fibrosis in crohn s disease

... uveitis occurs in approximately 4% of patients with Crohn' s disease Presentation with hypopyon is unusual and raises suspicion of either alternative systemic inflammatory disorders such as Behçet 's ... rifabutin levels, resulting in an increase frequency of uveitis, this could explain the acute onset of uveitis in our case[10] Conclusion The use of rifabutin to treat Crohn' s disease is controversial ... Shah SA: Ocular manifestations of inflammatory bowel disease Inflammatory bowel diseases 2004, 10(2):135-139 Duker JS, Brown GC, Brooks L: Retinal vasculitis in Crohn' s disease American journal...

Ngày tải lên: 11/08/2014, 10:22

... Clin Immunol 1997;99:179–85 25 Rautio M, Jousimies-Somer H, Kauma H, et al Liver abscess due to a Lactobacillus rhamnosus strain indistinguishable from L rhamnosus strain GG Clin Infect Dis 1999;28:1159–60 ... colonization in all the patients, including those taking metronidazole All patients in this study had active Crohn s disease, despite use of steroids and immunomodulatory drugs Their PCDAI scores improved ... et al Intestinal permeability in patients with Crohn s disease and ulcerative colitis and their first degree relatives Gut 1994;35:68–72 16 Salminen S, Isolauri E, Salminen E Clinical uses of...

Ngày tải lên: 05/03/2014, 12:20

... Dovepress Parashette et al to frequent relapses and less than favorable maintenance of clinical remission Since CD may progress from intestinal inflammation to strictures and penetrating disease, including ... achieved disease remission on mesalamine, less than 50% of patients were able to sustain disease remission after one year of maintenance therapy.9 Although studies have shown that corticosteroids are ... fatal sepsis, pneumonia, severe viral gastroenteritis, abdominal abscess, arm cellulitis, histoplasmosis).53 Other studies also suggest the occurrence of Listeria m ­ onocytogenes meningitis, cutaneous...

Ngày tải lên: 22/03/2014, 10:20

... Crohn' s disease susceptibility Using a case-control study, we have shown that a SNP in an intron of this gene is associated with Crohn' s disease Whether this SNP is in close proximity to another disease- causing ... and the host innate immune system [4] NOD2 is expressed in monocytes and in intestinal epithelial cells, including Paneth cells [5] Crohn' s disease- associated mutations in NOD2 result in defective ... to Crohn' s disease will be the focus of future studies The CSF1R gene is an intriguing candidate gene for Crohn' s disease susceptibility for several reasons First, it is involved in innate immunity...

Ngày tải lên: 11/08/2014, 10:23

... dermatosis (Sweet s disease. ) On days 4-6 of admission, his symptoms started to improve He was still having headaches and spiking temperatures of up to 38.9°C in the evenings but the skin lesions ... treatments are potassium iodide and colchicine Second-line agents include indomethacin, cyclosporine and dapsone Conclusion This is a case of aseptic meningitis secondary to neuroSweet disease in a ... with Crohn s disease The association of Crohn s disease with Sweet s syndrome was previously described in the literature This is the first case, to our knowledge, of the association of neuro-Sweet...

Ngày tải lên: 11/08/2014, 14:20

... colonic involvement and extraintestinal features in these patients The skin lesions have been observed in patients with active Crohn' s disease, but sometimes it can precede the onset of intestinal symptoms ... are 1) skin lesions preceded by a nonspecific respiratory or gastrointestinal tract infection, vaccination or associated with inflammatory diseases such as autoimmune disorders, infections, hemoproliferative ... Sweet 's syndrome is one of the groups of neutrophilic dermatoses that include pyoderma gangrenosum and whose association with ulcerative colitis and Crohn' s disease is well established Sweet 's syndrome...

Ngày tải lên: 11/08/2014, 21:22

... pathogenesis Therapeutic studies in AD models Access to good animal models is crucial to success in developing disease- modifying therapeutics However, AD neuropathology is incomplete in the Ab-expressing ... by crossing PDGF–a-synuclein and APP-SweInd, which led to a 1.6-fold increase in a-synuclein inclusions in comparison with transgenic mice that expressed only wild-type human a-synuclein Similar ... cross-breeding experiments is strengthened if expression and deletion of the gene (s) results in the opposite outcome, or if the results are substantiated by in vitro studies or analyses of clinical samples...

