exercise muscle damage and oxidative stress

... excitotoxicity leading to neuronal damage in anoxia The increased concentration of TBARS and decreased concentration of TAS supports the oxidative stress in anoxia and reperfusion and suggests a possible ... conditions and were given normal diet for days and decapitated and the different brain regions (CC, CB and BS) were used for study It was reported by Ananth et al (23) that days showed most severe damage ... direct and secondary excitotoxic neuronal injuries in vivo Excitotoxicity, oxidative stress and apoptosis comprise major routs of hypoxic-ischemic neuronal death Each route is likely activated and...

Ngày tải lên: 26/10/2012, 09:07

... in isolated heart preparations [195] and subsequently shown to be associated with tissue damage in this and other organs, including the kidney and skeletal muscle [196,197], but not in others, ... Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury Cell Calcium 36, 257–264 441 Ca2+, mitochondria, ROS in neuronal disease C Chinopoulos and V Adam-Vizi 17 Andreyev AY, ... proteins residing in both the inner and outer mitochondrial membrane, that is activated by mitochondrial Ca2+ overloading and other factors including oxidative stress [88,89] In neurons the presence...

Ngày tải lên: 07/03/2014, 12:20

... hormone signaling, biotic and abiotic stress responses, and development [15,16], whereas high concentrations of ROS can result in oxidative stress and cause irreversible damage and hypersensitive response-like ... signaling pathways Results Expression of GhMPK2 was upregulated by oxidative stress and phytohormones To study the effect of oxidative stress and signaling molecules on the expression of GhMPK2, total ... transgenic plants to oxidative stress To observe the growth performance of tobacco plants under oxidative stress conditions, the wild-type and transgenic seeds were surface-sterilized and germinated...

Ngày tải lên: 14/03/2014, 23:20

... reduced forms and a methionine residue The cluster is likely to be involved in redox reactions and might constitute the molecular basis of oxidative stress response by annexins Materials and methods ... annexins in the oxidative stress response Oxy5, an annexin-like protein from Arabidopsis, was shown to rescue E coli DoxyR mutants and protect mammalian cells from oxidative stress [8,9] In particular, ... live and breathe: free radicals and aging Correlative evidence from a number of fields suggests they may be key Biotechnology 12, 37–40 Chiueh, C (2001) Iron overload, oxidative stress, and axonal...

Ngày tải lên: 17/03/2014, 03:20

... was the same at t ¼ and h This indicates that the 14 C sucrose was trapped by loading and resealing and did not leak out of the ghost cells The ghost cells were incubated with and without modifiers ... were prepared as described in the methods section and incubated at 37 °C, 10 lL samples taken at t ¼ and t ¼ h and assayed Error bars represent standard deviation 2610 B K Derham et al (Eur J Biochem ... heart disease, hypertension and cataract Altered Na+ and K+ concentrations are observed in many forms of human cataract and correlate with increasing lens colour and with cortical opacification...

Ngày tải lên: 17/03/2014, 03:20

... type of oxidative damage that is found in AD, and it directly correlates with the presence of Aβ deposits [8,10,21] Oxidative stress also precedes amyloid deposition in human AD, the Tg2576 and a ... concept that oxidative imbalance and subsequent oxidative stress are among the earliest events in the pathogenesis of AD [4,5] Thus, an increase in lipid peroxidation, protein oxidation and DNA oxidation ... inflammation and oxidative stress [16,17] Our results confirm previous observation where low-dose curcumin, a drug with reported both anti-oxidant and anti-inflammatory activities, reduced total Aβ and...

Ngày tải lên: 19/06/2014, 22:20

... transforming growth factor, CD40 ligand, interleukin 1, or interleukin [10] Oxidative stress also promotes angiogenesis [13] The link between oxidative stress and angiogenesis is emphasised in ... the concentrations of adhesion molecules and oxidative damage markers The fact that VEGF and sVEGFR-1 concentrations were not changed whereas oxidative stress was ameliorated by nifedipine is ... adhesion (sVCAM-1) and angiogenesis (VEGF, sVEGFR-1) together with oxidative damage markers (carbonyl residues and advanced oxidation protein products [AOPP]) at baseline and, secondly, to look...

