exposure development of atopy and development of asthma

... questionnaire for childhood asthma Journal of Asthma 1993, 30(6):467-473 Rutishauser C, Sawyer SM, Bond L, Coffey C, Bowes G: Development and validation of the Adolescent Asthma Quality of Life Questionnaire ... development of the scale: Level of participation in self-selected activities offers a measure of one aspect of quality of life http://www.hqlo.com/content/6/1/37 Level of symptom control through use of ... development of the PLA Lifespan Development is an orientation, providing conceptual and methodological framing for the study of human development and change processes Principles of Lifespan Development...

Ngày tải lên: 18/06/2014, 22:20

... diagnosis of asthma (OR 2.04), wheeze, and asthma medication use (OR 2.83) but not for AHR, atopy, or airflow obstruction.23 Despite more symptoms consistent with asthma and use of more asthma medications ... and colleagues and Jarvis and colleagues found no association between BMI and atopy. 44,45 In a study of children with a mean age of 5.9 years, Guler and colleagues found that atopic asthmatics had ... relationship and understand the causal mechanisms of obesity and asthma association From a public health standpoint, these studies have substantial implications If asthma were added to the list of conditions...

Ngày tải lên: 08/08/2014, 21:20

... In order to increase our understanding of the mechanism and potential function of asthma susceptibility genes identified in published GWAS and “classic” asthma candidate genes, we evaluated their ... weeks) stages of development, and in the complete developing lung time series of mouse strains: A/J, SW and C57BL6 We show that overall, there was no over-representation of the asthma genes among ... Institute of Child Health and Human Development supported tissue databases and microarray profiled as previously described [14,15] Creation of the tissue repository was approved by the University of...

Ngày tải lên: 12/08/2014, 13:22

... collection and analysis of data, interpretation of results, and preparation of manuscript DDG and MBU participated in the study design, collection of data, interpretation of results, and preparation of ... at the level of the heart Korotkoff phase V (disappearance) was recorded as DBP Calculation of ‘summary measures’ of TC, SBP and DBP For each of TC, SBP and DBP, an arithmetic mean of all available ... analysis of data, interpretation of results, and preparation of manuscript PJH participated in the study design, interpretation of results, and preparation of manuscript All authors have read and...

Ngày tải lên: 12/08/2014, 18:20

... eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma American journal of respiratory cell and molecular biology 1998, 18(4):453-462 Tong J, Bandulwala ... expression and PGE2 release compared to cells from wild type mice These results show for the first time a role for LPA2 in the development of airway inflammation and pathogenesis of asthma Materials and ... outlined by the Animal Welfare Act and the National Institutes of Health guidelines for the care and use of animals in biomedical research PCR genotyping of LPA1+/- and LPA2+/- mice Extract-N-Amp...

Ngày tải lên: 12/08/2014, 14:20

... diversified set of bacteria and if they eat sufficiently contaminated food It would be interesting to determine the magnitude of exposure to orofaecal and food-borne infections [22], and to saprophytic ... Roell G, Thiemann HH: Prevalence of asthma and atopy in two areas of West and East Germany Am J Respir Crit Care Med 1994, 149:358–364 Strachan DP: Hay fever, hygiene and household size Br Med J 1989, ... 299:1259–1260 Cookson WOCM, Moffatt MF: Asthma: an epidemic in the absence of infection Science 1997, 275:41–42 Martinez FD, Holt PG: Role of microbial burden in aetiology of allergy and asthma Lancet 1999,...

Ngày tải lên: 12/08/2014, 18:20

... development of atopy and asthma The recent presentations at the ATS meeting 2001 showed the important role of the early years for the development of the immune system and for the onset of atopy or asthma ... University of Basel, Switzerland) reported that the timing and the duration of exposure to stables, and consumption of farm milk during Timing of sensitization in early childhood Exploring patterns of ... with higher exposure to endotoxin Also, based on previous reports of protective effects of cats or dogs on the development of atopy, endotoxin exposure may contribute to a lower risk of atopy in...

