factors affecting the micronisation process with respec

... with the help of transporters/carriers Some special transporters/carriers will even bring the drugs to the target proteins so that the drugs can then bind to the therapeutic target and cure the ... P450s The metabolites of drugs and the remaining drugs will be excreted out of the body with the help of some proteins The deposit of drugs or their metabolites is one of the causes of the cytotoxicity ... only the therapeutic targets but also other proteins in the non-pathological CHAPTER 23 biological pathways; the drugs may irreversibly bind to the therapeutic targets due to the high dosage or their...

Ngày tải lên: 17/09/2015, 17:19

... where the people live g) The standard model with relationship with Vietnamese people h) Visit the sawmill to learn about the mills they use i) Overall the concept is not suitable j) Join the sawmills ... suitable for the workforce c) Would like more photos in teaching, with relation to the International Standards, More practice rather than theory, d) The training was suitable for business e) they have ... suitable j) Join the sawmills together in an area for strengthening cooperation k) Intergrate theory with practice l) How to desighn the workshop to be able to choose the most suitable machine m)...

Ngày tải lên: 21/06/2014, 04:20

... not based on the needs of the customer is never satisfied with customer service Therefore, when using the service, if customers feel the high quality services they will satisfy with the service ... research process as mentioned above In the process of testing the theoretical model, from the information collected, the data analysis is done by following these steps: - Step 1: Check the reliability ... containing the coefficients represent standardized variables with growth factors (each of which is a polynomial of the factors) The coefficient (factor loading) represents the correlation between the factors...

Ngày tải lên: 24/09/2015, 16:18

... added to the above solution, and the mixture was subsequently stirred at 54°C for 48 h The reactant was precipitated with distilled water, and then washed with distilled water and methanol The solid ... MPS is the major contributor for the clearance of NPs, thus the reducing rate of MPS uptake could be considered as the best strategy for prolonging the circulation of NPs (Li & Huang, 2008) Therefore, ... Altogether, PA/EPI had the longer t1/2 and MRT, lower Vd and CL than the free drug in rats At the same time, the AUC of EPI and PA/EPI from 0–24 h were 48,128.269 and 91,006.508 µg h/L, respectively...

Ngày tải lên: 23/04/2013, 21:38

... most of the control variables came out with the same expected signs, where average monthly consumption increases with the increase in the # of occupants , the number of stories in the house The coefficient ... for homes with heat pumps The energy consumptions for homes with gas and homes with a combination method of heating are 1.9 and 1.6 times the consumption of house with heat pumps To further understand ... heat pump The figure shows the same trend for the two methods of heating The energy consumption is higher in the case of Electrical furnace use (dashed line) The average reduction of the energy...

Ngày tải lên: 05/09/2013, 16:10

... in the literature These frameworks are named as content theories and process theories In the following sections the main theories and theorists from each framework are discussed to clarify the ... present in the job These theories emphasize on the factors and needs that encourage and inspire the behavior as well as performance (Nel et al., 2004) 3.2 Process theories In process theories, ... Relevant Theories Category Content Process Theory Need Hierarchy Theory Two- Factor Theory Achievement Theory X and Y Theory Existence, Relatedness, and Growth Expectancy Theory Equity Theory Goal...

Ngày tải lên: 11/09/2013, 11:44

... using them on a regular basis Although they said they valued the exposure to these tools, they felt a bit removed from the exercises using the tools because they not see themselves ever using them ... contact with others after the end of the training Both hospital and state representatives noted the value of having peers to consult with, and they underscored their appreciation for the assistance ... teach teams how to train others within their state about patient safety skills and tools The goal of the train -the- trainer portion of the PSIC is to broaden the reach of the PSIC to more individuals...

Ngày tải lên: 06/03/2014, 21:20

... present in the final product The following estimation is based on the worst-case assumption that the enzyme is used in all processed food and beverages and remains in the products consumed The maximum ... in the final product However, the following estimation is based on the worst-case assumption that the enzyme is used in all processed food and beverages and remains in the products consumed The ... screening of the endosperm The ground endosperm is further purified by extraction with isopropanol The concentration of anthraquinones in cassia gum is below the 0.5 mg/kg detection limit The food...

Ngày tải lên: 15/03/2014, 00:20

... in the development process, with the intent of reducing risks as early as possible The first real critical decisions concerning the potential use of a compound in humans are the most difficult They ... safety assessment aspects of the process become extremely tightly connected with the other aspects of the development of a compound, particularly the clinical aspects These interconnections are ... synonym for bar chart The latest time an activity can be completed without extending the length of a project The latest time an activity can begin without lengthening a project The process of ‘‘smoothing’’...

Ngày tải lên: 11/04/2014, 01:13

... draft the manuscript BM participated in the data analysis and helped to draft the manuscript MZ participated in the design of the study and carried out the clinical treatment XL carried out the ... applications The reason for this is has been the argument that the potential adverse effects of myeloablative therapy outweigh possible regenerative activities The current study investigated the safety ... and 14 patients had other diagnoses (Table 1) The local institutional review board of the Nanshan Affiliated Hospital of Guangdong Medical College, under the auspices of the National Ministry...

