Ngày tải lên: 04/10/2012, 10:02
... positively associated with the risk of type 2 DM. There was an indication that the effect of unprocessed meat intake on type 2 DM may be modified by BMI. Key words: type 2 diabetes, meat intake, middle-aged ... the risk of type 2 diabetes mellitus (type 2 DM) in ecological and migrant studies [1;2]. However, data on associations between total meat and type of meat intake and the risk of type 2 DM are ... outcome criteria were met by 1094 participants, which are referred to herein as confirmed cases of type 2 DM. We performed analyses with both confirmed and all type 2 DM cases and found similar...
Ngày tải lên: 31/10/2012, 16:49
Tài liệu Báo cáo khoa học: Membrane targeting and pore formation by the type III secretion system translocon pdf
... LcrV facilitate type III secretion activ- ity by Yersinia pseudotuberculosis. J Biol Chem 285, 25269–25284. 61 Tengel T, Sethson I & Francis MS (2002) Conforma- tional analysis by CD and NMR ... encoded by the pcrGVH-popBD operon of the Pseudomonas aeruginosa type III secretion system. Infect Immun 71, 2230–2233. 86 Sundin C, Thelaus J, Broms JE & Forsberg A (2004) Polarisation of type ... formation by type III toxin translocators of Pseudomonas aeruginosa. Biochemistry 45, 8117–8123. 50 Bro ¨ ms JE, Sundin C, Francis MS & Forsberg A (2003) Comparative analysis of type III effector...
Ngày tải lên: 14/02/2014, 22:20
Tài liệu Báo cáo khoa học: TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor pdf
... family are regulated by endogenous protease inhibitors, which include Kunitz -type inhibitors and serpins [2]. Hepato- cyte growth factor activator inhibitor type 1 (HAI-1), a Kunitz -type serine protease ... not inhibited by HAI-1–K1. By contrast, the protease activity of TMPRSS13 was potentially inhibited by HAI-1–K1. We therefore T. Hashimoto et al. Protease TMPRSS13 is inhibited by HAI-1 FEBS ... [13]. This substrate was not cleaved by enterokinase itself, or by the untreated pro-TMPRSS13. The enterokinase-treated N C TM LDLA SRCR SPD SS Pro-TMPRSS13 (wild -type) AMTGR VGG 325 I 326 N myc-His- C SS DDDDKIVGG Recombinant...
Ngày tải lên: 15/02/2014, 01:20
Tài liệu Báo cáo khoa học: ¨ Induction of Kruppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I pptx
... determined by real-time PCR. (B) Protein levels of KLF4 were determined by western blot. (C) mRNA levels of hSR-BI were determined by real-time PCR. (D) Protein levels of hSR-BI were determined by western ... 24 h. KLF4 inhibition was detected by western blot (C). mRNA levels of hSR-BI were determined by real-time PCR (D) and protein levels of hSR-BI were determined by western blot (E). Ctrl, PMA-differentiated ... PMA-differentiated THP-1 macrophages stimulated by HDL 3 . The specificity of the assay was verified by using mutant oligonucleotides, which failed to bind to KLF4, and by antibody competition. Mean- while,...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: High-affinity ligand binding by wild-type/mutant heteromeric complexes of the mannose pptx
... of this type exhibit the predicted amount of binding only if the heterodimer is tethered by the wild -type partner. By contrast, we found that, if the heterodimer is tethered to the resin by the ... were analyzed by an immunoprecipitation assay using M2 anti-FLAG affinity resin. The resin pellets were washed to remove unbound proteins, separated by reducing SDS ⁄ PAGE, and analyzed by immunoblotting ... ligand binding by wild -type/ mutant heteromeric complexes of the mannose 6-phosphate/insulin-like growth factor II receptor Michelle A. Hartman 1 , Jodi L. Kreiling 2 , James C. Byrd 1 and Richard...
