fl 1200s byzantine of the paleologi family
Tài liệu Báo cáo khoa học: SREBPs: physiology and pathophysiology of the SREBP family ppt
Ngày tải lên :
18/02/2014, 13:20
... and pathophysiology of the SREBP family H Shimano at G1 [19] In particular, p21 is a direct target of SREBP [20] The role of SREBP-1a in the regulation of cell growth and the cell cycle might ... Physiology and pathophysiology of the SREBP family SREBP-1c and lipogenesis The SREBP family consists of three isoforms: SREBP1a, SREBP-1c, and SREBP-2 Each isoform has a different regulatory ... resistance [48] The exact roles of SREBP-1c ⁄ ADD1 are not yet fully defined SREBP and parasympathetic function in heart Parasympathetic stimulation of the heart involves activation of GIRK1 ⁄ 4,...
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Tài liệu Báo cáo khoa học: Proteasome involvement in the degradation of the Gq family of Ga subunits pptx
Ngày tải lên :
20/02/2014, 03:20
... activation of Ga16 and Gaq subunits Therefore the lack of change in the rate of degradation cannot be due to lack of receptor-activation of the alpha subunits Given that the activation of G proteins ... Accordingly, the levels of Ga16 decay were the same in the presence or absence of carbachol (Fig 4C) in cells expressing the M2R Also the activated mutant of A B C D Fig Functional assay of the Ga ... forms of Gaq and Ga16 have the same behavior as the wild-type forms argues in favor of the need of other proteins to stabilize the proteins in the membrane The interaction of Ga subunits with Gbc...
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Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
Ngày tải lên :
21/02/2014, 03:20
... factor of the Ets -family is involved in the regulation The members of the Ets -family of transcription factors bind to specific purine-rich sequences with a core motif of GGAA/T and control the expression ... CCAAT box at 324 bp upstream of the major transcription start site The presence of a CCAAT box and the absence of a TATA box seem to be one of the characteristics of the mouse integrin a3 gene ... previously reported the structures of the mouse a3 integrin subunit gene including the exon/intron organization and the alternative exon usage for the generation of variants of the a3 subunits (a3A...
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Báo cáo khoa học: Secondary transporters of the 2HCT family contain two homologous domains with inverted membrane topology and trans re-entrant loops docx
Ngày tải lên :
07/03/2014, 17:20
... ‘filtering’ of the blast searches strongly improves the specificity of the search (the ratio of true over false hits) but at the expense of much of the sensitivity of the search (the number of observed ... FEBS Structure of 2HCT transporters Fig Model of the structure of the transporters of the 2HCT family in class ST3 See text for explanation The charge distribution gives the sum of the positive ... the loop regions of a multiple sequence alignment of 16 representative members of the 2HCT family a2 repeats) enter the membrane from opposite sides of the membrane However, the position of the...
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Báo cáo Y học: Properties of group I allergens from grass pollen and their relation to cathepsin B, a member of the C1 family of cysteine proteinases pdf
Ngày tải lên :
08/03/2014, 22:20
... parasites of the genus Giardia are one of the earliest lineages of eukaryotic cells, and the Giardia protease is the earliest known branch of the cathepsin B family [23] Its phylogeny confirms that the ... concentrating the allergen according to the isoelectric point (pI) of the molecule A pH gradient from to 11 was established for the characterization of Phl p After completion of the run, the individual ... further explore the biochemical function of group I allergens Expression of glycosylated and nonglycosylated rPhl p reveals differing stability of these allergens The expression of rPhl p in the...
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Báo cáo khoa học: A structural overview of the PDI family of proteins docx
Ngày tải lên :
15/03/2014, 23:20
... Specifically, the side chains of Leu343 and Trp347, which are part of the linker between the b¢ and a¢ domains, are inserted into the PDI family of proteins hydrophobic cavity of the b¢ domain The binding ... Representation of the full-length ERp57 structure with the region recognized as the x-linker colored in red (B) The N-terminal part of the x-linker folds against the b¢ domain in the structures of the ERp57 ... conformations in the structures of the isolated b¢ domain and full-length proteins In the crystal structure of the b¢x fragment of human PDI, the C-terminal part of the x-linker turns back to contact the...
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Báo cáo khoa học: Characterization of ubiquitin-like polypeptide acceptor protein, a novel pro-apoptotic member of the Bcl2 family pptx
Ngày tải lên :
17/03/2014, 10:20
... performed immunoblotting of the 33.5 kDa Ubi-L adduct using an antibody against synthetic peptide based on the sequence of Bcl-G The results of the Fig Primary structure of Bcl-G (A) The predicted amino ... the gene products of Bcl-G and Ubi-L The fourth column indicates the number of the first and last amino acid of the identified Bcl-G and Ubi-L peptides, whereas the fifth shows the corresponding ... bonds between the C terminal of the glycine residue of Ubi-L and the lysine of Bcl-G The 33.5 kDa Ubi-L adduct was digested by V8 protease and subjected to MALDI-MS analysis The data in the first column...
