evaluation of innate immune signaling pathways in transformed cells
Báo cáo y học: "Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish" pdf
Ngày tải lên :
14/08/2014, 08:20
... Phylogenetic trees of the innate immune signaling adaptors and diagrams of their protein structures Phylogenetic trees of the innate immune signaling adaptors and diagrams of their protein structures ... representing the S100A and S100B domains, the red rectangle the intracellular domain of the ligand binding chains, and the gray rectangle the intracellular domain of the non-ligand-binding chains ... short intracellular domain; blue = no intracellular domain; and pink = intermediate length intracellular domain Circled names indicate ligand binding chains Round brackets denote groups of genes in...
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Báo cáo khoa học: Role of Ca2+/calmodulin regulated signaling pathways in chemoattractant induced neutrophil effector functions Comparison with the role of phosphotidylinositol-3 kinase ppt
Ngày tải lên :
08/03/2014, 10:20
... calmodulin and PtdIns3K In guinea pig neutrophils, it has been demonstrated that inhibition of calmodulin results in inhibition of Rac and p21 activated kinases [50] Involvement of Rac in ROS ... effector calmodulin in G-protein-coupled receptor regulated signaling pathways in human neutrophils was investigated Additionally, the role of calmodulin and PtdIns3K in chemoattractant induced neutrophil ... switch of a5b1 integrin in CHO cells, suggesting also a role for Ca2+/calmodulin-dependent molecules in regulating the affinity state of integrins on neutrophils [48] Although PtdIns3K has been...
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Báo cáo sinh học: " The involvement of survival signaling pathways in rubella-virus induced apoptosis" ppt
Ngày tải lên :
18/06/2014, 22:20
... magnitude of RV-induced apoptosis To evaluate the role of PI3K-dependent signaling during RV infection, the effects of PI3K inhibitor LY294002 on the development of RV-induced apoptosis were examined, ... 37°C in 5% CO2 in air Cells were treated, in a final volume of 100 µl, with RV and kinase inhibitors as described above At indicated times p.i., 50 µl of labeling mixture containing XTT (sodium ... Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation Biochem...
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Báo cáo y học: " Differential epithelial expression of the putative innate immune molecule SPLUNC1 in Cystic Fibrosis" pptx
Ngày tải lên :
12/08/2014, 15:21
... in the ionic strength and pH of the airway lining fluid and the increased levels of inflammatory cells present in the inflamed tissues [16] The defects in innate defences become self-sustaining, ... submucosal gland staining in "normal" human airways (A) and a lack of staining in the epithelium of smaller airways (B, C, an enlarged inset of B) Expression of SPLUNC1 is increased in cases of CF (D-H) ... predominantly seen within the inflammatory cell mass in the airway lumen or in isolated cells either infiltrating the epithelium or within the sub epithelial layer The lack of SPLUNC1 staining in...
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Báo cáo y học: "Participation of the PI-3K/Akt-NF-κB signaling pathways in hypoxia-induced mitogenic factor-stimulated Flk-1 " pot
Ngày tải lên :
12/08/2014, 16:20
... while TGF-β inhibits Flk-1/KDR expression through a mechanism that involves reduced binding of GATA-2 to a palindromic GATA site in the 5'-UTR [30] These findings indicate that the binding of specific ... [31] In unstimulated cells, binary complexes of these subunits are restricted to the cytoplasm by interaction with members of a family of inhibitory proteins, inhibitors of κB (IκBs) [32] In response ... transfection of Δp85, a dominant-negative mutant of PI-3K, into SVEC 4–10 cells abolished HIMF-induced phosphorylation of IKK and IκBα (Fig 7C), suggesting that PI-3K signaling acts at upstream of IKK...
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Báo cáo y học: " Lack of effect of glutamine administration to boost the innate immune system response in trauma patients in the intensive care unit" pdf
Ngày tải lên :
14/08/2014, 07:21
... beginning, Number of days since hospital admission before the patients were included in the study; TPN duration, Total duration of the TPN in days; Norepinephrine, Medium dose of norepinephrine ... effects of glutamine on the functionality of the innate immune system are poorly characterized although these effects might be the underlying explanation of glutamine clinical effect on reducing infectious ... complications Taking into account that TLRs play a central role in the activation of the innate system, hence leading to the activation of different intracellular signalling cascades involved in the activation...
