experimental design of vehicle and drug treatments of het mice

... proteomic platforms 38 Table Experimental design of vehicle and drug- treatments of HET mice 50 Table Gel setup for 2D-DIGE experiments for HET hepatic mitochondrial proteome characterisation ... of the iTRAQ™ experiment design of 4-plex and 8plex systems 63 Figure 14 Histogram of mean signal area (intensity) of reporter channels 73 Figure 15 Assessment of genotype and ... structures, (iv) elevation of H2O2, and O2•-, (v) uncoupling of State and inhibition of State respiration, (vi) inhibition of OXPHOS Complexes II + III, IV and V activities and sometimes (vii) inducing...

Ngày tải lên: 12/09/2015, 11:08

... the head of each phrase and the grammatical functions: TIME, SUBJ(ect) and P-0BJ(ect) Evaluation The performance of the parser partly depends on the output of the tagger and the rest of the preprocessing ... mean: (i) the recognition of multi-word tokens, phrasal verbs and idioms; (ii) sentence segmentation; (iii) part -of- speech tagging using Brill's (1994) part -of- speech tagger, and the EAGLES tagset ... into levels, with each level consisting of groups of patterns ordered according to their internal complexity and length A pattern consists of a category and a regular expression The regular expressions...

Ngày tải lên: 17/03/2014, 22:20

... thank Profs Mike Branicky and Ken Loparo of the Department of Electrical and Computer Engineering, and Prof Robert Edwards of the Department of Chemical Engineering of Case Western Reserve University ... ˛’s quantile of random quantity X resolution the set of all real numbers correlation coefficient of X and Y the standard deviation of a random quantity X power spectral density of a stationary ... Random Quantities and Random Vectors 3.1 Discrete, Continuous, and Singular Random Quantities 3.2 Expectations and Moments of Random Quantities...

Ngày tải lên: 05/09/2016, 23:35

... al Systematic review of the effectiveness and cost-effectiveness, and economic evaluation, of myocardial perfusion scintigraphy for the diagnosis and management of angina and myocardial infarction ... alone the prevalence of CAD is estimated at 5.9% of all Caucasians of age 18 and older [3] Accurate, non-invasive diagnosis of, and screening for, CAD and restenosis after coronary revascularization ... participant as a result of the disclosed non-risk designation of the study device All patients received a full explanation and gave verbal consent to the study and the use of their de-identified...

Ngày tải lên: 03/11/2012, 10:58

... (starch and soluble carbohydrates) during that time period of cold exposure Effect of cold exposure on levels of soluble carbohydrates and starch Contents of leaf starch, sucrose, hexoses and raffinose ... activities of enzymes in central carbohydrate metabolism during cold exposure (A–C) Vmax values of three invertase isoforms: vInv, nInv and eInv (D) Vmax of SPS (E, F) Vmax values of FrcK and GlcK ... compared with that of vInv, the activities of nInv and eInv were low, and became noticeably higher only in Rsch after days of cold exposure (Fig 3B,C) However, in both accessions, values of Vmax for...

Ngày tải lên: 14/02/2014, 22:20

... apoptosis and induces the synthesis of antioxidants [22] Alterations in mitochondrial proteins, on the other hand, are specifically linked to one of the major pathogenetic mechanisms of PD [5] Worthy of ... spots were manually excised and destained (1 · 10 50 lL of K3[Fe(CN)6] 30 mm and Na2S2O3 100 mm; · 10 100 lL of deionized water; · 20 100 lL of NH4HCO3 200 mm; · 20 100 lL of deionized water), dehydrated ... each sample and data were processed using CellQuest software (Becton-Dickinson) Fluorescent emission of propidium iodide and Annexin V-FITC were collected through a 575 and a 530 ⁄ 30 bandpass filter,...

