factors affecting the effective delivery of therapeutic agents to

... cells One of the challenges for glioma therapy is the limited tumor delivery of therapeutic agents The effective delivery of therapeutic agents to glioma cells is hindered by several factors such ... the tumor cell membrane (if the therapeutic agents need to take effect inside the cells) Table 1.1 Factors affecting the effective delivery of therapeutic agents to gliomas 1.3.1 Blood brain ... Amount of therapeutic agents able to cross the blood brain barrier (BBB) Diffusion of therapeutic agents across the brain parenchyma Amount of free, unbound therapeutic agents crossing the tumor...

Ngày tải lên: 11/09/2015, 16:06

... of import competing goods, who will have to adjust and shift to other sectors For this to happen, the institutional framework needs to be supportive of firms to raise their productivity and to ... and is commonly referred to as the relocation of parts of the production process from one country to another Most of the attention used to focus on fragmentation in the goods chain, but more ... 2.1.4 The impact of adhering to WTO on education service in Vietnam 2.1.4.1 The thought of education has changed 2.4.1.2 The impact of adhering to WTO on education service in Vietnam 2.2 The impact...

Ngày tải lên: 23/04/2013, 11:16

... and relaxing the vessels of the gums, it may impair the healthy condition of the vessels belonging to the membranes of the socket, with the condition of which, the state of the tooth is closely ... it capable of giving strength to the weary, vivacity to the stupid, and wisdom to men void of understanding; capable of soothing the sorrows of the afflicted, of healing the wounds of the spirit, ... applied to the region of the stomach in the form of a poultice, as when internally administered." Professor Barton says, he had recourse to an application of the moistened leaves of this plant to the...

Ngày tải lên: 17/02/2014, 22:20

... field of view) T2 and PD acquisitions consisted of 26 contiguous Methods Subjects The sample of subjects who participated to the present protocol is a sub-sample of the EVA (Epidemiology of Vascular ... to be excluded because of the poor technical quality of their scans, and 11 others because of previous history of stroke as confirmed by a neurologist Left with a sample of 802 subjects (471 women, ... June 1991 to June 1993 All participants gave their written informed consent to the EVA study protocol, which was approved by the Ethic committee of the Kremlin-Bicetre hospital A number of biological...

Ngày tải lên: 05/03/2014, 21:20

... bands resulting from the tautomerism of the imidazole Nd proton with respect to the donor and acceptor atoms of the proximal His and Asp H-bond [11] The only exception to this is the cationic ascorbate ... way to the wild type [16,17] The pKa for the alkaline transition being similar to that of the wild type, % 11.1 [18] Finally, comparison of the X-ray structures of the oxidized forms of the native ... ferrous state of the mutant may contribute to an increase in the disorder and hence entropy of the reduced state of the mutant compared to that of the wild-type protein In contrast to the present...

Ngày tải lên: 07/03/2014, 21:20

... suggests output declines by 60 to 90 percent, with no that salivary glands are vulnerable to the deleterecovery occurring unless the total dose to salirious effects of all of these conditions in elderly ... Syndrome B autoantibodies (50 to 90 percent of cases), with the presence of increased serum immunoglobulins.19 CLINICAL FINDINGS OF XEROSTOMIA AND SALIVARY HYPOFUNCTION Saliva is essential for the preservation ... stimulates gustatory receptors located on the taste buds and delivers tastants directly to the taste buds Patients with chronic xerostomia secondary to SS, head and neck radiotherapy and other conditions...

Ngày tải lên: 14/03/2014, 20:20

... respect to the role of HSP70 in the inhibition of the release of Smac and apoptosis GAPDH Ratio of HSP70 to GAPDH 14 # 12 # 10 * The role of the ATP-binding domain of HSP70 in the prevention of the ... In the transfected cells, HSP70 over-expression inhibited the release of Smac from mitochondria into the cytosol in a dosedependent manner Under the same conditions, the absence of another mitochondrial ... 30-fold compared to the control, as estimated by densitometry (Fig 1B), indicating the release of Smac from mitochondria into the cytoplasm Concordantly, the protein level in the mitochondria was...

Ngày tải lên: 16/03/2014, 01:20

... paths toward the surface, as shown in (a) The lines are guides for eyes (1) where E is the total energy of the system, mSi the total energy per atom of bulk Si, mH the total energy per atom of the ... [33] to obtain the quasiparticle energies and the excitonic effects through the solution of the Bethe-Salpeter equation (BSE) [34] The effect of local fields is also included, to take into account ... corresponds to the band-gap for the undoped Si-nw Fig 11 shows how the FE for the B and P codoped Si-nw changes as function of the position of the dopants within the nanowire In the figure, the inset...

Ngày tải lên: 16/03/2014, 15:15

... from the slight distortion of the ideal cubic {1 0} lattice planes These three reflections cannot be used solely to determine whether the crystalline structure is triclinic or monoclinic, since their ... close to the wavenumbers of the strongest modes of monoclinic tungsten oxide The two bands at 270 and 327 cm−1 had been assigned to O W O bending modes of the bridging oxide, while the 712 and ... with photoelectrons ejected from a Si substrate due to the highly porous nature of nanorod films Small amount of carbon impurities were confirmed to exist within the film probably due to the incorporation...

Ngày tải lên: 20/03/2014, 13:11

... in any one or several of the polymerases, in any one or several of the subunits of the given polymerase, or in "factors" which influence the specificity or efficiency of the enzyme A complex system ... densitometer based on the measured optical density The lower portion is the Zig-Zag time base integrator and is used to quantitate the area under the curve and thus, the concentration of the sample ... capable of modifying the structure of chromosomes or the numbers of chromosomes of a normal nuclear complement falls into the broad definition of a chromosomal mutagen However, the majority of investigations...

