examples of trend analysis
Báo cáo y học: "Evaluation of Fractional Analysis of Bronchoalveolar Lavage Combined with Cellular Morphological Features"
Ngày tải lên :
03/11/2012, 11:48
... activity of disease in sarcoidosis or HP In addition, finding of encapsulated exudates may suggest desquamation of early stage of Masson body which implies possible diagnosis in a limited number of ... records of a total of 2260 patients with various lung diseases between 1984 and 2006 at our Nippon Medical School affiliated hospitals (Table 1) Among them, 76 of sarcoidosis and 14 of HP patients ... Patients’ group showing the highest rate of lymphocytes Of the 2260 patients, 488 (21.6%) showed a lymphocyte rate of higher than 40% Clinical diagnoses of these patients included sarcoidosis (22.1%),...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 17)
Ngày tải lên :
18/10/2013, 00:15
... during storage of specimens, but also during the headspace analysis As shown in > Fig 8.1A, the decomposition product isobutyl alcohol is detected even in headspace GC analysis of the standard ... of 0.4 mL of blank blood and 0.4 mL of IS- containing pentane solution in a glass vial with a Teflon-septum screw cap, which has been cooled with ice, and vortex-mixed for s; a 3-µL aliquot of ... concentration of isobutyl nitrite detected by analysis only shows one at the time point of the injection into GC and does not reflect the in vivo level Under the present GC conditions, the peak of isobutyl...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 67)
Ngày tải lên :
18/10/2013, 00:15
... a stream of nitrogen gas at room temperature e iii The residue is dissolved in 100 µL of the dichloromethane solution of DAEMO (IS solution); a 1-µL of it is injected into GC/MS for analysis ... TIC and mass chromatograms; (b) an EI mass spectrum of the t-BDMS derivative of EMPA; (c) a CI mass spectrum of the same derivative of EMPA data of animals According to the reports by the US army ... JK, Paasivirta J et al (1981) Trace Analysis of Chemical Warfare Agents An Approach to the Environmental Monitoring of Nerve Agents Ministry of Foreign Affairs of Finland, Helsinki, pp 27, 28, 37–39,...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 20)
Ngày tải lên :
24/10/2013, 19:15
... GC/MS analysis of ∆9-THC-11-oic acid in human urine [15, 16] e) A method of silylation of glassware to be done before analysis was reported [17]; such treatment suppresses the adsorption of cannabinoids ... 10:316–323 14) Yamamoto I (1992) Methods for analysis of cannabis and its components In: The Pharmaceutical Society of Japan (ed) Standard Methods of Chemical Analysis in Poisoning – With Commentaries, ... 2.4 Mass spectra of the methyl ester plus TMS and TMS derivatives of ∆9-THC-11-oic acid The Substance Abuse and Mental Service Administration (SAMSA) in USA set the cutoff value of ∆9-THC-11-oic...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 21)
Ngày tải lên :
24/10/2013, 19:15
... method Qualitative analysis is made by the comparison of the retention time of a peak of a specimen with that of the authentic standard and also by the confirmation of the absence of such a peak ... low levels of morphine starting from a large amount of a specimen cannot be a proof of the intake of the drug The level of morphine in urine of healthy subjects determined by GC/MS was reported ... oxidoreductive potential of the hydroxyl group of the phenol moiety, it is not suitable for analysis codeine or M-3-G For cautions and cutoff values upon detection of trace levels of morphine, the readers...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 70)
Ngày tải lên :
24/10/2013, 19:15
... gas: He; flow rate: 2.1 mL/min Procedures i Analysis of nitrate i ii iii iv v vi A 0.2-mL volume of a test specimen, 20 µL of IS solution and 0.2 mL of the saturated silver acetate solution e ... ratio of nitrate to IS obtained from a test specimen is applied to the calibration curve to calculate its concentration ii Analysis of nitrite i A 0.2-mL volume of a test specimen and 0.1 mL of ... 0.2-mL volume of the supernatant solution is transferred to a new polypropylene tube of the same type, followed by addition of 0.5 mL of concentrated sulfuric acid f and 0.5 mL of mesitylene...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 71 and End)
Ngày tải lên :
24/10/2013, 19:15
... interfered with by the coexistence of high concentrations of CO-Hb [6] As low as about 0.2 % of Met-Hb can be measured accurately However, when high concentrations of sulfhemoglobin (SHb) may interfere ... cadavers of sulfide or polysulfide poisoning (see the chapter “Hydrogen sulfide and its metabolite” of this book) Met-Hb in blood is not stable at room temperature and even at –30 °C When analysis of ... x The percentage of Met-Hb is calculated by the following equation: Met-Hb % = 100 (A1–A2)/ (A3–A4) Assessment and some comments on the method The present method for analysis of Met-Hb in blood...