Ngày tải lên: 12/08/2014, 18:20

... discussion Although asthma and COPD have many risk factors in common and often coexist in clinical settings, and there is some evidence that asthma may be a risk factor for the development of COPD [40], ... between symptom exaggeration of adult asthma and NO2 exposure levels [12], and the Swiss SAPALDIA study observed an increase of asthma- related symptoms, although not current asthma, in relation to ... J, Kerkhof M, Heinrich J, Bellander T, Brunekreef B: Air pollution from traffic and the development of respiratory infections and asthmatic and allergic Page 13 of 15 (page number not for citation...

Ngày tải lên: 06/03/2014, 19:20

... Pathophysiology and Pathogenesis of Asthma, and Natural History of Asthma 11 Key Points: Definition, Pathophysiology and Pathogenesis of Asthma, and Natural History of Asthma ... Pathophysiology and Pathogenesis of Asthma, and Natural History of Asthma; Section 3—The Four Components of Asthma Management; Section 4—Managing Asthma Long Term; and Section 5—Managing Exacerbations of Asthma ... Pathogenesis of Asthma, and Natural History of Asthma SECTION 2, DEFINITION, PATHOPHYSIOLOGY AND PATHOGENESIS OF ASTHMA, AND NATURAL HISTORY OF ASTHMA KEY POINTS: DEFINITION, PATHOPHYSIOLOGY AND PATHOGENESIS...

Ngày tải lên: 17/03/2014, 15:20

... Findings of this study provide evidence of internal consistency reliability and construct validity of the PLA as a measure of one aspect of quality of life for children and adolescents with asthma ... child and adolescent acceptance of asthma model Ph.d.: THE UNIVERSITY OF ARIZONA; 1996 Kintner EK: Lack of relationship between acceptance and knowledge of asthma in school-age children and early ... persistent disease, and comparing scores and psychometric evaluation of this instrument with the activity limitation and physical functioning items of the Pediatric Asthma Quality of Life Questionnaire...

Ngày tải lên: 18/06/2014, 22:20

... significantly lower exposure rate of NSI and that small animal and mixed practice was associated with a significantly higher exposure rate of NSI are consistent with that observed in a study of female ... The exposure rate of NSI reported by Queensland veterinarians is high, if we extrapolate the crude 12 month exposure (75.3 per 100 person-years) However, it is similar to the exposure rate of ... combined "used" and "both" categories Conclusion The exposure rate of NSI is high for Queensland veterinarians and clearly remains a major occupational health problem Current guidelines and strategies...

Ngày tải lên: 20/06/2014, 00:20

... (PCS and MCS) and the respiratory symptoms were described by means and Voll-Aanerud et al Health and Quality of Life Outcomes 2010, 8:107 http://www.hqlo.com/content/8/1/107 standard deviations and ... comorbidity, and study centre Stratified analyses were performed with respect to diagnosis (neither asthma nor COPD; and asthma and/ or COPD) Respiratory symptoms often occur together, causing problems of ... and HRQoL, both in subjects with and without asthma and/ or COPD (data not shown) Voll-Aanerud et al Health and Quality of Life Outcomes 2010, 8:107 http://www.hqlo.com/content/8/1/107 Page of...

Ngày tải lên: 20/06/2014, 16:20

... rhinitis, and eczema.26 Shamssain and Shamsian, assessing 3,000 adolescents aged 13 to 14 years in Sunderland, England, verified the concomitance of asthma, rhinitis, and eczema in 5.1% of subjects.19 ... screening of asthmatic and nonasthmatic patients.29 A second limitation of this study was the absence of questions on possible risk factors such as diet, socioeconomic conditions,8 family history of atopy, ... smoking, the presence of pets, the mother’s education level, and exposure to pesticides30 and/ or insecticides31 (all of which, being important for epidemiologic studies of asthma and allergic diseases,...

Ngày tải lên: 08/08/2014, 21:20

... parental history of asthma and 25.0% had a parental history of atopy at the time of interview 9.3% of participants had no siblings Premature birth occurred for 9.3% of children and 8.6% required ... effect on early-onset asthma (OR, 2.01; 95% Table Effects of environmental tobacco smoke exposure (ETS) on subcategories of asthma Asthma Treatments for asthma Ever asthma Active asthma Medication ... education, parental history of asthma, parental history of atopy, gestational age, and community † Early-onset: asthma diagnosed ≦ yr of age ‡ Late-onset: asthma diagnosed > yr of age *Average cigarettes...