Ngày tải lên: 22/03/2014, 12:20

... lists The transliterators were not told of the origin of each word The entire corpus, therefore, was easily separated into three sub-corpora of 500 words each based on the origin of each word To ... to heuristics The probability of a resulting word is the product of the probabilities of the applied rules The result is a list of target words sorted by their associated probabilities, Li The ... inserted in the text to represent a source word, it is important that the word at the top of the system generated list of target words (by definition the most probable) is one of the words generated...

Ngày tải lên: 23/03/2014, 18:20

... position in order to verify the inuence of the nature of the amino acid at this position on determination of the cleavage sites and on the amount of their hydrolysis This series of peptides was ... addition, in the temperature range 45 C to 55 C, the enthalpy of inactivation of TOP in the presence of 0.1 M NaCl was 250 kJặmol)1, which is signicantly higher than the enthalpy of activation of the ... because the P2Â and P3Â positions were demonstrated to be very determinant on the specicity of neurolysin and TOP [5] The kinetic parameters of hydrolysis and the variations of the cleavage sites of...

Ngày tải lên: 23/03/2014, 21:21

... the relevancy of the indicator as a measure of women’s health and access to care, and the availability of the data by state The national rates for these 25 indicators are evidence of the considerable ... socioeconomic conditions of women in D.C At the other end of the spectrum, West Virginia had the lowest disparity score on of the 11 indicators—a finding related to the fact that women of color and White ... Ratio The factor by which the physician workforce would need to be changed so that the ratio of minority physicians to the minority population would match the ratio of White physicians to the White...

Ngày tải lên: 28/03/2014, 12:20

... grid of 128 · 128 · 128 points The PME tolerance was set to 10)5 nm)1 which, together with the cut-off of 1.2 nm, resulted in a Ewald coefficient of 2.57952 nm)1 The minimized system was further ... intervals Therefore, the cleavage location is partially dependent on the incubation time of the substrate with the protease, at least within the limits of the experimental protocol Cleavage at the ... processes of the apo form of the protein (apoNgb) as a result of the formation of an intermolecular disulfide bond The preparation of apoNgb was obtained from the corresponding holoprotein by the removal...

Ngày tải lên: 30/03/2014, 01:20

... correspond to polyubiquitinated forms of the receptor The decrease in the amount of TSHRs observed during the chase (Fig 2C) in the presence of MG132 could be explained by the fact that the TSHRs ... association with CNX and/or CRT therefore seems contribute to the stability and/or the maturation of the TSHR To obtain further insights into the contribution of CNX and CRT to Ó FEBS 2002 A 35S-TSHR ... Effects of interactions between TSHR with BiP To further investigate the folding and maturation of TSHR, we studied the possible involvement of BiP, one of the main molecular chaperones of the endoplasmic...

Ngày tải lên: 31/03/2014, 08:20

Ngày tải lên: 12/06/2014, 11:37

... understanding the optical and electrical performances of the materials We focused on the temperature-dependent PL measurements of various silver-doped ZnO (SZO) NWs to reveal the role of Ag acceptor in the ... catalyst Page of (c) EDS (b) (103) ZnO NW nm Figure TEM images of 3SZO NW (a) The location and the size of the Au catalyst, the present of Au catalyst, is demonstrated the VLS method (b) The HR-TEM ... adjusting the target composition since it guarantees the transfer of the composition from the target to the NWs [28] Figure 3b shows that the weight ratio of various SZO targets is transformed to each...

Ngày tải lên: 20/06/2014, 22:20

... an increase in the unit cell volume after adding NiO This increase may be due to the Ni ions substituting the Ti ions (at the B site) Therefore, substitution of the Ni ions at the B site may ... contribute to the diffuse phase transition of the samples From Figure 4, the increase of loss tangent with NiO content implies a higher electrical conductivity of the composites However, the highest ... breaking the long-range ordering, resulting in a reduction of the ferroelectric behavior with the transition becoming more diffuse [23] Further, with increasing NiO content, the structure of the composites...

Ngày tải lên: 20/06/2014, 23:20

... blue-shift of the energy peaks of the order of several meV in the studied spectra These results were found for two quantum dot sizes, in the first one the characteristic quantities of the harmonic ... the other hand, the Coulomb potential defines the effective Bohr radius a∗ and the effective Rydberg energy R∗ of the electron-hole interaction, 4π εh2 ¯ , μe2 a∗ = (3) where M = m∗ + m∗ is the ... optical coefficients due to the quantum confinement of the exciton However, the same figures show additionally a significant blue-shift of the OR and SHG peaks when both the harmonic and Coulomb...

Ngày tải lên: 21/06/2014, 04:20

... amount of the hydrogen bonds of water confined in SWCNTs with the diameter The relative amount is the ratio of the amount of the hydrogen bonds of the confined water to the amount in the bulk ... water (a) The relative amount of the hydrogen bonds of the confined water versus the diameter; (b) the comparison of the amount of the hydrogen bonds and the viscosity of the bulk water at the three ... SWCNTs versus the diameter at 298, 325, and 350 K The relative viscosity is the ratio of the viscosity of the confined water to the viscosity of the bulk water, i.e., hr = hcnt/hbulk Here, the viscosities...

Ngày tải lên: 21/06/2014, 06:20