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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... widely distributed throughout the cells, including the axons Notably, the KIND2 domain has a specific ability to localize to dendrites by itself, whereas the KIND1 domain alone has lost this ability ... the MAP2 binding core is not only critical for targeting of v-KIND to neuronal dendrites, but also is indispensable for the function of v-KIND in negatively controlling dendrite growth and branching ... KIND2 is critical for this signaling pathway [12] HMW-MAP2 (referred to hereafter as MAP2) is known to modulate polymerization, stability and rearrangement of microtubules in neuronal dendrites...
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Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt
... separated by SDS ⁄ PAGE, using 4–12% NuPAGE Bis–Tris gels (Invitrogen) Gels were stained with silver nitrate [53] Immunoblot analysis was performed with antiserum against M sexta Spatzle-C108 (diluted ... acid is aligned with the ¨ second nucleotide of the corresponding codon The stop codon is marked with ’Ã’ The predicted secretion signal peptide is underlined The proteolytic activation site is ... characters, and statistical analysis was performed by the bootstrap method, using 1000 repetitions Quantitative RT-PCR analysis of Spatzle-1 mRNA ¨ level Fifth instar day larvae were injected with formalin-killed...
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Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf
... of the mobility of its protein backbone Analysis of the 15 N-relaxation data shows that the protein core (residues 277–328 and 373–413) is rather rigid This is in full agreement with the results ... possible that stop codon specificity is regulated by the conformation of this flexible part of the C-domain His334, His366 and Glu370 are located outside this loop, and this may explain the absence ... interaction with the stop codon recognition sites It should be noted that loop 357–367 is one of the most variable regions in the sequence of class eukaryotic release factors [33] (Fig S10) The majority...
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Báo cáo khoa học: Structure and function of the 3-carboxy-cis,cis-muconate lactonizing enzyme from the protocatechuate degradative pathway of Agrobacterium radiobacter S2 pdf
... presence of citrate, with isocitrate as a negative control, in order to determine the nature of the inhibition Surprisingly, both citrate and isocitrate acted as noncompetitive inhibitors (Fig ... ive site CDA It is therefore possible that binding to this site modulates the activity in the active site The effect could be transmitted through loop 224–231; this lies below the active site ... æ, where I is an individual intensity measurement and ÆI æ is the average intensity for this reflection with summation over all data b R-factor is defined as Si Fobs Œ–Œ Fcalci ⁄ S ŒFobsŒ, where...
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structure and function of the arabic verb
... writes /is writing” ya ∆lisu “he sits /is sitting” ya sʔalu “he asks /is asking” yaktubu Crucial to our analysis is the fact that the affixes and the root are mutually dependent, given that neither ... metalinguistic level where various modalities are realized, that is, tense, wish, and so on The spirit behind this representation seems to parallel those we have discussed earlier It aims at establishing ... retrieval system, without permission in writing from the publishers British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library Library...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 1 pps
... 1972, with permission from Elsevier) FIGURE 1.4 The ossicular chain as it is normally placed within the middle-ear cavity (adapted from Tos, 1995, with permission from Thieme Medical Publishers) ... with tinnitus and other hyperactive auditory disorders The book provides the basis for a broad understanding of the anatomy and function of the ear and the auditory nervous system, and it discusses ... scientists It is my hope that such knowledge can guide basic auditory research into clinically relevant questions The book is the third edition of books on the auditory system, the first, Auditory...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 2 ppsx
... cavity of a cat Comparison between the change in the ear's acoustic admittance and change in its transmission The admittance is given in dB relative to 100 cgs units and the transmission is given ... system equipped with a piston (Fig 2.14C) The admittance, Y, is the inverse of the impedance, 1/Z It is also known as the compliance, because it is a measure of how easily a current is induced in ... increases the sensitivity and the frequency selectivity of the ear and it explains why metabolic energy is necessary to maintain the normal sensitivity and frequency selectivity of the ear It also explains...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 4 potx
... frequency is discriminated Frequency discrimination is a prominent feature of hearing and its physiologic basis has been studied extensively because it is assumed to play an important role in discrimination ... auditory nervous system is important for understanding many disorders of the auditory system and it is a necessity for developing better treatments of disorders of the auditory system The introduction ... inhibited by presentation of a second tone when that tone is within a certain range of frequencies and intensities (inhibitory tuning curves) Analysis of the discharge pattern of single auditory...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 6 pot
... monkey, consists of only four constant vertex positive peaks (Fig 7.29) The reason is that the auditory nerve is much shorter in animals used in auditory experiments than it is in humans This causes ... the auditory nerve in the CN They are followed by a slower deflection on which peaks are often riding It is assumed that this component is generated by dendrites in the nucleus and its polarity ... stimuli were applied The upper recording is shown with vertex positivity as an upward deflection, the middle curve is the same recording shown with positivity downward These two curves are recordings...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 7 pot
... plasticity is in its infancy but the possibilities are there and future development most likely will provide adequate treatment of such disorders as tinnitus and hyperacusis This section will discuss ... 1962, with permission from the American Institute of Physics) It is not known how the threshold of the acoustic middle-ear reflex is set but it is interesting to note that individuals whose auditory ... middle-ear cavity has attracted attention because it is involved in a common disorder known as otitis media with effusion (OME), which is an inflammation of the lining of middle-ear cavity, the mastoid...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 8 docx
... neural plasticity This can occur with or without morphological changes Neural plasticity is necessary for the developing organism and it is beneficial to the mature organism because it can change ... similarities with presbycusis It mainly affects outer hair cells and speech discrimination is little affected when the hearing loss is moderate and limited to frequencies around kHz It is mainly ... the auditory nervous system is necessary in order to make an accurate diagnosis of central auditory disorders 6.1 Auditory Nerve Lesions to the auditory nerve are the most common cause of disorders...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 9 pdf
... in the disorder [188] Lyme disease is another disorder that often is accompanied by hyperacusis (and tinnitus) Autism is also often associated with discomfort from loud sounds Hyperacusis often ... patients with severe tinnitus and hyperacusis or phonophobia are clearly miserable, it is not obvious which medical specialty is best suited for taking care of such individuals It is, however, ... (recruitment of loudness) is mainly associated with disorders of the cochlea Hyperactive disorders of the auditory system are subjective tinnitus, hyperacusis, and recruitment of loudness Tinnitus...