Ngày tải lên: 18/06/2014, 16:20

... [125,126] The possibility of damage to the oral mucosa also exists with the use of mouthwashes [127] An overview of the effect of ethanol on the oral mucosa is shown in Figure Local damage to the mucous ... example, beer Therefore, the possibility of a very high acetaldehyde concentration in the saliva arises, even without ingestion of the product (see below) For further information on the molecular ... gone beyond the scope of the current article, so it remains uncertain if "industry bias" or other factors such as superior design can explain the differences in outcome of the studies The possibility...

Ngày tải lên: 20/06/2014, 00:20

... were more highly correlated with their hypothesized subscale relative to the other subscales, and all 16 items were significantly correlated with the CSS Reliability The internal consistency reliability ... should be underlined that the design of The composition of the subscales is supported by the fact that the OPSAT-Q items were more highly correlated with their hypothesized scales than competing ... value The majority were Caucasian (64.4%), living with someone (74%), and not currently employed (58.7%) With respect to diagnosis, 73% were diagnosed with osteoporosis and the remaining 27% with...

Ngày tải lên: 20/06/2014, 15:20

... gated) and the difficulty to convince them to answer the questionnaire As for the collection process, the material produced each day was counted, checked, and filtered by the supervisors; the interviewer ... counted whenever the correlations between the item and its respective scale were at least two standard errors above the correlations between the same item and the other scales The percentage of ... gradients with regard to co-morbidities and reported health status (p < 0.05) The order of the means of item scores within each scale was consistent with the hypothesised expectations (Table 2) In the...

Ngày tải lên: 20/06/2014, 15:20

... When the “outer part” users are more than six (or seven), the total power, that is, the power to cover the inner part with FACH plus the power to cover the outer part with DCHs, exceeds the power ... services On the other hand, the performance of the available PtP channels for serving such services depends mainly on the number of the users that are served However, the utilization of these channels ... this approach, the FACH channel only covers the inner part of the sector (50% of the sector area) and provides the MBMS service to the users that are found in this part The rest of the users is...

Ngày tải lên: 21/06/2014, 22:20

... overlapped with those of literature Proper selection of patients, the careful definition of target volume and the respect to the dose tolerance of adjacent tissues are key factors to achieving these ... date confirms the adequacy of indications of the procedures and plans made More even than the concern about the pituitary function, we observe the maximum dose considered safe in the optic pathways ... optic pathways and often used the blockage of collimators with plugs in order to optimize the planning and restrict the marginal dose prescribed The median dose at the optic chiasm was 3.7 Gy (0,1-8...

Ngày tải lên: 09/08/2014, 09:20

... control of the procedures CB was responsible for the evaluation of the patients' records, collection of the data, letters to the patients and the referring doctors, and the entry of the data to the ... radiotherapy (1 pat.) Three further pediatric patients had undergone chemotherapy before IORT: one with rhabdomyosarcoma according to the CWS protocol, two with Ewing's sarcoma according to the ... and 0,5 cm from the surface) was prepared by inserting needles into the channels and connecting these to the transfer tubes The flap was inserted into the wound and fixed to the tumour bed by...

Ngày tải lên: 09/08/2014, 10:20

... instructed the ultrasound technology; TL, DH, XL and GW designed the project and drafted the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they ... incubation with Verapamil (Pharmacia Co., Italy) at the final concentration of 10 μg/ml to end the efflux function of P-glycoprotein Subsequently, cells were washed three times with PBS and the Daunorubicin ... of the four pSEBsiMDR1 plasmids transfection decreased the mRNA level Page of 11 of MDR1 in L2-RYC cells The highest silencing efficiency was observed in the pooled plasmids group (Figure 1C) Therefore,...

Ngày tải lên: 10/08/2014, 10:21

... (70%) of the patients considered they were satisfied with life (76% of the PM and 59% of the MS, p < 0.001) and only 9% of the patients were still dissatisfied (5% of the PM and 18% of the MS patients), ... patients (62%) and the PM (61%) The recovery rate, however, differed significantly between the PM and MS patients over the 24 months (46% for the PM vs 36% for the MS, p = 0.006) Most of the patients ... in the past 12 months Current episode At baseline, the mean overall score on the YMRS was 26.7, (27.4 for the PM and 25.3 for the MS, p = 0.001) (Table 2) The mean score was 4.7 (± 0.9) for the...

Ngày tải lên: 11/08/2014, 17:20

... contributions IH was responsible for the data analyses and prepared the first draft of the paper and the final manuscript AB assisted with the interpretation of the data, provided the main background content ... to the collection and evaluation of the presented data, the city of Zurich today has a much greater knowledge of the substances used, the consumption patterns, and above all the drug users themselves ... cannabis Nineteen percent of the evaluated sample consumed cocaine together with ecstasy, and 22.2% consumed ecstasy together with amphetamines during a typical party night The trend shows that polydrug...

Ngày tải lên: 11/08/2014, 18:20

... water from the flip-top bottle (Figure 1a) into the syringe barrel, filling its entire length; replacing the plunger; expelling the water out the metal needle Advantages include: a) the upper ... session was held in one community, and on the following day a session was held in the other community Thus the three rounds produced a total of six sessions At the beginning of each session, participants ... Teflon tubing affixed to the syringe with epoxy, and a thin layer of clear lacquer is applied to the numbers on the barrel La Criolla costs $0.27 each to produce and has the advantages of number...

Ngày tải lên: 11/08/2014, 18:20