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khoa học: Metabolic control of mitochondrial properties by adenine nucleotide translocator determines palmitoyl-CoA effects Implications for a mechanism linking obesity and type 2 diabetes pdf
... ADP ratios: the former decreased by 63 ± 4%, and the lat- ter increased by 352 ± 34%. The reduced to oxidized coenzyme Q ratio (QH 2 ⁄ Q) increased by 42 ± 9%, and Dw increased by 13 ± 1 mV (9%). The QH 2 ⁄ ... of the ATP in ⁄ ADP in ratio by ATP synthesis and the negative control by the proton leak. The negative control of the ATP in ⁄ ADP in ratio by the ANT increased by 100% and 82% with succinate ... to oxidized coenzyme Q (QH 2 ⁄ Q) by 42 ± 9%, Dw by 13 ± 1 mV (9%), and the intramitochondrial ATP ⁄ ADP ratio by 352 ± 34%, and decreases the extramitochondrial ATP ⁄ ADP ratio by 63 ± 4% in actively phosphorylat- ing...
Ngày tải lên: 19/02/2014, 05:20
Tài liệu Báo cáo khoa học: Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides ppt
... curves were generated by least-squares fit to the mixed -type noncompeti- tive inhibition model represented by Scheme 5. The underlying mathematical model was automatically derived by DYNAFIT [11] under the ... 0 Mixed type 5 0 0 0.951 0.989 S + E K m ES E + P K s k cat ES 2 K i EI + I K is ESI + I + S Scheme 5. Mixed -type mechanism. Table 2. Best-fit values of inhibition constants in the mixed -type kinetic ... competitive, whereas including high substrate concentrations reveals the mixed -type noncompetitive mechanism. Experimental procedures Materials Aminoglycosides were purchased from Sigma-Aldrich Corp. (St...
Ngày tải lên: 19/02/2014, 06:20
Tài liệu Orthodontists and patient´s aesthetic perception to different types of profi les modifi ed by a computer program pdf
... Quiroz MF et al. Orthodontists and patient ´s aesthetic perception to different types of profi les modifi ed by a computer program 168 www.medigraphic.org.mx Este documento es elaborado por Medigraphic In ... attractive, whereas lower-jaw prognathism was perceived by all three groups as the least attrac- tive. General public agrees with the research con- ducted by Mantzikos and Lew & al with respect to ... male profile with bimaxillary protrusion was not well accepted by either of the three groups. This differs with findings reported by Manganzini et al, where male profile with skeletal bimaxillary...
Ngày tải lên: 19/02/2014, 17:20
Tài liệu Báo cáo khoa học: Enzymatic properties of wild-type and active site mutants of chitinase A from Vibrio carchariae, as revealed by HPLC-MS pptx
... 20 °C by the addition of acetic acid to a final concentration of 10% and the glycosylation products were analyzed by using the calibrated HPLC-MS. The chitooligomers formed by the wild -type enzyme ... reaction times at 20 °C by the addition of acetic acid to 10% and applied to calibrated HPLC-MS. For each substrate, the calculated concentrations of the products formed by the wild -type (solid line) ... [34]. Acknowledgements This work was supported by the Thailand Research Fund for Young Researchers (TRG-4580058), by a grant from Suranaree University of Technology (SUT- 1-102-46-48-06), and by a grant from the German...
Ngày tải lên: 20/02/2014, 01:20
Tài liệu Báo cáo Y học: The Fc receptor c-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin ppt
... integrin a2b1 and CD36 was detected by flow cytometry using specific antibodies to either receptor (filled histograms). Background fluorescence was obtained with an isotype control antibody (empty histograms). Fig. ... coding for wild -type GPVI (K562/F1-c) or a cytoplasmic- tail-depleted GPVI (K562/C1-c). Cells were stimulated with PMA for the times indicated, and protein extracts separated by SDS/PAGE under ... aggregation induced by the glycoprotein VI agonist convulxin. Eur. J. Biochem. 268, 5242– 5248. 30. Poole, A.W. & Watson, S.P. (1995) Regulation of cytosolic calcium by collagen in single...