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Báo cáo khoa học: New members of the brachyurins family in lobster include a trypsin-like enzyme with amino acid substitutions in the substrate-binding pocket potx
Ngày tải lên :
23/03/2014, 03:20
... modelling The aim of the present work was to study the diversity of trypsins in the digestive gland of P argus, with focus on: (a) the position of lobster trypsins within the brachyurins family ... from the 3¢ UTR region of PaTry2 However, the 3¢ UTR sequence of PaTry4 differed to those of the other trypsins in more than 36% of its nucleotides All ORFs started at the first ATG codon of the ... the wall of the binding pocket and allow the access of bulky residues, like Arg and Lys, whereas the basic side chain of these residues is stabilized by Asp189 (chymotrypsin numbering) near the...
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Báo cáo khoa học: A hydrophobic segment within the C-terminal domain is essential for both client-binding and dimer formation of the HSP90-family molecular chaperone pptx
Ngày tải lên :
23/03/2014, 20:22
... required for the interaction with the middle domain, which mediates the dimerization of HSP90, and the other, the identification of the minimal region of the C-terminal domain for the client binding ... closely related to the client-binding function of the proteins [32,38] Taken together, we assumed that formation of the complex of the region carrying the hydrophobic segment of GRP94 is mediated ... explain the lack of the binding of the C-terminal domain of HtpG to a client protein [17] We critically reviewed the previous study that demonstrated dimer formation of the hydrophobic segment of...
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Báo cáo khoa học: The yeast stress response Role of the Yap family of b-ZIP transcription factors The PABMB Lecture delivered on 30 June 2004 at the 29th FEBS Congress in Warsaw potx
Ngày tải lên :
30/03/2014, 16:20
... the formation of an intermolecular bond occurs between the Orp1 Cys36 and the Cys598 of Yap1 leading to its activation The subsequent formation of the Yap1 Cys303-Cys598 disulfide bond masks the ... with activation of FRM2 transcription, but also with growth in increasing concentrations of cadmium but not of H2O2 Because of the high degree of homology to Yap1, the role of the Yap2 cysteine ... expression, often with overlapping functions [47] In all, the expression of 10% of the yeast the genome is affected by an osmotic upshift This includes most of the genes typically induced by the ESR,...
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báo cáo hóa học: " A psychometric evaluation of the PedsQL™ Family Impact Module in parents of children with sickle cell disease" pptx
Ngày tải lên :
18/06/2014, 18:20
... school functioning The total score is comprised of the average of all items in the questionnaire The psychosocial summary score is comprised of the average of the items in the emotional, social, ... (0.5) and large (0.8) [21] Floor/Ceiling Effects The percentage of scores on the PedsQL™ Family Impact Module that were at the ceiling (top of the scale) or floor (bottom of the scale) were calculated ... whether the Family Impact Module is a valid and reliable measure for assessing the impact of SCD on parents and families We therefore analyzed the following properties of the PedsQL™ Family Impact...
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Báo cáo y học: "Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues" doc
Ngày tải lên :
09/08/2014, 10:21
... immunoreactive The number of cells of a given type that reacted with a specific antibody divided by the total number of cells of that given type was defined as the percentage of reactivity The mean ... responsible for acquisition of data; AEK was responsible for design of the study, interpretation of the data and manuscript preparation, and all authors have approved the content of the manuscript Acknowledgements ... that they have no competing interests Authors' contributions SS was responsible for design of the study, acquisition of data, analysis and interpretation of the data and manuscript Page of 10...
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EXPRESSION AND FUNCTION OF THE PRL FAMILY OF PROTEIN TYROSINE PHOSPHATASE
Ngày tải lên :
24/08/2014, 11:44
... results of these studies have expanded our current understanding of the expression and function of the PRL family of enzymes as well as of the role these important signaling molecules play in the ... in the vascular endothelial cells, fibroblasts, and lymphocytes of the choroids, in the corneal epithelium and endothelium, and in the fibroblasts of the cornea and sclera In the corneal epithelium, ... of Thesis/Dissertation: Expression and Function of the PRL Family of Protein Tyrosine Phosphatase For the degree of Doctor of Philosophy Choose your degree I certify that in the preparation of...
