... life, with only 22% of the cases diagnosed before the age of 40 [26] We were unable to evaluate the histological characteristics of primary tumors because this information was not available for ... applied for 30 minutes, followed by three 5-min baths with PBS buffer The DAB kit was used for development Counterstaining was carried out with Harris hematoxylin for 20 s after serial rinsing with ... cutoff points for the evaluation of CM patients [3,21-23] In this study, we observed that patients older than 60 years were at greater risk for subcutaneous metastases of CM, and also that age had...
... allele was notassociatedwith an increased risk for RA in a recessive model (GG + GA genotypes versus AA genotype; OR = 0.93, 95% CI = 0.69–1.25) or a co-dominant model (GG versus genotype GA ... polymorphism has convincingly been associatedwith MHC2TA gene expression, it is unclear whether the polymorphism itself is functional or whether it is in linkage disequilibrium with one or more causal ... the need for replication of this association has been raised [13] The aim of this study was therefore to validate and extend the reported association of the MHC2TA -168A>G polymorphism with RA...
... used to distinguish between functional and nonfunctional protein [28] Unfortunately, no DNA is available from our patient cohort and for this reason we cannot correlate MBL genotype and risk of ... Microorganisms were isolated in 57 (50%) of the 115 infections Variables associatedwith major infectious episodes Univariate analyses Results of univariate analyses of potential risk factors for major ... number of opportunistic infections since lupus onset in our patients, a further analysis of variables associatedwith the occurrence of opportunistic infections was not performed The following...
... synovial tissue from patients with rheumatoid arthritis: comparison with patients with osteoarthritis and reactive arthritis Ann Rheum Dis 2005, 64:1780-1782 Page of (page number notfor citation ... similar to that reported in the T1D study [14] Genotypes were not significantly different, indicating that this polymorphism isnot a susceptibility gene for RA (Table 1) To determine whether this marker ... Biosystems) Genotyping was confirmed by DNA sequencing of the six A946T individuals, comprising two of each genotype Page of (page number notfor citation purposes) IFIH1 A946T isnotassociated with...
... number notfor citation purposes) The increased odds for GTPS in women were consistent with prior reports [4,33] The mechanism for increased odds for GTPS in women, however, is unclear [34] This ... with bilateral GTPS) and in 163 subjects without GTPS; therefore, 13.7% of subjects with GTPS had a LLI compared with 14.1% of those without GTPS (P = 0.86 by Fisher's exact test) Adjusting for ... http://arthritis-research.com/content/10/3/R62 Figure Results Participants A total of 1,482 subjects (2,877 lower limbs) were eligible for analysis of GTPS Leg-length information was missing for 52...
... Arthritis Research & Therapy Vol 11 No Toms et al Competing interests The authors declare that they have no competing interests Acknowledgements This work is supported by an Arthritis Research ... presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study Arthritis Res Ther 2008, 10:R145 Page of (page number notfor citation purposes) ... Arthritis Research Campaign infrastructure support grant (grant number 17682, given to the Dudley Group of Hospitals NHS Foundation Trust, Department of Rheumatology) HJ is supported by an Arthritis...
... variant appears to be associatedwith a decreased risk for developing lung cancer and laryngeal cancer [30] In this case, CHK2 alterations may be not predisposing but protective for head and neck ... denaturing for 15 sec at 94°C, annealing for 15 sec at 63°C, and extension for 45 sec at 72°C followed by cycles of denaturing for 15 sec at 94°C, annealing for 15 sec at 58°C, and extension for 45 ... and patients who are at low risk for SCCHN with regard to age or carcinogen abuse Methods and Patients Patients The study consists of 91 consecutive patients with histologically confirmed SCCHN,...
... SNP with disease isnot the same in all patient groups and categories, as has been noted in previous studies that could not always confirm the originally observed association of the -945GC SNP with ... We found that plasma CTGF levels were notassociatedwith this polymorphism, which further questions its relevance in diabetic kidney disease In contrast, it has recently been shown that the ... the polymorphism on in vivo CTGF transcription and translation Therefore, we compared genotype differences for the -945CG polymorphism with plasma CTGF levels in DN and NA patients with diabetes...
... the distortion caused by confounding effects, multivariate analysis was performed The multiple logistic regression analysis demonstrated that neither genotypes nor alleles were associatedwith ... with periodontitis, even after adjusting for covariates, including age, gender and smoking status (Table 2) Therefore, this polymorphism could not be considered a genetic risk for CP in the studied ... could be envisaged aiming prevention of disease establishment However, many studies with different populations would be needed to reach a high-risk profile for periodontal disease [16] Another important...
... (SALS), not showing any familial trait Approximately 10% of cases are familial (FALS), and within these lie several distinct forms of the disease The most common form of FALS is autosomal dominant for ... same geographical area, suggesting that this aminoacidic substitution isnot causative of the disease The data presented herein suggest that VAPB mutations are not a common cause of adult-onset ... ALS suggesting that mutations in this gene are a rare cause of non familial forms of ALS [14,15] The finding by Nishimura et al.[16] of a missense mutation in the VAMP/synaptobrevin -associated membrane...
