evidence of cytokine involvement in cns injury and disease
Báo cáo khoa học: " Science review: Mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids" pdf
Ngày tải lên :
12/08/2014, 20:20
... protein – a transducer of TNF-α and Fas ligand signals – may participate in TNF-α-induced blockade of GR transactivation by binding to nuclear receptor binding domain of GRinteracting protein Thus, ... corticosteroidbinding globulin and the free cortisol index during septic shock and multitrauma Intensive Care Med 2001, 27:1584-1591 46 Garrel DR: Corticosteroid-binding globulin during inflammation and burn injury: ... are continuous with the sinuses of the medulla, which drain into the central vein of the medulla The right adrenal vein drains into the inferior vena cava and the left into the renal vein Hence,...
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MECHANISMS OF HEXOSAMINE-INDUCED CHOLESTEROL ACCUMULATION AND THERAPEUTIC ACTIONS OF CHROMIUM
Ngày tải lên :
24/08/2014, 10:54
... gluconeogenesis in insulin-resistant states may also be due to a loss of insulin action in the CNS Regardless of the exact role of insulin action in the CNS, insulin resistance in the brain is known ... recruitment of GLUT4 to the PM in fat and muscle cells are complex and still imperfectly understood Upon binding of insulin to the PM localized insulin receptor, the intrinsic tyrosine kinase activity of ... hyperinsulinemia promotes a loss of PIP2 and F-actin structure and that exogenous add back of PIP2 restores F-actin structure and insulin responsiveness (8, 12) Of further note, hyperinsulinemia and...
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Mixture toxicity of POPs dioxins, PCBs, PBDEs considerations from mechanisms of actions and for risk assessment
Ngày tải lên :
16/04/2015, 08:52
... A Global Foodborne Burden of Disease? WHO-‐FERG In prep Es*ma*on of number of W-‐Europe children exceeding the TDI significantly (< 10x) in period 2005-‐2010 M ... almost exclusively derived from short Gme perinatal studies within a ‘sensi*ve window’ of life Weight of evidence points towards humans been less sensiGve (2-‐10 ... studies evaluated Mixtures of PCDDs, PCDFs and DL-‐PCBs s*ll a health risk? One order of magnitude decline in background human exposure since 1970’s due to remedial...
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Báo cáo y học: "Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells"
Ngày tải lên :
31/10/2012, 15:12
... many proteins involved in apoptosis, including the expression profiles of proteins involved in the mitochondrial (bcl-2, bax, and bcl-x, etc.) and stress reaction-related pathways of apoptosis ... importance of Fas and FasL [15], and that of TNF-R1 and TNF-α[16], in preeclampsia Thus, hypoxia-induced changes in the expression of both proapoptotic and antiapoptotic proteins, and 43 the balance of ... of protein changes for the experimental sample to control detected by using the Odyssey Infrared Imaging System (+) means an increase of signal intensity, and (-) means a decrease of signal intensity...
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Study on the Photolytic Mechanisms of Red 141 Dye Wastewaters with an 185nm Vacuum-UV lamp
Ngày tải lên :
05/09/2013, 09:08
... irradiation of contaminated water provides a simple technique for the oxidation and mineralization of water contaminants without the addition of supplementary oxidants For example, it has being used in ... of ultrapure water in the semiconductor industry However, intensive basic research is still necessary to completely understand the fundamental principles of the photochemical process of VUV-induced ... concentration of the pollutant is revealed in Figure indicating that the decoloration rates of Red 141decreased with increasing the initial - 24 - Journal of Water and Environment Technology, Vol.3,...
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ISOTOPE HYDROGRAPH SEPARATION FOR MODELING OF RUNOFF MECHANISMS OF ATMOSPHERICALLY DERIVED CHEMICAL AND RADIOACTIVE POLLUTANTS
Ngày tải lên :
05/09/2013, 09:08
... water in Japan J Japn Soc Hydrol Water Resource, Vol.16, No.5, 556-569 Metal Mining Agency of Japan (ed.) (2001) The Mining Industry of Japan Metal Mining Agency of Japan, Tokyo Ministry of Environment ... change in response to this increased runoff, as well as magnesium In contrast, concentrations of copper and antimony exhibited clear increase in response to increase in the flow rate To determine ... types of colloids including Ti, Y, U, and Th in freshwater (e.g Pokrovsky and Schott, 2002) Indeed, in this case their concentrations in river water are strongly correlated each other Taking into...