Ngày tải lên: 09/08/2014, 01:23

... ROS production assay and real-time RT-PCR experiments, and participated in the study design and in drafting the manuscript JG isolated and set up the chondrocyte cultures and performed some experiments ... endothelial and smooth muscle cells under high-glucose conditions Circ Res 2005, 97:1001-1008 Cohen G, Riahi Y, Alpert E, Gruzman A, Sasson S: The roles of hyperglycaemia and oxidative stress in ... Results Basal and IL-1β-induced glucose transport and GLUT-1 content in normal and osteoarthritis chondrocytes Figure 1a reveals that the basal 2-DG uptake was identical in normal and OA chondrocytes...

Ngày tải lên: 09/08/2014, 14:21

... levels of oxidative stress biomarkers and an increased mtDNA copy number in peripheral leukocytes Since mitochondria are a major source of ROS and are highly susceptible to oxidative damage, we ... levels of albumin, cholesterol, and sodium in dialysis patients as compared to control subjects Levels of oxidative stress variable markers and levels of blood TBARS and mtDNA copy number were higher ... depending on D310 alterations, and significant differences were observed in the levels of oxidative stress biomarkers and mtDNA copy number between dialysis patients and control subjects in the...

Ngày tải lên: 11/08/2014, 07:21

... oxidative stress altered transactivation by EBNA1 and Tat in a manner opposite to the effect of hypoxia Differing effects of the oxidizing agents menadione and paraquot on Tat and EBNA1 EBV and ... Hypoxia alters transactivation by Tat and EBNA1 EBNA1 and Tat contain redox-sensitive cysteines that are essential for transactivation [18,28], and oxidative stress is known to alter the ability ... generation and thereby circumvent the difficulty in inducing oxidative stress by solely increasing pO2 [49] Menadione and paraquot are most frequently used to increase intracellular hydroxyl and superoxide...

Ngày tải lên: 12/08/2014, 04:20

... The Netherlands) Q-PCR of oxidative- stress proteins, copper metabolism and other related signaling molecules Q-PCR was performed on a total of 17 genes involved in oxidative stress and copper ... Doberman pinchers copper accumulates in time and, finally, will have its negative effect on copper metabolism and induce oxidative stress Oxidative stress has been ascribed to copper toxicosis ... toxicity is often associated with oxidative stress, we also measured several oxidative stress related gene-products To determine a possible damaging effect of the oxidative stress, we investigated proteins...

Ngày tải lên: 13/08/2014, 13:20

... has been used in research to induce pulmonary fibrosis in mice and rats and produce an oxidative injury resulting in DNA damage and the destruction of alveolar epithelial cells [11] In addition, ... measurements and TGF-b1 and TNF-a in rats with lung fibrosis Sublethal and lethal lung irradiation can trigger a number of genetic and molecular events that can have both short-term effects and longer-term ... eosinophils and other cell types) along with increases of LDH activities, protein content and lung collagen accumulation These events are indicative of airway and/ or alveolar cell damage (Table...

Ngày tải lên: 13/08/2014, 14:20

... therefore focused on the inflammatory response as well as on the oxidative and nitrosative stresses in the heart and aorta Materials and methods The animal protocol was approved by the regional animal ... production and I/R-dependent iNOS expression and improved metabolic dysfunction • NaHS down-regulated NF-B, iNOS and I-CAM expressions in this model • NaHS reduced I/R-induced oxidative stress Abbreviations ... retransfusion of shed blood (i) limited the I/R induced-decrease in MAP and (ii) was associated with reduced inflammatory and oxidative stress responses Although H2S is usually considered as an endogenous...

Ngày tải lên: 13/08/2014, 21:21

... OXIDATIVE STRESS AND DISEASES Edited by Volodymyr Lushchak and Dmytro V Gospodaryov Oxidative Stress and Diseases Edited by Volodymyr Lushchak and Dmytro V Gospodaryov ... Between Thyroid States, Oxidative Stress and Cellular Damage 413 Cano-Europa, Blas-Valdivia Vanessa, Franco-Colin Margarita and Ortiz-Butron Rocio Chapter 19 Oxidative Stress in Human Autoimmune ... 4 Oxidative Stress and Diseases Evidences for connection of oxidative stress with the stresses induced by other factors are promptly gained The potency of transition metals, some herbicides and...

