for the mode of action in animals sufficient cont d

... Weight of Evidence – for the Mode of Action in Animals Sufficient? • Introduction, Proposed Mode( s) of Action, Key Events – Proposed MOA(s) would be described – Key events would be identified McLaughlin ... differences in either kinetic or dynamic factors between animals and humans? NO Implications of kinetic and dynamic data for dose –response 26 1.Weight of Evidence for the Mode of Action in Animals ... knowledge • E.g biology • Established MOA? 1.Is the Weight of Evidence – for the Mode of Action in Animals Sufficient? (Cont d) • • • • Introduction, Proposed Mode( s) of Action, Key Events Dose-Response...

Ngày tải lên: 15/04/2015, 09:16

... two dose-ranging studies in which indacaterol was delivered using the single-dose dry powder inhaler that is used for the commerciallyavailable product As one of these studies had a duration of ... years), study day, and study The final model equation is described in full in Appendix NLME modelling was carried out using SAS/STAT software (procedure NLMIXED), version 9.2 of the SAS system for Unix ... of the indacaterol data points indicated that with increasing dose the response asymptotically approached a maximum plateau The majority of study results for doses of 75 μg and above exceeded...

Ngày tải lên: 12/08/2014, 13:22

... essential for the continued existence of Hz-2V, since the development of the sterile, agonadal condition in all infected moths would lead to the extinction of the insect host, and the possibly the virus ... presented here demonstrate that virus dose affects both the level of infected progeny and the kind of infection found in insects hatching from eggs laid by virus infected females, indicating a direct ... competing interests Authors' contributions CPR participated in the design of the study, carried out the work with the insects, coordinated the project and assisted in the molecular analysis and drafting...

Ngày tải lên: 18/06/2014, 22:20

... essential for the continued existence of Hz-2V, since the development of the sterile, agonadal condition in all infected moths would lead to the extinction of the insect host, and the possibly the virus ... presented here demonstrate that virus dose affects both the level of infected progeny and the kind of infection found in insects hatching from eggs laid by virus infected females, indicating a direct ... competing interests Authors' contributions CPR participated in the design of the study, carried out the work with the insects, coordinated the project and assisted in the molecular analysis and drafting...

Ngày tải lên: 20/06/2014, 04:20

... and Lung Diseases in Adults • SD-standard deviation • TV- television Authors' contribution W Maziak, designed the study, conducted the analysis and wrote the 1st draft of the manuscript KD Ward, ... and sampling The target population consisted of adults 18–65 years of age residing in the greater city of Aleppo (around 2,500,000 inhabitants) Detailed description of the sampling design and ... categories, and recall period based on formative work conducted with key informants involved in the provision of health care as well as with residents, in addition to piloting in 20 randomly selected households...

Ngày tải lên: 12/08/2014, 18:21

... (brain and CNS) and 13 (salivary glands) carcinoma induction is plotted using the linear model indicated by the black line, the full model marked by the red line, the model neglecting fractionation ... quadratic model α = α + d = α + β D dT , DT (8) where DT and dT is the prescribed dose to the target volume with the corresponding fractionation dose, respectively For analyzing the Hodgkin data ... of point dose, the major disadvantage are the large errors involved when determining the location and dose to the origin of the tumor In this work another method was used by assuming certain shapes...

Ngày tải lên: 13/08/2014, 16:20

... accepted So in our study, we choose ASM 2D for the modeling WWTP c) Step Selection of modeling software With the development of mathematic models of wastewater treatment process, revelant modeling software ... and COD etc The instruments should be maintained regularly, cleaned on time and calibrated periodically, to guarantee the validity of data Table show what kinds of instruments are needed in Qinghe ... process The concept of Modeling WWTP was set up right for this kind of situation The Modeling WWTP was an integrated concept defined by collecting and abstracting all the elements in WWTP from the...

Ngày tải lên: 05/09/2013, 09:08

... Rationale Aims of the study Scope of the study Methods of the study Design of the study Research questions: What is the present situation of teaching and learning vocabulary at Pre – Intermediate level ... and expectation 1.What you think of the games your teachers used in your vocabulary lesson? a b c d Very interesting and useful Rather interesting and useful Interesting and useful Uninteresting ... Definition of Vocabulary 1.1.2 Concept of words 1.1.3 Words and their meanings 1.1.4 Words use 1.1.5 Form of words 1.2 Vocabulary in language teaching and learning 1.2.1 A neglect aspect of foreign...

Ngày tải lên: 29/01/2014, 14:36

... malnourished children, home-based management of fever, growth monitoring, and insecticide-treated bed net promotion and distribution The cost of maintaining the C-IMCI benefits of community-based models ... and Costs Scale-Up In Malawi, the USAID-funded Improving Livelihood Through Increased Food Security (I-LIFE) project adopted the Care Group model in mid2007 The five-year (2004–2009) integrated ... introduce innovations in communityoriented delivery and contribute to the global capacity and leadership for child survival and health through the dissemination of best practices For more information,...

