evaluation of the evidence for adequacy of the measurement properties

... number of variables, which were possibly relevant for the quality of patient ratings of HRQoL, were measured for the purpose of describing the sample of patients, as well as for assessing the quality ... and standard deviations for the QLQ-C30 scales, as well as for the characteristics of the patients were calculated The internal consistency of the multiitem scales of the QLQ-C30 was assessed ... and the EORTC QLQ-C30 questionnaire data collected during the previous (in-clinic) measurement wave at T2 Procedure To assess the impact of different MOA’s on the measurement performance of the...

Ngày tải lên: 12/08/2014, 01:21

... achieved by calculation of the portion of the total area under the curve occupied by the dimers peak The obtained value was divided by two MALDI-TOF MS was performed at The Institute of Nuclear Physics, ... compared to the 90% loss of Trp after the completion of this reaction We confirm that the process is nonstoichiometric and that the amount of LRET depends on the primary structure of the protein ... 2) The yields of fragmentation (Table 2) vary for these proteins Discussion In this work, we performed a comparative study of the oneelectron oxidation of six proteins from the c-type family of...

Ngày tải lên: 17/03/2014, 10:20

... not in the highest risk category The limitations of these studies notwithstanding, the weight of current evidence suggests that routine use of the PAC is not useful for the vast majority of patients ... outcome, therapy, clinician behaviour The majority of evidence to support the use of Presep ScvO2 catheters comes from the work of Rivers and coworkers [6], but there are also a number of optimization ... assess the adequacy of perfusion is an extremely attractive concept As a consequence of the stoichiometry of the reactions responsible for the substrate level phosphorylation of ADP to form ATP,...

Ngày tải lên: 12/08/2014, 22:22

... use evaluation often takes place before the course starts with the aim to select the appropriate materials most appropriate for the particular group of learners and for the aims of the course Formative ... designers Therefore, they can provide the most valid information in the evaluation process Also, their understanding of cultural and political factors of the institution in which the evaluation ... seeks their opinions about the content of the material Part C asks for their opinions about the methodology Part D requires them to offer suggestions for the material’s further improvement The...

Ngày tải lên: 07/11/2012, 14:50

... Another major factor was the reduction of water use in the factory through the utilization of WWR and water conservation efforts mainly due to their cost consciousness after the introduction of ... calls for water conservation They also continuously make efforts to promote the utilization of SWT devices including the distribution of free SWT-tap developed by them as shown in Fig.7 On the other ... parties during the time regarding the charging system The debate for the adequacy of such system was between the capitalist party and socialist party The capitalist party opposed it, since the system...

Ngày tải lên: 05/09/2013, 10:17

... validity The experts pointed out their level of accordance with the relevance of the items, ease of understanding and adequacy as an instrument to characterise the management models of the PA programmes ... on the reasons for the use of quality schemes and pointed out the advantages of their implementation in improving services [24,55,56] On the other hand, Ritchie and Dale suggest the existence of ... this criterion, most of the leaders of our study reported that everybody had full access to the information about the mission and objectives of the PA programme In the field of Higher Education,...

Ngày tải lên: 14/02/2014, 06:20

... on the preliminary conformation of the protein and the coordination properties of the incoming metal ions Metallation of apo-a-rhMT-1a with Cd2+ was carried out at pH 7.3 by raising the pH of the ... Sequence of the a domain of rhMT-1a, showing the connectivities of the four divalent metal cations to the 11 cysteinyl sulfurs The numbering of the cysteines (1–11 starting from the N-terminus) and the ... binding for M2+ (M ¼ Zn, Cd) initially to the a domain, thereby leading to formation of the M4a cluster prior to formation of the M3b cluster, demonstrating that the individual binding constants of...

Ngày tải lên: 19/02/2014, 00:20

... in the presence of substrate and a proton motive force [23] On the basis of these studies, it has been proposed that binding of substrate to the TatBC subunits triggers the recruitment of the ... of the mutants exhibited unexpected properties when compared with previous findings The effects of the mutations were analyzed using two types of export assay The first involves expression of the ... rearrangements of the TM spans of these subunits It has not been established whether these TM spans simply anchor the amphipathic regions and cytosolic 2272 domains to the membrane, or whether they serve...

Ngày tải lên: 19/02/2014, 17:20

... qualitative evaluation of lexical association measures, mainly for the following reasons: the instability of precision values obtained from the rst few percent of the data in the SLs; the lack of signicant ... precision values above 50% for the rst 10% of the list, but is outperformed by the t-test afterwards Looking at the rst 40% of the data, there is a big gap between the good measures (t-test, ... will often produce misleading results For instance, if we just look at the rst of the SLs for the PNV data, we might conclude that the t-test and frequency measures are equally well suited for the...

