... cells One ofthe challenges for glioma therapy is the limited tumor deliveryoftherapeuticagentsTheeffectivedeliveryoftherapeuticagentsto glioma cells is hindered by several factors such ... the tumor cell membrane (if thetherapeuticagents need to take effect inside the cells) Table 1.1 Factorsaffectingtheeffectivedeliveryoftherapeuticagentsto gliomas 1.3.1 Blood brain ... Amount oftherapeuticagents able to cross the blood brain barrier (BBB) Diffusion oftherapeuticagents across the brain parenchyma Amount of free, unbound therapeuticagents crossing the tumor...
... of import competing goods, who will have to adjust and shift to other sectors For this to happen, the institutional framework needs to be supportive of firms to raise their productivity and to ... and is commonly referred to as the relocation of parts ofthe production process from one country to another Most ofthe attention used to focus on fragmentation in the goods chain, but more ... 2.1.4 The impact of adhering to WTO on education service in Vietnam 2.1.4.1 The thought of education has changed 2.4.1.2 The impact of adhering to WTO on education service in Vietnam 2.2 The impact...
... and relaxing the vessels ofthe gums, it may impair the healthy condition ofthe vessels belonging tothe membranes ofthe socket, with the condition of which, the state ofthe tooth is closely ... it capable of giving strength tothe weary, vivacity tothe stupid, and wisdom to men void of understanding; capable of soothing the sorrows ofthe afflicted, of healing the wounds ofthe spirit, ... applied tothe region ofthe stomach in the form of a poultice, as when internally administered." Professor Barton says, he had recourse to an application ofthe moistened leaves of this plant to the...
... field of view) T2 and PD acquisitions consisted of 26 contiguous Methods Subjects The sample of subjects who participated tothe present protocol is a sub-sample ofthe EVA (Epidemiology of Vascular ... to be excluded because ofthe poor technical quality of their scans, and 11 others because of previous history of stroke as confirmed by a neurologist Left with a sample of 802 subjects (471 women, ... June 1991 to June 1993 All participants gave their written informed consent tothe EVA study protocol, which was approved by the Ethic committee ofthe Kremlin-Bicetre hospital A number of biological...
... bands resulting from the tautomerism ofthe imidazole Nd proton with respect tothe donor and acceptor atoms ofthe proximal His and Asp H-bond [11] The only exception to this is the cationic ascorbate ... way tothe wild type [16,17] The pKa for the alkaline transition being similar to that ofthe wild type, % 11.1 [18] Finally, comparison ofthe X-ray structures ofthe oxidized forms ofthe native ... ferrous state ofthe mutant may contribute to an increase in the disorder and hence entropy ofthe reduced state ofthe mutant compared to that ofthe wild-type protein In contrast tothe present...
... suggests output declines by 60 to 90 percent, with no that salivary glands are vulnerable tothe deleterecovery occurring unless the total dose to salirious effects of all of these conditions in elderly ... Syndrome B autoantibodies (50 to 90 percent of cases), with the presence of increased serum immunoglobulins.19 CLINICAL FINDINGS OF XEROSTOMIA AND SALIVARY HYPOFUNCTION Saliva is essential for the preservation ... stimulates gustatory receptors located on the taste buds and delivers tastants directly tothe taste buds Patients with chronic xerostomia secondary to SS, head and neck radiotherapy and other conditions...
... respect tothe role of HSP70 in the inhibition ofthe release of Smac and apoptosis GAPDH Ratio of HSP70 to GAPDH 14 # 12 # 10 * The role ofthe ATP-binding domain of HSP70 in the prevention ofthe ... In the transfected cells, HSP70 over-expression inhibited the release of Smac from mitochondria into the cytosol in a dosedependent manner Under the same conditions, the absence of another mitochondrial ... 30-fold compared tothe control, as estimated by densitometry (Fig 1B), indicating the release of Smac from mitochondria into the cytoplasm Concordantly, the protein level in the mitochondria was...
... paths toward the surface, as shown in (a) The lines are guides for eyes (1) where E is the total energy ofthe system, mSi the total energy per atom of bulk Si, mH the total energy per atom ofthe ... [33] to obtain the quasiparticle energies and the excitonic effects through the solution ofthe Bethe-Salpeter equation (BSE) [34] The effect of local fields is also included, to take into account ... corresponds tothe band-gap for the undoped Si-nw Fig 11 shows how the FE for the B and P codoped Si-nw changes as function ofthe position ofthe dopants within the nanowire In the figure, the inset...
... from the slight distortion ofthe ideal cubic {1 0} lattice planes These three reflections cannot be used solely to determine whether the crystalline structure is triclinic or monoclinic, since their ... close tothe wavenumbers ofthe strongest modes of monoclinic tungsten oxide The two bands at 270 and 327 cm−1 had been assigned to O W O bending modes ofthe bridging oxide, while the 712 and ... with photoelectrons ejected from a Si substrate due tothe highly porous nature of nanorod films Small amount of carbon impurities were confirmed to exist within the film probably due tothe incorporation...