Ngày tải lên: 12/02/2014, 16:20

... and Volodymyr I Lushchak Chapter Oxidative and Nitrosative Stresses: Their Role in Health and Disease in Man and Birds 47 Hillar Klandorf and Knox Van Dyke Chapter Nitric Oxide Synthase and Oxidative ... glycoxidation and carbonyl /oxidative stress 30 Oxidative Stress Molecular Mechanisms and Biological Effects The existence of a strong relation between carbonyl and oxidative stresses can be ... that oxidative stress can directly lead to pathologies, there are many evidences demonstrating a strong relationship between oxidative stress and 10 Oxidative Stress Molecular Mechanisms and...

Ngày tải lên: 12/02/2014, 16:20

... against oxidative stress- induced mitochondrial and cellular damage when present in low concentrations during the oxidative stress period [15,33] sih was rst synthesized in 1953 [34] and its iron ... following oxidative stress Cells were seeded (500 000 well) and 24 h later exposed to oxidative stress, with or without sih-protection as described before Directly after end of the oxidative stress ... further 15 before being exposed to oxidative stress After the oxidative stress period cells were returned to standard culture conditions for 15 and then scraped and assayed by ow cytouorometry The...

Ngày tải lên: 19/02/2014, 06:20

... upregulation and apoptosis The duration of exposure to oxidative stress affects c-Fos stability and BimEL expression by changing the duration of the ERK signal Therefore, the duration of oxidative stress ... lM) or vitamin C (1 mM), and then incubated for h in the presence or absence of ATZ (20 mM) and mercaptosuccinic acid (7 mM) Cell were collected and lysed, and both firefly and Renilla luciferase ... sustained oxidative stress This idea is supported by data showing that transient oxidative stress for or h did not induce apoptosis [38] In conclusion, ERK activation resulting from sustained oxidative...

Ngày tải lên: 06/03/2014, 00:21

... oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues Particle and Fibre Toxicology 2011 8:20 Submit your next manuscript to BioMed Central and ... lesions on a standard chow diet It is used for studies of hyperlipidemia and atherosclerosis, and has been used extensively in understanding the mechanisms of lipoprotein metabolism and atherosclerosis ... insights into the roles and mechanisms of PM2.5-associated physiology and pathology In summary, our data demonstrate the important effects of PM2.5 exposure on oxidative stress and mitochondrial alterations...

Ngày tải lên: 06/03/2014, 19:20

... Transcriptional analysis of bcp2 under oxidative stress and characterization of mRNA 5¢ end 0,3 0,2 0,1 • 10 Time (h) Fig S solfataricus P2 cultures treated with different oxidative stress agents Sulfolobus ... 2, pUC19 and 10 mM DTT; lane 3, pUC19 and lM FeCl3; lane 4, pUC19, 10 mM DTT, and lM FeCl3; lane 5, pUC19, 10 mM DTT, lM FeCl3, and 50 lgÆmL)1 rBcp2; lane 6, pUC19, 10 mM DTT, lM FeCl3, and 50 ... terminus and SR at the C terminus of the protein belong to different subunits and condense to form an intersubunit disulfide bond; in atypical 2-Cys Prxs, Sp and SR belong to the same subunit and establish...

Ngày tải lên: 07/03/2014, 12:20

... O2 exposure and ROS inhibition, which has not been previously evaluated in this enzyme; and (b) to analyze the effects of oxidative stress on glycolytic and fermentative enzymes and pathway uxes ... O2 exposure on the kinetics of oxidative stress damage for both glycolytic enzymes and uxes was examined, immediately after subjecting the parasites to O2 exposure and later during a phase of recovery ... prolonged and or acute aerobic conditions Owing to the higher PFOR sensitivity, this enzyme is proposed as a specic and sensitive marker of oxidative stress in E histolytica Both EhPFOR and EhADH2...

Ngày tải lên: 15/03/2014, 23:20