Ngày tải lên: 12/08/2014, 11:20

... a National Asthma Education and Prevention Program (NAEPPII) asthma severity score of Step with neither a firm diagnosis of asthma nor an exclusion of the diagnosis of asthma Step of NAEPPII ... predicted maximum at and minutes of 82.1% ± 5.6 and 86.6% ± 8.9 on Day and of 81.5% ± 6.7 and 89.9% ± 6.5 on Day in adults (p = NS) and 81.9% ± 5.7 and 85.9% ± 10.3 on Day and 81.8% ± 6.3 and 86.7% ± ... without other clinical signs and symptoms of asthma [9-11] EIB is often the first indication of asthma [12] so it is important to diagnose and then treat underlying asthma recognized by exercise...

Ngày tải lên: 12/08/2014, 11:22

... Allergy and Asthma Chest 2007, 132:1007-1014 37 Loza MJ, Foster S, Peters SP, Penn RB: Interactive effects of steroids and [beta]-agonists on accumulation of type T cells Journal of Allergy and Clinical ... desquamation and denudation of the epithelium are significant features of asthma [28] Although the causes of epithelial injury can be multiple, one source that is likely to be important is the release of ... airways [18] Inhalation of allergen is a common trigger of asthma and instigates an immediate release of mediators from mast cells that have the capacity to activate a number of pathways that lead...

Ngày tải lên: 12/08/2014, 13:22

... of data, analysis and interpretation of data, and drafting and revising the manuscript JK contributed to study design, acquisition of data, analysis and interpretation of data, and drafting and ... Figure Plot of R % predicted for asthmatic and nonasthmatic subjects Rmin %predicted for all 34 nonasthmatic (black) and 35 asthmatic (hatched) participants as well as the subgroup of 26 nonasthmatic ... acquisition of data, analysis and interpretation of data, and drafting and revising the manuscript SNS contributed to study design, acquisition of data, analysis and interpretation of data, and drafting...

Ngày tải lên: 12/08/2014, 13:22

... signs and symptoms suggestive of asthma according to the National Institute of Health (NIH) Questionnaire [17] but without a firm diagnosis of asthma or an exclusion of the diagnosis of asthma ... showed a sensitivity of mannitol and methacholine to identify EIB of 68.4% and 73.7% and a specificity of 44.4% and 55.5% respectively Sensitivity and specificity for mannitol and methacholine to ... clinical diagnosis of asthma at Visit (ClinDx5), 78% had a likelihood of asthma of less than 50% assigned at Visit Sensitivity and specificity of mannitol to predict ClinDx5+ was 55% and 73% The sensitivity...

Ngày tải lên: 12/08/2014, 14:20

... [2] A greater understanding of the genetic basis of asthma and atopy holds great promise for the identification of novel therapeutic targets Linkage analysis using short tandem repeats or microsatellites ... contributed to the design of the study and the writing of the manuscript JB and IPH contributed to the design of the study and the writing of the manuscript All authors read and approved the final ... consistency of results across studies and to identify regions that contain asthma and atopy susceptibility genes The aim of the current study was to complete the first meta-analysis of available...

Ngày tải lên: 12/08/2014, 15:21

... localization of caldesmon and calponin, leading to removal of inhibition of actin, resulting in contraction Evolution of asthma therapy By and large, the advances made in our understanding of excitation-contraction ... http://respiratory-research.com/content/7/1/123 A major and fundamental limitation in studies aimed at better understanding and treating asthma has been the lack of a good animal model of asthma Asthma is characterized, in ... plasmalemma and the SR [34]), inhibition of the RhoA/ ROCK signalling pathway [35] and direct stimulation of MLCP [34] A more recent development which builds on the knowledge of the actions of cAMP...

Ngày tải lên: 12/08/2014, 16:20