Ngày tải lên: 20/02/2014, 18:20

... followed their own customs and traditions in using the forest and land as they had done since the time of their ancestors The National Forest Meeting in 1989 raised the importance of the forest for the ... on the Management of Forest and Forest Land in 19892 certified the change in objectives for the use of the forest and forest land so that it can be used for the development of the economy, including ... Ministers on the protection of the Forest, 74, on 17 July 1979, (Forestry Strategy of Lao PDR 2020, 2005: 3) Decree of the Assembly of Ministers on the management and use of the forest and forest land...

Ngày tải lên: 21/02/2014, 04:20

... understanding of the function and organization of the enzyme complex, the analysis of mutant alleles of the genes involved in the biosynthetic pathway can certainly provide valuable information In ... to the loss of a functional myristoylation site could determine the alteration of the local molecular environment conditions required for the association of the different enzyme monomers or for ... sequence analysis of the carB mutant alleles To check if strain A486 was altered in the carB gene, and in order to get further insights into the nature of the mutations of the carB gene in strains...

Ngày tải lên: 22/02/2014, 04:20

... have the ability to convert the major circulating form of vitamin D, 25(OH)D, into the active hormonal form, 1,25(OH)2D So, there is a local mechanism in many tissues of the body for converting the ... urinary secretion of isothiocyanates, was inversely related to the risk of breast cancer; the quartile with the highest intake only had 50% of the risk of the lowest intake group [89] In the Nurses' ... protein) in the methylenetetrahydrofolate reductase and the methionine synthase genes which increase the relative amount of folate available for DNA synthesis and repair also reduces the risk of colon...

Ngày tải lên: 06/03/2014, 02:21

... addition, the majority of the lesions examined appear to be of the Class I type, rather than Class II lesions for which the technology would have the greatest potential benefit Finally, since 1/3 of the ... appropriate to the purpose of the test? Use examiners representative of the target or primary clinical providers of the test? Show evidence that the test can distinguish cancer/precancer from other conditions ... Critical evaluation of diagnostic aids for the , Oral Oncol (2007), doi:10.1016/j.oraloncology.2007.06.011 ARTICLE IN PRESS Critical evaluation of diagnostic aids for the detection of oral cancer then...

Ngày tải lên: 06/03/2014, 02:21

... coupling constant of the spectrum of the turnover form of the T2Cu center are slightly different from that of the as-puried form (cf Table 2) which suggests the existence of modications in the catalytic ... catalytic center of the enzyme These modications may be attributed to either the presence of the substrate and/or a product in the vicinity of the T2Cu active center rather than to disruption of this ... surface area of 0.018 cm2 Before each measurement, both the cell and the sample (70100 lL) were ushed with argon for 15 During the measurements the solution was kept under a ow of argon The voltammetric...

Ngày tải lên: 07/03/2014, 15:20

... clarify the binding properties of each of these domains we generated synthetic mRNA encoding only the C1 or C2 domains Expression of only the C1 domain resulted in the dorsalization of embryos ... and XI of the receptor serine ⁄ threonine kinase domain [22] Another striking point is the phase conservation of the intron– exon boundaries that lie either side of the exon encoding the extracellular ... end and C2 defines the domain closest to the cell membrane A comparison of the inferred amino acid sequence of the C1 and C2 domains reveals that only the approximate spacing of the 10 cysteine...

Ngày tải lên: 07/03/2014, 21:20

... disposition of the proximal His and Asp residues, affecting the imidazolate character of the His, but also by the formation of a LS species The latter indicating the probable binding of His42 to the ... consistent with the very subtle nature of the mutation, i.e the loss of a single methyl group, depicted in green in Fig In marked contrast, for the reduced state comparison of the RR spectra of the Thr171Ser ... impact on the properties of His170 The strength of the hydrogen bond between the proximal His and Asp residues, and thus the imidazolate character of the His is expected to modulate not only the strength...

Ngày tải lên: 07/03/2014, 21:20

... that the presence of the C-terminal domain is crucial for the acquisition of the correct enzyme fold Analysis of the interactions between the two domains led us to presume that expression of the ... or in the absence of chelators (90.94 ± 7.85 UÆmg)1) These results suggest that the presence of calcium is important for the optimal activity of BsArb43B Furthermore, to determine whether the role ... Together, these results confirm that the atom in the cluster is calcium To determine whether the calcium ion has a specific role in the activity of BsArb43B, assays were performed in the presence of...

Ngày tải lên: 15/03/2014, 23:20

... 2B) These results show that Mpl partially lost the cytochrome c; the densitometric analysis of the immunodecoration show a decrease of approximately 50% in the Mpl proteins On the other hand, the ... activation of the iron transport systems [37] Therefore, they are crucial in controlling iron storage and homeostasis in the plant cells Other functions of plant ferritins are, on the other hand, ... Table The theoric molecular mass, 23.6 kDa, calculated from the database sequence after removal of the N-terminus signal peptide, is in agreement with the value of 25–26 kDa estimated from the...

Ngày tải lên: 16/03/2014, 18:20