factors affecting the effective delivery of therapeutic agents to

... evaluate whether the decision to use the loan or the equity of the business is reasonable or unreasonable Regardingly, the purpose of this paper is to examine the factors affecting the capital ... progress, the size of this market is small when compared to the size of the stock market in terms of number of issuers and volume of deals Most of the bonds are government bonds, the number of corporate ... researchers are often interested in finding out what factors influence the decision to use the loan or financial leverage of the firm It is from the correlation between these factors and the capital...

Ngày tải lên: 22/06/2020, 21:35

... determining the extent of the particles to cross the BBB To further investigate the potential for the nanoparticles to cross the BBB, animal testing is important and necessary The second part of the thesis ... can be seen that the structure of the polymer also affected the EE of the nanoparticles The EE of sample was about 3.3 times of that of sample This may due to the hydrophilicity of polymer Sample ... NANOPARTICLES OF BIODEGRADABLE POLYMERS FOR DELIVERY OF THERAPEUTIC AGENTS AND DIAGNOSTIC SENSITIZERS TO CROSS THE BLOOD BRAIN BARRIER (BBB) FOR CHEMOTHERAPY AND MRI OF THE BRAIN CHEN LIRONG (B.Sc) A THESIS...

Ngày tải lên: 26/11/2015, 22:48

... kinetics of these molecules could be tailored according to the PEG block length and composition of the hydrogel Furthermore, the unique advantage of these materials was the ability to form gels ... for the delivery of the hydrophilic drug ketoprofen [85], hydrophobic drug spironolactone [85] as well as plasmid DNA [86] Later, by inverting the hydrophilic PEG in the middle of the triblock of ... properties and cytotoxicity were revealed to be attributable to the functional bonding, composition or structure of the polymer The appearance of the PCL–PEG–PCL triblock compartment in the multiblock...

Ngày tải lên: 18/12/2017, 09:50

... engineering at the molecular level, together with an appreciation of the pathophysiology of normal and disease tissue will help to realize the full therapeutic potential of the post-genomics ... from the organism [...]... Equilibrium favors polymer formation due to the alleviation of ring strain • Highly functional group tolerant, works at mild temperature • Amenable to the synthesis ... www.nlm.nih.gov/medlineplus/neuroblastoma.html Cancer affecting immature nerve cells, most commonly in the adrenal glands and the sympathetic nervous system ganglia of the abdomen Common drugs used to treat......

Ngày tải lên: 23/08/2015, 18:48

... Coefficients a…………………………………………………… 37 Page ABSTRACT The purpose of the study is to discuss factors affecting to the helping behaviors of employees in Institute of Vaccines and Medical Biologicals (IVAC) ... on the regime of information and reporting on nonbusiness operations of the. .. research adhere to the regulations of the Ministry of Science & Technology and the Ministry of ... appointed to work positions suitable to their ability and competence, further training to improve their professional skills,... is the social exchange theory, people help because they want to gain...

Ngày tải lên: 10/12/2015, 00:10

... are the factors: the marketing staff's efforts, the hopes and the attractiveness of the job, except the consistency factor In addition, the results of the work directly affect the level of satisfaction ... analysis of variance is the hypothesis test of the suitability of the overall linear regression model The idea of this test is the linear relationship between the dependent variable and the independent ... – always want to achieve a certain level of income with the lowest level of effort That is also the basic contradiction of the theory of economic aout the relationship between the owner – agent(...

Ngày tải lên: 28/02/2018, 10:31

... that, the thesis indicates the difference in impact of these factors on bank’s credit ratings between developed markets and emerging markets The empirical results of the thesis help us to answer the ... the BIC (Bayesian information criteria) to compare the crediability of the selected model to random models The results of BIC show that the selected models are the finest models 4.3 Test of the ... Test of multicollinearity in the models To access the affect of high multicollinearity on the variables in the model, we calculate VIF ratios of each proxies of the model The variables cause the...

Ngày tải lên: 07/01/2020, 20:26

... assessed to affect the CSR implementation of Vietnam Textile and Garment Group based enterprises? 1.4 Subject and scope of the study • Subject of the study: The subject of the thesis is the factors affecting ... necessary to determine the factors affecting the CSR implementation of enterprises Therefore, it is necessary and meaning for selection of study on CSR with the title “Factors affecting the CSR ... Objectivesof the thesis • Overall objectives: - Build a model of factors affecting the implementation of CSR in Vietnam Textile and Garment Group based enterprises - Test the scale of factors affecting...

Ngày tải lên: 07/01/2020, 20:56

... Analysis of the employment need satisfaction of the on-farm laborers Approach: The approach of the thesis is to apply the Exploratory Factor Analysis (EFA) theory to measure the factors that affect the ... Analysis of the factors affecting the employment needs of rural laborers For the approach of the regression analysis model, to measure the factors having employment needs according to the model of ... Analysis of factors affecting the employment needs of rural laborers (EFA) The Exploratory Factor Analysis (EFA) technique was used to analyze the factors affecting the employment needs of rural...