Ngày tải lên: 22/02/2014, 07:20
Professional SQL Server™ 2005 CLR Programming with Stored Procedures, Functions, Triggers, Aggregates, and Types docx
... framework for both value types and reference types (classes, pointers, and interfaces). This framework defines how types can be declared, used, and managed. The CTS describes type safety, 4 Chapter ... code base. In the Microsoft .NET context, this is implemented by the .NET Framework as well as custom types created by users (all types in .NET must derive from System.Object). CLS The CLS defines ... User-defined aggregates (UDA) ❑ User-defined types (UDT) Stored procedures are stored collections of queries or logic used to fulfill a specific requirement. Stored procedures can accept input parameters,...
Ngày tải lên: 05/03/2014, 20:20
Báo cáo khoa học: Regulated expression by PPARa and unique localization of 17b-hydroxysteroid dehydrogenase type 11 protein in mouse intestine and liver pdf
... be required to clarify these possibilities. Experimental procedures Animals and treatments All procedures involving animals were approved by the Meiji Pharmaceutical University Committee for Ethics ... expected, but were contaminated with the adjacent cytoplasmic proteins by our manual separation, as evidenced by significant contamination by L-FABP proteins. However, a significant amount of 17b-HSD11 ... portions indicated by circles were homogenized to obtain total proteins. (B) Equal amounts of proteins (20 lg) were separated by SDS ⁄ PAGE, and expression levels of 17b-HSD11 and L-FABP were analyzed by western...
Ngày tải lên: 07/03/2014, 05:20
Sentinel Event Data Root Causes by Event Type 2004-2012 doc
... Event Data Root Causes by Event Type 2004-2012 Office of Quality Monitoring - 17 © Copyright, The Joint Commission Root Cause Information for Maternal Events Reviewed by The Joint Commission ... Joint Commission Most Frequently Identified Root Causes of Sentinel Events Reviewed by The Joint Commission by Year The majority of events have multiple root causes (Please refer to subcategories ... www.jointcommission.org/Sentinel_Event_Policy_and _Procedures/ Sentinel Events are reported to The Joint Commission voluntarily by an accredited organization www.jointcommission.org/self_report_form/...
Ngày tải lên: 07/03/2014, 10:20
Liver Biopsy - Indications, Procedures, Results Edited by Nobumi Tagaya pptx
... orders@intechopen.com Liver Biopsy - Indications, Procedures, Results, Edited by Nobumi Tagaya p. cm. ISBN 978-953-51-0853-5 LIVER BIOPSY - INDICATIONS, PROCEDURES, RESULTS Edited by Nobumi Tagaya [16] Kalloo AN ... undergoing ancillary procedures such as measure‐ ment of pressures or opacification of the hepatic vein and inferior vena cava. It can also be Liver Biopsy – Indications, Procedures, Results24 Liver ... Biopsy – Indications, Procedures, Results24 Liver Biopsy - Indications, Procedures, Results http://dx.doi.org/10.5772/46113 Edited by Nobumi Tagaya Contributors Firpi, Alpna Limaye, Lisa Dixon, Ludmila...
Ngày tải lên: 07/03/2014, 19:20
Báo cáo khoa học: Plasminogen activator inhibitor type-1 inhibits insulin signaling by competing with avb3 integrin for vitronectin binding pptx
... prominent feature of type 2 diabetic patients is elevated blood levels of PAI-1 [3]. It is therefore reasonable to propose that PAI-1 may contribute to the development of type 2 diabetes by interfering ... inhibited by PAI-1 or echistatin, but not by decorsin (Fig. 2B). Furthermore, when the effect of mutants of PAI-1 were tested, only PAI-1A was able to inhibit VEGF secretion, as wild -type PAI-1, ... gene- deficient mice. I. Generation by homologous recombination and characterization. J. Clin. Invest. 92, 2746–2755. 16. Loskutoff,D.J.,Sawdey,M.&Mimuro,J.(1989 )Type1 plas- minogen activator inhibitor....
Ngày tải lên: 08/03/2014, 08:20
Báo cáo khoa học: Membrane type-1 matrix metalloprotease-independent activation of pro-matrix metalloprotease-2 by proprotein convertases docx
Ngày tải lên: 16/03/2014, 00:20
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