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SELECTED EXAMPLES OF NEWAPPLICATIONS
Ngày tải lên :
25/10/2013, 16:20
... Dextran esters of ketoprofen, diclofenac, ibuprofen and fenoprofen have been studied, showing that the dextran ester prodrug approach provides selective colon delivery systems of drugs possessing ... development of nanoparticle systems usable for parental injection, the use of hydrogels, and the preparation of hydrolytically instable prodrugs that are of recent importance Because of the fact ... devices is one of the major developments in the field of therapeutics In addition to controlled release mechanisms accom- 188 10 Selected Examples of New Applications Fig 10.4 Percentage of released...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 22)
Ngày tải lên :
29/10/2013, 01:15
... However, in Japan, such criteria set by official institutions are not available for drugs of abuse Upon judgements of analytical data, the idea of cutoff values should be adopted with reference ... confirmation of a target compound is usually achieved by agreement of its mass spectrum with that of the authentic standard Since, with simultaneous use of a deuterated IS, a mass spectrum of a target ... estimate the cause of death, time of death and time after drug use, using the ratio of cocaine to BE and the brain-to-blood ratios of cocaine and BE The ratios only give rough estimation of them References...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 23)
Ngày tải lên :
29/10/2013, 02:15
... added to mL of whole blood or urine M NaHCO3: a 8.4-g aliquot of NaHCO3 is dissolved in distilled water to prepare 100 mL solution Chloroform/ethanol (9:1, v/v): a 100-mL volume of the mixture ... eluted with mL of chloroform/ethanol (9:1) into a glass vial A small amount of upper aqueous layer is carefully removed by aspiration with a Pasteur pipette The organic layer (chloroform) is evaporated ... ng IS and one of various concentrations of pentazocine to each vial containing mL of blank whole blood or urine and mL distilled water, followed by the above procedure The number of different...
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The alchemy of meta-analysis
Ngày tải lên :
01/11/2013, 11:20
... stabilizer use or use of less proven agents) Meta -analysis as interpretation The above example demonstrates the dangers of meta -analysis, as well as some of its benefits Ultimately, meta -analysis is not ... for instance, the opinion of the construction worker does not count the same as the opinion of a professor of physics What matters is the consensus of those who are of similar background and ... definitive scientific reviews of evidence difficult to achieve Clinical example: meta -analysis of antidepressants in bipolar depression Recently, the first meta -analysis of antidepressant use in acute...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 24)
Ngày tải lên :
08/11/2013, 01:15
... acetone/chloroform (4:1, v/v); (B) chloroform/methanol/n-hexane (4:2:1, v/v) Assessment of the method The Rf values of LSD were 0.29 with the (A) solvent system and 0.55 with the (B) system The colors of ... solutions are combined After the pH of the solution is adjusted to 8.5, the solution is extracted with an appropriate amount of chloroform four times The combined chloroform extract is evaporated to ... TLC or LC, and extracted with chloroform The resulting residue is subjected to analysis by the direct inlet method of EI-MS Analytical conditions Any type of an MS instrument can be used; electron...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 25)
Ngày tải lên :
08/11/2013, 01:15