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Báo cáo y học: "Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the protein" ppsx
... analysis Click proteins proteins proteinsthe inanalysis analysis tionalhere assignments of analysis in the analysis analysis FuncFunctional File usedof of thethe proteins analysis analysis Phyletic ... reaction catalyzed by Ldh In higher organisms, most cells not convert pyruvate to lactate and the reaction is limited to few tissues [9] In germ cells, where lactate is a preferred energy source [10], ... function and tissue specificity is accounted for by the age of the gene The relationship between phyletic age and tissue specificity is not explained by a gene's function (test statistic 339.1,...
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EXPRESSION AND FUNCTION OF THE PRL FAMILY OF PROTEIN TYROSINE PHOSPHATASE
... patients with Alzheimer’s disease (n = 4), multiple sclerosis (n = 2), crohn’s disease (n = 2), heart disease (n = 7), coronary artery disease (n = 5), hepatitis (n = 2), liver steatosis (n = 2), ... PRL-2 is a highly tissue specific event This is consistent with observations of normal tissues, which have suggested that the PRL en- 96 zymes may be pleiotropic signaling molecules with a diversity ... plagiarism and all materials appearing in this thesis/dissertation have been properly quoted and attributed I certify that all copyrighted material incorporated into this thesis/dissertation is in...
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Regulation and function of the novel candidate tumor suppressor gene dlec1 in the HCT116 colorectal cancer cell line
... Cancer is a class of diseases or disorders characterized by uncontrolled cell growth and the ability of these cells to spread, either through invasion or metastasis The development of cancer is a ... carcinoma Colorectal cancer is a disease originating from the epithelial cells lining the gastrointestinal tract The transition from normal epithelium to carcinoma is associated with acquired molecular ... DNA damage to inhibit cell division or initiate apoptosis; code for proteins involved in cell adhesion INTRODUCTION to prevent tumor cells from dispersing, and inhibit metastasis (Hirohashi and...
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Tài liệu Body Size: The Structure and Function of Aquatic Ecosystems pptx
... place without the written permission of Cambridge University Press First published in print format 2007 eBook (EBL) ISBN-13 978-0-511-29508-9 ISBN-10 0-511-29508-1 eBook (EBL) ISBN-13 ISBN-10 ... just a little of this excitement and serves as a useful synthesis of this area of ecology Finally, we wish to thank all the contributors for their efforts and remarkable efficiency, the British Ecological ... Reynolds number is given by Re ¼ ul/, where u is velocity, l is the linear length scale of interest, and is the kinematic viscosity of the fluid Crudely, for biological systems where size and...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
... rate; that is, it is largely determined by the heteronuclear NOE and thus it is most sensitive to high-frequency motions of the protein backbone On the other hand, the value of J(xN) is extracted ... from MD simulation is not as detailed as that provided by relaxation analysis, but it is consistent overall with the local motions observed by MF and ⁄ or RSDM analysis and with previous NMR structural ... that the assumption of isotropic overall tumbling is correct within the experimental error This is consistent with previous evidence obtained for the vnd ⁄ NK-2 HD [28], which is very closely related...
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Tài liệu Báo cáo khoa học: Expression and function of Noxo1c, an alternative splicing form of the NADPH oxidase organizer 1 doc
... to phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P2] with the highest affinity, which is consistent with the recent report of Cheng & Lambeth [19]; it also interacted with 3670 PtdIns(3)P ... PX-mediated binding to phosphoinositides is involved in, but not absolutely required for, Nox3 activity This is in contrast with the observation that the PX domain by itself is essential for Nox3 activation ... membrane recruitment of Noxo1c is at present unknown It is well established that p47phox undergoes phosphorylation in response to PMA, which is essential for membrane translocation of this protein...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
... expresnAChRs Its competitive antagonistic activity on neuronal sion of the b2 subunit [72,73] but more surprisingly, also on nAChRs was tested on bovine chromaffin cells where it expression of b3 subunits ... particularly around its agonist binding site Surprisingly, subtype (Table 1) This wide spectrum of activities makes it subsequent studies on knockout mice revealed that most 125 less useful as a tool for ... [80] It inhibits a7 and a3b2 nicotinic nAChRs with similar subunit, which is highly homologous to the a3 subunit, low nanomolar potencies and also potently blocks the a4b2 particularly around its...
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Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf
... at residues 72–73 is conserved in almost all sbwAFP isoforms, and is located at the point where the coil changes from left- to right-handed This sequence, combined with the disulphide bonds Cys67-Cys80, ... activity (80% of wild-type TH activity) [53] This is probably due to the difficulty in folding the protein, rather than suggesting that this face of TmAFP interacts with the ice surface It is important ... motifs is less conserved than the second rank This observation has also been seen in the sbwAFP isoform studies noted above This substitution pattern is not as obvious for TmAFP, where Ala is found...
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