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Báo cáo y học: "Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo" ppsx
Ngày tải lên :
14/08/2014, 21:20
... between multiple signaling pathways, the ability to detect the activation status of individual pathways within a complex network of other pathways in the cell is of paramount importance In this manner, ... performed by heating sections in pH 6.0 citrate buffer Sections were then rinsed in PBS and incubated in blocking buffer (5% bovine serum albumin, 0.3% Triton X-100, 10% normal goat serum, in PBS) for ... signature for the TGFβ signaling pathway in mammary epithelial cells, we used a nontransformed murine mammary epithelial cell line (NMuMG) NMuMG cells respond to TGFβ by undergoing epithelial-tomesenchymal...
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Tài liệu An Evaluation of A Participatory Research Approach in Rainfed Lowland Area of Vinh Trach Village, B pptx
Ngày tải lên :
16/01/2014, 21:20
... Number of livestock raising increased - More intensive in farming practices and sustainable use of household resources Farmer’s aware/knowledge: - Active participation of farmers problem definition, ... Supporting Small-Scale Household Farming Development in Rainfed Lowland in Bac Lieu In: Proceedings of the 2002 annual workshop of JIRCAS Mekong Delta Project November 26-28, 2002 College of Agriculture, ... be used for community and household intervention for making plans, setting priorities and evaluating innovations in order to improve household farming and its incomes By those participatory approaches,...
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Trends in Cell Signaling Pathways in Neuronal Fate Decision Edited by Sabine Wislet-Gendebien potx
Ngày tải lên :
16/03/2014, 20:21
... effects in the injured as compared to the uninjured brain 15 16 Trends in Cell Signaling Pathways in Neuronal Fate Decision A major component of the brain post-injury in comparison to the uninjured ... excitotoxic injury to the hippocampus, ablating activin signaling by infusion of the activin inhibitor follistatin potently inhibits post-injury neurogenesis and exacerbates the inflammatory response of ... neurogenesis in the SVZ and DG whereas the BMP inhibitor noggin promotes it [96] In contrast, inhibition of BMP signaling by upre‐ gulation of the BMP inhibitor chordin after lysolecithin-induced demyelination...
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Báo cáo hóa học: "Evaluation of six CTLA-4 polymorphisms in highrisk melanoma patients receiving adjuvant interferon therapy in the He13A/98 multicenter trial" docx
Ngày tải lên :
18/06/2014, 16:20
... provocative findings stimulated detailed investigation of the polymorphisms of CTLA-4 in larger numbers of patients treated in a subsequent study of 152 stage IV melanoma patients at the NIH These investigators ... L, Winans MT, Gorelik E, Lokshin AE: Multiplex analysis of serum cytokines in melanoma patients treated with interferon alpha2b Clin Cancer Res 2007, 13(8):2422-8 Atkins MB, Mier JW, Parkinson ... the second mL was used for CTLA-4 testing The clinical outcome of patients was prospectively followed using standardized testing Clinical staging consisted of medical history, physical exams, blood...
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báo cáo sinh học:" Task shifting in Mozambique: cross-sectional evaluation of non-physician clinicians’ performance in HIV/AIDS care" pdf
Ngày tải lên :
18/06/2014, 17:20
... reports of deficiencies in quality of care, and decided to conduct a nationwide evaluation of quality of HIV/AIDS-related care as provided by TMs Page of description of the selection and training of ... hundred and sixty-nine técnicos were initially reported to have received ART training After inspection of training lists and consultation with provincial HIV/ AIDS coordinators, 53% of these names ... pre-service training 5.5 (0.5-24.5) Months since completion of in- service ART training 13 (3-24) Also completed in- service course on opportunistic infections 24 (54.6%) Months of experience providing ART...
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Báo cáo hóa học: " Evaluation of upper extremity robot-assistances in subacute and chronic stroke subjects" doc
Ngày tải lên :
19/06/2014, 08:20
... grasping, the correlation between the grasping and load force has been often employed in research of human motion and grasping [17,18] as a measure of the level of coordination between grasping ... task We were interested in the impact of various haptic parameters included in the human-robot interaction Catching efficiency and pickand-place efficiency are chosen as the indicators of the task ... subject to focus on a particular function of the exercise, such as reaching or grasping, or coordinated actions that combine reaching and grasping In clinical environments, it is important to appropriately...