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Mechanisms of Unstable Nitrite Inhibition of Aerobic Phosphate Uptake
Ngày tải lên :
05/09/2013, 09:38
... the alternating anaerobic(120min)-anoxic(190min) conditions During initial 120 minutes of anoxic phase, nitrate was introduced into the reactor to theoretically result in 46 mgN/l in the reactor ... denitrification activity Finally, the possibility of ordinary denitrification inside thick floc of the enriched PAOs was examined by adding nitrate instead of nitrite Since nitrate concentration ... concentrations Interestingly, the rest of batch tests also indicate that the sizes of inhibition are AA sludge < AO/N sludge < AO sludge in order And this order is the same as the order of their anoxic...
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Transmission mechanisms of monetary policy the evidence
Ngày tải lên :
05/01/2014, 17:01
... Weak link between nominal interest rates and investment spending does not rule out a strong link between real interest rates and investment spending • Interest-rate effects are only one of many ... Y ↑ Tobin’s q and wealth mechanisms allow for a general definition of equity that includes housing and land An ↑ in house prices, which ↑ their value relative to replacement cost, ↑ Tobin’s q ... firms The asymmetric view of credit market imperfections has proved useful in explaining the existence and structure of financial institutions and why crises are so damaging to the economy Monetary...
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Tài liệu Women''''s attitudes towards mechanisms of action of family planning methods: survey in primary health centres in Pamplona, Spain doc
Ngày tải lên :
13/02/2014, 06:20
... in inconsistent responses We found inconsistencies in 12.2% of the sample, indicating the difficulties in communicating the information about the mechanism of action To assess the influence of ... would consider using and would stop or continue using In addition, hypothetical choices were examined in terms of a non-specific "method of family planning" and not in terms of actual methods ... understanding of the beginning of human life This understanding is however not restricted to Catholicism and can also be found in other countries [28,29] The independent importance of religion...
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Tài liệu Báo cáo khoa học: Mechanisms of amyloid fibril formation – focus on domain-swapping doc
Ngày tải lên :
14/02/2014, 18:20
... structurally and functionally analogous and those studied so far show evidence of 3D domain-swapping both in vitro and in vivo Human cystatin C is a member of the cystatin II family of cysteine cathepsin ... accumulation of protein aggregates Understanding the rules governing protein folding should lead to a better understanding of protein ‘misfolding’ (i.e folding to an alternative, often multimeric ... et al Domain-swapping and amyloid fibril formation Fig Involvement of domain-swapping in amyloid fibril formation of cystatins (A) Stefin A monomer (Protein Data Bank code: 1dvc) and domain-swapped...
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Tài liệu Báo cáo khoa học: Survival mechanisms of pathogenic Mycobacterium tuberculosis H37Rv ppt
Ngày tải lên :
16/02/2014, 15:20
... be involved in the transport of lipids and shown to be required in the production of a sulfated glycolipid, sulfolipid-1 the Src family of protein tyrosine kinases These kinases result in the increased ... present In our earlier study, three G-proteins, Era, Obg and LepA of M tuberculosis, were cloned and expressed in E coli Purified proteins showed GTP-binding and hydrolyzing activities [104] A point ... GTP-binding protein Obg in regulating the initiation of sporulation in Bacillus subtilis J Bacteriol 177, 3308–3311 Kobayashi G, Moriya S & Wada C (2001) Deficiency of essential GTP-binding protein...
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Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx
Ngày tải lên :
18/02/2014, 06:20
... hormone-binding-globulin, leptin, insulin and insulin resistance in obese men Arch Androl 52, 355–361 Wannamethee SG, Shaper AG, Morris RW & Whincup PH (2005) Measures of adiposity in the identification ... factors and decreased antiinflammatory cytokines [125,126] Interestingly, testosterone therapy prevents a gain in visceral adipose tissue in non-obese aging men, and reduces the production of proinflammatory ... disrupter and in uence the endocrine milieu by reducing the levels of luetinizing hormone 5758 (LH) and testosterone resulting in hypogondoropichypogonadism The increased aromatase activity of the...
