factors affecting drug action

... Isopropyl alcohol Intravenous Steady state flux Total flux Drug permeability of the ionized drug Drug permeability of the unionized drug Drug permeability xiv KL kV LCST M MPZ Na O PBS PEG PEG-PPG-PEG ... Azidothymidine Carbon Initial drug concentration in the donor cell Concentration of the free drug Concentration of the ionized drug Maximum plasma concentration Concentration of the total drug Concentration ... permeation/accumulation of drugs ix LIST OF TABLES Table 1.1 Overview of lipid vesicle research in transdermal drug delivery 14 Table 1.2 Overview of cyclodextrin -drug inclusion research in transdermal drug delivery...

Ngày tải lên: 14/09/2015, 14:03

... exploring Factors that influence transdermal and topical drug delivery may be divided into three categories: 1) drug related, 2) vehicle related and 3) skin related factors Drug related factors ... the drug 21 Table 1.2 An overview of the drug- cyclodextrin inclusion research in transdermal drug delivery No Reference Formulations Drug Loftsson et al., 1995 HP- β-CD, RM- β-CD Acitretin 20 Drug- Cyclodextrin ... diffusion cell (human skin) - Drug quantity, partitioning from vesicle to the SC, drug release from the vesicle and diffusion of the free drug to the skin layers are some of the factors that influence...

Ngày tải lên: 14/09/2015, 14:03

... In vitro Drug Release Studies The release characteristics were carried out in PBS The cumulative amount of the drug released from the drug loaded fibers is illustrated in Fig 4.4 Total drug content ... Highest increase in drug solubility was observed when the drug was in its degree of ionized form in RM β-CD, resulting in a 128-fold increase in the intrinsic solubility of the drug Surface tension ... cavities and the interaction energies were computed The most likely conformation of each complex was the one with the lowest interaction energy 3.2.4 Phase Solubility Studies Drug- CD inclusion complexes...

Ngày tải lên: 14/09/2015, 14:03

... w/v PVA - No drug, (b) 10% w/v PVA, (c) 10%w/v PVA - 5% w/v PNIPAM, (d) 10% w/v PVA - 10% w/v PNIPAM, (e) 10% w/v PNIPAM and (f) 10% w/v PNIPAM - No drug All formulations contain drug unless otherwise ... LCST, the polymer is stable and the drug release is slow, however at higher temperatures the polymer collapses thereby enhancing drug release (Kato et al., 2000) Drug release from PVA fibers was ... periodically and the released drug was determined using HPLC The volume of the release medium was kept constant by replacement with same volume of fresh medium All drug release data were averaged...

Ngày tải lên: 14/09/2015, 14:03

... of a drug across the skin (Elsayed et al., 2006; Barry 2001) Greater drug permeation from cerosomes could be due to free uncapsulated diclofenac sodium, thus favoring drug uptake into skin Drug ... hydrophobic drugs (Yokomizo 1996) Results of the permeation study suggest that the solubility of the drug in SC lipids and the partitioning of the drug molecule from the vesicles to skin may be key factors ... then release the drug from the carrier and diffuse to allow the drug through the skin Therefore both drug and carrier characteristics can influence the permeation rate of the drug through the...

Ngày tải lên: 14/09/2015, 14:03

... 2010, factors, the role of biological factors affecting the drug absorption, distribution, metabolism or deletion has been investigated [1-9] Till now, the most significant biological factors ... basis and behavior after drug administration However, several epigenetic factors such as age, co-morbidity, disease seriousness, co-administrated drug therapies and their interactions, renal and hepatic ... is represented by n variables (within-subjects factors) Categorical factors are used to divide study population into subgroups (between-subjects factors) and 96 continuous variables are used as...

Ngày tải lên: 26/10/2012, 09:32

... after taking everything into consideration, we decided to choose and study the project: “THE FACTORS AFFECTING MONTHLY EXPENDITURE OF FTU’S STUDENT” Although the government has tried to implement ... that multicollinearity does not exist - Variance Inflation Factors (VIF) method: The following result is obtained: Variance Inflation Factors Minimum possible value = 1.0 Values > 10.0 may indicate ... that multicollinearity does not exist + Variance Inflation Factors (VIF) method: The following result is obtained: Variance Inflation Factors Minimum possible value = 1.0 Values > 10.0 may indicate...

Ngày tải lên: 27/10/2012, 16:53

... that factors other than BMD operate to influence fracture risk, for example physiologic loading of vertebral bodies and the neuromuscular characteristics of trunk musculature Previously, the factors ... consideration of their potential interactions may assist understanding of the complex aetiology of these fractures Therefore, the aim of this review is to highlight factors identified in the literature ... multifactorial aetiology underlying osteoporotic vertebral fracture Bone, macroscopic, local and global factors may interact to influence the risk of sustaining a vertebral fracture Cellular activity...

Ngày tải lên: 03/11/2012, 09:49

... vocabulary learning of English for Specific Purposes and factors affecting vocabulary acquisition Research Questions What are the factors affecting ESP Vocabulary Learning at Hanoi Community College? ... develop implicit learning 1.3 Some factors affecting vocabulary acquisition 1.3.1 Intralexical factors: According to Schmitt and McCarthy (1997:142-153) intralexical factors that affect the learning ... acquisition and factors affecting vocabulary learning according to prestigious linguists and researchers This will serve as a base for the study to get its aim: finding out some factors affecting ESP...