... we hypothesised that this risk would not be restricted to RA Therefore, we also genotyped TRAF1/C5 in a large cohort of elderly people that were prospectively followed in PROSPER This large cohort ... evidence for an association of this risk factor with mortality was observed Panoulas and colleagues recently observed an increased mortality risk for carriers of the TRAF1/C5 susceptibility risk genotype ... in women diagnosed with rheumatoid arthritis Circulation 2003, 107:1303-1307 doi:10.1186/ar2947 Cite this article as: van Nies et al.: TRAF1/C5 polymorphism isnotassociatedwith increased mortality...
... compared with Student's t test or analysis of variance for normal values, or with the Mann-Whitney test for nonparametric data p < 0.05 was considered to denote statistical significance The factors associated ... The patients with documented extra-digestive bleeding were excluded from this analysis aStatistical significance: p < 0.01 with univariate analysis bStatistical significance: p < 0.05 with univariate ... associatedwith bleeding during ICU stay were also studied with multivariate analysis Variables with p < 0.25 in univariate analysis were selected A multivariate logistic regression model with bleeding...
... patients that died soon after admission APACHE II expected mortality calculation is validated only after an eight-hour observation period [5] This isnot so for SAPS II but it is conceivable that ... mostly about ICUs without 24-hour intensivist coverage The present study isnot informative on this subject Finally, hospital mortality is only a small part of quality of care We did not study patient, ... study, in our opinion, this is unlikely However we cannot prove that the quality of care does not differ between daytime and off hours Excluding patients that were in the ICU for less than eight hours...
... admission, higher SAPS II score, older age comorbid liver cirrhosis, and mechanical ventilation on admission, but not a history of insulin-treated diabetes, were associatedwith an increased risk ... Characteristics of the study group on admission to the intensive care unit in patients with and without a history of insulin-treated diabetes No history of insulin-treated diabetes (n = 2921) History ... multivariate analysis in one study [23], but it was notassociatedwith increased mortality in patients with community-acquired bacteremia in another study [24] In patients with acute myocardial...
... recommended, isnotassociatedwith AKI, even in patients with kidney dysfunction on admission Key messages • Resuscitation with low volume of HES 130 kDa/0.4 isnotassociatedwith AKI Abbreviations ... limitations We performed a retrospective practice survey Our results not support that HES are not nephrotoxic, but suggest that in our daily practice, their use isnot directly associatedwith AKI However, ... Mortality was recorded in the ICU only Statistical analysis Comparisons between groups were performed using chisquared test or Fisher’s exact test for categorical parameters Continuous variables...
... patterns that did not depart from those expected, though a trend towards a deficiency of 2st in the progenies of males heterozygous for 2st was density was not under 2jzcannot be ruled 2st/jzperformed ... collections were performed in A Escobar in March 1989 by means of banana baits and with Opuntia vulgaris rotting cladodes, in order to test the assumption that flies were not differentially attracted ... this analysis it may be concluded st l /st that a deficiency of 2st bearing individuals occurred in all cases These results could suggest gametic selection against 2st To test this hypothesis,...
... kg/m2) was associatedwith a 3.1% increase in AHR risk (CI 1.01–1.05; p , 005) in all subjects For men, this risk was 3.4% (CI 1.01–1.06) for one unit of increased BMI (1 kg/m2) and for women ... significant risk factor for AHR at all levels of obesity for females but only for higher levels of obesity for men.11,21,22 Discussion We found obesity to be a significant risk factor for AHR in ... Study suggest that a 25 kg weight gain was associatedwith a 2.5-fold increase in the risk for diagnosis of asthma compared with no significant weight gain.11 In a cross-sectional analysis of 18,000...
... mechanisms associatedwith this unusual gene organization, which provided the opportunity for dsRNA formation as a result of the annealing of a sense and antisense transcript The assumption that ... Genome Biology 2005, Volume 6, Issue 6, Article R51 Jen et al R51.3 Table COPs with sense-antisense overlaps within the coding regions Annotation Antisense gene ID Annotation ORF overlap (bp) AT1G08260 ... data for all 1,437 microarrays that were available For each microarray, we calculated the proportion of transcripts that were expressed, both for the total gene pool comprising 22,746 genes and for...
... authors suggested that the homozygosity for the MTHFR C677T polymorphism was associatedwith an increased risk of coronary heart disease [9,22] whereas others failed to demonstrate this association ... compared with the control This impairment in the glycemic control most probably reflects a state of insulin resistance Elevated homocysteine isassociatedwith several cardiovascular disease risk ... statistically Statistical analysis of the data analysis was carried out using the ANOVA test Prevalence of alleles and genotype among cases and control subjects were counted and compared with...