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báo cáo hóa học: " Expression of innate immune complement regulators on brain epithelial cells during human bacterial meningitis" docx
Ngày tải lên :
19/06/2014, 22:20
... bind to several Cregs and so evading the host innate immune defense mechanisms [29,39-41] A better understanding of the cellular and molecular innate immune responses in the CNS and deciphering ... upregulated in choroid plexus epithelium in meningitis We next analysed the capacity of epndymal cells and the epithelial cells of the choroid plexus to express Cregs in healthy and inflamed brains Of ... control brains were free of any infiltrating leukocytes, we found robust PMN infiltration in all bacterial meningitis cases The local inflammation was associated with a strong GFAP staining of ependymal...
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báo cáo hóa học:" Evaluation of deformity and hand function in cerebral palsy patients" pdf
Ngày tải lên :
20/06/2014, 01:20
... function in the said population -0.519* 0.011 Informed consent for publication was obtained from patients or their guardians (in case of minors) during enrollment into the study Page of (page ... reliability and validity of Quality of Upper Extremity Skills Test Phys Occup Ther Pediatr 1993, 13(2):1-18 Bruininks H: Bruininks-Oseretsky Test of Motor Proficiency Bloomington, MN: Pearson Assessments; ... [9] and (2) evaluation of the subjects' per- formance in activities of daily living (ADLs) using the Functional Independence Measure for Children (WeeFIM, UB Foundation Activities Inc 2000) Two...
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Báo cáo hóa học: " An international evaluation of ultrasound vs. computed tomography in the diagnosis of appendicitis" doc
Ngày tải lên :
20/06/2014, 23:20
... its use is increasing [15,16,20] In this international study, we compared the performance of CT and US in the evaluation of suspected acute appendicitis in adults in two hospitals, one in the United ... MHz transducer, according to body size Visualization of an incompressible blind-ended appendix measuring more than mm in diameter with additional positive findings, including echogenic periappendicular ... Despite the increase in CT usage in the United States, ultrasound continued to serve as the primary modality in many hospitals in Israel The reasoning behind the use of ultrasound in Israel is...
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Báo cáo hóa học: " Numerical evaluation of laminar heat transfer enhancement in nanofluid flow in coiled square tubes" pdf
Ngày tải lên :
21/06/2014, 03:20
... Department of Mechanical Engineering, National University of Singapore, Engineering Drive 1, Singapore, 117576 Singapore 2Minerals, Metals and Materials Technology Centre, National University of Singapore, ... concentration, decreasing with higher amounts of nanoparticles Aside from higher heat transfer performance, keeping pressure drop at a minimum is of interest for reducing the operating cost and saving energy ... conductivity of working fluids Vajjha et al [24] showed that heat transfer rate increases up to 94% by adding 10% Al2O3 nanofluid and increase up to around 89% by adding 6% CuO nanofluid In addition,...
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báo cáo hóa học:" Research Article Automatic Speech Recognition Systems for the Evaluation of Voice and Speech Disorders in Head and Neck Cancer" pdf
Ngày tải lên :
21/06/2014, 20:20
... Music Processing Perceptual Evaluation A panel of voice professionals perceptually evaluated the intelligibility of each patient while listening to a play back of the recordings A five-point Likert ... favour of the equalappearing interval scale for the sake of comparability with earlier results of our group Hence, for statistical analyses one has to keep in mind that the equal-appearing intervals ... five-point scale and 2.5 ± 1.0 for the group of laryngectomees The effect of the language model is investigated in Table using the OC data With growing n-gram context, the recognition rate increases...
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Báo cáo hóa học: " Research Article Experimental Evaluation of Adaptive Modulation and Coding in MIMO WiMAX with Limited " docx
Ngày tải lên :
22/06/2014, 06:20
... positions resulting in the following three measurement scenarios TX RX (a) In Scenario 1, the table was placed two floors below the transmit antenna in the same building having a non-line -of- sight connection ... connection (b) In Scenario 2, the table was placed in a non-lineof-sight connection in the courtyard next to the transmit antenna (c) A line -of- sight connection was established in Scenario by placing the ... the derivation of the bit error probability of a × Alamouti transmission and a × transmission with maximum ratio combining in [26]) This results in a loss of all performance gains of the Alamouti...
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