... in any one or several ofthe polymerases, in any one or several ofthe subunits ofthe given polymerase, or in "factors" which influence the specificity or efficiency ofthe enzyme A complex system ... densitometer based on the measured optical density The lower portion is the Zig-Zag time base integrator and is used to quantitate the area under the curve and thus, the concentration ofthe sample ... capable of modifying the structure of chromosomes or the numbers of chromosomes of a normal nuclear complement falls into the broad definition of a chromosomal mutagen However, the majority of investigations...
... lists The transliterators were not told ofthe origin of each word The entire corpus, therefore, was easily separated into three sub-corpora of 500 words each based on the origin of each word To ... to heuristics The probability of a resulting word is the product ofthe probabilities ofthe applied rules The result is a list of target words sorted by their associated probabilities, Li The ... inserted in the text to represent a source word, it is important that the word at the top ofthe system generated list of target words (by definition the most probable) is one ofthe words generated...
... position in order to verify the inuence ofthe nature ofthe amino acid at this position on determination ofthe cleavage sites and on the amount of their hydrolysis This series of peptides was ... addition, in the temperature range 45 C to 55 C, the enthalpy of inactivation of TOP in the presence of 0.1 M NaCl was 250 kJặmol)1, which is signicantly higher than the enthalpy of activation ofthe ... because the P2Â and P3Â positions were demonstrated to be very determinant on the specicity of neurolysin and TOP [5] The kinetic parameters of hydrolysis and the variations ofthe cleavage sites of...
... the relevancy ofthe indicator as a measure of women’s health and access to care, and the availability ofthe data by state The national rates for these 25 indicators are evidence ofthe considerable ... socioeconomic conditions of women in D.C At the other end ofthe spectrum, West Virginia had the lowest disparity score on ofthe 11 indicators—a finding related tothe fact that women of color and White ... Ratio The factor by which the physician workforce would need to be changed so that the ratio of minority physicians tothe minority population would match the ratio of White physicians tothe White...
... grid of 128 · 128 · 128 points The PME tolerance was set to 10)5 nm)1 which, together with the cut-off of 1.2 nm, resulted in a Ewald coefficient of 2.57952 nm)1 The minimized system was further ... intervals Therefore, the cleavage location is partially dependent on the incubation time ofthe substrate with the protease, at least within the limits ofthe experimental protocol Cleavage at the ... processes ofthe apo form ofthe protein (apoNgb) as a result ofthe formation of an intermolecular disulfide bond The preparation of apoNgb was obtained from the corresponding holoprotein by the removal...
... correspond to polyubiquitinated forms ofthe receptor The decrease in the amount of TSHRs observed during the chase (Fig 2C) in the presence of MG132 could be explained by the fact that the TSHRs ... association with CNX and/or CRT therefore seems contribute tothe stability and/or the maturation ofthe TSHR To obtain further insights into the contribution of CNX and CRT to Ó FEBS 2002 A 35S-TSHR ... Effects of interactions between TSHR with BiP To further investigate the folding and maturation of TSHR, we studied the possible involvement of BiP, one ofthe main molecular chaperones ofthe endoplasmic...
... understanding the optical and electrical performances ofthe materials We focused on the temperature-dependent PL measurements of various silver-doped ZnO (SZO) NWs to reveal the role of Ag acceptor in the ... catalyst Page of (c) EDS (b) (103) ZnO NW nm Figure TEM images of 3SZO NW (a) The location and the size ofthe Au catalyst, the present of Au catalyst, is demonstrated the VLS method (b) The HR-TEM ... adjusting the target composition since it guarantees the transfer ofthe composition from the target tothe NWs [28] Figure 3b shows that the weight ratio of various SZO targets is transformed to each...
... an increase in the unit cell volume after adding NiO This increase may be due tothe Ni ions substituting the Ti ions (at the B site) Therefore, substitution ofthe Ni ions at the B site may ... contribute tothe diffuse phase transition ofthe samples From Figure 4, the increase of loss tangent with NiO content implies a higher electrical conductivity ofthe composites However, the highest ... breaking the long-range ordering, resulting in a reduction ofthe ferroelectric behavior with the transition becoming more diffuse [23] Further, with increasing NiO content, the structure ofthe composites...
... blue-shift ofthe energy peaks ofthe order of several meV in the studied spectra These results were found for two quantum dot sizes, in the first one the characteristic quantities ofthe harmonic ... the other hand, the Coulomb potential defines theeffective Bohr radius a∗ and theeffective Rydberg energy R∗ ofthe electron-hole interaction, 4π εh2 ¯ , μe2 a∗ = (3) where M = m∗ + m∗ is the ... optical coefficients due tothe quantum confinement ofthe exciton However, the same figures show additionally a significant blue-shift ofthe OR and SHG peaks when both the harmonic and Coulomb...
... amount ofthe hydrogen bonds of water confined in SWCNTs with the diameter The relative amount is the ratio ofthe amount ofthe hydrogen bonds ofthe confined water tothe amount in the bulk ... water (a) The relative amount ofthe hydrogen bonds ofthe confined water versus the diameter; (b) the comparison ofthe amount ofthe hydrogen bonds and the viscosity ofthe bulk water at the three ... SWCNTs versus the diameter at 298, 325, and 350 K The relative viscosity is the ratio ofthe viscosity ofthe confined water tothe viscosity ofthe bulk water, i.e., hr = hcnt/hbulk Here, the viscosities...