... it fails to get rid of any residual microscopicdisease. As a consequence, within few months these patients return with recurrent cancer[ 1]. In most cases, patients present themselves with multiple ... thirty years with a five-year survival of only30% [1,2]. The majority of patients are diagnosed with Stage 3 or 4 d isease, when the cancer has spread fromthe pelvis to the peritoneal cavity ... contrast to almost all other can-cers, ovarian cancer typically does not spread throughthe b loodstream. Instead, tumor growth is often limited to the abdominal (peritoneal) cavity, even in advanced cases....
... that CDC25Bautoantibodies were more prevalent in sera from patients with ad vanced ESCC than in sera from patients with early stage disease (P < 0.001) and that in the patients with clinical ... properly cited. than in patientswith early stage disease [22,38]. Over-expression of CDC25B in advanced ESCC may thus lead to high production of CDC25B-Abs in patients with advanced tumors. These ... adjuvant chemoradiation for patients with ESCC, the five-year survival rate of patients with advanced ESCC is still poor [2]. This poor survival rateis largely due to the lack of serological...
... vaccine andimmunotherapy approaches for cancer. There have beentwo large randomized trials suggesting that adjuvanttherapy withcancer vaccines may be detrimental to patientswith surgically treated ... oftherapeutic vaccination with dendritic cells (DC) in patientswith metastatic melanoma. The efficacy of thisapproach in patientswith favorable prognosis metastatic melanoma limited to the skin, subcutaneous ... t hey are known to trigger CD8 cytotoxic responsesin vivo [5,6]. An initial phase I/II study was performedpulsing IDD-3 with just one melanoma cell line lysate(M17) together with hepatitis...
... investigated bycomparing the ALDS between patientswith IC and patients with CLI, with ALDS scores to be expected higherin patientswith IC than in patientswith CLI.The VascuQol was used as benchmark ... and 3.1 in patientswith CLI)and the VascuQol domain Activity (4.0 in patients with claudication versus 2.4 in patientswith CLI). The effectsize values for the ALDS and the VascuQol total and ... wassignificantly higher in patientswith claudication (ALDSscore 80) than in patientswith CLI (ALDS score 64). Sim-ilar results were obtained for the VascuQol total score (4.5in patientswith claudication...
... Clinicians and researchers often have to rely on information from caregivers to assess patientswithadvanced cancer. This study aims to assess the validity (using patients& apos;assessment as the ... median total POS score than patients. Table 1: Demographic and clinical characteristics statistics for advancedcancerpatients and their caregiversVariable Patient n (%)* Caregiver n (%)*Total ... and Quality of Life OutcomesOpen AccessResearchCaregiver assessment of patientswithadvanced cancer: concordance with patients, effect of burden and positivityIrene J Higginson* and Wei GaoAddress:...
... investigated bycomparing the ALDS between patientswith IC and patients with CLI, with ALDS scores to be expected higherin patientswith IC than in patientswith CLI.The VascuQol was used as benchmark ... rest(in patientswith CLI)0.35 (0-0.59)Decrease ABI after exercise(in patientswith IC)a0.28 (0.09-0.55)Toe pressure mmHg(in patientswith CLI)19 (0-67)ALDS 71 (± 17)VascuQol total 3.7 ... wassignificantly higher in patientswith claudication (ALDSscore 80) than in patientswith CLI (ALDS score 64). Sim-ilar results were obtained for the VascuQol total score (4.5in patientswith claudication...
... older patients withoutextrathyroidal localization, either out of the thyroidalcapsule or at distance or without extrathyroidal localiza-tion or out of the thyroidal capsule and patientswith ... another important risk factor. In Mayo Clinic study5% of patientswith intracapsu lar cancer relapsed within20 years against 15% relapse in patientswith extracapsu-lar cancer. In the Lahey Clinic ... multifocality does notappear to be a significant risk factor in the developmentof local recurrence in patients who undergo total thyroi-dectomy (TT) or near total thyroidectomy (NTT) [23].When LR...
... treatmentfor patientswithadvanced or recurrent gastric cancer and to analyze prognostic factors in these patients. Patients and methods Patients The subjects of this study were 86 patients treatedbetween ... (S-1 alone). In total, 638 patients were enrolled (the originalTable 3: Hematologic and non-hematologic toxicitiesGrade of toxicities % of GradeToxicity 12343 or 4Hematologic toxicitiesLeukopenia ... with docetaxel and S-1 in patientswithadvanced or recurrent gastric cancer. Methods: Eighty-six patientswithadvanced or recurrent gastric cancer were enrolled. Patients received docetaxel,...
... of advanced CRC in anunselected, consecutive series of patients presenting with newly diagnosed disease. It reviews and compares the out-comes of patientswithadvanced bowel cancer treated with ... treatment in themajority of patientswithadvanced disease is palliation with a view to optimise quality of life (QoL) and survivaltime[4]. Patients diagnosed with Stage IV disease CRC present ... informed consent, for patients with stage IV colorectal cancer, as survival is comparable to thatof resection and without the burden of a stoma. Furtherstudies are required to assess the impact...
... 15 patients) concurrently with radiotherapy.Chemotherapy Patients were randomized into two groups: group 1 trea-ted with weekly cisplatin and group 2 treated with weekly paclitaxel. Group I patients ... comparingradiotherapy with concurrent weekly cisplatin or weekly paclitaxel in patients withadvanced cervical cancer. Radiation Oncology 2010 5:84.Submit your next manuscript to BioMed Centraland ... treatment response, overallsurvival, and time to relapse. Time to relapse wasdefined from the date of entry into the study to the dateof recurrence. Patientswith progressive disease whonever achieved...
... observedamong patients differing in expression of progesterone/estrogen receptors, which most apparently corresponded to ongoing anti-estrogen treatment of patientswith highexpression of these receptors. ... previously to have potential in the detection and classification of breast cancer. Here we aimed to identify changes in serum proteome patterns related to therapy of breast cancer patients. Methods: ... subgroup of patients treated with adjuvant therapy, but not in the subgroup subjected only to surgery. This suggests that the observed changes reflect overall responses of the patientsto the toxic...
... (2.5%) had follicular thyroid carci-noma. A total thyroidectomy was performed in 89.9%(284/316) of the patients, and 10.1% (32/316) had a sub-total thyroidectomy or lobectomy. Based on TNM sta-ging, ... non-toxic multi-nodular goiter andfound a decreased HRQOL in the DTC patients thatwas not related to blood TSH levels [7].In our stud y, 89.9% of the patients underwent totalthyroidectomy ... generalizing this study’ s results to all DTC patients. Further investigation with a larger number ofTable 5 HRQOL according to the mode of treatment of thyroid cancer Variables Surgeryalone(n...
... proportion of patientswith early gastric cancer, we wished to study the factors influencing thesurvival in Indian patientswith node-negative gastric cancer, most of whom have advanced gastric cancer. This ... prognostic factor in gastric cancer. There aresubgroups of patientswith different prognosis even in node-negative patients of gastric cancer. The aim of thisstudy is to analyze the factors influencing ... Yamagishi H:Efficacy of prophylactic extended lymphadenectomy with gastrectomyfor patientswith node-negative advanced gastric carcinoma.Hepatogastroenterology 2008, 55:755-759.26. Giuliani A,...