Ngày tải lên: 10/01/2020, 10:45

... Analysis of the employment need satisfaction of the on-farm laborers Approach: The approach of the thesis is to apply the Exploratory Factor Analysis (EFA) theory to measure the factors that affect the ... Analysis of the factors affecting the employment needs of rural laborers For the approach of the regression analysis model, to measure the factors having employment needs according to the model of ... Analysis of factors affecting the employment needs of rural laborers (EFA) The Exploratory Factor Analysis (EFA) technique was used to analyze the factors affecting the employment needs of rural...

Ngày tải lên: 17/01/2020, 20:51

... cells One of the challenges for glioma therapy is the limited tumor delivery of therapeutic agents The effective delivery of therapeutic agents to glioma cells is hindered by several factors such ... the tumor cell membrane (if the therapeutic agents need to take effect inside the cells) Table 1.1 Factors affecting the effective delivery of therapeutic agents to gliomas 1.3.1 Blood brain ... Amount of therapeutic agents able to cross the blood brain barrier (BBB) Diffusion of therapeutic agents across the brain parenchyma Amount of free, unbound therapeutic agents crossing the tumor...

Ngày tải lên: 11/09/2015, 16:06

... and relaxing the vessels of the gums, it may impair the healthy condition of the vessels belonging to the membranes of the socket, with the condition of which, the state of the tooth is closely ... it capable of giving strength to the weary, vivacity to the stupid, and wisdom to men void of understanding; capable of soothing the sorrows of the afflicted, of healing the wounds of the spirit, ... applied to the region of the stomach in the form of a poultice, as when internally administered." Professor Barton says, he had recourse to an application of the moistened leaves of this plant to the...

Ngày tải lên: 17/02/2014, 22:20

... field of view) T2 and PD acquisitions consisted of 26 contiguous Methods Subjects The sample of subjects who participated to the present protocol is a sub-sample of the EVA (Epidemiology of Vascular ... to be excluded because of the poor technical quality of their scans, and 11 others because of previous history of stroke as confirmed by a neurologist Left with a sample of 802 subjects (471 women, ... June 1991 to June 1993 All participants gave their written informed consent to the EVA study protocol, which was approved by the Ethic committee of the Kremlin-Bicetre hospital A number of biological...

Ngày tải lên: 05/03/2014, 21:20

... respect to the role of HSP70 in the inhibition of the release of Smac and apoptosis GAPDH Ratio of HSP70 to GAPDH 14 # 12 # 10 * The role of the ATP-binding domain of HSP70 in the prevention of the ... In the transfected cells, HSP70 over-expression inhibited the release of Smac from mitochondria into the cytosol in a dosedependent manner Under the same conditions, the absence of another mitochondrial ... 30-fold compared to the control, as estimated by densitometry (Fig 1B), indicating the release of Smac from mitochondria into the cytoplasm Concordantly, the protein level in the mitochondria was...

Ngày tải lên: 16/03/2014, 01:20

... in any one or several of the polymerases, in any one or several of the subunits of the given polymerase, or in "factors" which influence the specificity or efficiency of the enzyme A complex system ... densitometer based on the measured optical density The lower portion is the Zig-Zag time base integrator and is used to quantitate the area under the curve and thus, the concentration of the sample ... capable of modifying the structure of chromosomes or the numbers of chromosomes of a normal nuclear complement falls into the broad definition of a chromosomal mutagen However, the majority of investigations...

Ngày tải lên: 22/03/2014, 12:20

... the relevancy of the indicator as a measure of women’s health and access to care, and the availability of the data by state The national rates for these 25 indicators are evidence of the considerable ... socioeconomic conditions of women in D.C At the other end of the spectrum, West Virginia had the lowest disparity score on of the 11 indicators—a finding related to the fact that women of color and White ... Ratio The factor by which the physician workforce would need to be changed so that the ratio of minority physicians to the minority population would match the ratio of White physicians to the White...

Ngày tải lên: 28/03/2014, 12:20

... grid of 128 · 128 · 128 points The PME tolerance was set to 10)5 nm)1 which, together with the cut-off of 1.2 nm, resulted in a Ewald coefficient of 2.57952 nm)1 The minimized system was further ... intervals Therefore, the cleavage location is partially dependent on the incubation time of the substrate with the protease, at least within the limits of the experimental protocol Cleavage at the ... processes of the apo form of the protein (apoNgb) as a result of the formation of an intermolecular disulfide bond The preparation of apoNgb was obtained from the corresponding holoprotein by the removal...

Ngày tải lên: 30/03/2014, 01:20

... an increase in the unit cell volume after adding NiO This increase may be due to the Ni ions substituting the Ti ions (at the B site) Therefore, substitution of the Ni ions at the B site may ... contribute to the diffuse phase transition of the samples From Figure 4, the increase of loss tangent with NiO content implies a higher electrical conductivity of the composites However, the highest ... breaking the long-range ordering, resulting in a reduction of the ferroelectric behavior with the transition becoming more diffuse [23] Further, with increasing NiO content, the structure of the composites...

Ngày tải lên: 20/06/2014, 23:20