Ngày tải lên: 12/02/2014, 12:20

... of hours As a demonstration of the biological relevance, this methodology was used to model the P-selectin-binding domain of the mucin-like glycoprotein PSGL-1 [73,74] This ligand is involved ... allowing the chemistry to be performed in either order The disulfide formation method is more rapid than the cycloaddition method, but under optimized conditions, both allow complete conversion in ... accepting and loading glycosylated amino acids has allowed the introduction of O-b -d- GlcNAc-l-Ser [25] and O-a -d- GalNAc-l-Thr [26] into proteins with efficiencies of 96% and  40% respectively In addition...

Ngày tải lên: 18/02/2014, 17:20

... data loader executed in parallel on each node to read in each line of the data sets, prepare the data as needed, and then write the tuple into a plain text file in HDFS Loading the data sets in ... execute the UDF/parser and load the data into the table and the top segment is the time to execute the actual query DBMS-X performs worse than Hadoop due to the added overhead of row-by-row interaction ... between the UDF and the input file stored outside of the database Vertica’s poor performance is the result of having to parse data outside of the DBMS and materialize the intermediate results on the...

Ngày tải lên: 19/02/2014, 12:20

... combinatorially design proteins de novo by inserting random sequences into a loop of the SH2 domain and screening for binding to the phosphotyrosyl ligand peptide [67] In principle, folded insertions should ... of the B1 domain of IgG-binding protein G [42] Individual clones were examined for expression and grown in the presence of a 15N source, allowing 1H-15N HSQC NMR analysis of crude lysate for ... solventexposed regions and buried hydrophobic regions, the destabilizing effects of overpacking or underpacking the core, the role of buried hydrogen bonds and charge–charge interactions in specifying...

Ngày tải lên: 19/02/2014, 12:20

... function and involvement in diverse central nervous system pathologies including pain, they are targets for many drugs and toxins In addition to the ACh binding site, many other binding sites ... subunit is not involved in the competitive binding site [16] Finally, the important residues for the binding of ACh and other competitive ligands are conserved in the AChBP sequence, explaining why ... quality models The first one will be referenced as the Ômanual methodÕ The process of building a model for a protein using this method is divided into different steps The first and critical step in...

Ngày tải lên: 19/02/2014, 12:20

... Sherraden distinguished between assets (identified as the stock of wealth in a household) and income (the flows of resources associated with consumption of goods and series and standard of living) ... building Sherraden; Ford Foundation Asset building and community development Ford Foundation Asset building in financial holdings, natural resources, social bonds, and human capital Coady International ... Dilemmas of household response sequencing during food shortage Institute of Development Studies Bulletin 24: 52-59 DFID 2000 Sustainable Livelihoods – current thinking and practice London: DFID Fan,...

Ngày tải lên: 21/02/2014, 00:21

... outlines the triple role buffaloes play in the farmers‟ livelihood: (1) working animals on the paddy fields, (2) a source of income and, (3) producers of fertilizer for the paddy fields The issue ... provides for the establishment of key areas for industrial development in the northern regions including hydropower, export, trade, tourism, mining, agriculture, and forestry for processing purposes ... regulations Formally, they fulfill the contract agreements, but the interests of the district and the company are not actually met The strategy of avoidance is often adopted by farmers in the context of...

Ngày tải lên: 21/02/2014, 04:20

... and was designed to provide a more detailed in depth understanding of country situations The interviews were conducted by a local consultant identified and contracted through the networks of the ... use ¡ Demand for water has increased dramatically resulting from, inter alia, increased wealth and increased demand for food and energy; ¡ Competition between uses has increased resulting in difficult ... safe drinking-water and the proportion of the population without sustainable access to safe drinking-water and basic sanitation Monitoring draws on the findings ofof household surveys and censuses...

Ngày tải lên: 21/02/2014, 12:20

... remain unattended in the event of an accident The increasing use of telemonitoring to support independent living inside and outside of the home inevitably raises many ethical questions regarding ... The device was initially placed at the sacrum, but during testing, subjects complained of difficulty attaching the device and discomfort when sitting with the device attached It was decided to ... decision-making process used when selecting a therapy The clinician examines the advantages and disadvantages of employing telemonitoring, and also examines the advantages and disadvantages of...

Ngày tải lên: 05/03/2014, 21:20

... stakeholders and being inclusive, using data for decisionmaking and sharing information widely, having shared goals and implementing joint and coordinated actions, and gaining a stable funding base ... of Indicators 17 and flourished In addition, we reviewed the interviews for cross-site themes We briefed yearly findings to the foundation and the grantees, and the foundation used those findings ... operations In addition, they created and pursued successfully strategies to find stable and sustained funding.2 • It implemented coordinated or joint actions and developed joint products: Organizations...

Ngày tải lên: 06/03/2014, 01:22

... that does not divide the denominator of the j-invariant of E This is not true as j(E) = 16384/5, giving us a contradiction For the convenience of the reader we point out that in Bennett and Skinner’s ... (En ) depends only on the residue class of n modulo K(l) Proof By Lemma 3.3, the residue class of Ln modulo l depends only on the residue class of n modulo l − From the definition of the integer ... i)p−1 and Y p − (2 − i)(2 + i)p−1 Since the discriminant D1 (viewed as an algebraic integer in Z[i] and not as an ideal) of the extension K(i)/Q(i) divides the discriminant of each of these polynomials,...

Ngày tải lên: 06/03/2014, 08:21