Ngày tải lên: 16/02/2014, 09:20

... essential role for Parkin in oxidative stress [77] and Drosophila Parkin mutants show increased sensitivity to oxidative stress [78] Implication of PINK1 in oxidative stress processes has also ... Autosomal recessive genes in Parkinson s disease Protein phosphorylation and signalling pathways PINK1 has a strongly predicted, conserved serine ⁄ threonine kinase domain [12] and has been shown ... has been described [16,17] PINK1 is of great interest to research into mitochondrial dysfunction in PD PINK1 Autosomal recessive genes in Parkinson s disease contains a putative catalytic serine–threonine...

Ngày tải lên: 18/02/2014, 14:20

... ubiquitously expressed transcription factors Another possibility is that mutant huntingtin itself has a characteristic that is unique when this protein is expressed in the striatum It appears that ... neurotransmission, and abnormalities in cannabinoid signalling or modulation of dopamine signalling or both have been implicated in a number of neurodegenerative diseases including HD and Parkinson disease, ... (1993) Loss of cannabinoid receptors in the substantia nigra in Huntington s disease Neuroscience 56, 523–527 Richfield, E.K & Herkenham, M (1994) Selective vulnerability in Huntington s disease: preferential...

Ngày tải lên: 16/03/2014, 18:20

... either polyglutamine or polyalanine expansions in Huntington disease, Huntington related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies [27] Taken ... Foundation, SADF (Insamlingsstiftelsen for ¨ Alzheimer- och Demensforskning), Socialstyrelsens Stiftelser, Stiftelsen for Alderssjukdomar, and Svenska ¨ ˚ Lakaresallskapet ¨ ¨ FEBS Journal 272 ... eEF2 in its N-terminus (Thr56) that subsequently blocks eEF2 binding to ribosomes, resulting in decreased rates of protein synthesis Dephosphorylation of eEF2 relieves its translational restriction...

Ngày tải lên: 16/03/2014, 22:20

... a fellowship from the American Parkinson s Disease Association A.B.W is supported by the Michael J Fox Foundation for Parkinson s Disease Research, the American Parkinson s Disease Association, ... variants segregate with disease in large families The most common of the known LRRK2 mutations (G201 9S) increases in vitro kinase activity, analogous to mutations in the same kinase subdomain in ... kinase domain that inactive kinase activity likewise reduces toxicity In one cell model, LRRK2 expression may cause increases in caspase-8 activation as a result of a kinase-sensitive association...

Ngày tải lên: 23/03/2014, 04:20

... mechanisms of many disease processes and will continue to impact our understanding of disease pathogenesis This minireview will examine the previous studies of genes for ROCO or LRRK2 homologs in slime ... enhanced sensitivity to endoplasmic reticulum stress induced by tunicamycin, a specific inhibitor for N-linked glycosylation Interestingly, this enhanced sensitivity is suppressed in mutant worms with ... known as frequent ‘contaminants’ in the process of searching binding proteins, the in vivo evidence for the relationship between ROCO proteins and cytoskeletons in D discoideum suggests a need...

Ngày tải lên: 23/03/2014, 04:20

... family-based study, but varied in subsequent reports, depending on sample size, study design, inclusion of probands in the analysis and methods of calculation To address some of these issues, Healy ... other social issues Genetic testing should preferably be supported by a multidisciplinary team with expertise in handling pre-testing and post-testing related problems A recent study has demonstrated ... a haplotype that increases disease risk when present in two copies was identified among sporadic Chinese PD population in Singapore [32] However, other studies did not reveal association with any...