... monitored) The mass spectra of TFA derivatives of MDMA and its three metabolites obtained from the urine specimen are shown in > Fig 7.5 For the proof of the use of MDMA, detection of MDA along with MDMA ... stream of nitrogen and reconstituted in 0.1 mL of DPM (IS) solution A 1-µL aliquot of it is injected into the GC/MS system with a DB-17MS systemk i Assessment of the methods EI mass spectra of TFA ... proof of MDMA use, detection of MDMA and its metabolite MDA is being generally performed for urine specimens In this chapter, the procedures for GC/MS and LC/MS analyses of MDAs in the forms of...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 26)
Ngày tải lên :
08/11/2013, 01:15
... amounts of methanol; a 10–20 µL aliquot is spiked into mL of a whole blood or urine specimen M NaHCO3 solution: 8.4 g of NaHCO3 is dissolved in distilled water to prepare 100 mL solution Chloroform/methanol ... eluted with mL of chloroform/methanol (9:1) into a glass vial v A small amount of upper aqueous layer is carefully removed by aspiration with a Pasteur pipette The organic layer (chloroform) is evaporated ... procedure The number of different concentrations of PCP should not be smaller than The calibration curve is composed of PCP concentration on the horizontal axis and peak area ratio of PCP to IS on...
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Tài liệu The Insider’s Guide to PR: Chapter 6 PR IN PRACTICE The following case studies are examples of PR pptx
Ngày tải lên :
13/12/2013, 04:15
... reached two out of five mothers at least twice and just over half of all primary school children at least twice • 83% of coverage included tips on food hygiene, 83% included mentions of the schools ... who would campaign in favour of the amendment and table it on the floor of the House of Commons This included drafting speeches used in the House during the passage of the Bill • Identifying and ... practice • To encourage the teaching of food safety in the classroom • To raise awareness of and encourage basic food hygiene practice within the target group of 7-11 year olds Solution • Commission...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 27) ppt
Ngày tải lên :
15/12/2013, 12:15
... mg/mL solution of the free form of chlorpromazine, the amount of chlorpromazine hydrochloride to be dissolved in mL methanol is calculated as follows mg (MW of the free form 318.9 MW of the salt ... and a 2- µL of it was injected into GC/MS GC/MS analysis ii Preparation Each drug is dissolved in methanol to prepare mg/mL solutionb Many of the phenothiazine drugs are in the forms of hydrochloride ... elution with mL of chloroform/acetonitrile (8:2) The upper aqueous layer of the eluate is removed with a Pasteur pipette; the organic phase is evaporated to dryness under a stream of nitrogen The...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 28) pptx
Ngày tải lên :
15/12/2013, 12:15
... volume of urine or blood, 0.05 mL IS and 0.5 mL of M NaOH are placed in a 15-mL volume glass centrifuge tube with a ground-in stopper and mixed well, followed by addition of mL of the mixture of ... are compared for analysis of haloperidol and bromperidol, the LC/MS seems of the best choice for their trace analysis The HPLC method enables highly sensitive detection (ng/mL) of the compounds ... excellent The separation ability of GC or GC/MS is much superior to that of HPLC or LC/MS HPLC and LC/MS analysis Reagents and their preparation The sources for acquisition of haloperidol, bromperidol...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 29) ppt
Ngày tải lên :
15/12/2013, 12:15
... evaporated to dryness under a stream of nitrogen The residue is dissolved in 0.5 mL of each mobile phase; a 5-µL aliquot of it is injected into HPLC for analysis Assessment of the method > Figure 3.3 shows ... tentative identification of drugs, a UV absorbance spectrum can be measured together with the confirmation of coincidence of retention time of a test peak with that of an authentic compound Although ... number of them was largest for Tecipul (setiptiline maleate); as many as 200 tablets of Tecipul were found missing As results of GC/MS analysis, setiptiline was ⊡ Table 3.1 Blood concentrations of...
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