: 13/08/2014, 16:20

... into the new model Principles of choosing models To establish a modeling WWTP, the first task is to select a mathematic model to describe the process of the WWTP, and the selection must fit the ... Combination of model, software and practical process in plant After the finish all the steps mentioned above, the next and the final step is to join them into the object WWTP With mathematic models ... performance Besides, the methods of directly measuring or indirectly obtaining are generally accepted So in our study, we choose ASM2D for the modeling WWTP c) Step Selection of modeling software...

Ngày tải lên: 05/09/2013, 09:08

... Rationale Aims of the study Scope of the study Methods of the study Design of the study Research questions: What is the present situation of teaching and learning vocabulary at Pre – Intermediate ... expectation 1.What you think of the games your teachers used in your vocabulary lesson? a b c d Very interesting and useful Rather interesting and useful Interesting and useful Uninteresting and useless ... with one another  Games can motivate learners by bringing fun to classes Games are highly motivating because they are amusing and interesting (Ersoz, 2000)  By bringing fun to the language...

Ngày tải lên: 29/01/2014, 14:36

... village and district Instead of blindly passing this information up to others in authority, however, the volunteers discuss their findings together during the Care Group meetings, and act upon it immediately, ... local staff of the MOH and other government officers within their supervision area The total number of staff, therefore, varies with the coverage of the project, but the ideal ratio of staff to ... management of fever, growth monitoring, and insecticide-treated bed net promotion and distribution The cost of maintaining the C-IMCI benefits of community-based models also becomes increasingly affordable...

Ngày tải lên: 12/02/2014, 12:20

... chronic in ammation in mammalian brain tissue both in vitro and in vivo, including in the detection of cerebral malaria Retooling of this reporter system also allowed systematic investigation of the ... to obtain glycoproteins The natural expression of glycoproteins is highly dependent on the host cell glycosylation machinery However, the re-engineering of the glycosylation pathway in the yeast ... complete conversion in a matter of hours As a demonstration of the biological relevance, this methodology was used to model the P-selectin-binding domain of the mucin-like glycoprotein PSGL-1 [73,74]...

Ngày tải lên: 18/02/2014, 17:20

... distinct portion of the input file by the MR scheduler to process If there are M such distinct portions of the input file, then there are R files on disk storage for each of the M Map tasks, for ... function with the line contents as the value and the line number in which it appeared in the file as its key The Map function then uses a regular expression to find all of the URLs in each line For every ... then joins the qualifying records with records from the Rankings file The MR program is initially given all of the UserVisits and Rankings data files as input Map Function: For each key/value input...

Ngày tải lên: 19/02/2014, 12:20

... sequences into a loop of the SH2 domain and screening for binding to the phosphotyrosyl ligand peptide [67] In principle, folded insertions should reduce the entropic penalty for inserting a long ... the B1 domain of IgG-binding protein G [42] Individual clones were examined for expression and grown in the presence of a 15N source, allowing 1H-15N HSQC NMR analysis of crude lysate for well-dispersed ... but the C-terminus of helix has shifted away from the core to accommodate the overpacking (as indicated by the arrow) Interestingly, most of the core residues retained near-ideal rotameric conformations...

Ngày tải lên: 19/02/2014, 12:20

... exception of K183, which is on the b9b10 hairpin, I186 and T57 are in, or close to, the ACh binding site In this view, the MII binding site resembles the PnIB binding site The binding sites of ImII ... strands and the C-terminus of the b2 (–) strand In addition to these observations, several lines of experimental evidence reinforce these cavities as the obvious access routes for the binding of competitive ... involved in the competitive binding site [16] Finally, the important residues for the binding of ACh and other competitive ligands are conserved in the AChBP sequence, explaining why AChBP also binds...

Ngày tải lên: 19/02/2014, 12:20

... common theme: the increasing importance of communal, as opposed to individual, agency, not only in accessing assets, but also in ensuring their protection and long-term sustainability In the urban ... focus The accumulation of one asset often results in the accumulation of others, while insecurity in one can also affect other assets Table Operational approaches and associated interventions of international ... and increasing demand for conspicuous consumption, leaves households needing more income earners than before Others of the next generation have left to acquire homes of their own, repeating their...

Ngày tải lên: 21/02/2014, 00:21

... highest provincial officials of nine provinces in the North of Laos The plan provides for the establishment of key areas for industrial development in the northern regions including hydropower, ... to the introduction of rubber planting in the villages in the Mai district The concept of social interfaces (Long 2001) provides the framework for the analysis of the conflicts that arise during ... Remarkably, the villagers not seem to be aware of the local authority's intended changes As in the case of rubber planting, the zoning plans are made without involving the villagers in the decision-making...

Ngày tải lên: 21/02/2014, 04:20

... trends in inuseofthe resource base in in the various state of freshwater resources, trends use various on the state ofof freshwater resources,trendsinuse ofof theresource base in the various on the ... necessary for decision making (Benin, Costa Rica) or there may be other reasons for the lack of key information for decision making Systems for information sharing are often available to the public ... national finance streams in in support of sanitation and drinkingwater.ItItisasubstantive input into the activities substantive input into the activities in support of sanitation and drinking water...

Ngày tải lên: 21/02/2014, 12:20

... for the subject The VTAMN smart cloth (Fig 7)32 measures several parameters of daily living, including activity, using sensors incorporated into the garment The activity-measuring module of the ... refers to the amount of time he/she is involved in dynamic activities, such as walking or running, as well as the amount of time spent in the static activities of sitting, standing and lying Objective ... locationindependent monitoring; thus, fulfilling the six key aims for improvement of healthcare as proposed by the Institute of Medicine, Washington, DC.9 Telemonitoring has become increasingly popular in recent...

Ngày tải lên: 05/03/2014, 21:20

... the difficulty of gaining funding and the changing landscape of reform in their cities In particular, we note the following: • The Alianza in Puerto Rico (in 2008, at the end of the grant) had ... be the same as the Ford goal of creating a sustained funding source Our assessment of these factors in the spring of 2009 is summarized in Table 3.1 Overall, the data indicate that one of the ... These included Amanda Datnow of the University of California, San Diego; Julie Marsh of the University of Southern California; and Cathy Stasz of RAND We thank them for their insights and efforts...

Ngày tải lên: 06/03/2014, 01:22

... amount of local information about the solutions of the Diophantine equations For equations of the form (1) it is perhaps difficult to exploit this information successfully since we neither know of ... some of the ideas of the proof of Fermat’s Last Theorem In this paper we give new improved bounds for linear forms in three logarithms We also apply a combination of classical techniques with the ... proof of Theorem Finally, the proof of Theorem is completed in Section 13, which deals with step (viii), by applying estimates for linear forms in three logarithms proved in Section 12 The computations...

Ngày tải lên: 06/03/2014, 08:21