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Tài liệu The Unix Family of Operating pdf
Ngày tải lên :
21/12/2013, 11:15
... Versions of Unix There are several versions of Unix Until a few years ago, there were two main versions: the line of Unix releases that started at AT&T (the latest is System V Release 4), and another ... keyboard and then press the RETURN key The lefthand column tells you what will happen After you try the commands, you’ll have a better idea of the ones you want to learn more about You can then get ... first, and then break it into task-oriented sections Each section shows the best command to use for a task, explains what it does, and shows the syntax (how to put the command line together) The syntax...
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Tài liệu 77 Introduction to the TMS320 Family of Digital Signal Processors docx
Ngày tải lên :
25/12/2013, 06:16
... “opcode” of the instruction The opcode is the unique identifier of the instruction The next four bits, 1000, are the shift of the operand Then there is one bit (zero in this case) to signal that the ... simplified form the key features of the TMS320C30 The major parts of the DSP processor are the memory, the CPU, the peripherals, and the direct memory access (DMA) unit Each of these parts will ... ALU of the TMS320C30 The heart of the TMS320C30 is the CPU consisting, primarily, of the multiplier and the ALU The CPU configuration is shown in Fig 77.16 which depicts the multiplier and the...
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Tài liệu Đề tài " Statistical properties of unimodal maps: the quadratic family " pptx
Ngày tải lên :
16/02/2014, 05:20
... Sketch of the proof of the phase-parameter relation The proof of the phase-parameter relation uses ideas from complex analysis We will provide a sketch of the proof assuming familiarity with the ... Ξi (Ci ) ∩ Fκ then Ξi (Ci ) = Ji+1 [g] We will concentrate on the analysis of the regularity of Ξi for the special class of simple maps f : one of the good properties of the class of simple maps ... to the validity of the Law of Large Numbers Are other theorems still valid, like the Central Limit or Large Deviation theorems? Those questions are usually related to the rates of mixing of the...
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Tài liệu Báo cáo khoa học: Regulation of the members of the mammalian heat shock factor family doc
Ngày tải lên :
18/02/2014, 04:20
... by the recent findings that different members of the HSF family are able to interact, both structurally and functionally, thereby impacting the actions of their partners The interplay among the ... how the developmental activity of HSF1 is regulated The identity of the developmental signal that promotes a monomer-to-trimer transition of HSF1 in the olfactory epithelium warrants further ... In accordance with the fundamental role of HSF1 in the heat shock response, the requirement of HSF1 and HSF4 in development of the lens and olfactory epithelium is limited to the postnatal period,...
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Tài liệu Báo cáo khoa học: Arabidopsis thaliana BTB⁄ POZ-MATH proteins interact with members of the ERF⁄AP2 transcription factor family ppt
Ngày tải lên :
18/02/2014, 06:20
... in the central cylinder of the root, but not in the lower parts of the hypocotyl (a) Rosette leaves were stained in the vascular tissue of the leaf blade, whereas the petiole and older parts of ... interaction, as this has the potential to predict possible protein binding to the BPMs It will also be of importance to define the functional impact of the BPM family on the activity of ERF ⁄ AP2 transcription ... staining within the vascular tissue at the end of the leaf blade, whereas the basal parts close to the petiole remained almost unstained We observed clear GUS expression in the primary root of 7-day-old...
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Tài liệu Báo cáo khoa học: Looking for the ancestry of the heavy-chain subunits of heteromeric amino acid transporters rBAT and 4F2hc within the GH13 a-amylase family ppt
Ngày tải lên :
18/02/2014, 13:20
... and S Janecek Origin of rBAT and 4F2hc within the GH13 a-amylase family Fig The CSRs of the hcHAT proteins and the GH13 a-amylase family members A list of the abbreviations of proteins and enzymes ... lack of domain B protruding out of the TIM barrel in the place of loop connecting the b3-strand to the a3-helix [9,21] Sharing domain B by rBATs and GH13 enzymes, and especially the sequence of the ... of the hcHAT proteins and the GH13 a-amylase family members The tree is based on the alignment of complete sequences and calculated including gaps The numbers represent the bootstrap values The...
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Tài liệu Báo cáo khoa học: Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family pptx
Ngày tải lên :
19/02/2014, 00:20
... to the residue in the midpoint of the respective loop, as shown in Fig To the east of the active site the 37- and 60-loops border the S2¢ pocket of the proteinase The observed differences in the ... below) The southern boundary of the active site cleft of DESC1 is formed by the 145 autolysis loop The backbone of this loop differs markedly from the other serine proteinases, making the active ... that the most similar regions of these proteinases mediate interaction of the two b-barrels, formation of the catalytic machinery and structures required for binding of the main chain of the substrate...
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