Ngày tải lên: 23/03/2014, 04:20

... Epidemiologic, clinical, and therapeutic aspects of Parkinson s disease Parkinsonism and Parkinson s disease 34 Cognitive deficits in Parkinson s disease 55 Depression in Parkinson s disease 88 Anxiety, ... guidelines, case studies and rating scales will meet the needs of all clinicians working with Parkinson s disease patients Sergio E Starkstein was Assistant Professor of Psychiatry at Johns Hopkins ... the disease itself This subject is further discussed in chapter Clusters of parkinsonian signs and subgroups of the disease A question now arising is whether PD constitutes one single and clinically...

Ngày tải lên: 28/03/2014, 22:21

... ions were accelerated through 10 KeV Argon was used as the collision gas RESULTS AND DISCUSSION Analysis of LPS As shown in Fig 1, a ladder-like pattern was observed in the SDS/PAGE profiles of ... b in order of 1H chemical shift The 1H signals were assigned using DQF-COSY, TOCSY and ROESY spectra, and the 13C signals were assigned using HMQC and HMBC spectra Some of the coupling constants ... analysis As no other O-substituted sugar was observed in the methylation analysis, OPS had a linear structure Thus, the nonsubstituted Rha was estimated to be located at the nonreducing terminus...

Ngày tải lên: 31/03/2014, 23:20

... tissues were dissected from embryonic brain and trypsinized into single-cell suspension using sterilized micropipette tips The cells were resuspended in DMEM and Ham 's F12 at 1:1 (D-F12), supplemented ... expression, 15 mg wet tissues with microcarriersRPE cells and tissues with microcarriers were lysed for ELISA assay The lysis buffer was prepared according to the manual in a ratio of mg tissue ... used for the analysis of other data via the SPSS 10.0 soft packages (SPSS Inc., USA) The criterion for statistical significance was set at p < 0.05 Results RPE-CM protects against rotenone and...

Ngày tải lên: 18/06/2014, 15:20

... blow, sudden loss of consciousness, or paralysis [14] - Posture and Gait Score: This score includes questions 13-15 and 29-30 of the UPDRS, and has been used as an outcome measure to assess gait ... extremities [7] - Parkinson s Disease Questionnaire-39 (PDQ-39): This questionnaire examines dimensions of quality of life specific to PD patients and is scored on a 5point scale As a disease- specific ... unless otherwise stated Results Four participants completed all 10 sessions; one participant withdrew after four training sessions due to transportation issues There were no serious adverse events...

Ngày tải lên: 19/06/2014, 08:20

... an increased fall risk in older adults in general, as well as in patients with PD [9-13], suggesting that this aspect of gait may have clinical utility as an aid in fall risk assessment More specifically, ... they had clinically significant musculo-skeletal disease, cardio-vascular disease, respiratory disease, uncontrolled hypertension, diabetes or symptomatic peripheral vascular disease, other neurological ... reported are based on two-sided comparison A p-value = 0.05 was considered statistically significant All statistical analyses were performed using SPSS 11.5 and SAS 8.2 (Proc Mixed) Results Subject...

Ngày tải lên: 19/06/2014, 10:20

... sub-phases of the step Study Protocol The walking trials were done in the on medication state in PD subjects The insoles with VDs were inserted into the subject 's shoes Subjects walked for minutes ... Conclusion This study indicates that the step-synchronized vibration stimulation of the soles improves gait steadiness in Parkinson 's disease patients with predominant balance impairment The suprathreshold ... Boecker H, Ceballos-Baumann A, Bartenstein P, Weindl A, Siebner HR, Fassbender T, Munz F, Schwaiger M, Conrad B: Sensory processing in Parkinson 's and Huntington 's disease: investigations with 3D H(2)(15)O-PET...

Ngày tải lên: 19/06/2014, 10:20

... of Parkinson s Disease Figure stimuli Schematization of responsiveness of PD subjects to visual Schematization of responsiveness of PD subjects to visual stimuli The diagram represents schematically ... controls in response to an attentional stimulus (increasing stride length, decreasing cadence), would suggest that, in advanced stages of disease, as a consequence of progression of motor symptoms, ... of subjects included in the AS condition (data missing in four out of 15 PD subjects for AS), two distinct statistical comparisons have been performed: 1) baseline vs BOF vs FOF, 2) baseline vs...

Ngày tải lên: 19/06/2014, 10:20