Ngày tải lên: 15/02/2014, 01:20

... number of times term i occurs in D, idfi is the inverse document frequency of term i, N is the total number of documents and dfi is the number of documents that contain term i The utilization of ... document and avg dl is the average number of terms in all the documents For ease of reference, we also include the BM25 tf scheme The k1 and b parameters of BM25 are set to their default values of ... row of table and 4th row of table 2), therefore the weight wi of term i in document D according to the BM25 scheme is notated as SM ART.okn or okn Most of the tf weighting functions in SMART and...

Ngày tải lên: 20/02/2014, 04:20

... number of sentences and errors in the project, average number of errors per sentence, and how many sentences there are with certain numbers of errors The main part of the statistics is the number and ... system, and possibly for the source and reference sentences, and all error and support annotations The annotations are stored with the indices of the word(s) in the segments that were marked, and ... evaluation and postprocessing of statistical machine translation In Proceedings of LREC, pages 2175–2181, Valetta, Malta David Vilar, Jia Xu, Luis Fernando D’Haro, and Hermann Ney 2006 Error analysis of...

Ngày tải lên: 07/03/2014, 22:20

... a graph is defined by its set of vertices and its set of edges Therefore, the domain of a graph consists of a set of possible vertices, in our case for the atoms, and possible edges, in our case ... Analysis of Organic Substituents: Identification of the Most Common Substituents, Calculation of Substituent Properties, and Automatic Identification of Drug- like Bioisosteric Groups Journal of Chemical ... crucial role in classification of chemical compounds For example, hydroxy, used as a prefix of a name, specifies the presence of an OH-group (consisting of an oxygen atom and a hydrogen atom) A molecular...

Ngày tải lên: 08/03/2014, 01:20

... The construction of the )70/)36TATA LUC and 3x()70/)36)TATALUC involved the cloning of one or three copies of double stranded oligonucleotides spanning the region from )70 to )36 of the xMGP promoter ... kb of chromosomal DNA) which was further analyzed by restriction mapping and Southern Fig Sequence of the X laevis MGP gene promoter Nucleotide sequence of the 5Â end of X laevis MGP gene and ... transcription start site of the xMGP gene Fig Sites of intron insertions within the amino-acid sequence of Xenopus, human and mouse MGPs Conserved sites of intron insertions in mammalian and X laevis MGPs...

Ngày tải lên: 08/03/2014, 10:20

... deployment and use of ICT has been ratcheted up by technological transformations that have dramatically lowered the cost of goods and services and expanded the range of technology choices and development ... lowered the cost of ICT goods and services and expanded the range of technology choices and solutions It has also stimulated the entry of new players – principally the private sector - and increased ... the early waves of privatization of national PTTs and opening of markets in the industrial countries – led by the breakup of AT&T in the United States and the public offerings of shares in British...

Ngày tải lên: 15/03/2014, 19:20

... comparable and comprehensive measures of population health and comparative assessments of the burden of diseases, injuries and risk factors; and to investigate the costs, efficacy and effectiveness of ... the rate of growth of total population, ru is the rate of growth of utilization per capita, rp is the rate of growth of the general price level, rr is the rate of growth of the ratio of the medical ... period t-1, (2) (1+rate of growth of population), (3) (1+rate of growth of utilization (per capita) indicator), (4) (1+rate of growth of GNP deflator), (5) (1+rate of growth of medical prices relative...

Ngày tải lên: 22/03/2014, 13:20

Ngày tải lên: 12/06/2014, 11:37

... reaction contained µl of cDNA from the RT reaction, µl of 10× PCR Buffer, 1.5 mM MgCl2, µl of 10 mM each of dATP, dCTP, dGTP, and dTTP per reaction, µM each of primers and 2.5 units of Platinum Taq ... Sub-Programme (Dept of Agriculture and Food, Republic of Ireland) Thank you to Mr Noel Shanaghy and Mrs Breda Doody of Waterford Regional Hospital, Mr Eddie Beggan of Limerick Regional Hospital and Dr Jim ... right (B) Standard curve of GI assay R2 1.00 and a slope of -3.8 was obtained (C) Melting curve of GI standards showing melting point at 90°C in descending order 107 – 101 molecules GI and GII NoV...