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Tài liệu Báo cáo khoa học: Reaction mechanisms of thiamin diphosphate enzymes: redox reactions pdf
Ngày tải lên :
18/02/2014, 08:20
... suspected to bind Electron tunneling is likely to proceed dominantly in a through-bond mechanism involving the backbone and coordinating cysteinyl ligands of the iron-sulfur clusters Clusters B and C ... analysis of substrate turnover revealed that two moles of final oneelectron acceptor ferredoxin are reduced per mole of pyruvate in the presence of CoA There are several lines of evidence indicating ... additional E3 binding protein and specific kinases and phosphatases, which control the activity of the complex by reversible phosphorylation ⁄ dephosphorylation of serine side chains in E1 [4] Initially,...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
Ngày tải lên :
19/02/2014, 16:20
... benzene ring of aniline to yield p-aminophenol [151] Formation of the oxygenating species has been recognized to be facilitated by the binding to HbO2 of aniline and some of its derivatives, causing ... exhibiting insignicant sequence identity with P450s in the heme-binding region [282], but bearing a C-terminal avoprotein fragment in the single polypeptide chain structurally resembling NADPH-P450 ... reduction and oxidation of myoglobin and hemoglobin by nicotinamide adenine dinucleotides and avins J Biol Chem 244, 67026706 151 Adams, P.A & Berman, M.C (1982) Hemin-mediated para hydroxylation of...
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Motivating Better Hygiene Behaviour: Importance for Public Health Mechanisms of Change doc
Ngày tải lên :
05/03/2014, 21:20
... feeding, hand washing, food preparation, latrine cleanliness and hygienic handling of dung cakes for fuel Messages focused on practical understanding of — reused Understanding existing practices and ... law Enablings factors were time and housing space Water storage, infantfeeding, hand washing, food preparation, latrine hygiene and hygienic handling ofdung cakesforfuel; understanding, influence, ... fingertip rinses Hand- and dishwashing; facilitation, understanding; Thailand 36 Sandhu, S.K et al (1977) Adoption of modern health and family planning practices in a rural community in India International...
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Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt
Ngày tải lên :
07/03/2014, 03:20
... demonstrating that natural and synthetic CBs could attenuate neuronal injury in models of global [30,31] and focal [32–34] ischemia in vivo, although, at least in models of permanent MCAO, CB1-induced ... activation in ischemia, a role that was referred to as the ‘dark side’ of endocannabinoids in a report describing the toxic effects of intracerebroventricular administration of anandamide [43] In these ... post-ischemic increase in the levels of striatal anandamide with an increased activity of N-acylposphatidylethanolamine-hydrolyzing phospholipase D and reduced activity and expression of FAAH Both...
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Báo cáo khoa học: Molecular mechanisms of the phospho-dependent prolyl cis ⁄ trans isomerase Pin1 docx
Ngày tải lên :
07/03/2014, 05:20
... ARE-containing cytokine mRNAs interact with AUF1 factors, and this interaction targets them for degradation Pin1 interferes with this interaction, and hence stimulates cytokine production In the resting ... domain of IRF-4 In the same field of immunology, Pin1 also regulates the production of such proinflammatory cytokines as granulocyte–macrophage colony-stimulating factor [80], interleukin-2 and interferon-c ... Schematic view of the parallel between Pin1 and CKS in protein degradation Top: Model of the SCFCDC4 E3 ligase and the role of Pin1 Pin1 is brought in with the cyclin E substrate, through interaction...
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Báo cáo khoa học: Two L-amino acid oxidase isoenzymes from Russell’s viper (Daboia russelli russelli) venom with different mechanisms of inhibition by substrate analogs pdf
Ngày tải lên :
07/03/2014, 05:20
... funnel in L2, having one allosteric ligand-binding site of predominant hydrophobicity Binding of OAB in the substrate-binding site was proposed to be similar to binding of the natural substrate in ... Mutually exclusive binding of OAB, NAT and NATA indicates that the binding sites of these inhibitors are the same or overlapping Taken together, all these kinetic ndings are indicative of a different ... enzyme is composed of three parts: an FAD- C O H2O binding domain, a substrate-binding domain, and a helical domain The interface between the substrate binding and helical domains forms a 25 A...
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Báo cáo khoa học: Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail A comparative study of acylation systems of phospholipids in rat and the fish species Seriola quinqueradiata pot
Ngày tải lên :
08/03/2014, 08:20
... phosphatidylethanolamine (PtdEtn) and the mixture of phosphatidylserine (PtdSer), PtdIns and sphingomyelin The fatty acid compositions of PtdCho, PtdEtn, PtdSer and PtdIns of brain, heart, spleen, kidney and ... enrichment of arachidonate in PtdIns in mammals Further experiments are needed to clarify the involvement of the PtdIns cycle in the accumulation of arachidonic acid in PtdIns of fish Fig Effects of docosahexaenoic ... Protein kinase C activity in the spleen of trout (Salmo gairdneri) and the rectal gland of dogfish (Scyliorhinus canicula), and the effects of phosphatidylserine and diacylglycerol containing (n-3)...
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