Ngày tải lên: 07/11/2012, 14:54

... 4.1.2 The different affecting degrees of the learning factors studied Foreign language learning is a process that is affected by many factors In certain specific situations, those factors affect the ... that they can be divided into two groups: internal factors and external factors Weiner, B (qtd in Williams, M & Burden, R.L 1997) saw that internal factors arise from inside and external ones are ... learning factors “Many of us believe that learners have certain characteristics which lead to more or less successful language learning”, (Lightbown, P.M & Spada, N 1999) There are many factors affecting...

Ngày tải lên: 07/11/2012, 15:04

... vocabulary learning of English for Specific Purposes and factors affecting vocabulary acquisition Research Questions What are the factors affecting ESP Vocabulary Learning at Hanoi Community College? ... develop implicit learning 1.3 Some factors affecting vocabulary acquisition 1.3.1 Intralexical factors: According to Schmitt and McCarthy (1997:142-153) intralexical factors that affect the learning ... acquisition and factors affecting vocabulary learning according to prestigious linguists and researchers This will serve as a base for the study to get its aim: finding out some factors affecting ESP...

Ngày tải lên: 19/04/2013, 17:07

... equity costs and factors in emerging markets in general or Vietnam in particular 1.2 Research Objectives: The purpose of this thesis would be Indicating whether and how firm-specific factors relate ... would be suitable and used in this paper 3.2 Firm-level factors : 3.2.1 Beta: Beta (β) indicates the sensitivity of the company to market risk factors Beta represents the market risk for an asset ... model is more validity Similarly, we put other factors into model and check changes in p-value and Adjusted R-Square in order to check whether those factors have relationship with cost of equity...

Ngày tải lên: 10/08/2013, 17:41

... There are several factors affecting the students’ motivation in learning reading From the data analysis, they are the students’ factors, the teachers’ factors and reading material factors What is ... an agreement to some common factors affecting students' motivation These include students' factors, teacher's factor and reading materials factor 1.3.2.1 Students' Factors No one can deny that ... survey also reveals the reasons for the situation 4.1.2 Factors Affecting the Students’ Motivation in Learning the Reading Skill 4.1.2.1 Students’ Factors 4.1.2.1.1 Limited Background Knowledge When...

Ngày tải lên: 07/09/2013, 13:21

... aspects, it may be interaction, transaction or performance A talk is considered interactions when it have the following characteristics Above all, that talk can create social interactions among people ... essential if the talk is transaction or information exchange and when precise understanding is not required if it is interaction or relationship building or when there is no interaction if the talk is ... are as follows: To investigate the factors affecting speaking skill of the first year students at Vinh University To investigate the working mechanism of these factors on the students through which...

Ngày tải lên: 18/12/2013, 21:45

... 92 Cost Factors Affecting Productivity Automatic Product Removal Cavities in the mold can be laid out so that ... pieces/h) C B A C D Figure 3.55 Machine with a × 16 cavity stack mold for small containers 94 Cost Factors Affecting Productivity Ejection Stroke, Air Assist The ejection method used in the mold will ... output of the mold if required only for a shorter period A conservatively estimated cycle time Factors affecting cycle time have been discussed in Section 3.3 3.8.1 Available Operating Time There...

Ngày tải lên: 20/01/2014, 02:20

... 72-cavity 3-plate mold for a small cap (a), and a runner for a simple but heavy product (b) 72 Cost Factors Affecting Productivity As a rule, the shot weight SW should not be more than about 80% of the ... Note also that the condition of the screw is very important A worn screw (and/or 73 74 Cost Factors Affecting Productivity barrel) will have greater clearances than when new, and therefore will ... the machine is not the limiting factor when trying to improve a mold’s productivity 76 Cost Factors Affecting Productivity With the redesigned product, we now require 35 g · 12 cav · sh/min ·...

Ngày tải lên: 20/01/2014, 02:20

... 50 Cost Factors Affecting Productivity Another example: a mold and machine worked perfectly, but occasionally, ... ensure that the cooling channels in the mold are free from sediments (lime, rust, etc.) 52 Cost Factors Affecting Productivity is of great advantage The coolant must also be free from lime and dirt, ... the ejection and the cooling layout of the mold and the overall size of the mold 53 54 Cost Factors Affecting Productivity The mold must be equipped with all features that are compatible with...

Ngày tải lên: 20/01/2014, 02:20

... Quantification of Drug Action Concentration-Effect Relationship (A) The relationship between the concentration of a drug and its effect is determined in order to define the range of active drug concentrations ... license 55 Quantification of Drug Action Portal vein Mesenteric artery Coronary artery Saphenous vein Vasoconstriction Active tension Basilar artery 10 20 30 40 50 100 Drug concentration A Measurement ... to terms and conditions of license 100 56 Quantification of Drug Action Concentration-Binding Curves In order to elicit their effect, drug molecules must be bound to the cells of the effector organ...

Ngày tải lên: 26/01/2014, 19:20

... which factors were focused on and techniques were used to increase the students’ involvement With regard to the factors affecting the students’ participation, the study focused on the student factors ... employment aspect Third, the study concentrates to find out the factors including teacher factors, student factors and other classroom factors hindering the students’ involvement in oral activities ... of factors originating from students, teachers, speaking activities and other classroom-related factors In the following sections, some of the major factors will be discussed I.1 Student factors...

Ngày tải lên: 29/01/2014, 14:35