Ngày tải lên: 18/06/2014, 18:20

... reaction contained µl of cDNA from the RT reaction, µl of 10× PCR Buffer, 1.5 mM MgCl2, µl of 10 mM each of dATP, dCTP, dGTP, and dTTP per reaction, µM each of primers and 2.5 units of Platinum Taq ... Sub-Programme (Dept of Agriculture and Food, Republic of Ireland) Thank you to Mr Noel Shanaghy and Mrs Breda Doody of Waterford Regional Hospital, Mr Eddie Beggan of Limerick Regional Hospital and Dr Jim ... right (B) Standard curve of GI assay R2 1.00 and a slope of -3.8 was obtained (C) Melting curve of GI standards showing melting point at 90°C in descending order 107 – 101 molecules GI and GII NoV...

Ngày tải lên: 20/06/2014, 01:20

... common element of the set of solutions of a mixed equilibrium problem, the set of fixed points of an infinite family of nonexpansive mappings, and the set of solutions of a general system of variational ... tq-1Jq(x), and Jq(-x) = -Jq(x) for all x Î Page of 14 Chen and Wan Journal of Inequalities and Applications 2011, 2011:49 http://www.journalofinequalitiesandapplications.com/content/2011/1/49 Page of ... constants, and (x*, y*) Î E × E Then (x*, y*) is a solution of the problem (2.1) if and only if Chen and Wan Journal of Inequalities and Applications 2011, 2011:49 http://www.journalofinequalitiesandapplications.com/content/2011/1/49...

Ngày tải lên: 21/06/2014, 00:20

... Analysis of the properties of the solutions of Eq (1) In this section, we will present some results on the boundedness, uniqueness, and continuous dependence on initial data of the solutions of the ... we denote the set of all ℝ-valued functions on U by ℘(U), and denote the set of all ℝ+-valued functions on U by ℘+(U ) As usual, the collection of all continuous functions of a topological space ... direction only includes the work of Ma [3] to our knowledge We note in order to fulfill the analysis of qualitative and quantitative properties of the solutions of Eq (1), which has more complicated...

Ngày tải lên: 21/06/2014, 00:20

... Colao, G L Acedo, and G Marino, “An implicit method for finding common solutions of variational inequalities and systems of equilibrium problems and fixed points of infinite family of nonexpansive ... α-inverse-strongly monotone mapping of C into H, and let S be a nonexpansive mapping of C into itself such that F S ∩ GEP f, A / ∅ Let u ∈ C and x1 ∈ C, and let {yn } ⊂ C and {xn } ⊂ C be sequences generated ... bounded n subset B of C, ∞ sup{ Tn z − Tn z : z ∈ B} < ∞ 2.6 n Lemma 2.5 see 32 Let C be a nonempty and closed subset of a Hilbert space H, and let {Tn } be a family of mappings of C into itself...

Ngày tải lên: 21/06/2014, 07:20

... types of data The length of packet and data, number and size of flits, and the depth of VC are all parameterized The size of flits can be 8, 16, 32, or 64 bits, but we keep a header and tail of bits, ... size of FIFOs are the number of logic and registers With a depth of 32, 20% of the registers are used and 40% of the logic is used The use of logic grows more significantly with a depth of 32 ... results and commands A dedicated and optimized communication architecture is required and is most of the time designed from the algorithm requirements The Design Space Exploration (DSE) of an adaptable...

Ngày tải lên: 21/06/2014, 20:20

... of the above mutations of a gene, the exact sequence of bases named oligos should be printed on the LoC, (iii) the design of appropriate sources of RNA to be hybridized, and (iv) the number of ... information to optimize drug therapy increasing the efficiency and minimizing the adverse effects of the developed drugs Section of the paper describes the state of the art of the microfluidics sample ... variation (size of deletion or insertion and nature of substitutionmismatched base pairs not have equal stability), (v) analysis of both strands, (vi) length of linker, (vii) use of control probes...

Ngày tải lên: 21/06/2014, 22:20